• Archives of Pharmacal Research
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• v.28 no.7
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• pp.775-783
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• 2005

The ethanol extract of the peony root (Paeonia Lactiflora Pall, Paeoniaceae) as well as its major active components including gallic acid and methyl gallate were evaluated for their protective effects against free radical generation and lipid peroxidation. In addition, the protective effects against hydrogen peroxide-induced oxidative DNA damage in a mammalian cell line were examined. The ethanol extracts of the peony root (PREs) and its active constituents, gallic acid and methyl gallate, exhibited a significant free radical scavenging effect against 1,1-diphenyl-2-picryl hydrazine (DPPH) radical generation and had an inhibitory effect on lipid peroxidation, as measured by the level of malondialdehyde (MDA) formation. The PREs did not have any pro-oxidant effect. They strongly inhibited the hydrogen peroxide-induced DNA damage from NIH/3T3 fibroblasts, as assessed by single cell gel electrophoresis. Furthermore, the oral administration of 50% PRE (50% ethanol extract of peony root), gallic acid and methyl gallate potently inhibited the formation of micronucleated reticulocytes (MNRET) in the mouse peripheral blood induced by a $KBrO_3$ treatment in vivo. Therefore, PREs containing gallic acid and methyl gallate may be a useful antigenotoxic antioxidant by scavenging free radicals, inhibiting lipid peroxidation and protecting against oxidative DNA damage without exhibiting any pro-oxidant effect.

• Proceedings of the KACD Conference
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• 2001.05a
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• pp.243-244
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• 2001

Root resorption is conventionally divided into internal and external varieties. Internal resorption occurs where there is loss of the internal wall of the root canal. and is usually associated with a localized area of necrotic pulp(Trope '||'&'||' Chivian 1984). External resorption occurs where there is loss of the external surface of the root and the resorption may be either transient or progressive(Tronstad 1988). External inflammatory resorption usually occurs following damage to the periodontal ligament or where there is communication between the periodontal ligament and a necrotic pulp. via open dentinal tubules or accessory canals. This type of resorption is usually progressive until root canal treatment is instituted (Barclay 1993).

• Composites Research
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• v.20 no.6
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• pp.21-27
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• 2007

Low-velocity impact damage in a composite stiffened panel was detected using built-in piezoelectric active sensor arrays. Using these piezoelectric active sensors, various diagnostic signals were generated to propagate Lamb waves through the structure and the responses were picked up to detect changes in the structure's vibration signature due to the damage. Three algorithms - ADI(Active Damage Interrogation), TD RMS (Time Domain Root Mean Square) and STFT (Short Time Fourier Transform) - were examined to express the features of the signal changes as one damage index. From damage detecting tests, two impact induced delaminations were detected and the location was estimated with the algorithms and diagnostic signals.

• Proceedings of the Korean Institute of Building Construction Conference
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• 2014.05a
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• pp.230-231
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• 2014

This study is concerned with the root penetration resistance competence and constructability of a waterproofing and root penetration resistance layer of an eco-bridge which is applied with various types of seeding. For the review of root penetration resistance competence, the competence was tested using herbs, woody plants, and tall trees. As a result, there was no tear of or damage to the waterproofing and root penetration resistance layer as well as the sweeping-down phenomenon of a waterproofing and root penetration resistance layer by soil. Also, the effect of the root growth of herbs, woody plants, and tall trees on the root penetration resistance system was confirmed.

• The Plant Pathology Journal
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• v.39 no.6
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• pp.548-565
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• 2023

Armillaria root disease affects forests around the world. It occurs in many habitats and causes losses in the infested stands. Weather conditions are important factors for growth and development of Armillaria species. Yet, the relation between occurrence of damage caused by Armillaria disease and weather variables are still poorly understood. Thus, we used generalized linear mixed models to determine the relationship between weather conditions of current and previous year (temperature, precipitation and their deviation from long-term averages, air humidity and soil temperature) and the incidence of Armillaria-induced damage in young (up to 20 years old) and older (over 20 years old) coniferous stands in selected forest districts across Poland. We used unique data, gathered over the course of 23 years (1987-2009) on tree damage incidence from Armillaria root disease and meteorological parameters from the 24-year period (1986-2009) to reflect the dynamics of damage occurrence and weather conditions. Weather parameters were better predictors of damage caused by Armillaria disease in younger stands than in older ones. The strongest predictor was soil temperature, especially that of the previous year growing season and the current year spring. We found that temperature and precipitation of different seasons in previous year had more pronounced effect on the young stand area affected by Armillaria. Each stand's age class was characterized by a different set of meteorological parameters that explained the area of disease occurrence. Moreover, forest district was included in all models and thus, was an important variable in explaining the stand area affected by Armillaria.

