• Land and Housing Review
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• v.7 no.4
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• pp.165-175
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• 2016

The Sejong Metropolitan Autonomous City is launched on July 1, 2012, and Phase 1 of the Multifunctional Administrative City Construction Project was completed in late 2015. Therefore, it is necessary through the results of the first phase of the project to check whether Sejong city can achieve the target population and number of households by 2030 and to use to determine the number and type of housing to be supplied next. Based on the presented results of the Phase 1 project period, this study estimate the population and number of households in 2030. For forecasting future population the population growth rate seen in the future of Sejong City's population forecast published by the National Statistical Office and the performance against plans Step 1 were used for forecasting future population. The results of analysis showed that the Multi-functional Administrative City is difficult to attract five hundred thousand people and two hundred thousand houses. In the analysis of households by type The Multi-functional Administrative City is The large proportion of 3-4 person households and high-income earners and Homeowners. But it increased the proportion of households with 1-2 people and rent house of the city grows in size and it is likely to change the level of income. Therefore, it is determined that there is a need to reflect these elements in next housing.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.9 no.2
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• pp.360-369
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• 2008

The solar cells should be operated at the maximum power point because its output characteristics were greatly fluctuated on the variation of insolation, temperature and load. It is necessary to install an inverter among electric power converts by means of the output power of solar cell is DC. The inverter is operated supply a sinusoidal current and voltage to the load and the interactive utility line. In this paper, the proposes a photovoltaic system is designed with a step up chopper and single phase PWM voltage source inverter. Synchronous signal and control signal was processed by one-chip microprocessor for stable modulation. The step up chopper is operated in continuous mode by adjusting the duty ratio so that the photovoltaic system tracks the maximum power point of solar cell without any influence on the variation of insolation and temperature for solar cell has typical dropping character. The single phase PWM voltage source inverter is consists of complex type of electric power converter to compensate for the defect, that is, solar cell cannot be develop continuously by connecting with the source of electric power for ordinary using. It can be cause the efect of saving electric power, from 10 to 20%. The single phase PWM voltage source inverter operates in situation, that its output voltage is in same phase with the utility voltage. The inverter are supplies an ac power with high factor and low level of harmonics to the load and the utility power system.

• Proceedings of the Korean Vacuum Society Conference
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• 2013.02a
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• pp.108-109
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• 2013

Mitochondria play key roles in the production of cell's energy. Their dominant function is the synthesis of adenosine 5'-triphosphate (ATP) from adenosine diphosphate (ADP) and phosphate (Pi) through the oxidative phosphorylation. Evaluation of drug-induced mitochondrial toxicity has become increasingly important since mitochondrial dysfunction has recently been implicated in numerous diseases including cancer and diabetes mellitus. Mitochondrial functions have been monitored via oxygen consumption, mitochondrial membrane potential, and more importantly via ATP synthesis since ATP synthesis is the most essential function of mitochondria. Various analytical methods have been employed to investigate ATP synthesis in mitochondria, including high performance liquid chromatography (HPLC), bioluminescence technique, and pH measurement. However, most of these methods are based on destructive analysis or indirect monitoring through the enzymatic reaction. Infrared absorption spectroscopy (IRAS) is one of the useful techniques for real-time, label-free, and direct monitoring of biological reactions [1,2]. However, the strong water absorption requires very short path length in the order of several micrometers. Transmission measurements with thin path length are not suitable for mitochondrial assays because solution handlings necessary for evaluating mitochondrial toxicity, such as rapid mixing of drugs and oxygen supply, are difficult in such a narrow space. On the other hand, IRAS in the multiple internal reflection (MIR) geometry provides an ideal optical configuration to combine solution handling and aqueous-phase measurement. We have recently reportedon a real-time monitoring of drug-induced necrotic and apoptotic cell death using MIR-IRAS [3,4]. Clear discrimination between viable and damaged cells has been demonstrated, showing a promise as a label-free and real-time detection for cell-based assays. In the present study, we have applied our MIR-IRAS system to mitochondria-based assays by monitoring ATP synthesis in isolated mitochondria from rat livers. Mitochondrial ATP synthesis and hydrolysis were in situ monitored with MIR-IRAS, while dissolved oxygen level and solution pH were simultaneously monitored with O2 and pH electrodes, respectively. It is demonstrated that ATP synthesis and hydrolysis can be monitored by the IR spectral changes in phosphate groups in adenine nucleotides and MIR-IRAS is useful for evaluating time-dependent drug effects of mitochondrial toxicants.

