• Preventive Nutrition and Food Science
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• v.22 no.3
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• pp.157-165
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• 2017

Fruits of Sonneratia apetala (Buch.-Ham.), (English: mangrove apple, Bengali: keora) both seeds and pericarps, are largely consumed as food besides their enormous medicinal application. The fruit seeds have high content of nutrients and bioactive components. The seeds powder of S. apetala was successively fractionated using n-hexane, diethyl ether, chloroform, ethyl acetate, and methanol. The fractions were used to evaluate antibacterial, anti-diarrhoeal, analgesic, and cytotoxic activities. Methanol fraction of seeds (MeS) stronly inhibited Escherichia coli strains, Salmonella Paratyphi A, Salmonella Typhi, Shigella dysenteriae, and Staphylococcus aureus except Vibrio cholerae at $500{\mu}g/disc$. All the fractions strongly inhibited castor oil induced diarrhoeal episodes and onset time in mice at 500 mg extract/kg body weight (P<0.001). At the same concentration, MeS had the strongest inhibitory activity on diarrhoeal episodes, whereas the n-hexane fraction (HS) significantly (P<0.05) prolonged diarrhoeal onset time as compared to positive control. Similarly, HS (P<0.005) inhibited acetic acid induced writhing in mice at 500 mg extract/kg, more than any other fraction. HS and diethyl ether fractions of seed strongly increased reaction time of mice in hot plate test at 500 mg extract/kg. All the fractions showed strong cytotoxic effects in brine shrimp lethality tests. Gas chromatography-mass spectrometry analysis of HS led to the identification of 23 compounds. Linoleic acid (29.9%), palmitic acid (23.2%), ascorbyl palmitate (21.2%), and stearic acid (10.5%) were the major compounds in HS. These results suggest that seeds of S. apetala could be of great use as nutraceuticals.

• Asian-Australasian Journal of Animal Sciences
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• v.10 no.3
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• pp.308-312
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• 1997

Incidence of retained placenta in dairy cows was investigated in 120 parturitions. Prior to calving, cows were allotted into four groups; 1) control, 2) the infection of Vitamin E (500 IU), 3) the injection of selenium (40 mg), and 4) the infection of Vitamin E (500 IU) and selenium (40 mg). Selenium (Se) and Vitamin E were injected intramusculary 20 d prior to the estimated calving date. No effects of Se or Vitamin E administration alone was observed for number of service per conception, conception rate, and estrus rate (p > 0.05). But the Vitamin E administration with Se significantly (p < 0.05) reduced the incidence of retained placenta and the days required for calving the first service. Incidence of retained placenta was not significantly (p > 0.05) influenced by parity, but it was significantly (p < 0.01) influenced by season, especially, increased during July and August. Concentration of Se in plasma was not significantly (p > 0.05) changed during peripartum period whether the treatment. The results of this study on retained placenta suggest that this disorder will be reduced by the administration of Se and Vitamin E prior to calving in dairy cows.

• Korean Journal of Food Science and Technology
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• v.42 no.5
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• pp.533-540
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• 2010

Effects of pH (1.8-10.2) and time (56 sec-15 min 4 sec) at high hydrostatic pressure (500 MPa) on the reduction of volatile compounds in garlic were studied. Volatile components of garlic were obtained from the headspace, analyzed, and identified by gas chromatography (GC)-mass spectrometry and an electronic nose. Nineteen sulfur compounds were identified as major compounds in garlic, and furan, aldehydes, alcohols, and ketones were also detected. Off-flavor compounds were more effectively reduced under strong acidic conditions. As the residence time at 500 MPa increased from 56 sec to 15 min 4 sec, the total amount of volatile compounds decreased significantly. The total amount of sulfur compounds decreased about 70% compared to those of raw garlic when the garlic was soaked in buffer (pH 6.0) and treated at 500 MPa for 15 min 4 sec. A principal component analysis showed that the off-flavors of garlic were reduced by the operating time of high hydrostatic pressure as well as pH treatment. The correlation coefficient of the results between GC and the electronic nose analysis was 0.9620. Therefore, pH and high hydrostatic pressure treatment could be used as an efficient method for reducing of garlic off-flavor.

