• Biomolecules & Therapeutics
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• v.28 no.1
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• pp.45-57
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• 2020

In the neurovascular unit, the neuronal and vascular systems communicate with each other. O₂ and nutrients, reaching endothelial cells (ECs) through the blood stream, spread into neighboring cells, such as neural stem cells, and neurons. The proper function of neural circuits in adults requires sufficient O₂ and glucose for their metabolic demands through angiogenesis. In a central nervous system (CNS) injury, such as glioma, Parkinson's disease, and Alzheimer's disease, damaged ECs can contribute to tissue hypoxia and to the consequent disruption of neuronal functions and accelerated neurodegeneration. This review discusses the current evidence regarding the contribution of oxygen deprivation to CNS injury, with an emphasis on hypoxia-inducible factor (HIF)-mediated pathways and Notch signaling. Additionally, it focuses on adult neurological functions and angiogenesis, as well as pathological conditions in the CNS. Furthermore, the functional interplay between HIFs and Notch is demonstrated in pathophysiological conditions.

• Proceedings of the KSR Conference
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• 2008.11b
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• pp.846-853
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• 2008

Maglev System is expected to be a new public transportation for future because of its special characteristics. Sleepers of railway role on transferring the lateral load to guideway for Maglev and controlling the distance between rails. Variation of distance of sleepers can affect dynamic responses for maglev guideway. In this paper, Daejon maglev guideway is analyzed to find proper tie spacing of a maglev system. The analysis included using a maglev trainload and also the dead load as the primary forces on bridges. Not only the dynamic behavior of bridges is investigated under sleeper conditions, but also impact factor about vertical displacement on the guideway is produced. This guideway is analyzed in four cases followed by changing spacing of sleeper and then obtained dynamic characteristics such as displacements, acceleration and impact factor by Finite Element Analysis.

• Biomedical Science Letters
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• v.29 no.3
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• pp.137-143
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• 2023

Inflammation plays an important role in immune system's response to tissue injury and biological stimuli. However, excessive inflammation can cause tissue damage. Therefore, the development of naturally derived anti-inflammatory agents have received broad attention. In this study, we investigated the anti-inflammatory mechanism of Rubi Fructus (RF) extract on the mast cell-mediated inflammatory response. To determine the regulatory mechanism of RF in inflammatory reaction, we evaluated the effects of RF on secretion of interleukin (IL)-8, IL-6 and tumor necrosis factor (TNF)-α and activation of nuclear factor-κB (NF-κB) and caspase-1 in activated human mast cells-1 (HMC-1). The results showed that RF attenuated IL-8, IL-6 and TNF-α secretion in a concentration-dependent manner. Moreover, RF significantly attenuated caspase-1and NF-κB activation in activated HMC-1. Conclusively, the present results provide evidence that RF may be a promising agent for anti-inflammatory therapy.

• Journal of Life Science
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• v.22 no.4
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• pp.447-455
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• 2012

Akt plays an important role in a variety of cellular physiologies such as growth, proliferation, and differentiation. In skeletal muscle, Akt has been implicated in regulating regeneration, hypertrophy, and atrophy. In this study, the role of Akt has been examined during skeletal muscle differentiation. Culturing C2C12 myoblasts under low serum (1% horse serum) and high density converted cell morphology from a round shape to an elongated and multi-nucleated shape. Morphological changes were initiated from day 2 of differentiation. In addition, the expression of both myogenin G and myogenin D was elevated from day 2 of differentiation. Skeletal muscle differentiation was abolished by silencing Akt1 or Akt2, but was significantly enhanced by the over-expression of either Akt1 or Akt2. The activation of Akt was observed from day 2 of differentiation and disappeared after day 7. The expression of kruppel-like factor 4 was observed from day 6 of differentiation. Moreover, this expression was blocked in cells silencing either Akt1 or Akt2. In addition, the promoter activity of kruppel-like factor 4 was significantly reduced in cells silencing Akt1 or Akt2. These results suggest that Akt regulates skeletal muscle differentiation through the regulation of kruppel-like factor 4 expression.

