• Journal of Microbiology and Biotechnology
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• 제21권1호
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• pp.62-70
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• 2011

The antibacterial effects of nine lactic acid bacteria (LAB) against Campylobacter jejuni were investigated by using agar gel diffusion and co-culture assays. Some differences were recorded between the inhibition effects measured with these two methods. Only two LAB, Lb. pentosus CWBI B78 and E. faecium THT, exhibited a clear anti- Campylobacter activity in co-culture assay with dehydrated poultry excreta mixed with ground straw (DPE/GS) as the only growth substrate source. It was observed that the supplementation of such medium with a cellulase A complex (Beldem S.A.) enhanced the antimicrobial effect of both LAB strains. The co-culture medium acidification and the C. jejuni were positively correlated with the cellulase A concentration. The antibacterial effect was characterized by the lactic acid production from the homofermentative E. faecium THT and the lactic and acetic acids production from the heterofermentative Lb. pentosus CWBI B78. The antagonistic properties of LAB strains and enzyme combination could be used in strategies aiming at the reduction of Campylobacter prevalence in the poultry production chain and consequently the risk of human infection.

• Asian Pacific Journal of Cancer Prevention
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• 제13권11호
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• pp.5573-5579
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• 2012

Onions (Allium cepa L.) are widely used in the food industry for its nutritional and aromatic properties. Our studies showed that ethyl acetate extract of onion (EEO) had potent inhibitory effects on animal fatty acid synthase (FAS), and could induce apoptosis in FAS over-expressing human breast cancer MDA-MB-231 cells. Furthermore, this apoptosis was accompanied by reduction of intracellular FAS activity and could be rescued by 25 mM or 50 mM exogenous palmitic acids, the final product of FAS catalyzed synthesis. These results suggest that the apoptosis induced by EEO occurs via inhibition of FAS. We also found that EEO could suppress lipid accumulation during the differentiation of 3T3-L1 adipocytes, which was also related to its inhibition of intracellular FAS activity. Since obesity is closely related to breast cancer and obese patients are at elevated risk of developing various cancers, these findings suggested that onion might be useful for preventing obesity-related malignancy.

• 성인간호학회지
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• 제27권1호
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• pp.106-116
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• 2015

Purpose: The purpose of this review was to assess the quality and to evaluate the effectiveness of music interventions in reducing agitation in older adults with dementia. Methods: Randomized controlled studies and randomized crossover studies were identified by searching MEDLINE, EMBASE, CINAHL, PsycINFO, AGELINE, Cochrane Central Register of Controlled Trials, Korea Med, Kmbase, RISS, National Assembly Digital Library, KISS, and RICH. Two reviewers independently retrieved articles, extracted data, and assessed the quality of studies. Results: In total, 10 studies were selected from 1095 unique citations. All included studies were conducted in long term care settings. Overall, risk of bias for included studies was low to moderate. The weighted average effect size across studies was -0.39 (95%CI [-0.69, -0.10], p=.009, $I^2=63%$). Music therapy was effective to reduce agitation of the older adults with dementia. Conclusion: Music intervention can be an effective non-pharmacological intervention for the reduction of agitation in dementia. Future studies need to use rigorous research method and to provide description of research methods in greater detail. In addition, future studies are required to explore the effects of music therapy according to severity of agitation and dementia.

• Journal of Pharmaceutical Investigation
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• 제41권5호
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• pp.263-272
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• 2011

Tablet dosage forms have been preferred over other formulations for the oral drug administration due to their low manufacturing costs and ease of administrations, especially controlled-release applications. Controlled-release tablets are oral dosage forms from which the active pharmaceutical ingredient (API) is released over an intended or extended period of time upon ingestion. This may allow a decrease in the dosing frequency and a reduction in peak plasma concentrations and hence improves patient compliance while reducing the risk of undesirable side effects. Conventional singlelayered matrix tablets have been extensively utilized to deliver APIs into the body. However, these conventional single-layered matrix tablets present suboptimal delivery properties, such as non-linear drug delivery profiles which may cause higher side effects. Recently, a multi-layered technology has been developed to overcome or eliminate the limitations of the singlelayered tablet with more flexibility. This technology can give a good opportunity in formulating new products and help pharmaceutical companies enhancing their life cycle management. In this review, a brief overview on the multi-layered tablets is given focusing on the various tablet designs, manufacturing issues and drug release profiles.

