• Journal of Korean Neurosurgical Society
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• 제54권2호
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• pp.75-80
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• 2013

Objective : Aneurysms arising from the proximal segment of the anterior cerebral artery (A1) are rare and challenging to treat. The aim of this study was to report our experience with endovascular treatment of A1 Aneurysms. Methods : From August 2007 through May 2012, eleven A1 aneurysms in eleven patients were treated endovascularly. Six aneurysms were unruptured and 5 were ruptured. One patient with an unruptured A1 aneurysm presented with subarachnoid hemorrhage due to rupture of an anterior communicating artery aneurysm. Procedural data, clinical and angiographic results were reviewed retrospectively. Results : All of the aneurysms were successfully treated with coil embolization. Six were treated with a simple technique while the remaining 5 required adjunctive technique : double catheters (n=2), balloon-assisted (n=2), and stent-assisted (n=1). The immediate angiographic control showed a complete occlusion in all cases. Procedure-related complication occurred in only one patient : parent artery occlusion, which was not clinically significant. All patients had excellent clinical outcomes but one patient was discharged with a slight disability. No neurologic deterioration or bleeding was seen during the follow-up period in this cohort of patients. Follow-up angiography (mean, 20 months) was available in ten patients and revealed stable occlusion in all cases. Conclusion : Endovascular treatment is a feasible and effective therapeutic modality for A1 aneurysms. Tailored microcatheter shaping and/or adjunctive techniques are necessary for successful aneurysm embolization because of the projection and location of A1 aneurysms.

• BMB Reports
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• 제41권9호
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• pp.651-656
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• 2008

A mouse with cataract, Kec, was generated from N-ethyl-N-nitrosourea (ENU) mutagenesis. Cataract in the Kec mouse was observable at about 5 weeks after birth and this gradually progressed to become completely opaque by 12 weeks. Dissection microscopy revealed that vacuoles with a radial or irregular shape were located primarily in the cortex of the posterior and equatorial regions of the lens. At the late stage, the lens structure was distorted, but not ruptured. This cataract phenotype was inherited in an autosomal recessive manner. We performed a genetic linkage analysis using 133 mutant and 67 normal mice produced by mating Kec mutant (BALB/c) and F1 (C57BL/6 $\times$ Kec) mice. The Kec locus was mapped to the 3 cM region encompassed by D14Mit34 and D14Mit69. In addition we excluded coding sequences of 9 genes including Rcbtb2, P2ry5, Itm2b, Med4, Nudt15, Esd, Lcp1, Slc25a30, and 2810032E02Rik as the candidate gene that causes cataract in the Kec mouse.

• 대한족부족관절학회지
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• 제15권2호
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• pp.79-85
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• 2011

Purpose: The purpose of the present study was to compare and analyze the clinical outcomes of the percutaneous and open repair of acute Achilles tendon ruptures. Materials and Methods: We performed a retrospective study on 24 patients (group 1) managed with percutaneous repair, and 21 patients (group 2) managed with open repair for acute Achilles tendon rupture. The postoperative evaluations were done by an Arner-Lindholm scale and AOFAS score. Postoperative overall satisfaction and cosmetic satisfaction were also evaluated. Results: By Arner-Lindholm scale and AOFAS score, there was no difference between two groups (p<0.05). As for postoperative overall satisfaction, 5 cases were very satisfied, 16 cases were satisfied and 3 cases were fair in group 1. In group 2, 12 cases were very satisfied, 9 cases were satisfied. For postoperative cosmetic satisfaction, 13 cases were satisfied, 11 cases were fair in group 1. In group 2, 9 cases were very satisfied, 12 cases satisfied. In open repair group, a case of deep wound infection and three cases of skin necrosis were reported as complication. 2 cases of sural nerve injury were seen in percutaneous repair group and were recovered within 3 months. Conclusion: Percutaneous repair of acute Achilles tendon ruptures have high level of cosmetic satisfaction compared with open repair without any significant difference in clinical outcomes.

