• BMB Reports
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• v.55 no.12
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• pp.633-638
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• 2022

Liver regeneration is a well-known systemic homeostatic phenomenon. The N⁶-methyladenosine (m⁶A) modification pathway has been associated with liver regeneration and hepatocellular carcinoma. m⁶A methyltransferases, such as methyltransferase 3 (METTL3) and methyltransferase 14 (METTL14), are involved in the hepatocyte-specific-regenerative pathway. To illustrate the role of METTL14, secreted from non-parenchymal liver cells, in the initiation phase of liver regeneration, we performed 70% partial hepatectomy (PH) in Mettl14 heterozygous (HET) and wild-type (WT) mice. Next, we analyzed the ratio of liver weight to body weight and the expression of mitogenic stimulators derived from non-parenchymal liver cells. Furthermore, we evaluated the expression of cell cycle-related genes and the hepatocyte proliferation rate via MKI67-immunostaining. During regeneration after PH, the weight ratio was lower in Mettl14 HET mice compared to WT mice. The expressions of hepatocyte growth factor (HGF) and tumor necrosis factor (TNF)-α, mitogens derived from non-parenchymal liver cells that stimulate the cell cycle, as well as the expressions of cyclin B1 and D1, which regulate the cell cycle, and the number of MKI67-positive cells, which indicate proliferative hepatocyte in the late G1-M phase, were significantly reduced in Mettl14 HET mice 72 h after PH. Our findings demonstrate that global Mettl14 mutation may interrupt the homeostasis of liver regeneration after an acute injury like PH by restraining certain mitogens, such as HGF and TNF-α, derived from sinusoidal endothelial cells, stellate cells, and Kupffer cells. These results provide new insights into the role of METTL14 in the clinical treatment strategies of liver disease.

• The Korean Journal of Pain
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• v.36 no.1
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• pp.60-71
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• 2023

Background: The purpose of this research was to assess the role of heparanase (HPSE)/syndecan1 (SDC1)/nerve growth factor (NGF) on cancer pain from melanoma. Methods: The influence of HPSE on the biological function of melanoma cells and cancer pain in a mouse model was evaluated. Immunohistochemical staining was used to analyze HPSE and SDC1. HPSE, NGF, and SDC1 were detected using western blot. Inflammatory factors were detected using ELISA assay. Results: HPSE promoted melanoma cell viability, proliferation, migration, invasion, and tumor growth, as well as cancer pain, while SST0001 treatment reversed the promoting effect of HPSE. HPSE up-regulated NGF, and NGF feedback promoted HPSE. High expression of NGF reversed the inhibitory effect of HPSE down-regulation on melanoma cell phenotype deterioration, including cell viability, proliferation, migration, and invasion. SST0001 down-regulated SDC1 expression. SDC1 reversed the inhibitory effect of SST0001 on cancer pain. Conclusions: The results showed that HPSE promoted melanoma development and cancer pain by interacting with NGF/SDC1. It provides new insights to better understand the role of HPSE in melanoma and also provides a new direction for cancer pain treatment.

• Journal of the Korean Institute of Landscape Architecture
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• v.37 no.6
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• pp.73-84
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• 2010

The urban representative landscapes play a leading role in establishing city identity via a symbol of the city and a mediator to make the city all the more worthy of being peculiarized. The study aims at evaluating the perceptive factors in the representative landscapes around the metropolitan Seoul derived from the preliminary researches through questionnaire surveying, in an attempt to analyze their characteristics by type and reason, while further proposing progressive management plans. This study was mostly focused on the visibility factor, activity factor, aesthetic factor and cultural factor influencing on the cognition of urban representative landscapes. The important findings discovered in this research are as follows. First, it was found that people were being interested more on the cultural factors and the activity factors these days rather than visibility factors in the cognition of urban representative landscapes. Second, it was found that the priority rank of urban representative landscapes revealed in this study based on the total account of more diverse perceptive factors, showed so much alteration compared to the previous researches focused mostly upon the visual image.

