• Journal of Korean Neurosurgical Society
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• v.54 no.6
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• pp.540-543
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• 2013

The glomus tumor of the peripheral nerve is one of the mesenchymal tumors originating in the epineurium, and is extremely rare. A 56-year-old man presented complaining of lancinating pain on the left thigh, which was provoked by pressure or exercise. Subsequent image study revealed a mass in the femoral nerve. Total surgical excision with the aid of intraoperative ultrasonography was performed and the pain was successfully controlled. The authors report an unusual case of a patient diagnosed with glomus tumor in peripheral nerve, with a review of the clinical features, imaging, and pathological findings.

• Journal of Korean Neurosurgical Society
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• v.61 no.3
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• pp.319-332
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• 2018

Germline mutations in cancer causing genes result in high risk of developing cancer throughout life. These cancer predisposition syndromes (CPS) are especially prevalent in childhood brain tumors and impact both the patient's and other family members' survival. Knowledge of specific CPS may alter the management of the cancer, offer novel targeted therapies which may improve survival for these patients, and enables early detection of other malignancies. This review focuses on the role of CPS in pediatric high grade gliomas (PHGG), the deadliest group of childhood brain tumors. Genetic aspects and clinical features are depicted, allowing clinicians to identify and diagnose these syndromes. Challenges in the management of PHGG in the context of each CPS and the promise of innovative options of treatment and surveillance guidelines are discussed with the hope of improving outcome for individuals with these devastating syndromes.

• Journal of Korean Neurosurgical Society
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• v.61 no.3
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• pp.343-351
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• 2018

Diffuse intrinsic pontine glioma (DIPG) is a deadly paediatric brain cancer. Transient response to radiation, ineffective chemotherapeutic agents and aggressive biology result in rapid progression of symptoms and a dismal prognosis. Increased availability of tumour tissue has enabled the identification of histone gene aberrations, genetic driver mutations and methylation changes, which have resulted in molecular and phenotypic subgrouping. However, many of the underlying mechanisms of DIPG oncogenesis remain unexplained. It is hoped that more representative in vitro and preclinical models-using both xenografted material and genetically engineered mice-will enable the development of novel chemotherapeutic agents and strategies for targeted drug delivery. This review provides a clinical overview of DIPG, the barriers to progress in developing effective treatment, updates on drug development and preclinical models, and an introduction to new technologies aimed at enhancing drug delivery.

• Journal of Korean Neurosurgical Society
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• v.63 no.3
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• pp.327-337
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• 2020

Junctional neurulation represents the most recent adjunct to the well-known sequential embryological processes of primary and secondary neurulation. While its exact molecular processes, occurring at the end of primary and the beginning of secondary neurulation, are still being actively investigated, its pathological counterpart -junctional neural tube defect (JNTD)- had been described in 2017 based on three patients whose well-formed secondary neural tube, the conus, is widely separated from its corresponding primary neural tube and functionally disconnected from corticospinal control from above. Several other cases conforming to this bizarre neural tube arrangement have since appeared in the literature, reinforcing the validity of this entity. The cardinal clinical, neuroimaging, and electrophysiological features of JNTD, and the hypothesis of its embryogenetic mechanism, form part of this review.

• Journal of Institute of Convergence Technology
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• v.5 no.2
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• pp.13-19
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• 2015

Recently, quadcopters have been popular as aerial drones. The structure of quadcopters is simpler than traditional helicopters and they are easy to construct and maneuver. Various hardware platforms for quadcopters have been developed. However, the controller design is not easy due to the requirement of 6-DOF flights using 4 rotors(control inputs)(under-actuated systems). In order to overcome the underactuation problem, various control methods - PID, LQR, $H_{\infty}$, SMC, backstepping control, and etc. - have been suggested for the control of quadcopters. In this paper, dynamic features and control methods of quadcopters are reviewed and evaluated. Future works are proposed for designing the advanced controllers of quadcopters.