• Journal of Korea Water Resources Association
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• v.53 no.spc1
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• pp.785-795
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• 2020

Recently, the integrated management of the quantity and quality of water was been derived by the Ministry of Environment in Korea. This reconstruction in the national government organization can be recognized as the major politic measure. For this IWRM (Integrated Water Resources Management), it is necessary to be able to fairly distribute, operate and manage water resources in a situation where related techniques are needed to fully support, such as measuring exactly the demand and supply of water resources. The reason why IWRM is difficult, despite the development of related technologies, is because the management entities are highly diverse and their interests are much complicated. Thus, this study is tried to suggest specific improvement for current policies by benchmarking the KPX (Korea Power Exchange). In the field of water management as similar to the electric industry, there is an essential need for a working-level organization that can manage, control, monitor, and regulate water resources with practical and plenipotentiary control like the non-profit organization, KPX. Such time has come for decisive policy changes through benchmarking the structure, system, productivity, and challenges of the electricity industry in the water policy.

• Environmental and Resource Economics Review
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• v.19 no.3
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• pp.597-632
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• 2010

There is general agreement that global warming is occurring and that the main contributor to this probably is the buildup of green house gasses, GHG, in the atmosphere. Two main contributors are the utilization of fossil fuels and the deforestation of many regions of the world. The burning of fossil fuels increases atmospheric carbon while the burning of fuel-wood reducing fossil fuel consumption along with its forest source maintain an atmospheric carbon level. The standing timber in the forests is a carbon sink, as are wood buildings and structures, and fossil fuel in the ground. This paper is designed to examine a number of current issues related to mitigating the global warming problem through forestry. For this purpose, we develop a modeling approach by integrating timber market, fossil fuel market and carbon cycling model. We use discrete time optimal control theory to identify optimal time paths, the laws of motion, and stationary stats solutions of endogenous variables in the model. On the basis of these results, we identify the optimal amounts of subsidies to be provided or taxes to be imposed by the regulatory agency to mitigate atmospheric carbon accumulation. We also present a numerical example to help illustrate the characteristics of variables in the model when the social cost for atmospheric carbon incrementally shifts upward. A surprising result is that the social cost function for atmospheric carbon has a very smaller impact on the optimal rotation period than previous literature suggested.

• Interdisciplinary Bio Central
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• v.1 no.2
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• pp.7.1-7.7
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• 2009

"To be, or not to be?" This question is not only Hamlet's agony but also the dilemma of mitochondria in a cancer cell. Cancer cells have a high glycolysis rate even in the presence of oxygen. This feature of cancer cells is known as the Warburg effect, named for the first scientist to observe it, Otto Warburg, who assumed that because of mitochondrial malfunction, cancer cells had to depend on anaerobic glycolysis to generate ATP. It was demonstrated, however, that cancer cells with intact mitochondria also showed evidence of the Warburg effect. Thus, an alternative explanation was proposed: the Warburg effect helps cancer cells harness additional ATP to meet the high energy demand required for their extraordinary growth while providing a basic building block of metabolites for their proliferation. A third view suggests that the Warburg effect is a defense mechanism, protecting cancer cells from the higher than usual oxidative environment in which they survive. Interestingly, the latter view does not conflict with the high-energy production view, as increased glucose metabolism enables cancer cells to produce larger amounts of both antioxidants to fight oxidative stress and ATP and metabolites for growth. The combination of these two different hypotheses may explain the Warburg effect, but critical questions at the mechanistic level remain to be explored. Cancer shows complex and multi-faceted behaviors. Previously, there has been no overall plan or systematic approach to integrate and interpret the complex signaling in cancer cells. A new paradigm of collaboration and a well-designed systemic approach will supply answers to fill the gaps in current cancer knowledge and will accelerate the discovery of the connections behind the Warburg mystery. An integrated understanding of cancer complexity and tumorigenesis is necessary to expand the frontiers of cancer cell biology.