• Cement Symposium
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• no.1
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• pp.64-68
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• 1973

One of the most difficult problems in cement rotary kiln operation must be ring and coating formation. In the Dopol kiln with the capacity of 1,500 t/d($4.4m\phi\times70mL$, meal rings have been accreted on transit zone and end of the kiln and

• Tuberculosis and Respiratory Diseases
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• v.81 no.4
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• pp.299-304
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• 2018

Background: Roflumilast is the only approved oral phosphodiesterase-4 inhibitor for the treatment of severe chronic obstructive pulmonary disease (COPD) in patients with chronic bronchitis and a history of frequent exacerbations. The purpose of this study was to examine the incidence of adverse effects associated with roflumilast treatment in a real-world setting. Further, we compared the incidence of adverse effects and the discontinuation rate among patients receiving different doses. Methods: We identified all outpatients diagnosed with COPD at Seoul St. Mary's Hospital between May 2011 and September 2016 and retrospectively reviewed their medical records. Roflumilast was prescribed to patients in doses of $500{\mu}g$ and $250{\mu}g$. Results: A total of 269 COPD patients were prescribed roflumilast in our hospital during the study period. Among them, 178 patients were treated with $500{\mu}g$ and 91 patients were treated with $250{\mu}g$. The incidence of adverse effects was 38.2% in the $500{\mu}g$ group and 25.3% in the $250{\mu}g$ group (p=0.034). The discontinuation rate of roflumilast was 41.6% (n=74) in the $500{\mu}g$ group and 23.1% (n=21) in the $250{\mu}g$ group (p=0.003). When adjusted by age, sex, smoking status, and lung function, $500{\mu}g$ dose was significantly associated with the discontinuation of roflumilast (odds ratio, 2.87; p<0.001). Conclusion: There was a lower incidence of adverse effects and discontinuation among patients treated with $250{\mu}g$ compared with $500{\mu}g$ dose. Further studies regarding the optimal dose of roflumilast are required.

• Journal of The Geomorphological Association of Korea
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• v.17 no.2
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• pp.53-61
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• 2010

In this study, pollen analysis and a dating were performed on the alluvial deposits in the Tangjeong Plains in Asan-Si, Chungcheongnam-Do. Specimens were collected at the altitude of about 12m, which belongs to the mid-forest belt in the cool temperate zone. The followings show the results. In general, the target zone passed through TJ-I (the coniferous forest age in which the Pinus forest was dominant), TJ-II (the mixed conifer and deciduous broad-leaved forest age in which Pinus and Quercus were dominant) and TJ-III (the coniferous forest age in which the Pinus was dominant) respectively. TJ-II was subdivided into TJ-IIa and TJ-IIb. TJ-I is presumed to be between about 2,810 and 1,500yrB.P.; TJ-IIa to be between about 1,500 and 1,370yrB.P.; and TJ-IIb to be between about 1,370 and 770yrB.P. As for TJ-III, it is presumed to begin after about 770yrB.P. In comparison with the nationwide pollen zone during the Postglacial, TJ-I and TJ-II are contrasted with the R-IIIa period and also TJ-III is contrasted with RIIIb (so-called human interference age). It is also presumed that Pinus luxuriated there after about 770yrB.P. as forests began to be markedly destroyed in the Tangjeong Plains.

• International Journal of Quality Innovation
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• v.1 no.1
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• pp.106-120
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• 2000

The purpose of this research is to understand the effects of Quality Management Award on stock prices movement and to examine the comparative advantages of quality award system in Korea and the U.S. This study compares the performances of QM Award companies in the stock market with those of the market index in both countries. We develop Korean Quality Award Index(KQA Index) based on the Baldrige Index of NIST in the U.S. We inspect three studies. Study 1 tests if the performances of MB Award winners and S&P500 index have a difference in the stock market. Study 2 tests if the performances of KQA winners and KOSPI(Korean Composite Stock Price Index) have a difference in the stock market. Study 3 tests if the performances of KQA winners and MB Award winners have a difference in the stock market. From the empirical tests, the performances of KQA winners are superior to those of KOSPI and the performances of MB Award winners are superior to those of S&P500 and the performances of MB Award winners are superior to those of KQA winners.

