• Journal of Technology Innovation
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• v.7 no.1
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• pp.60-77
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• 1999

This study addresses the question of how to design the research system for national R&D programs that aim to promote creative innovation. This paper attempts to analyze the case of Creative Research Initiatives(CRI), a new national R&D program recently launched by the Ministry of Science and Technology of Korea. CRI is a strategic program intended to shift the national R&D paradigm from imitative innovation to creative innovation. The key features of the research system of the program include: a research-centered system, long-term research funding, the sunset approach, a dynamic and flexible research organization, and a centralized research system. This paper suggests theoretical rational of these key features based on the literature review on creative innovation. Based on an analysis of the results of implementing the CRI in 1997, this paper also examines how the research system design is reflected and embodied in the program implementation process. Finally, policy implications and future research directions are also discussed.

• Biomolecules & Therapeutics
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• v.29 no.6
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• pp.605-614
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• 2021

Autophagy is an important degradative pathway that eliminates misfolded proteins and damaged organelles from cells. Autophagy is crucial for neuronal homeostasis and function. A lack of or deficiency in autophagy leads to the accumulation of protein aggregates, which are associated with several neurodegenerative diseases. Compared with non-neuronal cells, neurons exhibit rapid autophagic flux because damaged organelles or protein aggregates cannot be diluted in post-mitotic cells; because of this, these cells exhibit characteristic features of autophagy, such as compartment-specific autophagy, which depends on polarized structures and rapid autophagy flux. In addition, neurons exhibit compartment-specific autophagy, which depends on polarized structures. Neuronal autophagy may have additional physiological roles other than amino acid recycling. In this review, we focus on the characteristics and regulatory factors of neuronal autophagy. We also describe intracellular selective autophagy in neurons and its association with neurodegenerative diseases.

• Journal of information and communication convergence engineering
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• v.17 no.1
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• pp.49-59
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• 2019

Biosensors, which are analysis devices used to convert biological reactions into electric signals, are made up of a receptor component and a signal transduction part. Graphene quantum dots (GQDs) and carbon quantum dots (CQDs) are new types of carbon nanoparticles that have drawn a significant amount of attention in nanoparticle research. The unique features exhibited by GQDs and CQDs are their excellent fluorescence, biocompatibility, and low cytotoxicity. As a result of these features, carbon nanomaterials have been extensively studied in bioengineering, including biosensing and bioimaging. It is extremely important to find biomaterials that participate in biological processes. Biomaterials have been studied in the development of fluorescence-based detection methods. This review provides an overview of recent advances and new trends in the area of biosensors based on GQDs and CQDs as biosensor platforms for the detection of biomaterials using fluorescence. The sensing methods are classified based on the types of biomaterials, including nucleic acids, vitamins, amino acids, and glucose.

• Journal of the Korean Magnetic Resonance Society
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• v.23 no.2
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• pp.51-55
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• 2019

Quantum dot (QD) is an emerging novel nanomaterial that has wide applicability and superior functionality with relatively low cost. Nuclear magnetic resonance (NMR) spectroscopy has been contributed to elucidate various features of QDs and to improve their overall performance. In particular, NMR spectroscopy becomes an essential analytical tool to monitor and analyze organic ligands on the QD surface. In the present mini-review, application of NMR spectroscopy as a superb methodology to appreciate organic ligands is discussed. In addition, it was recently noted that ligands exert rather greater influence on diverse features of QDs than our initial anticipation, for which contribution of NMR spectroscopy is briefly reviewed.

• BMB Reports
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• v.52 no.1
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• pp.35-41
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• 2019

Cellular senescence, a permanent state of cell cycle arrest, is believed to have originally evolved to limit the proliferation of old or damaged cells. However, it has been recently shown that cellular senescence is a physiological and pathological program contributing to embryogenesis, immune response, and wound repair, as well as aging and age-related diseases. Unlike replicative senescence associated with telomere attrition, premature senescence rapidly occurs in response to various intrinsic and extrinsic insults. Thus, cellular senescence has also been considered suppressive mechanism of tumorigenesis. Current studies have revealed that therapy-induced senescence (TIS), a type of senescence caused by traditional cancer therapy, could play a critical role in cancer treatment. In this review, we outline the key features and the molecular pathways of cellular senescence. Better understanding of cellular senescence will provide insights into the development of powerful strategies to control cellular senescence for therapeutic benefit. Lastly, we discuss existing strategies for the induction of cancer cell senescence to improve efficacy of anticancer therapy.