• Journal of The Korean Association of Information Education
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• v.8 no.3
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• pp.335-349
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• 2004

Recently, there is change the environment of education due to development of Science Technology Specially, As education information on web increased by internet, using education web data by mean of medium that aids learning by computer. Also It studied method that used the Computer as learning medium through the CAI(Computer Assisted Instruction), ICAI(Intelligent CAI), and ITS(Intelligent Tutoring System). But legacy system are not support efficient method that learns to vary learner suitable learning method by individual level. Specially It is not suitable the education course to direct current course of education, and not consider different of student capability, aptitude, need, interesting, not maximized the individual growable power and effect of education. To solve the this problem, our paper suggest the web-based self-directed MITS(Multimedia ITS) that supply the needed the information on web, make the environment that can self-directed learning. To maximized effect of individual learning, our paper structured coursed, characterized, related learning contents in region of numeral at mathematics of primary school. And then integrated contents and class, design and implement the web-based MITS that consist of 4 module to escape from limitation of learner grade, learning time, learning place.

• Journal of Korea Water Resources Association
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• v.48 no.6
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• pp.501-509
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• 2015

Lately multipurpose dam is required to consider various interests such as quality, ecological environment as well as flood control, water supply, hydropower generation, etc. The objective of this study is to investigation and analysis of water temperature in the areas where there are social conflicts due to cold water outflow. In this study, we monitored water temperature of Juam regulation dam, downstream river, Suncheon bay in a long term period and performed comparative analysis on a change of water temperature in downstream river and Suncheon bay by using three-dimensional numerical mode (EFDC) considering various external factors such as water outflow amount. The result of monitoring and numerical modelling indicates that effects of cold water outflow takes place from april to september. Also effects of the low temperature discharge of dam was complicatedly altered by various factors such as outflow time and amount, weather and tide level conditions etc. The result of this study can be utilized as a basic data for establishing improvement of dam operation plan to minimize negative effects of dam's cold temperature water outflow to downstream river and coastal area.

• Reproductive and Developmental Biology
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• v.30 no.3
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• pp.181-187
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• 2006

In recent years the number of patients waiting for organ transplantation has greatly outpaced the supply of human organs available, which leads to a renewed interest in pig-to-human xenotransplantation as an alternative. However, one of the biggest barriers in the xenotransplantation is presence of porcine endogenous retroviruses(PERV) that can infect human cells. In this study, to present a possible solution for this problem we tried to inhibit expression of PERVs using shRNAs(short hairpin RNA) at the level of RNA synthesis and virus release. The shRNA targeting the sequence of PERV A, B type was cloned into pSIREN-RetroQ vector under the control of polymerase-III U6-RNA gene promoter. Quantitative real-time PCR was performed to detect my alterations in mRNA production of PERV A, B targeted by the shRNA in each done. Depending on the target sequence of the shRNA, the transcription of PERV was decreased to as much as 4% and the number of progeny viruses was reduced to less than 1/200,000. Transgenic pigs producing such shRNAs may result in a highly reduced PERV expression in cells and organs, which is a prerequisite for safe xenotransplantations.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.15 no.10
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• pp.6114-6125
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• 2014

This paper analyzed the issues related to focus on farmers behaviors of energy saving facilities. This study conducted questionnaire and field surveys of controlled horticulture farmers and economic analysis using an IPA(Importance-Performance Analysis) matrix. According to the research results, the performance level was low on average ranging from 2.33 to 2.56 in a five point Likert-scale on greenhouse mandarin and grape-related facilities. On the other hand, the importance levels were high in the mean rating from 2.69 to 4.8. The results show that energy loss reduction of complementary facility and alternative energy supply support for low cost implementation are more important in terms of the respondents concerns than performance quadrant III. Therefore, it is important to provide financial support to energy-saving facilities to promote the use of energy efficiency improvement. In addition, the government should invest continuously in research and development.