• BMB Reports
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• v.51 no.12
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• pp.642-647
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• 2018

Ubiquitin-conjugating enzyme E2S (UBE2S), a family of E2 protein in the ubiquitination process, is involved in development of various cancers. However, its role in lung adenocarcinoma, has not been well elucidated. In this report, we attempted to investigate expression and function of UBE2S in lung adenocarcinoma. Up-regulation of UBE2S at mRNA, and protein level, was observed in human cancer tissues and lung adenocarcinoma cells. Higher UBE2S expression correlated with poorer prognosis of lung adenocarcinoma patients. UBE2S expression was efficiently suppressed by lentivirus-mediated shRNA strategy in A549 cells, and UBE2S silencing led to reduced cell proliferation, colony formation, and enhanced apoptosis. Inverse results were observed, in UBE2S over-expressed H1299 cells. Microarray analysis indicated that a large number of genes were regulated by UBE2S, and p53 signaling pathway may be critical, to the role of UBE2S in cancer development. Together, UBE2S could be a potential target for lung adenocarcinoma.

• Journal of Korean Society for Quality Management
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• v.31 no.4
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• pp.127-149
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• 2003

With the rapid change in today's R＆D environment and the enlargement of the expected quality level for R＆D outcomes, it has become increasingly necessary to effectively define the R＆D standard processes tailored for our organization and projects. To meet this needs, we defined the R＆D standard processes based on the standards for systems and software engineering and our traditional work methods and applied them to our ongoing projects. We will improve our defined R＆D standard processes continuously by monitoring of the processes and the feedback of the application results. In this paper, we introduce the R＆D standard processes developed by E Research Institute and the requirements and approaches used for their development. We compare our defined R＆D standard processes with ISO/IEC 15288 which is the first international standard for systems engineering.

• Journal of Sensor Science and Technology
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• v.24 no.6
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• pp.368-372
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• 2015

In this paper, we proposed a post-processing technique for improving classification performance of electronic nose (E-Nose) system which may be occurred drift signals from sensor array. An adaptive radial basis function network using stochastic gradient (SG) and singular value decomposition (SVD) is applied to process signals from sensor array. Due to drift from sensor's aging and poisoning problems, the final classification results may be showed bias and fluctuations. The predicted classification results with drift are quantized to determine which identification level each class is on. To mitigate sharp fluctuations moving-averaging (MA) technique is applied to quantized identification results. Finally, quantization and some edge correction process are used to decide levels of the fluctuation-smoothed identification results. The proposed technique has been indicated that E-Nose system was shown correct odor identification results even if drift occurred in sensor array. It has been confirmed throughout the experimental works. The enhancements have produced a very robust odor identification capability which can compensate for decision errors induced from drift effects with sensor array in electronic nose system.

• Journal of Information Technology Applications and Management
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• v.11 no.4
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• pp.181-208
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• 2004

By the developing of Internet. the environments of the company have rapidly been changed. Especially. managers in the Internet shoppingmall have been try to provide excellent e-Services to their customers. e-Service i~ defined comprised of all interactive services that are delivered on the Internet uSing advanced telecommunications. information, and multimedia technologies. but according to study of e-Satisfy. com［2000］. customer service through internet is still neither effective nor efficient and poor service will impact on company's profit but excellent service can improve their value and quality of the service or product. In order to customer-oriented e-Services. this study suggested the QFD linked with e-Service quality model for the Internet shoppingmall service system. which can help determine design characteristics being relevant to customer's e-Service quality requirements. this hybrid model have two stages. In the first stage. we do measure service quality and find priorities of service quality attribute by purchase process. and in the second stage. on the basis of priority of e-Service quality attributes, we find design characteristics to maximize customer satisfaction. From this study, we provide internet shoppingmall managers with the implications for improvement of service quality, measuring quality of e-service, providing design characteristics for customer-oriented service quality.

• Proceedings of the Korean Society of Precision Engineering Conference
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• 2006.05a
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• pp.195-196
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• 2006

Direct laser sintering (DLS) technology for the resign coated sand is one of attractive technologies to produce molds and cores for the foundry industry rapidly and cost effectively. The objective of this case study is to develop casting pilot models using computer simulation technology, DLS RP machine and industrial computed tomography. The proposed casting design was verified by the Z-Cast software in the fields of fluid flow and solidification during the casting process. Casting parts with aluminum alloy using the post-curing treated sand moulds and cores are accurate to dimension and defect free.