• Development and Reproduction
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• v.3 no.1
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• pp.95-100
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• 1999

Growth differentiation factor-9 (GDF-9) is a member of the transforming growth factor $\beta$ (TGF-$\beta$) superfamily. It has been known that GDF-9 is a growth factor having a crucial role in normal folliculogenesis and its expression is oocyte-specific. The present study was aimed to elucidate the expression of GDF-9 mRNA in the mouse primordial follicles as well as in the other developmental stages. The semiquantitative analysis of GDF-9 mRNA expression was conducted. Total RNA was extracted from the ICR mice ovaries at gestational day 19, postnatal day 1, day 10, day 21, and day 28, and RT-PCR was performed to measure GDF-9 and $\beta$-actin mRNA levels. Level of GDF-9 mRNA were normalized against the level of $\beta$-actin mRNA, and compared among different stages. GDF-9 mRNA was detected in all samples including the fetal ovaries that mainly consists of primordial follicles. The highest level of mRNA was observed in ovaries obtained at day 10 that mainly consists of growing follicles. The present result suggests that GDF-9 may play an important role in the early stage of folliculogenesis.

• Korean Journal of Bronchoesophagology
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• v.8 no.1
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• pp.35-41
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• 2002

Background and Objectives : Angiogenesis within malignant tumors has been considered to be essential for the growth and expansion of cancer cells, especially for solid tumors, and has been implicated in the overall growth and metastases of tumors. Such angiogenesis within tumors depends upon the secretion of vascular growth factor to allow the growth of newly formed vessels from peripheral tissue into the malignant tumor. %n, an exploration of the relations between cancer cells and vascular growth factors is absolutely critical to understanding the growth of malignant tumors. According to recent reports, vascular endothelial growth factor(VEGF) has been found to play a role in lymphatic metastases, tumor recurrence and survival in various human tumors. To evaluate the role of VEGF in head and neck squamous cell carcinoma(HNSCC) we performed this study. Materials and Methods : We examined the expression of VEGF and microvessel density in 39 HNSCC by immunohistochemistry and correlated them with various clinical data such as stage, cervical lymphatic metastasis, recurrence, and overall survival. Results : The expression of VEGF was not correlated with overall stage, T stage and N stage. There was no statistical correlation between the expression of VEGF and recurrence in the Primary site, cervical lymph node, and the distant metastases. There was no statistical correlation between the expression of VEGF and microvessel density. Conclusion : Based on these results, it is suggested that the expression of vascular endothelial growth factor is not a major prognostic factor for head and neck squamous cell carcinoma. Further studies are needed to evaluate significance of VEGF expression in head and neck squamous cell carcinoma.

• Journal of Fashion Business
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• v.16 no.3
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• pp.107-124
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• 2012

The purpose of this study was to classify types in sense of gender role identity and to figure out the difference among sociocultural attitude, benefits of clothing pursuit, and appearance management behaviors by sense of gender role identity types. Questionnaires were administered to 455 people in their twenties and thirties living in Daegu and Kyoungbuk area. Data were analyzed by using frequency, factor analysis, credibility, $X^2$-test, ANOVA, Duncan-test, and t-test. The findings are as follows. First, Men of androgyny group showed the highest rate of 38.5% followed by undifferentiation(22.9%), masculineness(21.0%), and feminineness(17.6%). Women of undifferentiation group showed the highest rate of 33.2% followed by feminineness (25.2%), androgyny(22.0%), and masculineness(19.6%). Second, factors of sociocultural attitude were internalization and recognition. Benefits of clothing pursuit consists of the factors such as consciousness of others, personality, and vogue pursuit. Factors of appearance management behaviors were dressing, skin management, plastic surgery management, weight management, health management, and hair management. Third, the result from the difference between sociocultural attitude and benefits of clothing pursuit by sense of gender role identity types, men of androgyny and feminineness showed highest in recognition while women of androgyny showed highest in internalization and recognition. The result of the difference in benefits of clothing pursuit by sense of gender role identity shows that both men and women of androgyny group have high tendency for being conscious of others, personality pursuit, and vogue pursuit while men of undifferentiation and masculineness have low interest in dressing in relationship with others. Fourth, the examination of the difference in appearance management behavior by sense of gender role identity types found men of androgyny group managed dressing, skin, weight, health and hair most while women dress and health most. Men of undifferentiation group managed dressing and weight least, while men of masculineness health, and men of feminineness hair least.