• Proceedings of the Ginseng society Conference
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• 2002.10a
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• pp.424-455
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• 2002

Diabetes mellitus is reaching epidemic proportions worldwide. The insufficiency of medication to cope with this burden has coincided with a dramatic rise in the prevalence of use of complementary and alternative therapies, especially herbal treatments. This surge in demand presents a challenge to prove the safety and efficacy of these treatments in diabetes. Korean red ginseng (steam treated Panax ginseng C.A. Meyer) is a strong candidate to succeed. It has been shown to possess a multitude of hypoglycemic effects and improve metabolic disturbances related to diabetes in in vitro and animal models. Data in humans is also emerging to support these benefits. Whether these results can be replicated in a rigorous clinical testing program is unclear. We therefore investigated the antidiabetic effects of Korean red ginseng in a series of 2 acute and 1 longterm randomized, double-blinded, placebo-controlled clinical trials. This paper provides the rationale for this program of study, expanding on the problem of diabetes, its management, and the possible role for Korean red ginseng. It then describes the design and expected findings.

• International Area Studies Review
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• v.15 no.3
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• pp.191-213
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• 2011

This study empirically examines whether income smoothing effectively contributes to consumption smoothing. Since international factor movement plays an important role for income smoothing across countries, net factor income across countries deserves more attention in considering income smoothing than attention having been paid by previous studies in the literature. Most of previous studies assume that net factor income has the same degree of effects on consumption as GDP. For the case of 12 EU countries during the period from 1999 to 2010, our empirical investigation observes that the response of consumption with respect to net factor income is severely lower than the response of consumption with respect to GDP, and further net factor income has ignorable effects on the consumption. This evidence implies that the income smoothing via international factor movement is less significant in contributing to the consumption smoothing. In the sequel, our finding suggests that legal and institutional process for transferring net factor income across countries should be eased further to improve contribution of income smoothing to consumption smoothing.

• Earthquakes and Structures
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• v.16 no.2
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• pp.185-196
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• 2019

One of the shortcomings of seismic bridge design codes is the lack of clarity in defining the role of different seismic isolation systems with linear or nonlinear behavior in terms of R-factor. For example, based on AASHTO guide specifications for seismic isolation design, R-factor for all substructure elements of isolated bridges should be half of those expressed in the AASHTO standard specifications for highway bridges (i.e., R=3 for single columns and R=5 for multiple column bent) but not less than 1.50. However, no distinction is made between two commonly used types of seismic isolation devices, i.e., elastomeric rubber bearing (ERB) with linear behavior, and lead rubber bearing (LRB) with nonlinear behavior. In this paper, five existing bridges located in Iran with two types of deck-pier connection including ERB and LRB isolators, and two bridge models with monolithic deck-pier connection are developed and their R-factor values are assessed based on the Uang's method. The average R-factors for the bridges with ERB isolators are calculated as 3.89 and 4.91 in the longitudinal and transverse directions, respectively, which are not in consonance with the AASHTO guide specifications for seismic isolation design (i.e., R=3/2=1.5 for the longitudinal direction and R=5/2=2.5 for the transverse direction). This is a clear indicator that the code-prescribed R-factors are conservative for typical bridges with ERB isolators. Also for the bridges with LRB isolators, the average computed R-factors equal 1.652 and 2.232 in the longitudinal and transverse directions, respectively, which are in a good agreement with the code-specified R-factor values. Moreover, in the bridges with monolithic deck-pier connection, the average R-factor in the longitudinal direction is obtained as 2.92 which is close to the specified R-factor in the bridge design codes (i.e., 3), and in the transverse direction is obtained as 2.41 which is about half of the corresponding R-factor value in the specifications (i.e., 5).

• Journal of Korean Society of Rural Planning
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• v.27 no.3
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• pp.35-46
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• 2021

Ecosystem services play a role in promoting sustainable development by contributing to human welfare. For sustainable development, a balance between supply and demand for ecosystem services must be made. In this regard, in this study, factor analysis was performed using the results of measuring ecosystem services for the supply of ecosystem services and national statistical data representing socio-economic factors for demand for ecosystem services The results of analysis for Gyeong-gi Province are as follows. The service supply based on the result of ecosystem services was divided into the mixed service provisioning as factor1, the food provisioning as factor2, and the P retention service provisioning area as factor3. As for the demand for services based on socio-economic factors, factor1 is divided into urbanized areas, factor2 is forest development area, and factor3 is agricultural activity development area. Local governments that maintain balance were evaluated as Pocheon, Yangpyeong, Icheon, Pyeongtaek, Goyang, Suwon, Gwangmyeong, and Osan, and imbalanced local governments appeared in Gimpo, Uiwang, Anseong, and Yeoju. A management plan to maintain the balance between supply and demand of ecosystem services was suggested. The analysis method and results of this study are expected to be applicable to various local governments through regional expansion.

