• Structural Engineering and Mechanics
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• 제85권6호
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• pp.781-791
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• 2023

Lateral pressure plays a significant role in the stress-strain relationship of compressed concrete. Concrete's internal cracking resistance, ultimate strain, and axial strength are improved by confinement. This phenomenon influences the nonlinear behavior of reinforced concrete columns. Utilizing behavior factors to predict the nonlinear seismic responses of structures is prevalent in seismic codes, and this factor plays a vital role in the seismic responses of structures. This study aims to evaluate the confining action on the behavior factor of reinforced concrete moment resisting frames (RCMRFs) with shear walls (SWRCMRFs). To this end, a diverse range of mid-rise SW-RCMRFs was initially designed based on the Iranian national building code criteria. Second, the stress-strain curve of each element was modeled twice, both with and without the confinement phenomenon. Each frame was then subjected to pushover analysis. Finally, the analytical behavior factors of these frames were computed and compared to the Iranian seismic code behavior factor. The results demonstrate that confining action increased the behavior factors of SW-RCMRFs by 7-12%.

• The Journal of Asian Finance, Economics and Business
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• 제8권8호
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• pp.503-511
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• 2021

The emerging competitive environment in today's global marketplace is one where businesses no longer compete with each other as autonomous, individual firms. Global, economic, and technological development pressure forces organizations to continually enhance their performance through knowledge sharing and innovativeness. The purpose of this paper is to explore the moderating role of knowledge sharing and the mediating role of innovativeness in the relationship between transformational leadership and organizational performance. The data was collected from 389 employees in Vietnamese industrial enterprises through a questionnaire survey. The information was then analyzed by explanatory factor analysis (EFA) confirmatory factor analysis (CFA) as well as structural equation modeling (SEM). The results show that the mediating role of innovativeness and the moderating role of knowledge sharing in the relationship between transformational leadership and performance, are supported. Organizations may reap the benefits of an innovative workforce by selecting, nurturing transformational leaders. This study contributes to the field of human resources management, particularly leadership, by exploring the role of transformational leadership. Moreover, this is the first study to test the moderating role of knowledge sharing and the mediating role of innovativeness in the relationship between transformational leadership and the organizational performance.

• Toxicological Research
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• 제29권3호
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• pp.165-172
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• 2013

Acetaminophen (APAP) known as paracetamol is the main ingredient in Tylenol, which has analgesic and anti-pyretic properties. Inappropriate use of APAP causes major morbidity and mortality secondary to hepatic failure. Overdose of APAP depletes the hepatic glutathione (GSH) rapidly, and the metabolic intermediate leads to hepatocellular death. This article reviews the mechanisms of hepatotoxicity and provides an overview of current research studies. Pharmacokinetics including metabolism (activation and detoxification), subsequent transport (efflux)-facilitating excretion, and some other aspects related to toxicity are discussed. Nuclear factor erythroid 2-related factor 2 (Nrf2)-regulated gene battery plays a critical role in the multiple steps associated with the mitigation of APAP toxicity. The role of Nrf2 as a protective target is described, and potential natural products inhibiting APAP toxicity are outlined. This review provides an update on the mechanism of APAP toxicity and highlights the beneficial role of Nrf2 and specific natural products in hepatoprotection.

• 지역사회간호학회지
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• 제17권4호
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• pp.521-529
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• 2006

Purpose: This study was to measure the degree of job stress and job satisfaction and the relationship between job stress and job satisfaction of 119 relief squads. Methods: The subjects were 170 members of 119 relief squads in the Fire Department of D City, and data were collected from 1 April to 20 April, 2006 through a survey using a questionnaire composed of questions on general characteristics (11 items), job stress (6 items) and job satisfaction (20 items). Collected data were analyzed through frequency, percentage, t-test, ANOVA and Pearson's correlation using the SPSS program. Results: The average item score for job stress was 2.77. Role sharing with peers was highest as 3.05. There were significant differences in the degree of job stress according to religion, working period and applying motive. The average item score for job satisfaction was 2.93. Group conflict was highest as 3.18. There were significant difference in the degree of job satisfaction according to religion, working period and applying motive. There were significant differences in the negative correlation between role-sharing with peers among the job stress factors and decision-making factor (r=.53), group conflict factor (r=.58), role implementation factor (r=.63) and personal social-culture factor (r=.53) among the job satisfaction factors. Also, there were significant differences in the negative correlation between co-workers among the job stress factors and decision-making factor (r=.607), group conflict factor (r=.51) and personal social-culture factor (r=.45) among the job satisfaction factors. Conclusion: It is important to develop various methods of job stress management to increase job satisfaction in 119 relief squads.

• 아동학회지
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• 제12권1호
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• pp.91-112
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• 1991

The impact of gender, sex-role identity and cultural background on self - control behaviors was studied with the use of reports from 410 college students(201 Koreans and 209 Americans), who were administered both the Bem Sex Role Inventory and the Missouri Self Control Instrument. Gender, sex - role identity and cultural background significantly affected self - control and satisfaction. Regardless of cultural background, males showed a higher level of self - control and satisfaction than females. Androgenous students from both nations used a higher level of expressed/yielded self - control and more satisfied than the students with other sex - role identities. There were some differences in self - control between the Korean and American students. For the American students, the level of expressed self - control was the critical factor in explaining self - control behavior, whereas the level of yielded self - control was the critical factor for the Korean students. This was explained as a phenomenon of culture - bound relationships. Regardless of sex and sex - role identity, the level of satisfaction of Korean students was significantly lower than that of American students. The present results suggested that Korean students have some sort of conflict between self - control and satisfaction. The conflict can probably be attributed to the recent influx of western culture emphasizing goal - oriented control.

