• Toxicological Research
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• v.20 no.3
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• pp.195-203
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• 2004

4-Tert-Octylphenol (OP) is a surfactant additive widely used in the manufacture of a variety of detergents and plastic products. OP can disrupt endocrine function in humans and animals. This study was carried out to obtain toxicokinetic parameters of OP in male Sprague-Dawley (SD) rats. Male rats were administered with OP by single oral application of 200 mg/kg body weight. Blood, urine and tissues samples were taken at several time intervals after administration. Analysis of samples for OP was performed by column-switching high performance liquid chromatography (HPLC). In addition, we exam-ined tissue distribution and accumulation of OP after single oral application of 50, 100, and 200 mg/kg, single intravenous injection of 1, 5 and 10 mg/kg or daily application of 50 mg/kg for 14 consecutive days. After single oral administration of 200 mg/kg, Cmax of 213 $\pm$ 123 ng/ml was reached within the first 1.3 hr (Tmax) in the plasma. AUC was calculated for 1,333$\pm$484 ngㆍhr/ml. The final elimination half-life of plasma was longer than that of urine, but urinary clearance was lower than oral. A very small fraction of OP (Fe < 0.0017%) was excreted in urine within 24 hr. These results indicated that the major excretion route of OP was not urine. The mean maximal tissue distribution of OP was obserbed at 6 hr after treatment and slowly decreased time-dependently. High OP concentrations were detected in fat at 24 hr. The OP in fat was slowly released with longer elimination half-life and lower clearance than that of other tissues. OP was not accumulated in the liver following single oral application but 14-day oral treatments resulted in two-fold accumulation. It was probably due to the saturation of detoxification pathways. On the other hand, the mRNA expression of cytochrome P450 isoforms except CYP2C11 was not affected by OP at any dose. The expression of CYP2C11 mRNA decreased in a dose-dependent manner. This result suggests that OP changes expression of the male-specific cytochrome P450 isoforms in rat liver, and these changes are closely related to the toxic and estrogenic effect of OP.

• Biomolecules & Therapeutics
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• v.21 no.2
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• pp.170-172
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• 2013

The pyrimidine nucleoside uridine has recently been reported to have a protective effect on cultured human corneal epithelial cells, in an animal model of dry eye and in patients. In this study, we investigate the pharmacokinetic profile of uridine in rabbits, following topical ocular (8 mg/eye), oral (450 mg/kg) and intravenous (100 mg/kg) administration. Blood and urine samples were serially taken, and uridine was measured by high-performance liquid chromatography-tandem mass spectrometry. No symptoms were noted in the animals after uridine treatment. Uridine was not detected in either plasma or urine after topical ocular administration, indicating no systemic exposure to uridine with this treatment route. Following a single intravenous dose, the plasma concentration of uridine showed a bi-exponential decay, with a rapid decline over 10 min, followed by a slow decay with a terminal half-life of $0.36{\pm}0.05$ h. Clearance and volume of distribution were $1.8{\pm}0.6$ L/h/kg and $0.58{\pm}0.32$ L/kg, respectively. The area under the plasma concentration-time curves (AUC) was $59.7{\pm}18.2{\mu}g{\cdot}hr/ml$, and urinary excretion up to 12 hr was ~7.7% of the dose. Plasma uridine reached a peak of $25.8{\pm}4.1{\mu}g/ml$ at $2.3{\pm}0.8$ hr after oral administration. The AUC was $79.0{\pm}13.9{\mu}g{\cdot}hr/ml$, representing ~29.4% of absolute bioavailability. About 1% of the oral dose was excreted in the urine. These results should prove useful in the design of future clinical and nonclinical studies conducted with uridine.

• Korean Journal of Veterinary Research
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• v.42 no.2
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• pp.283-288
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• 2002

The present study was carried out to examine the effect of insulin formula on blood glucose change in normal Sprague-Dawley male rats. Also, this study was performed to investigate the feasibility of oral insulin formula development. To administrate the insulin formula into intestine, the surgical technique, celiotomy, was performed in rats. Insulin formula was administrated at a dose of 24.5 IU/kg via duodenum, ileum, and colon of the rats, and the blood glucose level was measured. For the comparison, the vehicle without insulin was administrated into ileum via celiotomy. Also, this insulin formula was administrated into rats orally using sonde and the same parameter was treasured. The bloods of all groups were collected from tail veins using syringes at given time interval. Orally administrated group did not show the change of blood glucose level and control group slightly show the change of blood glucose level at 1 hour after celiotomy. All intestinally administrated groups showed the change of blood glucose level. Among the tested groups, ileac administration group and colonic administration group showed the significant change of blood glucose level. Particularly, ileac administration group showed the lowest blood glucose level. To calculate the bioavailability of intestinal and oral administration, insulin solution was injected subcutaneosly, common insulin injection route, into another normal rats. The bioavailability of ileac group was 8.3% when compared with subcutaneous injection, duodenal group was 1.8%, colonic group was 4.2%, and oral group was 0.2%, respectively.

