• The Korean Journal of Applied Statistics
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• v.32 no.4
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• pp.463-483
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• 2019

Since 2000, Korea's total fertility rate (TFR) has been different from that of Japan, Germany, and France where irreversible constants do not change easily in the fertility rate increasing or decreasing phase. It also showed a gradual increase from the minimum fertility level 1.08 in 2005 to 1.23 in 2015, which dropped to 1.17 in 2016, to 1.05 in 2017 and to 0.98 in 2018. This is similar to a double dip in the economic status of a recession. This paper investigates such a TFR increase and decrease factor that predicts the number of births affecting TFR, examines trends in the proportion of married and marital fertility rate broken down by TFR decomposition method. We also examined how these changes affect the change in TFR. According to the results, the number of births is estimated to be between 320 and 330 thousand in 2018, 300 thousand in 2020, 230 and 240 thousand in 2025. The proportion of married is steadily decreasing from 1981 to 2025, and the marital fertility rate is predicted to decline until 2002, then increase from 2003 to 2016 and decrease from 2017 to 2025. Finally, the trend of TFR in terms of number of births, TFR decomposition and statistical model is expected to show 0.98 in 2018, 0.93 to 1.11 in 2020 and 0.76 to 1.08 in 2025.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.20 no.9
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• pp.182-187
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• 2019

With the transition to the era of the Fourth Industrial Revolution, movements of overall change, including technology, society and culture, are becoming increasingly diverse. Among these, even the manufacturing industry, which can be regarded as Korea's leading core industry, is also seeing great changes centered on smart factories. Expert analyses and corporate opinions suggest that smart factories are needed to be competitive in the manufacturing sector. In this study, the impact of small and medium manufacturers' awareness regarding smart factories was analyzed through a survey. The results showed that the need for smart plant construction and the degree of awareness regarding this was very high. In a survey of the planned or implemented level, more companies were expected to deploy, implement, and reduce instruments than those that did not have a plan to build smart factories. The main difficulties involved in deployment were funding problems and the results of the preliminary review phase were derived in order to successfully build a smart factory. Therefore, financial support was most needed to build smart factories, and a need to upgrade the support amount, match it with suppliers for a preliminary review and expand consulting was found.

• Journal of Life Science
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• v.29 no.1
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• pp.29-36
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• 2019

We investigated the fermentation conditions for extracts of leave/branches and sap from Korean Dendropanax morbifera (D. morbifera) using Lactobacillus plantarum (L. plantarum) ilchiwhangchil 1785 and L. plantarum ilchiwhangchil 2020. Log growth phase cultured L. plantarum ilchiwhangchil 1785 and L. plantarum ilchiwhangchil 2020 were used for fermentation. The pH and growth of the microorganisms in broth were monitored during the fermentation period. The results revealed that the optimum fermentation conditions for 20 wt% of leave/branches extracts and 1 wt% of sap extract was 2 days incubation at $37^{\circ}C$. The minimum inhibitory concentration (MIC) method and a disk diffusion assay were used to evaluate the antimicrobial activity of the fermented extracts of the leave/branches and sap against Escherichia coli, Staphylococcus aureus, and Pseudomonas aeruginosa. The antimicrobial activity increased in all three strains grown on the medium containing fermented extracts of the leave/branches and sap as compared with that of the strains grown on medium containing non fermented extracts. Furthermore, the antimicrobial activity increased in proportion to the contents of the fermented extracts. Our data suggest that fermented extracts of leave/branches and sap of D. morbifera have applications as natural bio functional materials, such as preservatives, cosmetic materials, and natural packaging materials.

• Journal of the Korean Institute of Gas
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• v.23 no.1
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• pp.41-46
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• 2019

LNG is supplying to consumers as gas phase vaporized by major seawater vaporizer, i.e.. open rack vaporizers. But as soon as the temperature of seawater drops below $5^{\circ}C$ in winter, the submerged evaporators should be operated and cause a lot of energy consumption because of their natural gas combustion. In order to reduce the consumption amount, in this study new two-way supplying method of seawater instead of the present one-way supplying system is introduced and analysed the technical possibilities and economical savings. The results showed that in case of the temperature of seawater becomes below $2.5^{\circ}C$, LNG can be evaporated using ORV without operating S MV. If this system is applied in Incheon LNG terminal, the energy saving reaches 11,770 Ton of LNG as 11,760 million won. By the analysis, the two-way supplying system of seawater in ORV can be the most effective method to be able to save huge amount of energy every year.

