• Journal of Applied Biological Chemistry
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• v.50 no.4
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• pp.249-253
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• 2007

Thirteen edible plants previously reported to show inhibitory activities on farnesyl protein transferase (FPTase) and phosphatase of the regenerating liver-3 (PRL-3) were evaluated for inhibitory activity on the proliferation of human umbilical vein endothelial cells (HUVECs). Four plant extracts, Oenothera erythrosepala, Perilla frutescens, Panicum miliaceum, and Quercus acutissima, significantly inhibited the proliferation of HUVECs induced by the basic fibroblast growth factor (bFGF) without cytotoxicity at 100 ${\mu}g/mL$. Myristica fragrans, Rosmarinus officinalis, and Syringa patula also showed inhibitory activity on the proliferation with only mild cytotoxicity.

• Journal of the Korean Institute of Landscape Architecture
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• v.46 no.1
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• pp.96-105
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• 2018

This study examined the growth of herb plants in response to irrigation on a green rooftop area in order to select herb plants that can be used for rooftop greening. Apple Mint (Mentha suaveolens), Lemon balm (Melissa officinalis), Spearmint (Mentha spicata), Pineapple sage (Salvia elegans), Choco Mint (Mentha ${\times}$ piperita 'Choco Mint'), Ox-eye Daisy (Chrysanthemum leucanthemum), Roman Chamomile (Anthemis nobilis) and Thyme (Thymus vulgaris) showed increased growth when irrigated. Conversely, Lavender (Lavendula angustifolia ), Peppermint (Mentha ${\times}$ piperita ), Vicks Plant (Plectranthus tomentosa), Feverfew (Tanacetum parthenium), Rosemary (Rosmarinus officinalis), Tansy (Tanacetum vulgare), Lemon Verbena (Aloysia triphylla), Heliotrope (Heliotropium arborescens), Soapwort (Saponaria officinalis) and Lady's mantle (Alchemilla vulgaris) demonstrated satisfactory growth regardless of irrigation. Peppermint, Tansy, Lemon Verbena, Soapwort, and Lady's mantle seem to be suitable for green rooftop because of their overwintering ability and drought hardiness. Pineapple sage, Apple Mint and Thyme would seem to be inappropriate for rooftop greening because they showed negative growth response to drought and failed overwintering. Although Spearmint, Lemon balm, Choco Mint, Ox-eye Daisy and Roman Chamomile had reduced growth during dry conditions, they were able to overwinter satisfactorily and can be used as rooftop plants with irrigation.

• Journal of People, Plants, and Environment
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• v.23 no.5
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• pp.521-535
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• 2020

Background and objective: This study investigated plant type and color preference and conducted a psychological assessment for gardening activities of firefighters in a high-risk occupational group. Methods: A survey was conducted on 117 firefighters aged 39.01±9.17 in Sunchang in March 2020 to examine their preferences in plant type and color and conduct a psychological assessment of firefighters on gardening activities. Results: For plant experience and awareness, plant-related event showed the highest score, followed by plant preference tendency and plant growing experience. The level of plant gardening activities was higher among older age and higher job position. As a result of examining the quality of life according to the demographic characteristic with WHOQOL-BREF (World Health Organization Quality of Life Assessment Instrument), it was found that the quality of life was higher among the 20s-30s than 50s, firefighter position than fire lieutenant or higher, those with higher average monthly income, and the singles group than married (p < .05). The administration group showed lower scores than the fire suppression group working in the field, showing statistical significance. Most firefighters showed high preference for herbal plants among the 12 types of flowering plants, in the order of Rosmarinus officinalis>Lavandula spp.>Mentha piperita, Calendula officinalis. Pelargonium spp. was preferred the least out of the flowering plants, Lycopersicon esculentum was preferred the most out of 12 types of vegetable plants, while Angelica acutiloba was preferred the least statistical significance. For the preference of plant colors, yellow was the most preferred color, followed by white, blue, orange, red, and green, showing statistical significance. For the psychological survey responses of emotion words toward 6 plants colors, it was found that 'bright' was the emotion felt most strongly by the white, yellow, and orange groups, 'calm' and 'comfortable' by the green and blue groups, and 'fancy' by the red group. Conclusion: The effect of agro-healing programs can be increased by using mostly yellow plants when creating indoor healing gardens at the workplaces of fire officials in a high-risk occupational group, and using herbal plants and Lycopersicon esculentum in the gardens for agro-healing activities.

