• Asian Pacific Journal of Cancer Prevention
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• 제17권12호
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• pp.5251-5256
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• 2016

Background: Diagnostic karyotyping analysis is routinely used in acute myeloid leukemia (AML) clinics. Categorization of patients into risk stratified groups (favorable, intermediate and adverse) according to cytogenetic findings can serve as a valuable independent prognostic factor. Method and Material: A retrospective descriptive study was conducted based on the patient records of newly diagnosed non-M3 AML young adult cases undergoing standard 3+7 i.e, Daunorubicin and Ara-C (DA) as remission induction chemotherapy. Diagnostic cytogenetic analysis reports were analyzed to classify the patients into risk stratified groups according to South West Oncology Group criteria and prognostic significance was measured with reference to achievement of haematological remission after 1st induction chemotherapy. Results:A normal karyotype was commonly expressed, found in 47.2% of patients, while 65% (n=39) appeared to have intermediate risk cytogenetics, and 13.3% (n=8) adverse or unclassified findings. Favourable cytogenetics was least frequent in the patient cohort, accounting for only 8.3 % (n=5).The impact of cytogenetic risk groups on achievement of haematological remission was evaluated by applying Pearson Chi-square, and was found to be non-significant (df=12, p=0.256) but when the outcomes of favourable risk groups with intermediate, adverse and unclassified findings compared, results were highly significant (df=6, p=0.000) for each comparison. In patients of the favourable cytogenetic risk group, HR?? was reported in 40% (n=2/5), as compared to 62.2% (n=23/37) in the intermediate cytogenetic risk group, 57.1% (n=4/7) in the adverse cytogenetic risk group and 28.6% (n=2/7) in hte unclassified cytogenetic risk group. Conclusion: Cytogenetic risk stratification for AML cases following criteria provided by international guidelines did not produce conclusive results in our Pakistani patients. However, we cannot preclude an importance as the literature clearly supports the use of pretreatment karyotyping analysis as a significant predictive marker for clinical outcomes. The apparent differences between Pakistani and Western studies indicate an urgent need to develop risk stratification guidelines according to the specific cytogenetic makeup of South Asian populations.

• Asian Pacific Journal of Cancer Prevention
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• 제16권17호
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• pp.7485-7489
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• 2015

Background: Breast cancer is the most common type of cancer in women throughout the world. However, in comparison with Western women, it presents relatively early in women of Asian ethnicity. Early menarche, late menopause, use of OCP's, family history of benign or malignant breast disease, exposure to radiation and BMI in the under-weight range are well known risk factors for the development of breast cancer in premenopausal women. Early detection with the use of breast self-examination (BSE) and breast cancer screening programs can lead to a reduction in the mortality rates due to breast cancer. The aim of our study was to assess the risk factors for breast cancer among young women and to emphasize the importance of early screening among them. Materials and Methods: We conducted a cross-sectional study among women aged 18 to 25 using a self-administered questionnaire. Data was collected over a period of 6 months from June to December, 2014. A total of 300 young women selected randomly from Dow Medical College and various departments of Karachi University successfully completed the survey. Results: Respondents were 18-25 years of age (mean age=21.5). Out of the 300 young females, 90 (30%) had at least one risk factor, 90 (30%) had two, 40 (13%) had three, 8 (2.7%) had four, 2 (0.7%) had five while one female was found to have six positive risk factors for breast cancer. Some 66 women (22%) experienced symptoms of breast cancer such as non-cyclical pain and lumps. While 222 women (74%) had never performed breast self-examination, 22 (7.3%) had had a breast examination done by a health professional while 32 (10.7%) had participated in breast screening programs. A total of 223 (74.3%) women considered breast cancer screening important for young women. Conclusions: The percentage of young women with risk factors for breast cancer was found to be alarmingly high. Therefore, screening for breast cancer should start at an early age especially in high risk groups. Awareness about breast self-examination should be emphasized. Moreover, screening programs should be started to ensure early detection and reduction of mortality rates caused by breast cancer also in young Pakistani females.