• Journal of Contemporary Eastern Asia
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• v.19 no.2
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• pp.1-19
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• 2020

Trends toward an influx of new migrants have been pronounced in East Asia through a development we call the third round of migrant incorporation. At the same time, other features of East Asian societies, such as strong levels of ethnic nationalism, have changed little, posing challenges to multiculturalism. In this introduction to this special issue, we review the latest research trends broadly concerning multiculturalism, migrant groups that have received little attention, racism and xenophobia. We first discuss the state of migrant incorporation in East Asia and the limits of multiculturalism in this region, where various features of the developmental state persist. We then introduce research on voices opposing multiculturalism in East Asia. This introduction highlights what is peculiar―and ordinary―about migrant incorporation and the associated challenges in East Asia.

• Journal of the Korean Magnetic Resonance Society
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• v.26 no.2
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• pp.21-23
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• 2022

High-pressure (HP) NMR is a powerful method to elucidate various structural features of amyloidogenic proteins. Following the previous mini-review recapitulating the HP-NMR application for amyloid-β peptides of the last issue [J. H. Kim, J. Kor. Mag. Reson. Soc. 26, 17 (2022)], the recent advancements in the HP NMR application for α-synuclein (α-Syn) are briefly summarized and discussed here. Although α-Syn is a well-known intrinsically disordered protein (IDP), several studies have shown that it can also exhibit heterogeneous yet partially folded conformations, which may correlate with its amyloid-forming propensity. HP NMR has been a valuable tool for investigating the dynamic and transient structural features of α-Syn and has provided unique insights to appreciate its aggregation-prone characters.

• Korean Journal of Schizophrenia Research
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• v.23 no.2
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• pp.45-50
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• 2020

Schizophrenia is one of serious mental illnesses and is often described as a heterogeneous disorder. Approximately one-third of schizophrenia cases are treatment-resistant schizophrenia (TRS). The aim of this study was to review the definitions and clinical features of TRS. Though it was found that the criteria for TRS were considerably diverse, the Treatment Response and Resistance in Psychosis (TRRIP) consensus criteria were recently introduced. According to the TRRIP criteria, TRS should be suspected if symptoms persist alongside psychotic symptoms despite sufficient treatment for ≥12 weeks, or two or more symptoms persist significantly for ≥6 weeks. The clinical characteristics of TRS includes an earlier age of onset, more severe and familial form, possibly more rural residence, unlikely association with male sex, and an increase in cognitive deficits.

• Journal of Sport and Applied Science
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• v.7 no.1
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• pp.1-10
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• 2023

Purpose: This paper analyzed the features of Winter Olympics mascots in chronological order by examining the evolution of mascots and presented the attributes of the Winter Olympics mascots from Innsbruck 1976 to Beijing 2022. Research design, data, and methodology: This paper conducted an exploratory study on the thinking to understand the characteristics of 13 Winter Olympics Mascots through literature review. Results: First, the mascot is a fictional character, usually an artificial character that represents the locality of the host city, including animals, human figures, and local inhabitants. Second, Schneemann, Innsbruck 1976 was known as the first official Winter Olympics mascot. Third, 19 mascots out of a total of 24 mascots were created using animals. Conclusions: The six attributes of the Winter Olympics mascots were identified: friendliness, symbolic meaning, originality, diversity, value, and identity of a special location. Above all, Winter Olympics has a locality that includes areas covered with ice and snow. From this point of view, the Olympics mascot highlights the image of snow and ice and the physical environment that includes it.

• Clinical Pain
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• v.20 no.1
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• pp.7-14
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• 2021

Musculoskeletal ultrasound has evolved as the essential tool to diagnose and guide intervention procedures in people with neuromusculoskeletal conditions. Image optimization and understanding device operations are core components for ultrasound guided intervention procedure training. All ultrasound machines share the common operative features and there are various buttons for the features in the device control panel. Ultrasound "knobology" refers to the thorough understanding of imaging optimization. This review addressed basic information for the transducers, depth setting, gain and focus control, different modes focusing on brightness and doppler modes.