• Biomolecules & Therapeutics
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• v.25 no.5
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• pp.535-544
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• 2017

Carnosol is a phenolic antioxidant present in rosemary (Rosmarinus officinalis). It is known for anti-inflammatory effects, analgesic activity and anti-cancer effects. However, no study has been dedicated yet to its effect on atopic dermatitis (AD). Here, we show that carnosol effectively inhibited LPS-induced nitric oxide (NO) generation and expression of inflammatory marker proteins (iNOS and COX-2) in RAW 264.7 cells. In addition, carnosol effectively inhibits the phosphorylation of STAT3 and DNA binding activity in RAW 264.7 cells. Pull down assay and docking model analysis showed that carnosol directly binds to the DNA binding domain (DBD) of STAT3. We next examined the anti-atopic activity of carnosol ($0.05{\mu}g/cm^2$) using 5% Phthalic anhydride (PA)-induced AD model in HR1 mice. Carnosol treatment significantly reduced 5% PA-induced AD like skin inflammation in skin tissues compared with control mice. Moreover, carnosol treatment inhibits the expression of iNOS and COX-2 in skin tissue. In addition, the levels of $TNF-{\alpha}$, $IL-1{\beta}$, and Immunoglobulin-E in blood serum was significantly decreased in carnosol treated mice compared with those of 5% PA treated group. Furthermore, the activation of STAT3 in skin tissue was decreased in carnosol treated mice compared with control mice. In conclusion, these findings suggest that carnosol exhibited a potential anti-AD activity by inhibiting pro-inflammatory mediators through suppression of STAT3 activation via direct binding to DBD of STAT3.

• Journal of Korean Biological Nursing Science
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• v.12 no.3
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• pp.133-139
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• 2010

Purpose: The purpose of this study was to evaluate the effectiveness of aromatherapy on headache, anxiety, and serum cortisol level in middle-aged women with recurrent headaches. Methods: Nineteen patients in the intervention group and 21 in the control group participated in the exercise. They were randomly selected volunteers whose average headache score over 6 months with above 4 points on the visual analogue scale (VAS). The experimental group received aromatherapy for 5 days; inhalation (3 times per day) and an application on the neck and both shoulders (one time per day). Prior and post treatment scores in headache, anxiety, and measurement of serum cortisol in experimental group were measured. Then, these were compared with the control group. The headache score was measured by VAS; anxiety score was measured by State Trait Anxiety Inventory; serum cortisol was measured by Radio-Immune-Assay method. Results: Decrease in headache, anxiety, and serum cortisol level in the experimental group was greater than those in the control group. Conclusion: It confirmed aromatherapy is effective in reducing headache, anxiety, and serum cortisol level.

• Nutrition Research and Practice
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• v.7 no.4
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• pp.294-301
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• 2013

