• Asian Pacific Journal of Cancer Prevention
• /
• v.15 no.19
• /
• pp.8041-8046
• /
• 2014

In-depth analysis of how TRAIL signals through death receptors to induce apoptosis in cancer cells using high throughput technologies has added new layers of knowledge. However, the wealth of information has also highlighted the fact that TRAIL induced apoptosis may be impaired as evidenced by experimental findings obtained from TRAIL resistant cancer cell lines. Overwhelmingly, increasing understanding of TRAIL mediated apoptosis has helped in identifying synthetic and natural compounds which can restore TRAIL induced apoptosis via functionalization of either extrinsic or intrinsic pathways. Increasingly it is being realized that biologically active phytochemicals modulate TRAIL induced apoptosis, as evidenced by cell-based studies. In this review we have attempted to provide an overview of how different phytonutrients have shown efficacy in restoring apoptosis in TRAIL resistant cancer cells. We partition this review into how the TRAIL mediated signaling landscape has broadened over the years and how TRAIL induced signaling machinery crosstalks with autophagic protein networks. Subsequently, we provide a generalized view of considerable biological activity of coumarins against a wide range of cancer cell lines and how coumarins (psoralidin and esculetin) isolated from natural sources have improved TRAIL induced apoptosis in resistant cancer cells. We summarize recent updates on piperlongumine, phenethyl isothiocyanate and luteolin induced activation of TRAIL mediated apoptosis. The data obtained from pre-clinical studies will be helpful in translation of information from benchtop to the bedside.

• Imaging Science in Dentistry
• /
• v.43 no.3
• /
• pp.135-143
• /
• 2013

Purpose: This study was performed to obtain a quantitative evaluation of the cortical and cancellous bone graft harvestable from the mental and canine regions, and to evaluate the cortical vestibular thickness. Materials and Methods: This study collected cone-beam computed tomographic (CBCT) images of 100 Italian patients. The limits of the mental region were established: 5 mm in front of the medial margin of each mental foramen, 5 mm under the apex of each tooth present, and above the inferior mandibular cortex. Cortical and cancellous bone volumes were evaluated using SimPlant software (SimPlant 3-D Pro, Materialize, Leuven, Belgium) tools. In addition, the cortical vestibular thickness (minimal and maximal values) was evaluated in 3 cross-sections corresponding to the right canine tooth (3R), the median section (M), and the left canine tooth (3L). Results: The cortical volume was $0.71{\pm}0.23mL$ (0.27-1.96 mL) and the cancellous volume was $2.16{\pm}0.76mL$ (0.86-6.28 mL). The minimal cortical vestibular thickness was $1.54{\pm}0.41mm$ (0.61-3.25 mm), and the maximal cortical vestibular thickness was $3.14{\pm}0.75mm$ (1.01-5.83 mm). Conclusion: The use of the imaging software allowed a patient-specific assessment of mental and canine region bone availability. The proposed evaluation method might help the surgeon in the selection of the donor site by the comparison between bone availability in the donor site and the reconstructive exigency of the recipient site.

• Korean Institute of Interior Design Journal
• /
• v.17 no.6
• /
• pp.11-20
• /
• 2008

The purpose of this study is to find out the theoretical background of spatial fantage effects in Piranesi etching "Le Carceri" called 'Architectural Capriccio'. In a life time Piranesi created a prodigious oeuvre of dramatic and fantastic images about magnificent buildings and mysterious ruins and prison. The increasing "tourism" after the middle of the 18th century contributed a lot to Piranesi's success. He was famous for his poetic views of Rome and also his fantastic imaginary interiors. The terms "Capriccio" and "Veduta" are strongly connected with Piranesi's work. The term Veduta describes a form of landscape depiction in print with close to reality imitation of the scenery, whereas the "Capriccio" contains the elements of invention in artificial architectural landscape. Trained in Venice as an engineer and architect, his studies had included perspective and stage design. These skills, allied to his deep knowledge of archaeology, provided the substance for his Veduta, etchings of ancient Rome. But his most remarkable etchings are those of imaginary interiors, the Carceri d'Invenzione(Imaginary Prisons), a series of capric plates issued in 1750. It appears to Piranesi etching 'Le Carceri' that 18th century experimental scenography's effect very strongly. Also, it can understand about "Scena per Angolo" which was revealed by Ferdinando Galli Bibiena that Piranesi spatial view and viewpoint deconstruction operate motive and cause. Piranesi's spatial fortification was influence by Filippo Juvarra's spatial concept. As a result of this research will be foundation of understanding deeply that Piranesi etching has been affect to present architecture and art.

