• Annals of dermatology
• /
• 제30권6호
• /
• pp.676-687
• /
• 2018

Background: Rosacea is associated with chronic systemic disease. However, research is lacking in Asian countries. Objective: To evaluate the association between rosacea and cardiovascular diseases (CVDs) related systemic comorbidities, and the use of antihypertensive and antihyperlipidemic drugs in Korea. Methods: A five-year retrospective study, using hospital database, was conducted in five medical centers for five years. Totally 1,399,528 patients were evaluated. Results: The overall frequency for diagnosed rosacea was 0.18% over five years (2,536 rosacea patients). Patients with diabetes and patients with dyslipidemia were more likely to have rosacea (odd ratio [OR] 2.724, 95% confidence interval [CI] 1.295~5.730, p=0.016; OR 1.788, 95% CI 1.445~2.212, p<0.001). Patients with CVD were less likely to have rosacea (OR 0.431, 95% CI 0.244~0.760, p=0.003). Patients with ${\alpha}$-blocker prescriptions and patients with ${\beta}$-blocker prescriptions showed a tendency diagnosed with rosacea frequently (OR 1.963, 95% CI 1.200~3.212, p=0.006; OR 3.939, 95% CI 3.512~4.419, p<0.001). Patients with [beta]-hydroxy-[beta]-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor, and those with fibrate, were prone to have rosacea (OR 1.599, 95% CI 1.390~1.839, p<0.001; OR 1.660, 95% CI 1.056~2.609, p=0.026). As adjusted results, among the patients who took HMG-CoA reductase inhibitor without dyslipidemia, rosacea was less likely to be diagnosed (OR 0.780, 95% CI 0.620~0.982, p=0.034). Conclusion: Rosacea is associated with chronic diseases and drugs.

• 한방안이비인후피부과학회지
• /
• 제15권2호
• /
• pp.228-236
• /
• 2002

Persistent facial telangiectasia, erythema and flushing are the major cosmetic problems in patients with rosacea. However various therapeutic modalities for rosacea are not effective. Five patients who had a history of rosacea which poorly controlled by oral and topical medications, were given Herb-medication and Acupuncture treatment. The size of erythema and the number of papules had been gradually decreased and finally all the symptoms were gone except telangiectasia.

• 한국버섯학회지
• /
• 제13권1호
• /
• pp.1-10
• /
• 2015

Russula rosacea, a mycorrhizal fungus, has been used for edible and medicinal purposes. This study was conducted to evaluate the in vitro antioxidant, anti-hyperglycemic, anti-cholinesterase, and nitric oxide inhibitory effects of the fruiting bodies from R. rosacea extracted with methanol, and hot water. The 1,1-diphenyl-2-picryl hydrazyl (DPPH) radical scavenging activities of the methanol and hot water extracts (2.0 mg/ml) of R. rosacea were comparable with BHT, the positive control. The chelating effects of the mushroom and hot water extracts were significantly higher than that of BHT. The reducing power of methanol and hot water extract (6 mg/ml) were significantly lower than that of BHT. Seven phenolic compounds were detected from acetonitrile and hydrochloric acid solvent extract of the mushroom. alpha-amylase and alpha-glucosidase inhibitory activities of methanol and hot water extracts were lower than that of acarbose, the positive control. The acetylcholinesterase and butyrylcholinesterase inhibitory effects were moderate compared with galanthamine, the standard drug. Nitric oxide (NO) production in lipopolysaccharide (LPS) induced RAW 264.7 cells were inhibited significantly by the mushroom extracts in a concentration dependent manner. Therefore, we demonstrated that fruiting bodies of R. rosacea possess in vitro antioxidant, anti-hyperglycemic, anti-cholinesterase, and NO production inhibitory activities. The experimental results suggest that the fruiting bodies of R. rosacea are good natural antioxidant, anti-hyperglycemic, anti-cholinesterase, and anti-inflammatory sources.

• Annals of dermatology
• /
• 제30권6호
• /
• pp.653-661
• /
• 2018

Background: Citron is well known for an abundance of antioxidative and anti-inflammatory ingredients such as vitamin C, polyphenol compounds, flavonoids, and limonoids. Objective: In this study, we aimed to evaluate the effects of citron essential oils on rosacea mediators in activated keratinocytes in vitro. Methods: Normal human epidermal keratinocytes (NHEKs) were stimulated with $1{\alpha}$, 25-dihydroxyvitamin $D_3$ ($VD_3$) and interleukin 33 (IL-33) with LL-37 to induce rosacea mediators such as kallikrein 5 (KLK5), cathelicidin, vascular endothelial growth factor (VEGF), and transient receptor potential vanilloid 1 (TRPV1). These mediators were analyzed by performing reverse-transcription polymerase chain reaction (PCR), quantitative real-time PCR, immunocytofluorescence and enzyme-linked immunosorbent assay after NHEKs were treated with citron seed and unripe citron essential oils. Results: The messenger RNA (mRNA) and protein levels of KLK5 and LL-37 induced by $VD_3$ were suppressed by citron seed and unripe citron essential oils. Furthermore, the mRNA and protein levels of VEGF and TRPV1 induced by IL-33 with LL-37 were also suppressed by citron essential oils. Conclusion: These results show that citron essential oils have suppressive effects on rosacea mediators in activated epidermal keratinocytes, which indicates that the citron essential oils may be valuable adjuvant therapeutic agents for rosacea.