In this study, we examined the hepatic anti-steatosis activity of carnosic acid (CA), a phenolic compound of rosemary (Rosmarinus officinalis) leaves, as well as its possible mechanism of action, in a high-fat diet (HFD)-fed mice model. Mice were fed a HFD, or a HFD supplemented with 0.01% (w/w) CA or 0.02% (w/w) CA, for a period of 12 weeks, after which changes in body weight, blood lipid profiles, and fatty acid mechanism markers were evaluated. The 0.02% (w/w) CA diet resulted in a marked decline in steatosis grade, as well as in homeostasis model assessment of insulin resistance (HOMA-IR) index values, intraperitoneal glucose tolerance test (IGTT) results, body weight gain, liver weight, and blood lipid levels (P < 0.05). The expression level of hepatic lipogenic genes, such as sterol regulating element binding protein-1c (SREBP-1c), liver-fatty acid binding protein (L-FABP), stearoyl-CoA desaturase 1 (SCD1), and fatty acid synthase (FAS), was significantly lower in mice fed 0.01% (w/w) CA and 0.02% (w/w) CA diets than that in the HFD group; on the other hand, the expression level of ${\beta}$-oxidation-related genes, such as peroxisome proliferator-activated receptor ${\alpha}$ (PPAR-${\alpha}$), carnitine palmitoyltransferase 1 (CPT-1), and acyl-CoA oxidase (ACO), was higher in mice fed a 0.02% (w/w) CA diet, than that in the HFD group (P < 0.05). In addition, the hepatic content of palmitic acid (C16:0), palmitoleic acid (C16:1), and oleic acid (C18:1) was significantly lower in mice fed the 0.02% (w/w) CA diet than that in the HFD group (P < 0.05). These results suggest that orally administered CA suppressed HFD-induced hepatic steatosis and fatty liver-related metabolic disorders through decrease of de novo lipogenesis and fatty acid elongation and increase of fatty acid ${\beta}$-oxidation in mice.

• Horticultural Science & Technology
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• v.28 no.5
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• pp.871-876
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• 2010

Seven native and four introduced herbs namely $Thymus$ $quinquecostatus$, $Chrysanthemum$ $zawadskii$ var. $latilobum$, $Rosmarinus$ $officinalis$, etc. were selected for analysis of the DPPH radical scavenging and anti-microbial activity of their extracts. These perennial herbs are classified as $Labiatae$ and $Compositae$ except for $Saururus$ $chinensis$ and can be propagated through seedling and cuttage. These edible herbs are used as medicinal as well as ornamental plants. Their extract has electron donating ability which ranges from 69.7 to 78.7% for native herbs and 67.4 to 75.4% for introduced herbs. Native herbs have higher (3.54%) average DPPH radical scavenging than introduced herbs. In native herbs, maximum DPPH radical scavenging activity was observed in $Agastache$ $rugosa$ (78.7%) followed by $Saururus$ $chinensis$ while $Chamaemelum$ $nobile$ showed highest activity among the introduced herbs. Many herbs viz. $Saururus$ $chinensis$, $Chrysanthemum$ $zawadskii$ var. $latilobum$ and $Solidago$ $virga-aurea$ var. $gigantean$ showed excellent anti-microbial activity against gram positive $Enterococcus$ $faecalis$, maximum (80.0%) by $Saururus$ $chinensis$. Other herbs viz. $Solidago$ $virga-aurea$ var. $gigantea$, $Chrysanthemum$ $zawadskii$ var. $latilobum$, $Salvia$Salvia $plebeia$, $Chrysanthemum$ $indicum$, $Rosmarinus$ $officinalis$, $Chamaemelum$ $nobile$ and $Lavandula$ $stoechas$ showed anti-microbial activity against gram negative $Citrobacter$ $freundii$. Especially, the inhibition of colony growth of $Citrobacter$ $freundii$ was highest in the extract of $Chrysanthemum$ $zawadskii$ var. $latilobum$, and $Chamaemelum$ $nobile$.

• Journal of Life Science
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• v.21 no.3
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• pp.375-384
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• 2011

This study was performed to evaluate the antioxidant and antimicrobial activity of methanol extract from Rosmarinus officinalis L. and its fractions. The ethyl acetate fraction of rosemary had a higher antioxidant activity in both DPPH ($3.22\;{\mu}g/ml$) and ABTS ($5.05\;{\mu}g/ml$) compared to other extracts and fractions. Based on the results of the FRAP assay, the ethyl acetate fraction of rosemary showed a value of $5.9{\pm}0.3\;{\mu}M/{\mu}g$, and buthanol fraction and rosmarinic acid exhibited values of $4.8{\pm}0.2\;{\mu}M/{\mu}g$ and $5.1{\pm}0.1\;{\mu}M/{\mu}M$, respectively. Measurements of the antimicrobial activities of the extracts, fraction against gram positive, negative bacteria revealed that the methanol extract, hexane, ethyl acetate, and chloroform fraction of rosemary caused Staphylococcus aureus and Escherichia coli to form clear zones greater than 12 mm. Furthermore, the methanol extract and chloroform fraction showed high antibacterial activity, with inhibition zone exceeding 13 mm. The methanol extract and chloroform fraction of rosemary had broad antimicrobial spectrums and low MIC values. Therefore, methanol extracts of rosemary could serve as potential antibacterial agents to inhibit pathogen growth in food and hand sanitizers.