• Journal of Korea Water Resources Association
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• v.33 no.1
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• pp.61-72
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• 2000

The purpose of this study is to improve the method of evaluating groundwater recharge by using grid-based soil moisture routing technique. A model which predicts temporal variation and spatial distribution of soil moisture on a daily time step was developed. The model uses ASCII-formatted map data supported by the irregular gridded map of the GRASS(Geographic Resources Analysis Support System)-GIS and can generate daily and monthly spatial distribution map of surface runoff, soil moisture content, evapotranspiration within the watershed. The model was applied to Ipyunggyo watershed($75.6\;\textrm{km}^2$) located in the upstream of Bocheongchun watershed. Seven maps; DEM(Digital Elevation Mode]), stream, flow path, soil, land use, Thiessen network and free groundwater level, were used for input data. Predicted streamflows resulting from two years (l995, 1996) daily data were compared with the observed values at the watershed outlet. The results of temporal variations and spatial distributions of soil moisture are presented by using GRASS GIS. As a final result, the monthly predicted groundwater recharge was presented.sented.

• The Journal of the Convergence on Culture Technology
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• v.6 no.2
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• pp.529-534
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• 2020

The development of civilization is in line with evolution of cities and transportation technology caused by industrialization. Up to now, a city has been developed owing to transportation cost reduction and needs for land utilization as a limited core business district. Continuous increase of urban population density has accompanied by lots of problems socioeconomically such as rise of land value, traffic congestion, gap between the rich and poor, air pollution, etc. Those issues are difficult to be solved in existing city ecosystem. However, a clue for solving the problems could be found in there. The design of Seoul mid-night bus route was from analysis of movement of people in the rural area by using ICT so that a city ecosystem should be firstly analyzed for solving rural issues. If the cause of those is found, big data platform construction is required to raise the life quality of citizen and the problems could be solved. Big data should be located in the middle of the platform connected with every element of city based on ICT for real-time collection, analysis and application. This paper addresses construction of big data platform and its application for sustainable smart city.

• KIPS Transactions on Computer and Communication Systems
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• v.10 no.10
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• pp.269-276
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• 2021

Recently, smart sensors are used in various environments, and the implementation of ad-hoc sensor networks (ASNs) is a hot research topic. Unfortunately, traditional sensor network routing algorithms focus on specific control issues, and they can't be directly applied to the ASN operation. In this paper, we propose a new routing protocol by using the Q-learning technology, Main challenge of proposed approach is to extend the life of ASNs through efficient energy allocation while obtaining the balanced system performance. The proposed method enhances the Q-learning effect by considering various environmental factors. When a transmission fails, node penalty is accumulated to increase the successful communication probability. Especially, each node stores the Q value of the adjacent node in its own Q table. Every time a data transfer is executed, the Q values are updated and accumulated to learn to select the optimal routing route. Simulation results confirm that the proposed method can choose an energy-efficient routing path, and gets an excellent network performance compared with the existing ASN routing protocols.

• Journal of Korean Society of Industrial and Systems Engineering
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• v.44 no.1
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• pp.26-36
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• 2021

The topic of this study is the field of humanitarian logistics for disaster response. Many existing studies have revealed that compliance with the golden time in response to a disaster determines the success or failure of relief activities, and logistics costs account for 80% of the disaster response cost. Besides, the agility, responsiveness, and effectiveness of the humanitarian logistics system are emphasized in consideration of the disaster situation's characteristics, such as the urgency of life-saving and rapid environmental changes. In other words, they emphasize the importance of logistics activities in disaster response, which includes the effective and efficient distribution of relief supplies. This study proposes a mathematical model for establishing a transport plan to distribute relief supplies in a disaster situation. To determine vehicles' route and the amount of relief for cities suffering a disaster, it mainly considers the urgency, effectiveness (restoration rate), and uncertainty in the logistics system. The model is initially developed as a mixed-integer nonlinear programming (MINLP) model containing some nonlinear functions and transform into a Mixed-integer linear programming (MILP) model using a logarithmic transformation and piecewise linear approximation method. Furthermore, a minimax problem is suggested to search for breakpoints and slopes to define a piecewise linear function that minimizes the linear approximation error. A numerical experiment is performed to verify the MILP model, and linear approximation error is also analyzed in the experiment.