• Journal of Dairy Science and Biotechnology
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• 제21권2호
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• pp.125-137
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• 2003

Bifidobacteria are normal inhabitants of the human gastrointestinal tract throughout lift, starting just days after birth, and are one of several predominant species of the colonic microflora, along with Peptostreptococcus, Eubacteria, Clostridia, and Bacteroides. Bifidobacteria differ from lactic acid bacteria in that they produce not only lactic acid but also acetic acid as major fermentation products. The classification of bifidobacteria has changed numerous times since they were discovered in 1899 in the feces of breast-fed infants. Since 1994, three additional species have been included in the list (B. lactis, B. inopinatum, and B. denticolens), with a current total of 32 species. A variety of probiotic effects of bifidobacteria are currently being investigated. Research reports suggests several potential probiotic advantages, in particular antimicrobial effects, immune-modulation reduction of the cancer risk, and modulation of gastrointestinal flora. As technological challenges related to viability and enumeration are being overcome, milks fermented with these anaerobic microorganisms(alone or in combination with lactic acid bacteria) are more able to provide consistently satisfying with large numbers of viable microorganisms. Over 70 products containing bifidobacteria are currently offered around the world, including fermented milks, cheese, buttermilk frozen desserts, candy, and pharmaceutical preparations.

• 한국IT서비스학회지
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• 제11권1호
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• pp.173-196
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• 2012

Cloud computing is provided on demand service via the internet, allowing users to pay for the service they actually use. Since cloud computing is emerging stage in industry, many companies and government consider adopting the cloud computing. Actually a variety of factors may influence on the adopting decision making of cloud computing. The objective of this study is to explore the significant factors affecting the adoption decision of enterprise cloud computing. A research model has been suggested based on TOE framework and outsourcing decision framework. Based on 302 data collected from managers in various industries, the major findings are following. First, the benefit factors of cloud computing service such as agility and cost reduction have direct and positive effects on adoption of the service. Second, lock-in as a risk factor of cloud computing service has a negative effect while security has not. Third, both internal and external environment factors have positive effects on adoption of the service.

• Journal of Gastric Cancer
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• 제22권3호
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• pp.169-183
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• 2022

Gastric cancer is prevalent in Korea and ranked as the third most common cancer in 2019, followed by lung and thyroid cancers. The National Cancer Screening Program (NCSP) for gastric cancer has been implemented in adults aged ≥ 40 since 1999 and involves endoscopic screening every 2 years. The beneficial effects of the current NCSP on early cancer detection, cost-effectiveness, and mortality reduction are evident. However, the screening program results in a large socioeconomic burden and the consumption of medical resources, as it focuses solely on secondary prevention (early detection) rather than primary prevention of cancer. Helicobacter pylori is defined as a group I carcinogen by the International Agency for Research on Cancer. Hence, its eradication has been suggested as an important primary gastric cancer prevention strategy. Well-designed randomized controlled trials involving high-risk groups (post-endoscopic resection of early gastric cancer and family history of gastric cancer) and long-term follow-up studies in the general population have provided high-quality evidence regarding the effects of H. pylori eradication on gastric cancer prevention. In this review, we discussed the evidences for a possible modification of the current gastric cancer secondary prevention strategy by introducing primary prevention through H. pylori eradication. Areas for future research to optimize primary prevention strategies were also suggested.

• Physical Therapy Rehabilitation Science
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• 제12권2호
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• pp.140-148
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• 2023

Objective: Meniscal injuries are a common and high-risk condition among military personnel, leading to difficulties in performing missions.The objective of this study is to investigate the effects of combining electrical muscle stimulation therapy with exercise therapy during rehabilitation on pain, muscle strength, and function in patients after meniscectomy. Design: A two-group pretest-posttest design Methods: A total of 30 subjects were included in this study. They were randomly assigned to either the experimental group (n=15), which received knee extensor strengthening exercise along with electrical muscle stimulation, or the control group (n=15), which received only knee extensor strengthening exercise. Pre-test was conducted prior to the intervention, which consisted of 30 minutes of treatment five times a week for a total of 20 sessions. Post-test was performed after a 4-week period. Pain, strength, and function were assessed before and after the intervention. Results: The results of the study showed that there was a significant difference in pain reduction and muscle strength improvement in the experimental group, and a significant difference was also found between the experimental group and the control group in terms of functional evaluation. Conclusions: The combination of exercise therapy and electrical muscle stimulation therapy resulted in greater improvements in pain, strength, and function assessment, contributing to improved overall function.