• Proceedings of the IEEK Conference
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• 2003.07b
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• pp.955-958
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• 2003

본 논문에서는 개방형 파이프라인 구조를 이용한 8비트 500Msamples/s ADC를 제안하였다. 8-비트의 해상도에 적합하면서 전력 소모가 적은 5 단 파이프라인 구조로 설계하였으며, 고속 동작에 적합하게 MUX 스위치에서 선택한 신호를 인터폴레이션하는 개방형 구조를 채택하였다. 전력 소모와 전체 칩 면적을 줄이기 위해서, 각 단에서 필요한 신호의 수를 줄이도록 설계하였다. 설계된 ADC 는 3 개의 신호를 이용하여 구현 함으로서 각 단에서의 증폭기 수틀 줄일 수 있었다. 또한 1.8V 의 낮은 전원 전압에 의한 작은 입력 범위에서 8-비트의 해상도를 만족하기 위해서 Offset Cancellation 기법을 사용하였다. 제안된 ADC 는 0.18μ m 일반 CMOS 공정을 이용하여 설계되었으며 시뮬레이션 결과 500Msamples/s에서 220mW의 전력 소모를 가지며, 1.2Vp-p (Differential) 입력 범위에 대해서 약 48dB의 SNDR을(8-비트의 해상도) 가짐을 확인할 수 있었다.

• Journal of Embryo Transfer
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• v.16 no.3
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• pp.173-182
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• 2001

The present study was carried out to examine the effect of superoxide dismutase (SOD) on in vitro maturation (IVM) of porcine follicular oocytes and oxygen concentration with SOD on in vitro development (IVD) of porcine IVM/IVF embryos. The results were summarized as follows : 1. The rates of nuclear maturation, penetrated oocytes, polyspermic oocytes and mean numbers of the penetrated sperm were not different in the NCSU-23 maturation media with 0, 100, 500 and 1,000 units/ml SOD. However. the pronucleus formation rates were significantly lower in oocytes matured with addition groups than those of no addition groups of SOD (P>0.05). 2. The rates of blastocyst formation and total cell numbers of blastocyst at day 7 after in vitro fertilization were significantly lower in addition groups than those of the no addition groups of SOD (P>0.05). 3. The rates of blastocyst formation at day 7 after in vitro fertilization were higher in the NCSU-23 culture medium with 100 units/ml SOD than in those cultured with 0, 500 and 1,000 units/ml SOD under the 5% and 20% $O_2$concentrations. However, no differences was found in the total cell numbers of blastocyst among the treatments. In conclusion, these results suggested that the addition of SOD was not adequate for porcine oocyte maturation and further development, also the rates of blastocyst formation and total cell numbers of blastocyst at day 7 of porcine IVM/IVF embryos were not different in the NCSU-23 culture medium under the 5% and 20% $O_2$concentrations.

• Journal of Ecology and Environment
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• v.29 no.6
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• pp.559-563
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• 2006

This work was investigated the effects of the elevated $CO_2$ and Pb contamination on the growth of Pinus densiflora. Two-years pine trees were planted in Pb-contaminated soils (500 mg/kg-soil) and uncontaminated soils, and cultivated for 3 months in the growth chamber where $CO_2$ concentration was controlled at 380 or 760 ppmv. The growth of P. densiflora were comparatively analyzed in 4 kinds of soil samples (CA : $CO_2$ 380 ppmv + Pb 0 mg/kg, CB : $CO_2$ 380 ppmv + Pb 500 mg/kg, EA : $CO_2$ 760 PPmv + Pb 0 mg/kg, EB : $CO_2$ 760 ppmv + Pb 500 mg/kg). It was measured the growth changes of the p. densiflora caused by $CO_2$ concentration and Pb contamination. The growth of P. densiflora was remarkably inhibited in the Pb-contaminated soil, although the biomass and the root elongations were not significantly affected by the elevated $CO_2$. These results suggested that the growth of p. densiflora was sensitively influenced by Pb contamination rather than $CO_2$ concentration. Compared to the initial soil, total Pb concentration in the soil samples was decreased at 760 ppmv $CO_2$ as well as at 380 ppmv $CO_2$ after 3 months. The accumulation of Pb in the roots at 760 ppmv $CO_2$ was two-fold of that at 380 ppmv $CO_2$, indicating that Pb bioavailability in the root of p. densiflora might be affected by the elevated $CO_2$.