• The Journal of Korea Institute of Information, Electronics, and Communication Technology
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• v.17 no.2
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• pp.83-92
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• 2024

Currently, various countries are enhancing accessibility by providing bicycle rental services for convenient usage within daily life. This paper introduces the Nubija public bicycle service in Changwon, South Korea, aiming to address the imbalance between demand and supply of Nubija bicycles. We propose a Highest Priority Reallocation Scheme to prevent this disparity. Comparing this scheme with others that randomly visit terminals for redistribution and those that prioritize terminals closest to current locations, we illustrate its superior efficiency. Our proposed Highest Priority Reallocation Scheme prioritizes terminals with the highest demand and shortest distances nearby. Through experiments, our proposed scheme demonstrates superior performance, with the lowest average of 817.44km distance and an average of 6437.45 times, i.e., 88.14% successful rental occurrences. This highlights its superiority over the other two algorithms.

• Journal of Life Science
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• v.12 no.4
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• pp.433-441
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• 2002

There has been an increasing public concern about environmental safety and human health of field crops while customer consumes more and more field crops, to which overdose and residual chemicals were applied. As a solution for the problems, construction of sustainable agroecosystem is spreading out to pursuit the economic value of agricultural management as well as to meet environment concern. Public has extended their understanding on the preservation of environment and safeness of agricultural products, and governmental policy toward sustainable agriculture drives rapid increase of the production of sustainable agricultural products. Under this circumstances, it is time to encourage more consumption and to activate market system for the sustainable agricultural products. This study was initiated to diagnose the problems and future direction of domestic sustainable agriculture by analyzing the overall opinions of consumer on the sustainable agriculture. The results are as follows: The pursuit of low input management is a prerequisite to creat high valued agricultural products, and serious consideration should be taken to produce clean crops using natural products. Consummers are willing to pay 10∼50% more prices if the products get certified by official eco-label programs. It is believed that practice of sustainable agriculture using biopesticide and natural pesticide would accelerate the rapid extension of this pro-environmental agricultural management. To activate production and consumption of sustainable agricultural products correct informations on safety should be addressed to customer, and confidence has to be brought about from customer. This could be done by obtaining various and efficient distribution route, product competency for quality, upgraded sales strategy, maximum utilization of certificate system, and practice of recall system, so on.

• Journal of Korean Society for Atmospheric Environment
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• v.23 no.2
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• pp.169-182
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• 2007

To evaluate the possibly potent role of Asian Dust (AD) on the long range transport of Hg, statistical analyses were carried out using the hourly concentration data of gaseous elemental mercury (Hg) along with relevant environmental parameters. For the purpose of this study, Hg data were collected from Yang-Jae monitoring station in Seoul, Korea during Sept. 1997 to June 2002. During the study period, Hg concentrations in non-AD period ranged from $0.03\;to\;32.70\;ng\;m^{-3}$ with a mean $5.27{\pm}3.06\;ng\;m^{-3}$, while those in AD period from $1.79\;to\;32.60\;ng\;m^{-3}$ with a mean $5.20{\pm}3.06\;ng\;m^{-3}$. The air quality during AD were typically deteriorated by enhanced PM10 mass concentration (by $2{\sim}5$ times) compared to non-AD period, however comparison of the Hg concentration data indicates that they are not critically distinguished between events of AD and non-AD, except for the high minimum level of Hg during AD. The results of correlation and factor analysis also indicated somewhat complex patterns; in the case of AD events, Hg and $SO_{2}$ were assorted concurrently into a same factor. Evidence collected from this study thus suggests that long-range transport of Hg, if occurring, is unlikely to raise statistically Hg concentration levels such as seen during AD event. However, in nighttime of winter season, Hg concentrations are higher during AD (along with PM10 levels) than non-AD period. Although such observations suggest the effect of long range transport on the enhancement of Hg concentrations, more deliberate analysis may be required to track down the effect of such mechanism in relation with various factors including the air mass transport route.