• Journal of Practical Engineering Education
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• v.10 no.1
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• pp.1-7
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• 2018

The dual security system that manages user's account information and uses NFC and OTP has been proposed. It also enhances the security of the user authentication phase by using the features that recognize within the range of less than 1m of NFC and the high security of NFC itself. During the graduation work design process which was carried out for one year and six months in a group of two in the electronics engineering major of the four-year undergraduate system was conducted. In the interim results, we participated in the conferences and thesis contest at the Institute of related to major for three times. Finally passed the examination process for three times judged by 6 professors in the major. The results were published in a graduation thesis together with other people who passed and composed in thesis form. Through the experience gained through these stages of design and production, it has gained the confidence to gain employment opportunities and actively pursue the growth stage, and presented a methodology to practice engineering education through employment.

• Journal of Platform Technology
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• v.9 no.2
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• pp.38-45
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• 2021

A frequently used bioimpedance analytical method in Korea is the segmental multi-frequency BIA (SMF-BIA) method, but it is not directly determined at a segmented impedance. This study was to compare SMF-BIA determinations with direct segmented determinations for accuracy and appropriateness of segment parameters. This study is to compare the segment parameters, accuracy and appropriateness of the multi-frequency segmental bioimpedance analysis. To this end, 108 elderly individuals were measured. Segmented bioelectrical measurements obtained from a SMF-BIA (Inbody S10) at 50 kHz and measured with a phase sensitive single frequency device (SF-BIA, bia-101, RJL / akern systems) were compared. The significant difference (%) was demonstrated between single - and multiple frequency determinations of the right upper limb (R = 35.5 ± 6.2%, P < 0.001; Xc = 2.7 ± 7.6%, P < 0.01), left upper limb difference (R= 33. 9 ± 6.0%, P < 0.001; Xc = 2.8 ± 8.3%, P < 0.01), right lower limb difference (R = 18.6 ± 4.3%, P < 0.001; Xc = 25.8 ± 10.0%, P < 0.001), left lower limb difference (R = 18.0 ± 4.7%, P < 0.001; Xc = 31.8%). Of the results determined with the two BIA methods, the impedance measurements of the limbs and whole body showed a high correlation (RA: R = 0. 950, LA: R = 0. 949, RL: R = 0.899, LL: R = 0.88), and in the agreement test, the impedance values of the upper limbs and whole body also showed strong agreement (ICC > 0.9), but in the Xc, the correlation was weak. In conclusion, it was found that although bioimpedance devices had significantly different characteristics and inconsistent cross sectionally, there was a high population level agreement in the upper and lower extremities in determining segmental resistance value changes. But a large error was found on the trunk. Further studies were needed for reducing the error.

• Animal Bioscience
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• v.34 no.6
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• pp.993-1005
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• 2021

Objective: Zearalenone (ZEA) has estrogen-like effects. Our previous study has shown that ZEA (0.5 to 1.5 mg/kg) could induce abnormal uterine proliferation through transforming growth factor signaling pathway. To further study the other regulatory networks of uterine hypertrophy caused by ZEA, the potential mechanism of ZEA on porcine endometrial epithelial cells (PECs) was explored by the Illumina Hiseq 2000 sequencing system. Methods: The PECs were treated with ZEA at 0 (ZEA0), 5 (ZEA5), 20 (ZEA20), and 80 (ZEA80) µmol/L for 24 h. The collected cells were subjected to cell cycle, RNA-seq, real-time quantitative polymerase chain reaction, immunofluorescence, and western blot analysis. Results: The proportion of cells in the S and G2 phases decreased (p<0.05), but the proportion of cells in the G1 phase increased (p<0.05) in the ZEA80 treatment. Data analysis revealed that the expression of Wnt pathway-related genes, estrogen-related genes, and mitogen-activated protein kinase pathway-related genes increased (p<0.05), but the expression of genetic stability genes decreased (p<0.05) with increasing ZEA concentrations. The relative mRNA and protein expression of WNT1, β-catenin, glycogen synthase kinase 3β (GSK-3β) were increased (p<0.05) with ZEA increasing, while the relative mRNA and protein expression of cyclin D1 (CCND1) was decreased (p<0.05). Moreover, our immunofluorescence results indicate that β-catenin accumulated around the nucleus from the cell membrane and cytoplasm with increasing ZEA concentrations. Conclusion: In summary, ZEA can activate the Wnt/β-catenin signaling pathway by up-regulating WNT1 and β-catenin expression, to promote the proliferation and development of PECs. At the same time, the up-regulation of GSK-3β and down-regulation of CCND1, as well as the mRNA expression of other pathway related genes indicated that other potential effects of ZEA on the uterine development need further study.