• Journal of Bio-Environment Control
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• v.33 no.3
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• pp.156-162
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• 2024

This study was conducted to investigate the effect of rooting volume on the productivity of fresh shoots when growing rosemary in multi-layer cultivation. The 10 cm middle cuttings from which the common rosemary (Rosmarinus officinalis L.) apical bud was removed were planted in a 128-hole tray, rooted, and then transplanted into pots of 125, 200, 550, 750, 1,300, and 2,000 mL to determine the growth characteristics and quantity of young shoots of 1-year-old and 2-year-old rosemary. In the case of 1-year-old rosemary, there was no clear difference in initial growth (30 days after transplanting) between treatments in pot size larger than 550 mL, in the case of 2-year-old rosemary, growth tend to be proportional as the pot became larger. The fresh weight of the underground part of 1-year-old and 2-year-old rosemary was the lowest at 6.9 g and 24.4 g, respectively, when surveyed on July 25 in a 550 mL container, and 10.3 g and 24.9 g, respectively, when surveyed on November 24, and there was a difference between treatments in containers of 750 to 2,000 mL. On the other hand, in the case of 1-year-old rosemary, the fresh weight of the above-ground part increased as the pot became larger, but there was no statistical difference above 1,300 mL, and the fresh weight of 2-year-old rosemary was also significantly higher as the pot became larger. The quality of young shoots was the best for 1-year-old rosemary in a pot of 2,000 mL, but for 2-year-old rosemary, there was a difference in quality depending on the season. Shoot productivity per unit pot was highest at 1,300 mL, but when converted to per unit area, the best was observed at 750 mL. Therefore, the most suitable pot size for intensive production through multi-layer cultivation of rosemary young shoots is judged to be 750 mL (12.5 × 11.5 cm).

• Korean Journal of Ichthyology
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• v.26 no.3
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• pp.171-178
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• 2014

Myogenesis is the formation process of multinucleated myofiber with a contractile capacity from muscle satellite cell (MSCs) during life. This process is tightly controlled by several transcription factors such as Pax3 and Pax7 (paired box protein 3 and 7), MEF2C (myocyte enhancer factor 2) and MRFs (myogenic regulatory factors) etc. On the contrary, myostatin (MSTN) is a transforming growth factor-${\beta}$ superfamily, which functions as a negative regulator of skeletal muscle development and growth. Carnosic acid (CA) is a major phenolic component in rosemary (Rosmarinus officinalis) and have been reported various biological activities such as anticancer, antioxidant, antimicrobial and therapeutic agents for amnesia, dementia, alzheimer's disease. This study was confirmed to effects of CA on muscle cell line and muscle tissue alteration of zebrafish by intramuscular injection or feeding methods. $10{\mu}M$ CA showed a non-cytotoxic on myoblast and a complete inhibition effect against myostatin activity on luciferase assay. In intramuscular injection experiment, the total protein and triglyceride amount of $10{\mu}M/kg$ of CA injected group increased by 11% and decreased by 13% compared to these of the no injected group. In histology analysis of muscle tissues by hematoxylin/eosin staining, the number of muscle fiber of $10{\mu}M/kg$ of CA injected group decreased by 29% and fiber area increased 40% compared to these of no injected group. In feeding experiment, the total protein and triglyceride amount no significance difference compared to these of the normal feeding group. In histology analysis, the number of muscle fiber of 1% CA fed group decreased by 35% and fiber area increased 56% compared to these of normal fed group. We identified that CA have an effect on hypertrophy of muscle fiber in adult zebrafish and the results of this study are considered as the basic data that can reveal the mechanisms of muscle formation via gene and protein level analysis.