• 한국콘텐츠학회논문지
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• 제17권5호
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• pp.574-590
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• 2017

이 논문의 목적은 IPPs에서 발생할 수 있는 리스크 요소를 규정하고 퍼지 다기준 결정 방법론(Fuzzy MCDM)을 활용하여 사업 리스크의 우선순위와 가중치의 중요도를 분석함으로써 IPP 개발자에게 투자 의사결정 도구를 제공하는 것이다. Fuzzy MCDM은 응답자의 고유한 의견을 표현할 때 발생할 수 있는 불확실성을 보다 명시적으로 반영할 수 있는 추정방법이다. 이 논문은 광범위한 문헌 조사를 통해 신용 리스크, 준공 리스크, 시장 리스크, 연료조달 리스크, 운영 리스크, 재무 리스크, 환경 리스크, 그리고 불가항력 등 PF조달과 관련한 8 개의 주요 사업리스크를 도출한다. 실증분석 결과는 시장 리스크가 사업리스크와 관련된 의사결정에서 있어 가장 중요한 리스크임을 보여준다. 이는 IPP에서 장기 전력판매계약이 가장 중요한 리스크 요소임을 보여주고 있으며, 점차 발주국 정부의 장기 전력판매계약에 대한 보증이 없는 자유시장에서 전력을 판매하는 소위 머천트 발전사업에서 시장 리스크를 줄이는 것이 중요함을 암시한다.

• 복식
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• 제51권7호
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• pp.123-134
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• 2001

The purpose of this study to compare the purchasing behaviour of men's business suits, among custom suits, system order, and ready-made suits, centering around the choice of information source, risk perception and benefits sought. The survey of this study was collected from 450 adult male in Seoul. The data was analyzed by factor analysis and ANOVA. The result of this study were as follows : 1. Custom suits, system order, and ready-made suits consumers have a significant difference in the choice of information source. The consumer attaching most importance to the impersonal information source is the system order users, custom suits users, and ready-made suits users respectively. However there was no significant difference in the personal source among 3 different purchasing behaviour of men's suits. 2. For the risk perception, 1) the group who perceived the highest in economic risk is the system order users, followed by custom suits users, and ready-made suits users. 2) the group who perceived performance risk as being the highest concern is the ready-made suits consumers, followed by system order user, and custom suits user. 3) the group who perceived the socio-psychological risk as the highest is the ready-made suits consumers, and followed by custom suits user and system order users. 4) there is no difference among the three groups with respect to the fashionability loss risk. 5) the group of the highest perceiving the useful loss risk is the ready-made suits consumers, and the next is system order users, custom suits users. 6) the group of the highest perceiving the time and convenience loss risk is ready-made suits users, and the next is system order users, custom suits users. 3. For the benefit sought, the group of the highest perceiving the aesthetics is custom suits consumers, and the next is system order users, ready-made suits users.

• Asian Pacific Journal of Cancer Prevention
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• 제13권2호
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• pp.665-669
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• 2012

Aim: The distribution of DNA repair gene XRCC1 and XRCC3 genotypes was used to assess the potential influence of genetic polymorphisms on risk of colorectal cancer, and interactions with other factors. Methods: a 1:2 matched case-control study was conducted with 485 cases and 970 controls. XRCC1 and XRCC2 genotype polymorphisms were based upon duplex polymerase-chain-reaction with the confronting-two-pairprimer (PCR-CTPP) method. Results:The XRCC1 399Cln allele polymorphism was found to be associated with an increased colorectal cancer risk, while an non-significant inversely association was noted for XRCC3 241Thr/Thr genotype. We also found that individuals with the XRCC1 399 Gln and XRCC3 241Met alleles had an elevated risk, while XRCC3241Thr/Thr was proctective. Conclusion: This study is the first to provide evidence of importance of XRCC1 and XRCC3 gene polymorphisms for risk of colorectal cancer in the Chinese population.

• 복식문화연구
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• 제28권4호
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• pp.409-419
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• 2020

Building on Technology Readiness and Acceptance Model(TRAM), the study aimed to examine how technology readiness affects consumers' perceptions of ease of use, usefulness, and risk, which in turn predict their intention to use retail service robots. Specifically, the study proposed that technology readiness motivators (optimism and innovativeness) would influence perceived ease of use and usefulness, while technology readiness inhibitors (discomfort and insecurity) would affect perceived risk. The study further examined if the perception factors (ease of use, usefulness, and risk) contribute to intention to use retail service robots. A survey method was used with data collected from Korean consumers. The final sample size was 418. The data was analyzed using structural equation modeling. Findings of the study revealed that technology readiness motivators positively affected perceived ease of use and usefulness while innovativeness had no impact on usefulness. All the inhibitors increased perceived risk. Lastly, as hypothesized, perceptions of ease of use, usefulness, and risk predicted intention to use retail service robots. This study extended the retail technology literature by applying and validating TRAM to the context of consumer acceptance of retail service robots. The study further helped marketers and retailers by highlighting the importance of technology readiness in improving consumer perceptions and responses towards retail service robots.

