• Journal of Life Science
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• v.31 no.2
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• pp.237-247
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• 2021

Immune responses in the central nervous system (CNS) function as the host's defense system against pathogens and usually help with repair and regeneration. However, chronic and exaggerated neuroinflammation is detrimental and may create neuronal damage in many cases. The NOD-, LRR-, and pyrin domain―containing 3 (NLRP3) inflammasome, a kind of NOD-like receptor, is a cytosolic multiprotein complex that consists of sensors (NLRP3), adaptors (apoptosis-associated speck like protein containing a caspase recruitment domain, ASC) and effectors (caspase 1). It can detect a broad range of microbial pathogens along with foreign and host-derived danger signals, resulting in the assembly and activation of the NLRP3 inflammasome. Upon activation, NLRP3 inflammasome leads to caspase 1-dependent secretion of the pro-inflammatory cytokines IL-1β and IL-18, as well as to gasdermin D-mediated pyroptotic cell death. NLRP3 inflammasome is highly expressed in CNS-resident cell types, including microglia and astrocytes, and growing evidence suggests that NLRP3 inflammasome is a crucial player in the pathophysiology of several neuroinflammatory and psychiatric diseases, such as Alzheimer's disease, Parkinson's disease, multiple sclerosis, stroke, traumatic brain injury, amyotrophic lateral sclerosis, and major depressive disorder. Thus, this review describes the molecular mechanisms of NLRP3 inflammasome activation and its crucial roles in the pathogenesis of neurological disorders.

• International Area Studies Review
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• v.20 no.1
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• pp.105-125
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• 2016

The expansionary monetary policy was practiced after 2001 in Japan to treat the deflation spiral, and reduced only the nominal interest rates and domestic household demand. One of the most serious factors for this failure was the change of private sector's expectancy. This paper has studied the effect of Japanese monetary policy in 21c., with empirical research based on a renewed macroeconomic model and the VAR. The empirical analysis shows that the effect of monetary policy on the national income during 2001.01-2015.03 is weaker than that of 1985.01-1994.04. Money volume has a diminutive effect on the growth of GDP within a short term after 2001. The change in the expectations of the private sectors might have been the cause of ineffectiveness of the expansive monetary policy. Economic agents learned from the past Japanese financial crisis that an expansive monetary policy increased the inflation rate and caused the 'bubbles to burst' afterwards. The VAR analysis says that the effectiveness of monetary policy on the economic depression declined over the past 20 years and the expansion of money volume has no influence on exchange rate and net export. This means that the expansive monetary policy lost its effect on net export and national income steadily. Monetary policy makers have to recognize this fact, and to consider another anti-cycle political instrument, i.e. the fiscal policy with government debt.

• The Southeast Asian review
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• v.28 no.4
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• pp.77-114
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• 2018

The purpose of this article is to verify whether recent political change in Thailand and the Philippines is temporarily shown "democratic recession" or "returning to authoritarianism". For the purpose this research establishes three propositions based on previous academic researches of political change. The is to verify characteristics of liberal democracy based on democratic procedures and institutions as well as civilian control over the military. The is to analyze the characteristics of authoritarianism such as the control over individual freedom and rights, concentration of power, and populist ruling behavior contrary to constitutionalism. The last one, , is to check either the coincidence or discrepancy between democratic institutions and popular understanding of democracy during democratic transitions. The finding through testing those propositions is that recent political change in two countries is more likely "returing to authoritarianism" rather than provisional "democratic recession". Implications of the finding has two aspects. One is that the only change in democratic procedures and institutions including the competition among political parties and peaceful change of governments are not enough to ensure a successful transition to liberal democracy. The other is that a half-democracy lacking the change of popular understanding and belief toward democracy as well as democratic practices cannot survive long enough. These are confirmed through this study on the cases of Thailand and the Philippines.

