• 대한본초학회지
• /
• 제23권4호
• /
• pp.179-189
• /
• 2008

Objectives: Effects of Rhodiola rosea root on immunity were examined. Methods: Water extracts and methanol extracts of Rhodiola rosea root were treated on the increase of immunity cells and the activation of cytokines were examined. Results: 1. Water extracts and methanol extracts of Rhodiola rosea root had positive effects on the increase of B-cells, T-cells, and NK cells, and on the facilitation of cytokines such as IL-6 and TNF-${\alpha}$. 2. Water extracts and methanol extracts of Rhodiola rosea root activated NK cells, and induced the generation of NO- of NK cells and macrophages. Conclusions: Rhodiola rosea root can be used to increase immunity.

• 대한본초학회지
• /
• 제21권1호
• /
• pp.79-87
• /
• 2006

Objectives : Effects of Rhodiola rosea root on cancers on stomach, breast, lung, and liver were examined. Methods : Water extracts and methanol extracts of Rhodiola rosea root were treated on cancer cells, and its effects on cancers were examined. Results : 1. Water extracts and methanol extracts of Rhodiola rosea root was less harmful in its lowest density 0.25 mg/mL (9.l%와 10.5%), but became more harmful as its density increased. 2. As for human stomach adenocarcinoma cells AGS, breast adenocarcinoma cells MCF-7, and lung carcinoma cells A549, methanol extracts showed 70-77% inhibition of cancer cells in high density(1 mg/mL), and water extracts showed 60-70% inhibition rate and its selective death rate was less than 2.5. Conclusion : Rhodiola rosea root can be used to treat cancers and to increase immunity.

• 대한본초학회지
• /
• 제26권4호
• /
• pp.169-180
• /
• 2011

Objectives : This study aimed at evaluation of the effects of Rhodiola rosea on brain edema and expressions of matrix metalloproteinases (MMPs) related to blood-brain barrier (BBB) disruption. Methods : Brain edema following intracerebral hemorrhage (ICH) was induced by the stereotaxic intrastriatal injection of bacterial collagenase type VII in rats (Sprague-Dawley). Then ethanol extract of Rhodiola rosea was treated once a day for 3 days. Brain edema % and water contents, and BBB leakage were examined. Immunohistochemistry was processed for MMP-9, MMP-12, and iNOS expressions in the brain sections and each immuno-labeled cells were analyzed with image analysis software. Results : 1. Ethanol extract of Rhodiola rosea reduced brain edema following ICH in rats significantly. 2. Ethanol extract of Rhodiola rosea reduced excessive brain tissue water contents following ICH in rats significantly. 3. Ethanol extract of Rhodiola rosea reduced BBB leakage in the cerebral cortex following ICH in rats. 4. Ethanol extract of Rhodiola rosea reduced cellular edema of neurons in peri-hematoma and the cerebral cortex following ICH in rats significantly. 5. Ethanol extract of Rhodiola rosea reduced MMP-9 positive cells in the cerebral cortex following ICH in rats significantly. 6. Ethanol extract of Rhodiola rosea reduced MMP-12 positive vessels in the cerebral cortex following ICH in rats significantly. 7. Ethanol extract of Rhodiola rosea reduced iNOS positive cells in the cerebral cortex and external capsule following ICH in rats significantly. Conclusions : These results suggest that Rhodiola rosea reveals protective effect against brain edema and cytotoxic edema of neurons by means of down-regulation of MMPs and iNOS expressions, and inhibition of BBB leakage.

• Preventive Nutrition and Food Science
• /
• 제20권1호
• /
• pp.38-42
• /
• 2015

Rhodiola rosea is a perennial plant which grows in the alpine regions of Europe and Asia. Although the protective effects of R. rosea extract from fatigue due to exercise stress have been reported, studies on fermented R. rosea extract remain insufficient to date. Therefore, this study was conducted to examine the protective effects of fermented R. rosea extract against fatigue and exercise stress. As a result, fermented R. rosea extract was found to significantly increase swimming time, hepatic superoxide dismutase content, and serum lactate dehydrogenase in mice, while decreasing serum blood urea nitrogen content compared to R. rosea extract. Given the above results, it is considered that fermented R. rosea extract effectively protects against fatigue caused by strenuous exercise.

• 대한본초학회지
• /
• 제27권6호
• /
• pp.91-98
• /
• 2012

Objectives : Rhodiola rosea L. (Crassulaceae) is a plant living at the areas of high-altitude mountain, and Rhodiolae Radix(the root of R. rosea) has been used as a traditional medicine to decrease the symptoms of mental- or physical-stress in Asia and Europe. To examine the efficacy of Rhodiolae Radix on the oxidative stress, the anti-oxidative effects of the radix were examined, Methods : The effects of Rhodiolae Radix on several oxidative factors were examined in vitro, and also the effects were tested in the liver of rats which were treated with a high dose of alcohol during 2 weeks. Results : The extract of Rhodiolae Radix in vitro scavenged some oxidants, such as DPPH, Superoxide anion radical and LDL, and the extract also inhibited the oxidative capacity of linoleic acid, significantly. Meanwhile, in the in vivo test, the methanol-extract decreased some oxidation parameters, such as relative liver weight, TBARS and SOD activities, and also increased catalase activity in the liver of alcohol-loaded rats, But, the extract had no effects on GSH content and GSH-px activiy in the rats. Conclusion : The root of Rhodiola rosea has a strong anti-oxidative capacity, and also has some preventive properties aginst the alcoholic stress.