• Journal of architectural history
• /
• v.7 no.4 s.17
• /
• pp.191-198
• /
• 1998

The form of Pantheon in Rome is graphically analyzed in relation to the angle of the Sun that varies through four seasons of the year. These are worked out in the Autocad drawing files for exactitude and efficiency. Some of the results suggest that the Pantheon is carefully designed to predict the equinoxes and the solstices.

• Korean Journal of Applied Biomechanics
• /
• v.20 no.3
• /
• pp.253-259
• /
• 2010

The aim of IAAF's Biomechanics project, initially launched at the 1987 World Championships in Rome, is to support athletes and coaches in the optimization and improvement of their training and competition performance. The IAF and the IAAF supports biomechanical projects, as a service to their Member Federations, starting from the IAAF World Championships in Rome 1987. In 1997, at the IAAF World Championships of Athens. In 1995, at the IAAF World Championships in Goteborg and in co-operation with the Swedish Sport Institute of Karlstad and under the leadership of Anders Bergstrom a biomechanical research on "Throws" was conducted. In 2005, at the IAAF World Championships in Helsinki on 100m - Pole vault, High Jump, Triple Jump, Javelin, under the leadership of Prof. Paavo Komi. The IAAF published the final report in 2008 with a supplement of NSA. In 2007, at the IAAF World Championships of Osaka, in co-operation with Osaka University of Health and Sport Sciences and under the leadership of Prof. Michiyoshi Ae the IAAF received a final report on; short sprint, distance running, high jump, long jump, shot put and javelin. In 2009, at the IAAF World Championships of Berlin, in co-operation with the DLV and the leadership of Helmar Hommel (GER). The purpose of this study is to draw up a plan to perform an effective biomechanics project at 2011 IAAF World championship in Daegu.

• Clinical and Experimental Pediatrics
• /
• v.50 no.7
• /
• pp.655-659
• /
• 2007

Purpose : The aim of this study was to document the causes of chronic abdominal pain in children referred to a hospital setting and evaluate the frequency and characteristics of functional gastrointestinal disorder (FGID) classified by Rome III criteria. Methods : One hundred thirty two patients with chronic abdominal pain were evaluated. Examinations were performed in order to find organic causes in patients when organic disease was suspected. Results : Among the 132 patients, 20 patients (15.2%) had organic diseases and 112 patients (84.8%) were diagnosed as having FGIDs. Functional dyspepsia was the most common cause of FGIDs, followed by irritable bowel syndrome. Overlap of some FGIDs was observed in seven patients (5.3%). Conclusion : FGIDs are the main causes of chronic abdominal pain in children and functional dyspepsia was the most prevalent disorder.

• Archives of Plastic Surgery
• /
• v.41 no.5
• /
• pp.588-593
• /
• 2014

Lymphedema is a chronic disorder characterized by lymph stasis in the subcutaneous tissue. Lymphatic fluid contains several components including hyaluronic acid and has many important properties. Over the past few years, significant research has been performed to identify an ideal tissue to implant as a filler. Because of its unique composition, fat harvested from the lymphedema tissue is an interesting topic for investigation and has significant potential for application as a filler, particularly in facial rejuvenation. Over a 36-month period, we treated and assessed 8 patients with lymphedematous limbs who concurrently underwent facial rejuvenation with lymphedema fat (LF). We conducted a pre- and postoperative satisfaction questionnaire survey and a histological assessment of the harvested LF fat. The overall mean general appearance score at an average of 6 months after the procedure was $7.2{\pm}0.5$, demonstrating great improvement. Patients reported significant improvement in their skin texture with a reading of $8.5{\pm}0.7$ and an improvement in their self-esteem. This study demonstrates that LF as an ideal autologous injectable filler is clinically applicable and easily available in patients with lymphedema. We recommend the further study and clinical use of this tissue as it exhibits important properties and qualities for future applications and research.

