• Journal of Yeungnam Medical Science
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• 제34권2호
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• pp.149-160
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• 2017

Streptococcus pneumoniae, pneumococcus, is the most common cause of community-acquired pneumonia (CAP). CAP is an important infectious disease with high morbidity and mortality, and it is still one of the leading causes of death worldwide. Many genetic factors of the host and various environmental factors surrounding it have been studied as important determinants of the pathophysiology and outcomes of pneumococcal infections. Various cytokines, including transforming growth factor $(TGF)-{\beta}1$, are involved in different stages of the progression of pneumococcal infection. $TGF-{\beta}1$ is a cytokine that regulates a wide range of cellular and physiological functions, including immune and inflammatory responses. This cytokine has long been known as an anti-inflammatory cytokine that is critical to preventing the progression of an acute infection to a chronic condition. On the other hand, recent studies have unveiled the diverse roles of $TGF-{\beta}1$ on different stages of pneumococcal infections other than mitigating inflammation. This review summarizes the recent findings of the role of $TGF-{\beta}1$ on the pathophysiology of pneumococcal infections, which is fundamental to developing novel therapeutic strategies for such infections in immune-compromised patients.

• 대한간호학회지
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• 제50권2호
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• pp.228-241
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• 2020

Purpose: The purpose of this study was to develop an instrument to assess nursing professional pride. Methods: Fifty-six preliminary items were identified through literature review and focus group interview of nurses working in a hospital. Of these, 45 preliminary instruments were completed over 0.80 of content validity index. To verify the reliability and validity of the preliminary instrument, data were collected from 294 nurses. The data were analyzed using factor analysis and multidimensional scaling analysis. Results: From the factor analysis, 27 significant items were divided into 5 subscales. These subscales were as follows: feeling of vocation, role satisfaction, role of problem solver, self-achievement, and willingness to stay. The nursing professional pride also established criterion-related validity, discriminant validity, and group validity. Cronbach's α of the instrument was .92, and the subscales ranged from .74 to .85. Conclusion: The developed scale for nursing professional pride shows validity and reliability. The significance of this study is the development of an instrument capable of measuring nursing professional pride. To verify the relevance of this instrument, conducting comparative studies is suggested.

• The Journal of Asian Finance, Economics and Business
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• 제7권7호
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• pp.509-517
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• 2020

The study seeks to understand the effects of boredom proneness on impulse purchasing and smartphone addiction of young consumers. Moreover, the possible mediating role of smartphone addiction is tested for the effect of boredom proneness on impulse purchasing. Nowadays, the effect of emotions on human behavior is generally accepted, and boredom is one of the important and common problematic feelings or moods at various levels of life due to factors like unemployment, not being able to work in a suitable job, not getting appropriate education matching individual abilities, monotony of tasks, and feeling life is meaningless. Investigating the effect of boredom on specific consumer behavior would increase our knowledge about consumer behavior. For the research, a survey was conducted 313 students from Kirikkale University, Keskin Vocational High School; the data were collected by convenience sampling method. The data were processed through statistical tools like exploratory factor analysis, coefficient alphas, and regression analysis. The results of the study reveal that boredom proneness affects impulse purchasing and smartphone addiction. In addition, it is understood that smartphone addiction plays a mediating role in the effect of boredom proneness on impulse purchasing. These results indicate that boredom can be an important factor affecting certain negative consumer behaviors.

• 한국의류학회지
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• 제32권1호
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• pp.88-98
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• 2008

The purpose of this study were to examine the effect of fashion brand personality on the consumer's brand loyalty and to investigate the role of brand identification as mediator. The questionnaire data from 218 women who had purchase experience of fashion luxury brands were collected. Factor analysis and multiple regression analysis were used in data analysis. The results of this study were as follows. First, the consumer's fashion brand personality was composed of eight factors; Status-oriented, appearance-oriented, trend-oriented, leisure-oriented, physical activity-oriented, self achievement-oriented, fun-oriented and relation-oriented factor. Second, brand identification had significantly influence on brand loyalty. Third, fashion brand personality significantly influenced on brand loyalty and brand identification. Especially, the status-oriented, appearance-oriented, trend-oriented and self achievement-oriented fashion brand personality was proved to have a crucial role in brand identification and brand loyalty. Fourth, the status-oriented, appearance- oriented, trend-oriented and self achievement-oriented fashion brand personality had both direct and indirect effects on brand loyalty mediated by brand identification.

• 대한가정학회지
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• 제39권12호
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• pp.271-284
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• 2001

The purpose of this study was to find out the relationship of attitudes of parents and their unmarried adult child concerning the family value orientation. In addition to this study examined the relationship to child's family value orientation and related variables. The major findings 1) Gender, mother's value of marriage, religion were influential factors on the child's value of marriage.2) Gender and mother's value of sex role were influential factors on the child's value of sex role. 3) Child's gender was only influential factor on child's value of child. 4) Gender, mother's value of filial piety, father's value of filial piety were significant factors which have some effects on child's attitudes toward value of final piety. 5) Gender, mother's value of familism, religion were significant factors which have some effects on child's attitudes toward value of familism. 6) Gender, mother's family value orientation, father's family value orientation were influential factors on child's family value oreintation. In conclusion, this study found that child's gender was the most influential factor on child's family value orientations. And mother's family value orientations had strong effects on children's family value orientations.