• 한국압력기기공학회 논문집
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• 제10권1호
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• pp.37-43
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• 2014

Nuclear power plants(NPPs) are consisted of power production functions and safety functions preventing leakage of radiation. Operators working in NPPs shall maintain these functions during an operation period through various activities such as improvement & modification, corrective maintenance, preventive maintenance and surveillance test. According to the performance of these work activities, there are configuration changes in NPPs systems. Its changes cause the increase of safety risks(CDF) and plant trip risks. Recently, the importance of risk management is increasing gradually in the operation process of NPPs. Therefore, this paper presents the work management methods using the various risk monitoring systems during power operation and overhaul period. Also this paper suggests the optimum application ways of risk systems for work management.

• Asian Pacific Journal of Cancer Prevention
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• 제15권22호
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• pp.10033-10038
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• 2014

The aim of this study was to determine the prevalence of tobacco use, beliefs and risk awareness and psychosocial correlates of tobacco use among university students in 24 low, middle and emerging economy countries. Using anonymous questionnaires, data were collected from 16953 undergraduate university students (mean age 20.9, SD=2.9) from 25 universities in 24 countries across Asia, Africa and the Americas. Results indicate that overall 13.3% of the university students were current tobacco users, 22.4% for men and 6.6% for women, ranging from 3.8% in Singapore to 32.5% in Cameroon. The risk awareness of the smoking lung cancer link was 83.6%, while the risk awareness of the smoking heart disease link was 46.5%. Multivariate logistic regression found that older age, male gender, having a wealthy family background, living in a low income country, residing off campus on their own, poor beliefs in the importance not to smoke, awareness of the smoking heart disease link, hit by a sexual partner, depressive symptoms, and substance use (binge drinking and illicit drug use) were associated with current tobacco use.

• 간호행정학회지
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• 제17권4호
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• pp.432-442
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• 2011

Purpose: The purpose of this study was to identify the factors influencing the intention of the reuse in patients admitted in university hospital emergency medical center. Method: The participants were 253 patients admitted to a niversity hospital emergency medical center. Data were collected with self-administrated questionnaires and analyzed by hierarchical multiple regression. Results: Patient satisfaction with nursing care service and switching cost were positively correlated with reuse by patients while the perceived risk was negatively correlated. As levels of satisfaction with nursing care services and switching cost increase, intention of reuse increases. Satisfaction with nursing care service, switching cost and perceived risk in emergency medical center influence intention to reuse and explain 68.8% of total variation of intention to reuse. Conclusion: Findings provide strong empirical evidence for importance of atient satisfaction with nursing care service, the switching costs and the perceived risk in explaining the intention of reuse an emergency medical center.

• 한국건설관리학회:학술대회논문집
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• 한국건설관리학회 2008년도 정기학술발표대회 논문집
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• pp.353-357
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• 2008

건설 프로젝트는 불확실성 및 복잡성의 특성으로 인해 다양한 리스크 인자를 내포하고 있다. 이러한 리스크를 어떻게 관리하는가에 따라서 보다 성공적인 프로젝트로 이끌어나갈 수 있다. 이러한 리스크 관리는 확인, 분석, 대응의 절차를 통해 이루어지며 분석과정에서 위험요소들의 중요도 및 우선순위를 객관적이고 정확하게 분석해내는 것이 리스크관리의 성공여부를 좌우할 수 있다. 본 연구는 건설 프로젝트의 공정 리스크 중요도를 산출하는데 사용된 기존 AHP 분석 기법에서 리스크 인자의 추가 및 삭제 시 쌍대비교 등 복잡한 중요도 산출 절차를 거쳐야하는 문제점을 파악하고, AHP 분석 기법의 단점을 보완할 수 있는 공정리스크 중요도 산출 방법으로 PROMETHEE 분석 기법을 적용하였다. 또한 PROMETHEE 분석 기법의 수행을 위한 기본 설정을 통해 공정리스크 인자 분석이 가능한 프로세스을 제시한다.