• 한국의상디자인학회지
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• 제21권4호
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• pp.55-67
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• 2019

This study analyzed the fabric and product size of the burn patient's custom compression garment and measured the pressure applied by the garment to assess whether proper pressure is being delivered for treatment. The test clothes were presented to the market by body size and commissioned with the same design. The subjects selected four people close to the average body size of men in their 20s determined by 7th Size Korea. The experiment was conducted by wearing a compression suit, performing activities and measuring changes in the pressure of the garment according to changes in posture. The fabric used for the compressive clothing was not ruptured even at 216 kPa, the elasticity recovery rate was measured between 80.5 and 94.5%. The product dimensions of the experimental clothing varied by up to 8cm from brand to brand, requiring the standardization of compression clothing. The experiment showed that four types of compression suit varied in pressure, and the pressure range, excluding the gastric arm (17.9mmHg), was between 2.5-14.1mmHg, which failed to meet the level of pressurization for treatment purposes. The clothing pressure in the chest area dropped when performing movements rather than standing still. This was interpreted to be a result of reduced the adhesion of the compression suit during operation. The peak pressure (31.68mmHg) and the lowest pressure (2.2mmHg) was noted in the scapula, indicating that no pressure was being transmitted on the vertebrae. The pressure of the garment on the right shoulder blade was elevated in a supine position. Because much time is spent laying down, it is necessary for the pattern design to accommodate for the increased clothing pressure on the shoulder blades. Standardization of the level of pressurization for burn patient's custom-made pressure suits for each stage of treatment is urgently required.

• 대한정형외과스포츠의학회지
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• 제6권2호
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• pp.126-129
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• 2007

도수정복이 불가능한 슬관절 탈구는 아주 드물게 발생하며, 대부분의 도수정복이 불가능한 슬관절 탈구는 후외방 탈구 시 연부조직이 끼이면서 발생하게 되는데 저자들은 51세 여자환자의 슬관절 탈구에서 박리된 대퇴 내과 연골편에 의해 정복이 불가능했던 지금까지 보고가 없었던 예를 경험하였고, 이를 관절경을 이용한 변연절제술로 연골편을 제거하여 관혈적 수술이 필요 없이 정복을 얻을 수 있었으며 지연성 전방 및 후방 십자인대 재건술을 시행하여 만족할 만한 결과를 얻었다.

• Toxicological Research
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• 제22권4호
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• pp.315-322
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• 2006

TALP-32 is highly basic protein with a molecular weight of 32 kDa purified from human term placenta. Some basic proteins such as defensins and cecropins are known to induce cell death by increasing membrane permeability and some of them are under development as an anticancer drug especially targeting multi-drug resistant cancers. Therefore, we investigated cytotoxic effect and mechanism of TALP-32 When HeLa cell was incubated with TALP-32, cytotoxicity was increased in time and dose dependent manner. As time goes by, HeLa cells became round and plasma membrane was ruptured. Increase of plasma membrane permeability was determined with LDH release assay. Also in transmission electron microscopy, typical morphology of necrotic cell death, such as cell swelling and intracellular organelle disruption was observed, but DNA fragmentation and caspase activation was not. And necrotic cell death was determined with Annexin V/Pl staining. The cytotoxicity of TALP-32 was minimal and decreased or RBC and Hep3B respectively. These data suggests that TALP-32 induces necrosis on rapidly growing cells but not on slowly growing cells implicating the possibility of its development of anticancer peptide drug.

• Archives of Plastic Surgery
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• 제33권1호
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• pp.120-123
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• 2006

Spontaneous extensor pollicis longus tendon rupture is commonly caused by attrition of the tendon from trauma or inflammatory processes. We experienced a patient with extensor pollicis longus tendon rupture after steroid injection, in which the rupture may have been caused by the effects of steroid itself as well as direct damage from the needle. A 51-year-old woman complained of inability to extend her right thumb at the first metacarpophalangal & interphalangeal joint level. The patient had a history of local steroid injection into the dorsal & radial side of wrist on two occations, and had no history of trauma or rheumatologic disease. After a physical examination of the patient, we decided to explore the wrist. The patient agreed with operation. Intraoperatively, an incision was made into the wrist and the proximal and distal ends of the ruptured extensor pollicis longus tendon were identified. The defect between the proximal and the distal end was measured to approach 8cm, and a palmaris longus tendon graft was performed. After three months of rehabilitation, the first metacarpophalangal & interphalangeal joint recovered the normal range of motion. Steroid injection has been widely used in various musculoskeletal disorders such as rheumatoid arthritis and osteoarthritis. However, inadvertent steroid injection into the extra or intra articular spaces may lead to tendon rupture. Steroids reduce tensile strength by decreasing tenocyte activity and collagen synthesis. Also, the physical effect of direct needle-stick injury into the mesotenon and blood vessels around the tendon may cause damage. In addition, hematoma and edema may increase pressure around the tendon and compromise blood supply, leading to tendon degeneration and subsequent rupture. When injecting steroid into an articular area, all physicians should have a complete understanding of the surrounding anatomy and always keep in mind the hazards of such procedures.