• Journal of architectural history
• /
• v.21 no.5
• /
• pp.19-32
• /
• 2012

The purpose of this paper is a study on the dome plan of S. M. del Fiore Church of F. Brunelleschi. The results of study are as follows: 1. The planning of floor, elevation and cross section plan of S. M. del Fiore church is basically planned by each other correlation. In particular, the octangular form of geometrical standard which is formed with altar as the center at the crossing part is important component elements which is decided by not only the dome, but form and size of the drum and floor plan form of the lantern 2. The dome which has been planned by F. Brunelleshi has completed the new dome, preserving gothic thought intended by the church plan after study on architecture of ancient Rome with Pantheon. And the dome which is a main space of church through all aspects of plan, structure, function and construction about the dome is a opportunity in the beginning of Renaissance architecture which is a new epoch and a turning point of architecture on various point of view. 3. The dome which is constructed by F. Brunelleshi has been planned through the innovative solution by the refusal of traditional semicircle form dome, centering use and creation double-shell structure form for the first time in history. And the construction of dome has been solved with the invention of various construction equipments and machineries, the stone rib planned for connection and reinforcement about shells of the octangular form, the support method for reduction the gravity of bricklayers work and the brick work of nock-patterned shape which is masonry construction method of the architecture of ancient Rome.

• Korean Institute of Interior Design Journal
• /
• no.27
• /
• pp.152-161
• /
• 2001

At the multi-cultural society, research is needed to encourage a social atmosphere for enhanced understanding and respect for different cultures & countries. The purpose was to analyze the characteristics of spatial arrangement, space connection, Interior decoration and the relationship among these three features, which showed each country's unique housing form tradition. Three representative cases of historic residences from each country were selected on the basis of a recognized historic architecture directory. Total 18 residences from 6 countries - Korea, China, Japan, Rome, Egypt, and Italy - were comparatively analyzed. As results, aspects generally found in Eastern countries, were the fence as the semi-open boundary between the inside and the outside of the house, the flexibility of spatial opening and partitions between rooms, and finally simple and movable decoration features. On the other hands, aspects appeared in Western countries, were the outer wall of the building as the boundary to the outside, the closed and fixed properties of the room partitions, and finally complex and fixed decoration features. The research also showed that even within the same culture, the degree of openness varied. Each feature of space was related and could be explained within the same context. Housing, regardless of country and culture, tried to accommodate the exterior space inside the building as much as possible. The common pursuit was transformed to various visible forms and its reason might be due to different socio-cultural and environmental backgrounds that need to be continuously explored in academic area.

• ETRI Journal
• /
• v.42 no.5
• /
• pp.669-685
• /
• 2020

5G AgiLe and fLexible integration of SaTellite And cellulaR (5G-ALLSTAR) is a Korea-Europe (KR-EU) collaborative project for developing multi-connectivity (MC) technologies that integrate cellular and satellite networks to provide seamless, reliable, and ubiquitous broadband communication services and improve service continuity for 5G and beyond. The main scope of this project entails the prototype development of a millimeter-wave 5G New Radio (NR)-based cellular system, an investigation of the feasibility of an NR-based satellite system and its integration with cellular systems, and a study of spectrum sharing and interference management techniques for MC. This article reviews recent research activities and presents preliminary results and a plan for the proof of concept (PoC) of three representative use cases (UCs) and one joint KR-EU UC. The feasibility of each UC and superiority of the developed technologies will be validated with key performance indicators using corresponding PoC platforms. The final achievements of the project are expected to eventually contribute to the technical evolution of 5G, which will pave the road for next-generation communications.