• The Journal of Asian Finance, Economics and Business
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• 제7권8호
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• pp.353-360
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• 2020

The main aim of study is to identify the factors that affect the purchasing intention of young adults. The reference group is an important factor in determining the underlying causes of young adults' purchasing intentions. However, the literature states that young adults prefer to buy brands they trust in order to eliminate the risks that may arise when buying products they may not know. Moving from this perspective, the study proposes a conceptual model that including structural relationships between brand trust, reference group, and purchasing intention. The study aims to contribute to the literature by discussing the moderator role of brand trust in this structure. A series of hypotheses are tested via a survey completed by 749 young people between the ages of 20 and 30 living in Istanbul, Turkey. The data were analyzed with IBM SPSS-23 and AMOS-18 program. In addition to descriptive, reliability, and factor (exploratory and confirmatory) analysis, hierarchical regression analysis was performed to test the research hypotheses. The results show that the reference group positively influences the purchasing intention, and brand trust plays a moderating role in this relationship. The findings are discussed and some practical suggestions are made for mobile phone manufacturers.

• The Journal of Asian Finance, Economics and Business
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• 제7권8호
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• pp.435-444
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• 2020

This study investigates the role of logistics capability and logistics outsourcing on the performance of manufacturing companies in Pakistan. It examines how logistics capability affects firm's performance, why outsourcing is essential and how firms benefited if they outsource the service rather than establishing their own logistics capability. This research is based on a survey using structured a questionnaire to collect the primary data. The target population is logistics specialists of manufacturing companies in Pakistan with head offices based on Karachi, that have their own logistics or outsource their logistics. The questionnaire has been distributed to 500 respondents in 113 manufacturing companies in Pakistan. Confirmatory factor analysis has been used as statistical techniques to check the factor loading of the components, and SEM (Structural Equation Model) is used to check the impact of logistics capability on firm's performance as well as the role of logistics outsourcing as a mediator. The findings of the research suggest logistics capability has positive impact on the performance of the manufacturing companies in Pakistan, and logistics capability has also an impact on logistics outsourcing. On the other hand, the study found that logistics outsourcing has no significant impact on the manufacturing companies in Pakistan.

• 대한가정학회지
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• 제50권8호
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• pp.41-52
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• 2012

The purpose of the current study is to examine the role of mothers' personality traits in predicting their parenting stress. The study subjects were married working woman who live at Gyeonggi-do and has their first child studying in elementary, middle, or high school. Collected data were analyzed with SPSS WIN 18.0 program. The results were as follows.: First, it has been shown through examination of the general tendency of observation subjects' relative factor, that many have above average parenting stress. The compositing factor for parenting stress were mainly the burden and distress of the parent role. Second, the differences in parenting stress were affected by relative variables in accordance with the general features of the study object. If the younger the parent, the higher the education, the lower the age of the first child, and if there were a child assistant after school, the parenting stress became larger. Third, after controlling for demographic characteristics, employed mothers' neuroticism significantly predicted greater parenting stress. When mothers had more conscientiousness and openness, they reported less parenting stress which implied that interpretation and perception of child rearing experiences can vary depending on personality and predict parenting stress of working mothers.

• BMB Reports
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• 제37권2호
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• pp.139-143
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• 2004

The antioxidant responsive element (ARE) is a cis-acting regulatory element of genes encoding phase II detoxification enzymes and antioxidant proteins, such as NAD(P)H: quinone oxidoreductase 1, glutathione S-transferases, and glutamate-cysteine ligase. Interestingly, it has been reported that Nrf2 (NF-E2-related factor 2) regulates a wide array of ARE-driven genes in various cell types. Nrf2 is a basic leucine zipper transcription factor, which was originally identified as a binding protein of locus control region of ss-globin gene. The DNA binding sequence of Nrf2 and ARE sequence are very similar, and many studies demonstrated that Nrf2 binds to the ARE sites leading to up-regulation of downstream genes. The function of Nrf2 and its downstream target genes suggests that the Nrf2-ARE pathway is important in the cellular antioxidant defense system. In support of this, many studies showed a critical role of Nrf2 in cellular protection and anti-carcinogenicity, implying that the Nrf2-ARE pathway may serve as a therapeutic target for neurodegenerative diseases and cancers, in which oxidative stress is closely implicated.

• Journal of Ginseng Research
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• 제39권4호
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• pp.299-303
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• 2015

Panax ginseng is a well-known economic medical plant that is widely used in Chinese traditional medicine. This species contains a unique class of natural products-ginsenosides. Recent clinical and experimental studies have presented numerous lines of evidence on the promising role of ginsenosides on different diseases including neurodegenerative diseases, cardiovascular diseases, and certain types of cancer. Nowadays, most of the attention has focused on ginsenoside Rd as a neuroprotective agent to attenuate ischemic stroke damages. Some of the evidence showed that ginsenoside Rd ameliorates ischemic stroke-induced damages through the suppression of oxidative stress and inflammation. Ginsenoside Rd can prolong neural cells' survival through the upregulation of the endogenous antioxidant system, phosphoinositide-3-kinase/AKT and extracellular signal-regulated protein kinase 1/2 pathways, preservation of mitochondrial membrane potential, suppression of the nuclear factor-kappa B, transient receptor potential melastatin, acid sensing ion channels 1a, poly(ADP-ribose) polymerase-1, protein tyrosine kinase activation, as well as reduction of cytochrome c-releasing and apoptosis-inducing factor. In the current work, we review the available reports on the promising role of ginsenoside Rd on ischemic stroke. We also discuss its chemistry, source, and the molecular mechanism underlying this effect.