• Journal of Chest Surgery
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• 제43권1호
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• pp.92-95
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• 2010

고위험군의 대동맥 질환 환자에서 고전적인 수술에 대한 대안책으로서 혈관내 스텐트 그라프트를 고려할 수 있다. 본원에서는 유방암에 대한 항암 방사선 치료로 인한 전 흉부 괴사와 그에 따른 상행 대동맥 파열이 발생한 79세 여자 환자에 대해 혈관내 스텐트 그라프트를 이용하여 효과적으로 치료하였기에 문헌 고찰과 함께 보고하는 바이다.

• Journal of Welding and Joining
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• 제31권1호
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• pp.58-64
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• 2013

The following results were obtained, microstructures and tensile properties in arc brazed joints of DP(dual phase) steel using Cu-5.3wt%Sn insert metal was investigated as function of brazing current. 1) The Fusion Zone was composed of ${\alpha}Fe+{\gamma}Cu$ and Cu23Sn2. The reason for the formation of these solid solutions. Despite, Fe & Cu were impossible to solid solution at room temperature. It's melting & reaction to something of insert metal & Base Metal (DP Steel) by Arc. Brazing Process has faster cooling rate then Cast Process, Supersaturated solid solution at room temperature. 2) The increase Hardness of Fusion Zone was directly proportional to the rise of welding current. Because, ${\alpha}Fe+{\gamma}Cu$ phase (higher hardness than the Cu23Sn2.(104.1Hv < 271.9Hv)) Volume fraction was Growth, due to increasing the amount of base metal melting by High current. 3) The results of tensile shear test by Brazing, All specimens happen to fracture in Fusion Zone. On the other hand, when Brazing Current increasing tend to rise tensile load. but it was very small, about 26-30% of the base metal. 4) The result of fracture analysis, The crack initiate at Triple Point for meet to Upper B.M/Under B.M/Fusion Zone. This Crack propagated to Fusion zone. So ruptured by tensile strength. The Reason to in the fusion zone fracture, Fusion zone by Brazing of hardness (strength) was very lower then the base metal (DP steel). In addition the Fusion Zone's thickness in triple point was thin than the base metal's thickness in triple point.

• Journal of the Korean Wood Science and Technology
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• 제11권3호
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• pp.31-38
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• 1983

파티클보드의 단점중(短點中) 하나인 저(低)휨강도(彈度)를 개선(改善)하고 건축재료(建築材料)로서 개발(開發)하기 위한 목적(目的)으로, 본(本) 실험(實驗)에서는 톱밥보드를 프라스틱 강(網)과 철강(鐵網)으로 보강(補强)시켜 보드의 물리적(物理的), 기계적(機械的) 성질(性質)을 개선(改善)하고자 하였다. 실험결과(實驗結果), 밀도(密度)에서는 철강(鐵網)을 3장 구성(構成)시킨 보드가 가장 높은 값을 나타내었고, 휨 강도에서도 밀도(密度)가 가장 높았던, 철망을 3장 구성(構成)시킨 보드가 가장 높은 값을 보였다. 고지(古紙)를 섞어서 만든 보드도 다른 보드와 비슷한 강도(强度)를 보여 고지혼용(古紙混用)보도의 가능성(可能性)을 나타냈다. 철강(鐵網)을 구성(構成)시킨 보드는 정하중(靜荷重)에 의(依)해 영구변형(永久變型)이 발생(發生)되어도 쉽게 파괴되지 않는 현상(現象)을 보였다. 보강(補强)된 보드와 합판(合板)과의 강도적(强度的) 성질(性質)을 비교(比較)해 본 결과(結果), 보강(補强)된 보드보다 합판(合板)이 훨씬 높은 수준(水準)을 보였다.