• Proceedings of the Korean Operations and Management Science Society Conference
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• 2007.11a
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• pp.256-263
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• 2007

Corporate managers look at IT outsourcing as long-term strategic choices not as short-term tactical ones, and maximizing the effect that IT outsourcing brings about is the main concern to them. Emerging different types of IT outsourcing and their effects on the corporate business decisions necessitate the research on this subject. According to previous researches, the Intent for IT outsourcing is categorized as IS Improvement, Business Impact, and Commercial Exploitation. The decison factors for these IT outsourcing include corporate strategy types, IT role, and interaction between these two. Firm size and IT maturity are selected as moderating factors to add the credibility to the research of the effect of IT outsourcing decision making. Analyzing IT outsourcing data collected from 61 large-size and mid-size domestic firms revealed that corporate strategy rather than IT role is more significant factor affecting the intent for IT outsourcing decision. That means the decision of outsourcing intent is affected by corporate strategy types. Defenders(as in corporate strategy types) tend to use IT outsourcing more as a means to improve information systems, compared to analyzers and reactors. Prospectors tend to use IT outsourcing more as a commercial exploitation, compared to analyzers and reactors. These outcomes prove that corporate strategy characteristics reflect outsourcing intent. There were previous researches that showed outsourcing decision depends on IT role however the hypothesis was rejected that IT role determines outsourcing intent. It was also rejected that the interaction between corporate strategy types and IT role determines outsourcing intent. Corporate decision makers should first analyze corporate strategy, and reflect it on the outsourcing intent when they make IT outsourcing decisions. Only the precise defining of IT outsourcing intent will lower the risk and increase the possibility of success.

• The Journal of Korean Academic Society of Nursing Education
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• v.6 no.1
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• pp.92-102
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• 2000

Social trends influence the need for inclusion of basic concepts of occupational health into generic nursing education. Several techniques have been used to incorporate occupational health into baccalaureate programme. These include clinical preceptorships in employee health services, lectures on occupational health issues into community health nursing courses and the integration of occupational health concepts throughout the nursing curriculum and organize an independent course of occupational health nursing for two semester hours. The purpose of this study was to examine the impact of this course to the role orientation of nursing students. In March 1998, pre-test was conducted with all 39 students. Post- test for the subjects and the survey for the other comparison group were conducted after the course in May. Structured questionnaires were distributed which were composed of 42 items related to the role of occupational health nurse and each item was measured on a scale of 1 to 5. Results are as follows: 1) The paired t-test supported the hypothesis that role orientation of students was improved through the occupational health nursing course (t=-3.93, p=.000), 2) As the result of t-test between the subject and the comparison group, the mean score of the role orientation in the case of subject was significantly higher than that of the comparison group(t=13.3449, p=.0005). The enlargement of occupational health nursing course must be a facilitating factor to the improvement of the role orientation of baccalaureate students. It is needed to measure occupational health nursing competence of them in the future.

• Korean Journal of Social Welfare
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• v.41
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• pp.7-42
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• 2000

Little empirical study has been conducted concerning social worker' empowerment that has very important function on clients' empowerment. Using the sample of 222 social workers selected from 92 community welfare centers, this study attempted to identify social workers' empowerment level and its predictors. This study used the empowerment scale developed by Leslie, Holzhalb, Holland (1998) that focuses on measurement of social workers's empowerment in social work agencies. Using confirmatory factor analysis, it was confirmed that the scale has three factors such as control of work environment, work relationships, and personal work orientation. This study showed that using 5 points scale, mean of social workers' empowerment is 3.67. In identifying predictors of the empowerment, this study used variables from the following aspects: organizational characteristics, job characteristics, and individual characteristics. Using regression analysis, it was found that variables related to job characteristics such as role ambiguities, role conflicts, and skill varieties are statistically very significant predictors of social workers' empowerment. Self-esteem in personal characteristics and participation in decision making and transformational leadership in organizational characteristics are also statistically significant predictors of social workers' empowerment. This study also revealed that self-control and self-esteem variables function as moderator in the relation with variables such as role ambiguities and role conflicts. Finally, this study discussed the direction of future research in social workers' empowerment and the areas that management efforts should be focused on for promoting social workers' empowerment.