• 한국자기공명학회논문지
• /
• 제21권4호
• /
• pp.145-151
• /
• 2017

Rhodiola rosea, also known as gold root or rose root, is a perennial plant in the family of Crassulaceae. The rhizhome of R. rosea has been widely used as a hemostatic, tonic for burns and contusions in traditional Chinese medicine. Recent studies reported its strong antioxidant and adaptogenic properties. In this paper, we attempted to isolate compounds from the methanolic extract of R. rosea rhizomes. Four compounds including one new compound (1), two kaempferol glycosides (3 and 4) were isolated from chloroform and ethyl acetate soluble fraction of R. rosea extract. The structures of 1~4 including relative stereochemistry were determined by MS and NMR analysis.

• 한국토양비료학회지
• /
• 제42권6호
• /
• pp.423-429
• /
• 2009

인산과 칼리비료의 처리량 차이가 바위돌꽃의 수량 및 유효성분인 salidroside의 함량변화에 미치는 영향을 구명하여 고품질의 바위돌꽃을 생산할 수 있는 최적의 시비조건을 확립하고자 하였다. 1. 인산과 칼리비료의 처리수준별 바위돌꽃 뿌리의 건물생산량을 조사한 결과 각각 $8kg\;P_2O_5\;10a^{-1}$ 와, $30kg\;K_2O\;10a^{-1}$ 처리구에서 가장 높은 바위돌꽃 뿌리의 건물생산량을 나타내었다. 2. 인산 및 칼리비료의 처리량별 바위돌꽃 뿌리중 salidroside 함량간에는 유의성 있는 차이가 나타나지 않았다. 3. 인산과 칼리비료의 식물체 이용효율, 바위돌꽃 뿌리의 건물생산량 그리고 바위돌꽃 뿌리에 함유되어 있는 유효성분인 salidroside의 함량 등을 고려하였을 때, 인산비료는 $8{\sim}10kg\;10a^{-1}$ 그리고 칼리비료는 $20kg\; 10a^{-1}$ 가 합리적일 것으로 판단된다.

• 한국약용작물학회지
• /
• 제16권2호
• /
• pp.124-130
• /
• 2008

본 연구에서는 질소비료의 종류 및 처리량 차이가 바위돌꽃의 뿌리 수량 및 유효성분인 salidroside의 함량변화에 미치는 영향을 구명하여 고품질의 바위돌꽃을 생산할 수 있는 최적의 시비조건을 확립하고자 하였다. 요소비료와 유안비료 모두 48kg N/10 a까지는 처리량이 증가할수록 바위돌꽃 뿌리의 건물 생산량이 증가하는 경향이었으나, 그 이상의 처리량부터는 오히려 건물 생산량이 감소하였다. 요소비료와 유안비료 모두 화학비료 성분 처리량 48-8-20-10-10 kg/10a에서 가장 높은 salidroside 함량을 나타내었다. 곡선회귀 방정식에 기준한 요소와 유안비료의 적정 시비량은 45-8-20-10-10 kg/10 a로 나타났으나, 요소비료와 유안비료의 처리후 토양중 질소 축척과 토양 산성화, 식물체로의 질소 흡수이행량, 바위돌꽃 뿌리의 건물생산량 그리고 바위돌꽃 뿌리에 함유되어 있는 약리성분인 salidroside의 함량 등 제반사항을 고려하였을 때, 요소비료는 질소성분량으로 40 kg/10 a, 유안비료는 질소성분량으로 35 kg/10 a가 합리적일 것으로 판단된다.

• Archives of Pharmacal Research
• /
• 제23권4호
• /
• pp.349-352
• /
• 2000

A reversed-phase high performance liquid chromatographic method was developed to determine salidroside and tyrosol simultaneously in the Rhodiola rosea. The optimum condition was Nova-pak $C_18$as stationary phase, 6.5% methanol in water as mobile phase and detection at UV 225 nm. The identification was carried out by comparing the retention time and LC/MS spectrum of the relevant peaks with those of isolated standards. The contents of salidroside and tyrosol in the samples gathered from various area in China were ranged over 1.3-11.1 ${m}g/g$ and 0.3-2.2 ${m}g/g$, respectively.

• 한국자원식물학회:학술대회논문집
• /
• 한국자원식물학회 2003년도 춘계 학술발표대회
• /
• pp.133-135
• /
• 2003