• 한방안이비인후피부과학회지
• /
• 제35권3호
• /
• pp.123-132
• /
• 2022

Objectives : The purpose of this study is to report a case of erythematotelangiectatic type rosacea and peripheral facial palsy improved by Korean medicine treatment with Soshioho-tang gagambang. Methods : The patient visited our clinic due to facial flushing and peripheral facial palsy symptoms. Based on Sanghallon provision, we treated this case with Soshiho-tang gagambang. The result of treatment was evaluated by Visual Analogue Scale(VAS), Dermatology Life Quality Index(DLQI) and House-Brackmann Grading System(HBGS). Results : After 12 days of taking Soshiho-tang gagambang, VAS of rosacea was decreased from 9 to 4 and DLQI was decreased from 22 to 5. After treatment, rosacea with facial flushing was improved and HBGS was reduced from 3 to 1. Conclusions : This study shows the possibility of taking Soshiho-tang gagambang for erythematotelangiectatic type rosacea and peripheral facial palsy derived from stress, fatigue and sleep disturbance according to Sanghallon provision.

• 한방안이비인후피부과학회지
• /
• 제32권3호
• /
• pp.235-243
• /
• 2019

Objectives : The aim of this study is to report the effects of Yangdokbaekho-tang and Hwangryunhaedok-Tang wet dressing on the treatment of erythrotelangiectatic rosacea patient. Methods : A patient with Erythrotelangiectatic Rosacea treated with Yangdokbaekho-tang, Hwangryunhaedok-Tang wet dressing and acupuncture. We evaluated the score(frequency ${\times}$ intensity) of the hot flush, the main symptom of rosacea and NRS(numeral rating scale) for the subjective symptom. Results : After treatment, the score of the hot flush decrease from 20 to 6. the NRS changed and NRS score improved from 7 to 1. There are no adverse effects and no relapse of erythrotelangiectatic rosacea after 18 days of discharge. Conclusions : According to the result, Korean Medicine such as Yangdokbaekho-tang and Hwangryunhaedok-tang wet dressing can be effective for the treatment of erythrotelangiectatic rosacea.

• Journal of Mycology and Infection
• /
• 제23권4호
• /
• pp.115-117
• /
• 2018

• Annals of dermatology
• /
• 제30권6호
• /
• pp.688-693
• /
• 2018

Background: There are few pharmacologic options to reduce erythema and flushing in patients with recalcitrant erythematotelangiectatic rosacea (ETR). We previously reported two cases of refractory flushing and erythema of rosacea that were successfully treated with intradermal botulinum toxin injection, and additional research is needed to prove the efficacy and safety of this treatment. Objective: To report the efficacy and safety of botulinum toxin injection as an aid in persistent erythema of rosacea patients. Methods: A total of 20 Korean patients with recalcitrant ETR were enrolled to receive treatment by injection of botulinum toxin. Patients received one treatment of intradermal botulinum toxin injection and were assessed 1, 2, 4, and 8 weeks after treatment. The severity of erythema and telangiectasia was investigated by a non-treating physician, and the Erythema Index (EI) was assessed by mexameter at each visit. Patient satisfaction and any adverse events were also assessed at each visit. Results: 17 patients completed all follow-up visits and were included in the analysis. Intradermal injection of botulinum toxin significantly reduced erythema severity and EI in ETR patients. Patients reported a satisfaction score of $2.94{\pm}0.56$ at 8 weeks after treatment. Except for three patients who discontinued the study early due to inconvenience of facial muscle paralysis, 17 patients participating in the final analysis did not report side effects except injection pain at the time of the procedure. Conclusion: Intradermal injection of botulinum toxin can be used as an effective and relatively safe adjuvant agent for recalcitrant and persistent erythema of ETR patients.

• 대한한의학회지
• /
• 제41권3호
• /
• pp.173-179
• /
• 2020

양명열증(陽明熱證)으로 변증(辨證)된 안면홍조형 주사피부염 환자 1례에게 백호탕(白虎湯)을 투여한 결과, 약 1~2주 후 안면홍조가 호전되었음을 확인하였으며, 주증상에 동반되었던 열감 및 기타 제반증상 역시 전반적으로 호전되는 모습을 보였다.

• 한국균학회지
• /
• 제36권1호
• /
• pp.84-92
• /
• 2008

장미무당버섯은 담자균문, 주름버섯목, 무당버섯과에 속하며 맛이 좋은 식용 버섯으로 예로부터 암의 치료에 효과가 있다고 알려져 있다. 본 연구에서는 장미무당버섯의 자실체로부터 중성염용액, 열수 및 메탄올을 이용하여 조다당류를 추출하고 ICR mice에 주사하여 항암 및 면역증강 효과를 조사하였다. Sarcoma 180, HepG2, HT-29, NIH3T3 등의 암세포에 대한 독성을 조사한 각각의 암세포는 $10{\sim}2000\;{\mu}g/ml$의 조다당류 농도에서 세포독성을 나타내지 않았다. 각각의 조다당류가 투여된 실험군은 대조군에 비해 수명이 각각 $21.4{\sim}45%$ 연장되었다. 열수로 추출한 조다당류는 B 임파구의 alkaline phosphatase 활성을 $500\;{\mu}g/ml$의 농도에서 대조군에 비해 약 6.8배의 증가시켰다. 중성염추출 조다당류를 50 mg/kg body weight의 농도로 투여한 생쥐의 총 복강 세포 수와 백혈구의 수는 대조군에 비하여 각각 6배 와 2.6배로 증가하였다. 또한 면역에 관련된 장기인 간, 비장 및 흉선의 체중이 대조군에 비하여 소폭 증가된 것으로 조사되었다. 따라서 장미무당버섯의 자실체에서 추출한 조다당류가 Sarcoma 180에 대한 항암작용을 나타내는 것은 이들 조다당류가 Sarcoma 180에 대한 세포독성효과가 아니고 면역을 증강시킨 효과에 의한 것으로 사료된다.