• 종양간호연구
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• 제5권2호
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• pp.146-158
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• 2005

Purpose: This study was to obtain a understanding of breast cancer women with high risk for hereditary cancer syndrome. Method: A micro-ethnography was used, including participation observation, open-ended in-depth interviews. Results: Two major arguments were derived. First, When Korean women at high risk to hereditary breast cancer make a decision about whether to take a genetic test, they are strongly motivated by a desire to preserve close kinship bonds and "family love" among their siblings, parents and children. Second, Even after genetic risk assessment and counseling services, Korean women at high-risk for developing a hereditary breast cancer who have been informed that they are mutation carriers, still hold onto previous beliefs about cancer causation. Their cancer prevention strategies are constructed according to their unchanged perceptions and beliefs about cancer causation. Conclusion: More sensitive genetic counseling program needs to be developed. Referral programs and clinical services must be attentive to cultural values and beliefs otherwise cultural attitudes and practices toward genetic counseling will not change.

• International Journal of Safety
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• 제9권2호
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• pp.22-28
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• 2010

This paper describes a web-based design review system as a knowledge management system relating reliability and safety system design. Since people's consciousness for safety and security become sensitive and increases the need of establishing a proactive prevention method for internal failures and relating risks in products. It also means that prevailing tacit knowledge in retired workers, in order to transform them to be easily used to support new system development, become more important. When considering safety and reliability design, at least two data sheet are necessary; Failure Modes and Effects Analyses (FMEA) and Risk Assessment (RA). These two data are practically made separately. However, it includes the concerns that a risk by failures during long-term use may not be noticed. To overcome this insufficiency, a support tool for integrating reliability evaluation and risk assessment data simultaneously is expected to be revealed. The authors have then developed a web-based design review system for reliability and safety system design. The system include various profitable functions; making FMEA and RA sheet, retrieving past data sheet for engineering change management and new product development and web-based discussion to increase the efficiency of discussion. The system is applied to one practical development works in order to demonstrate its effectiveness that is to be made clear by interviewing user's qualitative comment.

• Preventive Nutrition and Food Science
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• 제1권2호
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• pp.269-277
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• 1996

Bacteriocins are proteins produced by a heterogeneous group of bacteria that have a bactericidal effect on closely related organisms. Recently, bacteriocins from lactic acid bacteria and other food-related organisms have been the subject of much research because of their potential as food biopreservatives. Various modifications of agar plate diffusion assays are the most widely used methods even though the limitations of such assays are generally recognized. The ability to obtain a concentrated crude preparation on bacteriocin by optimizing production parameters greatly simplifies recovery of bacteriocin on subsequent purification steps. Some studies performed to optimize bacteriocins have been purified to homogeneity, and the amino acid sequences of many of these purified bacteriocins have been determined. Obtaining characterization data on purified bacteriocin will minimize the risk of overlapping of research and confusion on identification of these compounds. Several me-chanisms leading to cell death have been hypothesized. These include depletion of the proton motive force(PMF) across the cell membrane: RNase and/or DNase activity within the sensitive cell; and pore formation and lysis of sensitive cells at the cell membrane.

• International Journal of Oral Biology
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• 제47권4호
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• pp.49-54
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• 2022

Taste is a basic sensation to get attracted toward nutritious foods or avoid possible harmful substances. The basic taste qualities in humans consist of sweet, bitter, umami, salty, and sour. Basically, sweet and umami tastes make food attractive, whereas bitter and sour tastes make it avoidable. Salty taste comprises basic salty and high salt taste. The basic salty taste is known as amiloride-sensitive salty taste, which is inhibited by amiloride, but the high salt taste is not sensitive to amiloride. Moreover, high salt taste can also cause avoidance behavior in human beings. Sodium, one of the most important cations in the body fluids of vertebrates, controls the volume of total body fluids and is a risk factor for cardiovascular diseases, such as hypertension. The concentration of sodium in body fluids must be under delicate control. A distinction between the salty taste and high salt taste would be a contributing mechanism to control the volume and/or osmolarity of body fluids.

• 인터넷정보학회논문지
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• 제24권4호
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• pp.15-24
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• 2023

Digital therapeutics (DTx) are utilized to replace or supplement drug therapy to treat patients. DTx are developed as a mobile application for portability and convenience. The government requires security verification to be performed on digital medical devices that manage sensitive information during the transmission and storage of patient data. Although safety verification is included in the approval process for DTx, the cybersecurity checklist used as a reference does not reflect the characteristics of mobile applications. This poses the risk of potentially overlooking vulnerabilities during security verification. This study aims to address this issue by comparing and analyzing existing items based on the mobile tactics, techniques, and procedures of MITRE ATT&CK, which manages globally known and occurring vulnerabilities through regular updates. We identify 16 items that require improvement and expand the checklist to 29 items to propose improvement measures. The findings of this study may contribute to the safe development and advancement of DTx for managing sensitive patient information.