• Asian Pacific Journal of Cancer Prevention
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• 제16권10호
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• pp.4409-4419
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• 2015

The Bhopal gas tragedy involving methyl isocyanate (MIC) is one of the most horrific industrial accidents in recent decades. We investigated the genotoxic effects of MIC in long-term survivors and their offspring born after the 1984 occurrence. There are a few cytogenetic reports showing genetic damage in the MIC-exposed survivors, but there is no information about the associated cancer risk. The same is true about offspring. For the first time, we here assessed the micronucleus (MN) frequency using cytokinesis-blocked micronucleus (CBMN) assay to predict cancer risk in the MIC-affected population of Bhopal. A total of 92 healthy volunteers (46 MIC-affected and 46 controls) from Bhopal and various regions of India were studied taking gender and age into consideration. Binucleated lymphocytes with micronuclei (BNMN), total number of micronuclei in lymphocytes (MNL), and nuclear division index (NDI) frequencies and their relationship to age, gender and several lifestyle variabilities (smoking, alcohol consumption and tobacco-chewing) were investigated. Our observations showed relatively higher BNMN and MNL (P<0.05) in the MIC-affected than in the controls. Exposed females (EF) exhibited significantly higher BNMN and MNL (P<0.01) than their unexposed counterparts. Similarly, female offspring of the exposed (FOE) also suffered higher BNMN and MNL (P<0.05) than in controls. A significant reduction in NDI (P<0.05) was found only in EF. The affected group of non-smokers and non-alcoholics featured a higher frequency of BNMN and MNL than the control group of non-smokers and non-alcoholics (P<0.01). Similarly, the affected group of tobacco chewers showed significantly higher BNMN and MNL (P<0.001) than the non-chewers. Amongst the affected, smoking and alcohol consumption were not associated with statistically significant differences in BNMN, MNL and NDI. Nevertheless, tobacco-chewing had a preponderant effect with respect to MNL. A reasonable correlation between MNL and lifestyle habits (smoking, alcohol consumption and tobacco-chewing) was observed only in the controls. Our results suggest that EF and FOE are more susceptible to cancer development, as compared to EM and MOE. The genotoxic outcome detected in FOE reflects their parental exposure to MIC. Briefly, the observed cytogenetic damage to the MIC-affected could contribute to cancer risk, especially in the EF and FOE.

• 한국응용과학기술학회지
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• 제40권2호
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• pp.290-300
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• 2023

본 연구는 노인들의 낙상 위험 기전을 이해하고 필라테스 재활 운동 원리가 노인들의 균형 능력과 자세 안정화에 긍정적 효과를 기대할 수 있는지 선행 연구 자료를 고찰하였고, 재활 필라테스 운동의 낙상 예방 효과에 대한 문헌적 기초자료를 제시하는데 연구의 목적이 있다. 이에 다음과 같은 결론을 제시하고자 한다. 첫째, 재활 필라테스 운동은 척추와 골반의 안정화를 위한 신체 중심부의 강화 운동이 가능하고, 신경근을 촉진시켜 균형과 관절 안정화에 효과가 있다. 둘째, 노화에 따른 고유수용기 감각 저하와 근골격계 퇴행 질환은 균형 능력 상실과 자세 유지의 불안정성을 높여 운동 기능 수행의 어려움과 보행 장애로 낙상 손상 위험을 높이게 된다. 셋째, 재활 필라테스 운동은 노인들의 코어 근력 향상으로 균형과 반응시간 운동 기능 향상을 기대할 수 있으며, 낙상 예방에 관여되는 신체 불균형 개선과 움직임 안정성에 긍정적 영향을 미쳐 낙상 위험률 감소에 기여할 가능성을 제시할 수 있다. 결론적으로 재활 필라테스가 노인운동 프로그램으로서 신체의 근력 향상, 균형 감각 향상, 코어의 안정화 효과를 나타내 근골격계 퇴행에 따른 낙상 손상의 위험 요인을 감소시키고, 노인성 만성질환에 따른 심각한 활동 장애를 예방할 수 있음을 고찰하였다.