• Restorative Dentistry and Endodontics
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• v.44 no.4
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• pp.38.1-38.8
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• 2019

Navigation of the main root canal and dealing with a dens invaginatus (DI) is a challenging task in clinical practice. Recently, the guided endodontics technique has become an alternative method for accessing root canals, surgical cavities, and calcified root canals without causing iatrogenic damage to tissue. In this case report, the use of the guided endodontics technique for two maxillary lateral incisors with multiple DIs is described. A 16-year-old female patient was referred with the chief complaint of pain and discoloured upper front teeth. Based on clinical and radiographic findings, a diagnosis of pulp necrosis and chronic periapical abscess associated with double DI (Oehler's type II) was established for the upper left lateral maxillary incisor (tooth #22). Root canal treatment and the sealing of double DI with mineral trioxide aggregate was planned for tooth #22. For tooth #12 (Oehler's type II), preventive sealing of the DI was planned. Minimally invasive access to the double DI and the main root canal of tooth #22, and to the DI of tooth #12, was achieved using the guided endodontics technique. This technique can be a valuable tool because it reduces chair-time and, more importantly, the risk of iatrogenic damage to the tooth structure.

• Smart Structures and Systems
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• v.15 no.4
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• pp.997-1018
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• 2015

Structural health monitoring along with damage detection and assessment of its severity level in non-accessible reinforced concrete members using piezoelectric materials becomes essential since engineers often face the problem of detecting hidden damage. In this study, the potential of the detection of flexural damage state in the lower part of the mid-span area of a simply supported reinforced concrete beam using piezoelectric sensors is analytically investigated. Two common severity levels of flexural damage are examined: (i) cracking of concrete that extends from the external lower fiber of concrete up to the steel reinforcement and (ii) yielding of reinforcing bars that occurs for higher levels of bending moment and after the flexural cracking. The purpose of this investigation is to apply finite element modeling using admittance based signature data to analyze its accuracy and to check the potential use of this technique to monitor structural damage in real-time. It has been indicated that damage detection capability greatly depends on the frequency selection rather than on the level of the harmonic excitation loading. This way, the excitation loading sequence can have a level low enough that the technique may be considered as applicable and effective for real structures. Further, it is concluded that the closest applied piezoelectric sensor to the flexural damage demonstrates higher overall sensitivity to structural damage in the entire frequency band for both damage states with respect to the other used sensors. However, the observed sensitivity of the other sensors becomes comparatively high in the peak values of the root mean square deviation index.

• Advances in concrete construction
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• v.9 no.4
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• pp.413-421
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• 2020

For steel-concrete girders made composite using shear studs, initial damage on studs induced by weld defect, unexpected overloading, fatigue and others might degrade the service performance and even threaten the structural safety. This paper conducted a numerical study to investigate the static behavior of damaged stud shear connectors that were embedded in ultra high performance concrete (UHPC). Parameters included damage degree and damage location. The material nonlinear behavior was characterized by multi-linear stress-strain relationship and damage plasticity model. The results indicated that the shear strength was not sensitive to the damage degree when the damage occurred at 2/3d (d is the stud diameter) from the stud root. An increased stud area would be engaged in resisting shear force as the distance of damage location from stud root increased and the failure section becomes inclined, resulting in a less reduction in the shear strength and shear stiffness. The reduction factor was proposed to consider the degradation of the shear strength of the damaged stud. The reduction factor can be calculated using two approaches: a linear relationship and a square relationship with the damage degree corresponding to the shear strength dominated by the section area and the nominal diameter of the damaged stud. It was found that the proposed method is preferred to predict the shear strength of a stud with initial damage.

• Proceedings of the Korean Society of Applied Pharmacology
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• 2003.11a
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• pp.61-61
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• 2003

The ethanol extract of peony root (Paeonia Lactiflora Pall, Paeoniaceae) and its major active components including gallic acid and methyl gallate were evaluated for their protective effects against free radical generation and lipid peroxidation. And protective effects against hydrogen peroxide-induced oxidative DNA damage in a mammalian cell line were performed. The ethanol extract of peony root (PRE), gallic acid and methyl gallate were shown to possess the significant free radical scavenging effect against 1,1-diphenyl-2-picryl hydrazine (DPPH) radical generation and were revealed the inhibitory effect of lipid peroxidation as expressed by malondialdehyde (MDA) formation. They were also found to strongly inhibit hydrogen peroxide-induced DNA damage from NIH/3T3 fibroblasts, assessed by single cell gel electrophoresis. Furthermore, oral administration of 50% PRE (50% ethanol extract), gallic acid and methyl gallate potently inhibited micronucleated reticulocyte (MNRET) formation of mouse peripheral blood induced by KBrO3 treatment in vivo. Therefore, PRE containing gallic acid and methyl gallate may be a useful natural antioxidant by scavenging free radicals, inhibition of lipid peroxidation and protecting oxidative DNA damage.

• Toxicological Research
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• v.23 no.1
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• pp.25-31
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• 2007

To evaluate the protective effect of Houttuynia cordata on hydrogen peroxide-induced oxidative DNA damage in HepG2 cell line, we used an alkaline single-cell gel electrophoresis (SCGE; comet assay). The DNA damage was analyzed by tail moment (TM) and tail length (TL), which used markers of DNA strand breaks in SCGE. The $100{\mu}g/ml$ of methanolic extract of Houttuynia cordata root showed significant protective effects (p < 0.01) against hydrogen peroxide-induced DNA damage in HepG2 cells and increased cell viability against hydrogen peroxide. The results of this study indicate that Houttuynia cordata root methanol extract acts as a potential antioxidant, and exhibits potential anticancer properties, which may provide a clue to find applications in new pharmaceuticals for oxidative stability.