• 인지과학
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• 제23권2호
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• pp.205-224
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• 2012

낮은 확률이지만 손실이 큰 위험한 사건에 대비해서 보험을 들려는 사람들은 확률의 차이에 어떻게 반응할까? 본 연구는 네 개의 실험에서 가상적인 화학 공장에서 발생할 위험한 사고의 확률을 직접 제시하거나 보험료, 보험금, 그리고 배율 보험금과 같은 간접적인 단서 정보를 제시하고 참여자의 위험 평정과 보험 구매 의사를 물었다. 참여자들은 보험료나 보험금보다는 배율 보험금으로 제시된 조건들에서 위험 사고의 확률 차이에 예민하게 반응하여 위험 지각을 평정하였다. 네 실험은 수렴해서 위험지각에 영향을 주는 직접 확률 정보에 대한 생태학적 타당도가 높은 단서가 배율 보험금임을 밝혔다. 본 연구의 결과는 위험의 지각에서 확률보다 빈도 정보를 강조하는 생태학적 단서 가설(Gigerenzer, 2000)의 예측과 일치한다.

• 한국환경보건학회지
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• 제45권1호
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• pp.9-17
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• 2019

Objectives: This study examined the safety of tattoo ink by analyzing the phenol contents in tattoo inks and its risk assessment of selected phenol. Methods: A sample of 30 tattoo inks was purchased, the phenol contents were analyzed, and a risk assessment on dermal exposure from tattooing was carried out. Hazard identification was collected from toxicity data on systemic effects caused by dermal exposure to phenol, and the most sensitive toxicity value was adopted. Exposure assessment ($Exposure_{phenol}$) was calculated by applying phenol contents and standard exposure factors, while dose-response assessment was based on the collected toxicity data and skin absorption rate of phenol, assessment factors (AFs) for derived no-effect level ($DNEL_{demal}$). In addition, the risk characterization was calculated by comparing the risk characterization ratio (RCR) with $Exposure_{phenol}$ and $DNEL_{dermal}$ Results: The phenol concentration in the 30 products was from 1.4 to $649.1{\mu}g/g$. The toxicity value for systemic effects of phenol was adopted at 107 mg/kg. $Exposure_{phenol}$ in tattooing was from 0.000087 to 0.040442 mg/kg. $DNEL_{dermal}$ was calculated at 0.0072 mg/kg (=toxicity value 107 mg/kg ${\div}$ AFs 650 ${\times}$ skin absorption rate 4.4%). Thirteen out of 30 products showed an RCR between 1.02 and 5.62. The RCR of all red inks was above 1. Conclusions: Phenol was detected in all of the 30 tattoo inks, and the RCR of 13 products above 1 indicates a high level of risk concern, making it necessary to prepare safety management standards for phenol in tattoo inks.

• 한국환경과학회지
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• 제11권9호
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• pp.851-855
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• 2002

A comparison of Daphnia magna, Ceriodaphnia dubia and Simocephalus mixtus toxicity test was performed to study the relative sensitivities and discrimination abilities with both pore and elutriate water of Woopo wetland sediments. Sediment risk assessment has been done by standardized preparation method of pore and elutriate water described in the joint US EPA-US Army Crops of Engineers manual. Simocephalus mixtus which was obtained from Woopo wetlands in Korea was cultured and applied to sediment toxicity test. Water quality in Woopo wetland had great site and seasonal variations. S. mixtus was more sensitive than D. magna in heavy metal toxicity test. The toxicity results with S. mixtus reflected the water quality of elutriate and pore water. The results also suggested that S. mixtus could be used as a test organism in estimating potential risk of contaminated sediments.

• 재무관리연구
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• 제26권4호
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• pp.103-140
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• 2009

This paper investigates various channels through which liquidity can affect stock returns and examines whether behavioral explanation for liquidity risk is reasonable. First, we examine whether liquidity level (average liquidity) plays a significant role in determining asset returns. The result is consistent with the hypothesis that a stock with higher average illiquidity will have a higher expected return. Second, we focus on the argument that liquidity has a non-diversifiable systematic component. If systemic liquidity has a different impact across individual securities, a stock that is more sensitive to systematic liquidity will have a higher expected return. The results of various tests are inconsistent with each other, not completely supporting the argument. Finally, the intra-market tests in Korea support the behavioral explanation for the liquidity premium, and the effect is stronger in the liquidity level than in the liquidity beta related to systematic liquidity.

• 자원ㆍ환경경제연구
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• 제24권3호
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• pp.551-572
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• 2015

지구 온난화와 그에 따라 발생빈도가 늘어난 이상기온 현상으로 인해 제조업과 서비스 업종에서 감당해야 할 기후위험 역시 증가하는 추세에 있다. 본 연구는 Pardo et al. (2002)이 이용한 간단한 실증모델 추정을 통해 품목별 기후리스크를 측정한다. 실증분석의 결과, 제조업 품목의 26.7%, 서비스 업종의 27.9%가 날씨여건에 따라 판매량이나 경영성과에 유의미한 변화를 경험하고 있는 것으로 나타났다.