• Journal of Korea Entertainment Industry Association
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• v.14 no.8
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• pp.487-499
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• 2020

This study aims to planned Elementary Multicultural Education Program for Promoting Self Esteem. To this end, consider the application force of education and teaching system designed to reorganize the ADDIE Model study was carried out in accordance with the analysis, design, development, process evaluation. To this end, analyzing the between self-esteem and group theory related to them and the social identity theory and key concepts to consider in the context of multicultural education programs for elementary self-esteem enhancement identity, prejudice, cooperation and was composed of equality. Four key concepts are sub-elements of self-esteem individuals, homes, schools, set up a detailed learning objectives in accordance with the social and selecting the learning content and organization, which was composed of a total of 16 class periods. Considering the characteristics and interests of the target students, the teaching-learning method was designed to utilize various methods, including games, quizzes, and discussions, and each class was designed to be developed by organizing them into subjects-learning goals-activities(recognition-exploration-clearing). Since in the three-member expert review, modify the content on the basis of opinions and presented the final program. The program planned by this study, further research is required to verify the effectiveness and utilization in the educational field and expects effective multicultural education.

• The Korean Society of Law and Medicine
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• v.23 no.1
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• pp.149-176
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• 2022

South Korean law strictly prohibits engagement in medical activities by non-medical practitioners. In the country, tattooing is classified as a medical practice, and non-medical practitioners who engage in it are penalized because they are unauthorized to carry out this procedure. In reality, however, people rarely seek tattooing services from medical personnel. Arguing that their freedom of job selection is violated, non-medical personnel who make a living as tattoo artists reject the characterization of the procedure as a form of medical treatment and demand the decriminalization of tattooing by non-medical practitioners. Nevertheless, tattooing can cause health- and hygiene-related dangers when it is not performed by medical professionals because it involves penetration into the skin using needles. Hence, stringent management is necessary for infection prevention. The gap between reality and the law gives rise to the need for proactive thinking about the institutionalization of tattoo practice by non-medical personnel. Policymakers should reflect on the fact that only minimal tattooing services are currently performed by medical staff while also accounting for health and safety. On this basis, this study examined tattoo-related legislation in South Korea to determine whether the procedure corresponds to medical practice and identify ways to solve problems that occur from the perspective of health care. As a response that promotes safety and reflects reality, this research proposed a three-phase approach.

• Korean small business review
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• v.42 no.4
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• pp.285-308
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• 2020

This paper analyzes the factors which affect University professors and students on their startup activities, such as (a) University factors: their industrial cooperation organization and systems, their resources for startup support, their knowledge assets, and (b) socioeconomic characteristics in which Universities are located. We used the data and information from the University Information System and the National Statistical Office Publication to analyze 157 4-year Universities in Korea who uploaded their startup-related information on the system. Our analysis shows that Universities' systems, such as the term for Professors' leave of absence for startup activities, and their amount of knowledge assets affect the number of Professor startups significantly positively, while there is no significant effect on their performance, in terms of sales, from those factors, except for the amount of patents that the University has. In the meantime, the number of practical startup courses, the number of startup clubs, and the number of professor startups in the University affect the number of student startups, while the size of industrial cooperation body, the amount of knowledge asset, the area's socioeconomic characteristics didn't affect their performance. The result implies that we need to take different approaches to boost University professor startups and their student startups: better system and more knowledge for the former, more practical courses and programs for the latter. Further study is needed to get a more robust result because this analysis used only one year data, and personal trait data was not included in the analysis. A panel data analysis for several years is recommended for further research.

• Journal of the Korea Convergence Society
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• v.13 no.5
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• pp.21-34
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• 2022

This study attempted to identify the life and death reproduced in literary works and present well-aging and well-dying using literary studies that considered Korean literature. Literary works such as poems, novels, and plays recorded between the 13th and 20th centuries covered in 10 literary studies in this study were investigated and analyzed. The survey methods include general and outline sections, literary genre sections, period sections, and keyword review. As a result of the analysis, most of the literature studies corresponded to details including author theory. They were concentrated on the novel and poem, and mainly dealt with 20th century literary works. In addition, the relationship between death, life patterns, well-dying, and well-aging inherent in literary works was identified. It was the concept of a whole set and a subset. In conclusion, this study has a limitation in studying literary works at a specific period. Nevertheless, we examined the nature of well-aging in life as a hope to secure a prospect from Korean literature. And this study recognized the nature of well-dying in death and meaningful death as a rite of passage derived from Korean literature. In the future, it is expected to contribute to the realization of well-dying, well-aging, and application of convergence research in Korean society in the 21st century.