• Animal cells and systems
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• 제2권1호
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• pp.117-122
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• 1998

D-raf, a Drosophila homolog of the human c-raf-1, is known as a signal transducer in cell proliferation and differentiation. A previous study found that the D-raf gene expression is regulated by the DNA replication-related element (DRE)/DRE-binding factor (DREF) system. In this study, we found the sequences homologous to transcription factor C/EBP, MyoD, STAT and Myc recognition sites in the D-raf promoter. We have generated various base substitutional mutations in these recognition sites and subsequently examined their effects on D-raf promoter activity through transient CAT assays in Kc cells with reporter plasmids p5'-878DrafCAT carrying the mutations in these binding sites. Through gel mobility shift assay using nuclear extracts of Kc cells, we detected factors binding to these recognition sites. Our results show that transcription factor C/EBP, STAT and Myc binding sites in D-raf promoter region play a positive role in transcriptional regulation of the D-raf gene and the Myo D binding site plays a negative role.

• Human Ecology Research
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• 제58권4호
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• pp.539-560
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• 2020

This study presents work-family multiple-role planning by female university students as a new approach to worklife balance. Accordingly, this study examines university years as a key time frame during which students establish their career paths. This study integrates the social cognitive career theory and the planned behavior theory to design and evaluate a model that explains the work-family multiple-role planning process; in addition, it develops an optimal model to predict the intentions of female university students in work-family multiple-role planning. This study has conducted a structural survey with 500 female university students. After inspecting the data, the responses of 435 participants were used in the data analysis (SEM) with SPSS 21.0 and AMOS 21.0. The findings include the following. First, suitability of predictive model presents a satisfying fit. The major factors in this study's model (parental support, subjective norms, attitudes toward multiple-role planning, career decision self-efficacy, and outcome expectations) are verified as direct and indirect predictors of the work-family multiple-role planning intent of female university students. Second, the strongest predictive factor for the work-family multiple-role planning intent is the social environment factor (subjective norms), indicating that the influence of social pressure on intent is relatively large. The predictive model formulated under this study's integrated theoretical framework supplements existing research that focused on attitudes toward multiple-role planning as well as provides a more profound theoretical foundation on which work-family multiple-role planning behaviors can be better understood.

• 가정과삶의질연구
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• 제9권2호
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• pp.119-135
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• 1991

The purpose of this study is; 1)to identify the overall levels of household role perception, performance, and evaluation of the low-income employed wives residing in the city. 2) to investigate the relations of them. 3) to examine the factors affecting them. For the purpose of this study, the samples were selected form the low-income employed wives living in the poor area of Seoul and engaging in the poor jobs. The significant results are as follows; 1) The household role perception score is 3.45. This significantly differs to the marriage duration. 2) The household role performance is 3.65. This significantly differs to the communicative satisfaction between husband and wife. 3)The urban low-income employed wives have evaluated that they do their best in the economic role. 4)There are positive correlations between the household role perception and the household role performance of the low-income employed wives. 5) The communicative satisfaction between husband and wife is observed to have the significant factor among the variables which are related to the household role.

• 치위생과학회지
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• 제2권2호
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• pp.75-83
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• 2002

By extracting the variables related to the work stress generated from dental hygiene, identifying their relationships, this study aims to contribute to academic progress on work stress. The test results of this study are as follows for each hypothesis: 1. Among the work stress sensing factors, role ambiguity showed correlation to the active coping strategy and the passive coping strategy, whereas it did not have any correlation to the evasive reation. However, the physical resource environmental factor showed correlation to the active coping strategy, whereas it did not have any correlation to the other reation. 2. The passive coping strategy, among the work stress coping strategies, influences the role ambiguity, B type, work ambiguity, physical resource environmental factor by about 18.7%. 3. The active coping strategy, among the work stress coping strategies, influences the social support, role ambiguity, work place of health center factor by about 18.9%. 4. The evasive reaction, among the work stress coping strategies, was influenced by only the 36 years old over factor by approximately 4.2%. 5. It was found in all work stress sensing factors that the group with lower social support had a more degree of experiencing stress than the group with higher social support. In case of the behavior pattern, the type A experienced more stress than the type B only in role ambiguity. 6. It was found that the group with the higher social support tended to choose more active coping strategy than the lower social support. In case of behavior pattern, the type B coped more actively than type A in the passive coping strategy.

• Toxicological Research
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• 제23권3호
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• pp.197-205
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• 2007

Cancer metastasis is a major determinant of cancer patient mortality. Mounting evidence favors a strong positive role for $TGF-{\beta}$ in human cancer progression. The complex pattern on cross-talk of $TGF-{\beta}$ and the related other signaling pathways is an important area of investigation that will ultimately contribute to understanding of the bifunctional role of $TGF-{\beta}$ in cancer progression. This review summarizes some of the current understanding of $TGF-{\beta}$ signaling with a major focus in its contribution to the tumor cell invasion and metastasis. Five issues are addressed in this review: (1) $TGF-{\beta}$ signaling, (2) $TGF-{\beta}$ and EMT, (3) $TGF-{\beta}$ and MMP, (4) $TGF-{\beta}$ and Ras, and (5) Role of $TGF-{\beta}$ in invasion and metastasis. Due to the bifunctional cellular effects of $TGF-{\beta}$, as a tumor promoter and a tumor suppressor, more precisely defined $TGF-{\beta}$ signaling pathways need to be elucidated. According to the current literature, $TGF-{\beta}$ is clearly a major factor stimulating tumor progression through a complex spectrum of the interplay and cross-talk between various signaling molecules. Understanding the role of $TGF-{\beta}$ in invasion and metastasis will provide valuable information on establishing strategies to manipulate $TGF-{\beta}$ signaling which should be a high priority for the development of anti-metastatic therapeutics.