• Journal of the Korea Society of Computer and Information
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• v.26 no.4
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• pp.1-9
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• 2021

In this paper, we propose a training algorithm of support vector machine (SVM) with a sensitive variable. Although machine learning models enable automatic decision making in the real world applications, regulations prohibit sensitive information from being used to protect privacy. In particular, the privacy protection of the legally protected attributes such as race, gender, and disability is compulsory. We present an efficient least square SVM (LSSVM) training algorithm using a fully homomorphic encryption (FHE) to protect a partial sensitive attribute. Our framework posits that data owner has both non-sensitive attributes and a sensitive attribute while machine learning service provider (MLSP) can get non-sensitive attributes and an encrypted sensitive attribute. As a result, data owner can obtain the encrypted model parameters without exposing their sensitive information to MLSP. In the inference phase, both non-sensitive attributes and a sensitive attribute are encrypted, and all computations should be conducted on encrypted domain. Through the experiments on real data, we identify that our proposed method enables to implement privacy-preserving sensitive LSSVM with FHE that has comparable performance with the original LSSVM algorithm. In addition, we demonstrate that the efficient sensitive LSSVM with FHE significantly improves the computational cost with a small degradation of performance.

• Applied Chemistry for Engineering
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• v.31 no.6
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• pp.688-696
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• 2020

Petroleum coke (petcoke) is widely used, next to coal, as a gasification feedstock. In gasification processes, the viscosity of the ash and the formation of crystalline phases must be understood to ensure the continuous removal of slag. This study investigates the effect of CaO and V2O3 on petcoke slag viscosity. The viscosity of the molten slag was measured in the temperature range of 1100~1600 ℃ while varying the concentration of each component. The crystalline phases formed in a cooled slag were examined. The most slag samples tested in this study exhibited crystalline slag behavior. The increased CaO concentration resulted in a lower viscosity and a lower Tcv. The viscosity behavior changed from the glassy to crystalline slag and also showed a higher Tcv as the concentration of V2O3 increases. Most slag samples showed different crystalline phases from top to bottom. Anorthites and Ca-V phases were observed in the top and middle section, while the bottom section mainly showed V2O3 and anorthite. The vanadium in the ash forms Ca-V and V-Fe phases and also remains in molten slag. A low melting Ca-V phase can contribute to lowering the viscosity.

• Journal of Life Science
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• v.31 no.3
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• pp.266-279
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• 2021

The present study examined the cytotoxic effects of a Smilax china L. extract (SCLE) in human cancer (A-549, MCF-7, MDA-MB-231, U87-MG, AGS, MKN-74, and SNU-601) and normal MRC-5 fibroblasts, as well as in mesenchymal stem cells derived from dental tissue (DSC). The 50% inhibitory concentration (IC50) values for SCLE were significantly (p<0.05) lower in the cancer cell lines (A-549, MCF-7, MDA-MB-231, U87-MG, AGS, MKN-74 and SNU-601) than in the MRC-5 and DSC cells. Cell growth was significantly (p<0.05) more inhibited in the cancer cell lines treated with 200 ㎍/ml SCLE than in the normal MRC-5 and DSC, and anoikis-like floating cell morphology was observed in the SCLE-treated cancer cells. The cells detached by SCLE treatment were retrieved daily and assayed for viability and telomerase activity. Cells retrieved at 4 days showed significantly decreased viability and telomerase activity (p<0.05), as well as apoptosis-like abnormal morphology, when compared to cells retrieved in the previous 3 days. The ratio of apoptosis and cells in the G1 phase was significantly (p<0.05) increased in the A-549, AGS, and MCF-7 cancer cells treated with SCLE for 4 days compared to untreated controls. However, after SCLE treatment, cell adhesion was not increased by application of an inhibitor of the associated protein kinase (ROCK) that mainly contributes to the increase in cell attachment. This suggests that the cellular detachment by SCLE is probably controlled by a Rho-independent mechanism(s). These observations indicate that SCLE readily induces anoikis in cancer cells and could serve as a potent agent for cancer chemotherapy.