• Composites Research
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• v.35 no.6
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• pp.371-377
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• 2022

Triboelectric nanogenerator (TENG) devices have generated a lot of interest in recent decades. TENG technology, which is one of the technologies for harvesting mechanical energy among the energy wasted in the environment, is obtained by the dual effect of electrostatic induction and triboelectric charging. Recently, a multilayer thin film stacking method (or layer-by-layer (LbL) self-assembly technique) is being considered as a method to improve the performance of TENG and apply it to new fields. This LbL assembly technology can not only improve the performance of TENG and successfully overcome the thickness problem in applications, but also present an inexpensive, environmentally friendly process and be used for large-scale and mass production. In this review, recent studies in the accomplishment of LbL-based materials for TENG devices are reviewed, and the potential for energy harvesting devices reviewed so far is checked. The advantages of the TENG device fabricated by applying the LbL technology are discussed, and finally, the direction and perspective of this fabrication technology for the implementation of various ultra-thin TENGs are briefly presented.

• Journal of the Korean Institute of Traditional Landscape Architecture
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• v.40 no.3
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• pp.46-56
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• 2022

This study aimed to analyze the locational characteristics of heritage sites in Seoul in order to identify flood susceptibility by type. As for the location factors related to flood susceptibility, elevation, slope, distance to streams, and topographic location were analyzed. Literature review was supplemented for the historical and humanistic environments of heritage sites. The results of the study are as follows. First, heritage sites in Seoul are distributed throughout the city, and are especially highly dense in the Hanyangdoseong fortress. It was also confirmed that heritage sites were concentrated around Jung-gu, Jongno-gu, Jingwan-dong, and Ui-dong in the quantitative spatial analyses. Second, types of heritage sites at the circumstance susceptible to flood damage were related to commerce and distribution, traffic, modern traffic and communication, geological monument, residence, government office, and palace. Third, heritage types with locational characteristics that showed low flood susceptibility were found to be natural scenic spots, telecommunication, ceramics, Buddhism, tombs, and tomb sculptural heritage assets. In a time when risk factors that can damage the value of heritage are gradually increasing due to anthropogenic influences along with changes in the natural environment, this study provides basic data for vulnerability analysis that reflects the unique characteristics of heritage assets. The results can contribute to more comprehensive and comprehensive insights for the management and protection of heritage by including the humanities and social science data together with natural factors in the analysis.

• The Journal of the Korea Contents Association
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• v.21 no.12
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• pp.748-756
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• 2021

In this study, as the first attempt to develop an experiential game tourism program using Korean classical literature, the primary research was conducted on Kim Soo-Jang and his anthology "Hae Dong Ga Yo". To this end, a theoretical review of the value of hands-on games and Korean classical literature as tourism content was conducted first. Afterwards, the consumers for the program were set up into three categories: family unit, MZ generation including lovers, and foreigners. A survey was conducted to confirm the program preference of each group. According to the analysis framework, the main value of each historical and cultural resource in "Hae Dong Ga Yo" and seven sijo pieces created by Kim Soo-Jang was discovered and, based on the survey, the preferences of the consumer related to the target were analyzed. Accordingly, the narrative structures were organized differently for each group. An adventure plot was designed for the family unit, a love plot for MZ generation and lovers, and a mixture of adventure and love for foreigners. Utilizing stories from Kim Soo-Jang and his works, which are rarely used despite their value, this study attempted to develop them into hands-on game tourism programs to create new outlets in terms of both Korean classical literature and the tourism area. In the future, if various Joseon literati are discovered and their storytelling is continued, we can expect the vitalization of the travel product line with the concept of classical literature travel.