• Journal of Fashion Business
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• v.16 no.5
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• pp.164-177
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• 2012

The purpose of this study was to classify sex role identity into groups and analyze the difference of social face sensitivity and appearance management behaviors by sex role identity. Questionnaires were administered to 306 people in their twenties and thirties living in Daegu Metropolitan City and Kyoungbuk province. The data was analyzed by using frequency, factor analysis, credibility, ${\chi}^2$-test, ANOVA, Duncan-test, and t-test. The findings were as follows. Sex role identity were classified into four groups (androgyny, masculineness, feminineness, and undifferentiation). Men in androgyny group showed the highest rate of 41.3% followed by undifferentiation(24.7%), masculineness(21.3%), and feminineness(12.7%). Women in undifferentiation group showed the highest rate of 35.9% followed by feminineness(24.4%), androgyny(23.7%), and masculineness(16.0%). Social face sensitivity were composed of four factors (consciousness of being embarrassed, social formality, other consciousness, and prestige). Appearance management behaviors were composed of six factors (skin management, fashion image management, plastic surgery management, weight management, hair management, and health management). According to the result of a significant difference between social face sensitivity and appearance management behaviors by sex role identity, male showed significant difference between the sub-variables of social face sensitivity factors (consciousness of being embarrassed, social formality, and other consciousness). Both of the male and female showed a significance of difference in consciousness of being embarrassed, and social formality. Male showed significant difference between the sub-variables of appearance management behaviors factors (fashion image management, weight management, hair management, and health management). Both of the male and female showed a significance of difference in fashion image management. Gender of twenties and thirties showed distinction between the sub-variables of social face sensitivity factors (consciousness of being embarrassed, and prestige) and appearance management behaviors (skin management, fashion image management, plastic surgery management, weight management, and hair management).

• Journal of the Korean Home Economics Association
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• v.43 no.2
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• pp.81-103
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• 2005

The main purpose of the research was to prove, in a practical sense, the relationship among perceived equity, role stress and life satisfaction of employed wives working in sales departments. The subjects were employed wives working in sales departments who have at least one child and a spouse, living in Seoul and the Metropolitan area. The final data analysis used 487 out of 668 questionnaires. Statistical analyses were carried out using SPSS/PC WIN which included frequencies, mean, percentages, Pearson's correlation, Cronbach's ${\alpha}$, factor analysis, multiple regression analysis. The findings of the study were as follows: 1) As their education level was low, the education level of their spouse was high, the communication level between couples was high, and the self-oriented perfectionism was low, their perceived emotional relationship was equal. As they were old, the communication level between couples was high, and the self-oriented perfectionism was low, their perceived position in sharing household chores was equal. On the other hand, as they were younger, the education level of their spouse was high, the reason for getting a job lay in supporting the family, and overtime hours worked, there was a higher level of role stress. 2) The influential variables which affect the life satisfaction, in order of importance, were communication level between couples, mother's role stress, age, non-financial reason of getting a job, and sharing household works. For relative contribution degree about life satisfaction, psychological variables among independent variables were revealed as the most influential ones. Thus, efficient communication between couples affected the life satisfaction to a great degree. Furthermore, the study proved that not only role stress variables but also perceived equity variables contributed to the life satisfaction.

• Journal of Digital Convergence
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• v.12 no.6
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• pp.449-456
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• 2014

This study aims to contribute to our knowledge on gender role identity of middle-aged women within the Korean context. This research adapting Q methodology created a sampling distribution of P with 40 middle-aged women between 40-60 years old. We put each of 40 Q samples to become a forced distribution into 9 scales. And then we conducted a secondary analysis of the results from the principal component factor analysis by the PC QUANL program. Gender role identities of middle aged women were classified as four types: "affectionate-sensitive type", "affectionate-confident type", "assertive-confident type", and "sensitive-dominant type". Most of the middle-aged women in Korea tend to keep their original gender role identities. Some of women, however, experience the gender role identity change over time that their traits of traditional caring become more prominent than their affectionate character.