• The Journal of Korean Medicine
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• v.33 no.2
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• pp.25-33
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• 2012

Objectives: To obtain the features of prevalence of chronic fatigue and chronic fatigue syndrome worldwide. Methods: All research reports for prevalence of chronic fatigue and chronic fatigue syndrome were selected from PubMed, KMbase and KISS database, and the prevalence were analyzed according to the symptoms and countries. Results: A total of 39 articles from 13 other countries and 4 articles from Korea met the criteria of this study. The prevalence of chronic fatigue and chronic fatigue syndrome was about 10% and 1% respectively. The prevalence for Korean was 17.7% and 1.4% respectively, however the data have a limitation due to the lack of well-designed studies. Conclusions: This report can provide essential information to build a strategy for development of therapeutics against chronic fatigue and chronic fatigue syndrome using traditional Korean medicine.

• Korean Institute of Interior Design Journal
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• v.24 no.1
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• pp.144-151
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• 2015

With expansion of modern cities, a huge number of old industrial facilities have been abandoned. Thus, in the development of ecological city, this study aims to conclude on these old facilities and their ecological landscape designs by analyzing successful cases. The approaches adopted are as follows. Starting with literature review, whereby old industrial facility's definition and developing process are pinpointed, the paper studies representative cases with reuse and re-development theories of ecological design for old industrial facilities, of which renovation types, reuse effects, and design features are particularly examined. Case studies also demonstrate considerations in ecological reuse designs, such as ecological restoration, energy conservation, rainwater collection, and utmost pollution reduction, etc. However, technology, environment and circumstance differences determine that each design project requires concrete analysis, which should also be considered in future ecological design for old industrial facilities.

• Parasites, Hosts and Diseases
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• v.22 no.1
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• pp.72-77
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• 1984

A case of congenital malaria infection has been studied in a 46-day old female Korean infant. Her mother suffered from malaria infection during pregnancy in Uppervolta, Africa, and returned to Korea at the 9th month of gestation for delivery. At 39 days of age, the clinical features characterized by fever, irritability, pallor, jaundice and hepatosplenomegaly were developed. The laboratory data revealed a hemolytic anemia with thronbocytopenia, hyperbilirubinemia and increased hepatic enzyme values. A peripheral blood smear demonstrated intraerythrocytic malarial parasites and gametocytes of Plasmodium falciparum. She was successfully treated with quinine solfate (25mg/kg/day in three doses for 5 days) and trimethoprimejsulfamethoxazole (8mg/kg/day in two doses for 5 days) orally, and repeated blood smear had been negative for malaria. This report also signifies the first description of congenital malaria in Korea imported from Uppervolta in Africa. A brief review of related literature was made.

• Journal of Oriental Neuropsychiatry
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• v.25 no.3
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• pp.213-224
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• 2014

Objectives: The Temperament and Character Inventory (TCI), initially developed by Dr. Cloninger in 1986, has been studied from various perspectives in many countries; however, its application in Korea has been limited due to a lack of information regarding the clinical use of integrative medicine. Methods and Results: A systematic review of previous studies on the theoretical development, structure, and content of temperament and character scales, as well as their stability and variability, is presented. In addition, the distinctive features of TCI as a biopsychosocial model and its clinical application regarding well-being, coherence therapy, and person-centered medicine were systematically reviewed. Discussion and Conclusion: The promotion of well-being with Cloninger's personality model and its importance for integrative medicine were discussed. This study would contribute to the clinical application of TCI in Korea.

• Annals of Clinical Neurophysiology
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• v.19 no.2
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• pp.79-92
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• 2017

Paraproteinemia is caused by a proliferation of monoclonal plasma cells or B lymphocytes. Approximately 10% of idiopathic neuropathies are associated with paraproteinemia, where a certain paraprotein acts like an antibody targeted at constituents of myelin or axolemma in peripheral nerves. The relationship between paraproteinemia and peripheral neuropathy remains unclear despite this being of interest for a long time. Neurologists frequently find paraproteinemia during laboratory examinations of patients presenting with peripheral neuropathy, especially in the elderly. The possibility of a relationship with paraproteinemia should be considered in cases without an explainable cause. We review the causal association between paraproteinemia and neuropathy as well as clinical, laboratory, and electrophysiologic features, and the treatment options for paraproteinemic neuropathy.