• Biotechnology and Bioprocess Engineering:BBE
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• v.7 no.6
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• pp.371-374
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• 2002

Production of poly(3-hydroxybutyrate-co-3-hydroxyvalerate)［P(3HB/V)］, by fed-batch culture of recombinant Escherichia coli harboring a plasmid containing the Alcaligenes latus polyhy-droxyalkanoate (PHA) biosynthesis genes, was examined in two pilot-scale fermentors with air supply only, In a 30 L fermentor having a XLa value of 0.11 S­$^1$, the final P(3HB/V) concentration and the P(3HB/V) content obtained were 29.6 g/L and 70.1 wt%, respectively giving a productivity of 1.37 g P(3HB/V)/L-h. In a 300 L fermentor having a XLa of 0.03 S­$^1$, the P(3HB/V) concentration and the P(3HB/V) content were 20.4 g/L and 69 wt%, respectively giving a productivity of 1.06g P(3HB/V)/L-h. These results suggest that economical production of P(3HB/V) is possible by fed-batch culture of recombinant E. coli in a large-scale fermentor having low KLa value.

• Transactions of Materials Processing
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• v.18 no.1
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• pp.67-72
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• 2009

This paper covers finite element simulations to evaluate tube bending process of auto chassis component i.e. trailing-arm product. The rear of the auto chassis structure is primarily composed of CTBA and trailing-arm. When a car rolls into a corner, the trailing arm reacts to roll in the same degree as the car body. During the bending process of trailing arm the tube undergoes significant deformation. Thus forming defects such as excessive thinning and flattening of the tube will be formed in the outside of the tube. In this paper, we analyzed the effect of process parameters in rotary draw bending process and searched the optimized combination of process parameters using orthogonal arrays method to minimize the forming defects. In this process we analyzed several parameters which are displacement of pressure die, boosting force, initial position of mandrel bar, dimensions of mandrel in regarding to the thinning and flattening of the tube.

• Proceedings of the KIEE Conference
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• 1997.07a
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• pp.86-88
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• 1997

The detection of the normal zones in the coil winding and the initiation of the proper dump sequence have been one of the most important areas in the superconducting magnet technology. In this paper, the process to derive optimal dump sequence has been investigated through quench simulation and analysis of magnetically coupled superconducting magnet system. The magnet terminal voltage and maximum temperature rise in the quench initiated point are calculated with respect to various input variables such as operation current, dump resistance, etc. The experimental system is comprised of sc solenoidal coil, data aquisition device, external circuit breakers and dump resistor. The quench behavior of the magnet(e.g., temperature profile and the voltage signal) was measured. From this results, theoretical predictions were found to coincide with the experimental observations.

• Journal of the Korea Institute of Information Security & Cryptology
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• v.26 no.5
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• pp.1171-1183
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• 2016

Today, many domestic companies often face the lawsuits from the U.S. companies as they expand their business in the U.S. market and it is necessary for the domestic companies to prepare for the e-Discovery process in the systematic manner. Yet, the e-discovery system has not been properly established in Korea, however, domestic companies are growing more and more interests in e-Discovery processes and procedures so that they are seeking for the appropriate actions that they should take when facing lawsuits. When adopting the e-Discovery system in Korea, there are three main considerations including the differences in laws and regulations, enterprise system and language and company culture. This study aims to draw the problems for the Korean domestic companies in responding the U.S. lawsuits and to suggest the specialized e-discovery processes and procedures to effectively overcome them.

• Korean Journal of Materials Research
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• v.23 no.10
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• pp.580-585
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• 2013

To observe the formation of defects at the interface between an oxide semiconductor and $SiO_2$, ZnO was prepared on $SiO_2$ with various oxygen gas flow rates by RF magnetron sputtering deposition. The crystallinity of ZnO depends on the characteristic of the surface of the substrate. The crystallinity of ZnO on a Si wafer increased due to the activation of ionic interactions after an annealing process, whereas that of ZnO on $SiO_2$ changed due to the various types of defects which had formed as a result of the deposition conditions and the annealing process. To observe the chemical shift to understand of defect deformations at the interface between the ZnO and $SiO_2$, the O 1s electron spectra were convoluted into three sub-peaks by a Gaussian fitting. The O 1s electron spectra consisted of three peaks as metal oxygen (at 530.5 eV), $O^{2-}$ ions in an oxygen-deficient region (at 531.66 eV) and OH bonding (at 532.5 eV). In view of the crystallinity from the peak (103) in the XRD pattern, the metal oxygen increased with a decrease in the crystallinity. However, the low FWHM (full width at half maximum) at the (103) plane caused by the high crystallinity depended on the increment of the oxygen vacancies at 531.66 eV due to the generation of $O^{2-}$ ions in the oxygen-deficient region formed by thermal activation energy.