• BMB Reports
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• v.53 no.9
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• pp.458-465
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• 2020

Metastasis is the main culprit of the great majority of cancerrelated deaths. However, the complicated process of the invasion-metastasis cascade remains the least understood aspect of cancer biology. Telomerase plays a pivotal role in bypassing cellular senescence and sustaining the cancer progression by maintaining telomere homeostasis and genomic integrity. Telomerase reverse transcriptase (TERT) exerts a series of fundamental functions that are independent of its enzymatic cellular activity, including proliferation, inflammation, epithelia-mesenchymal transition (EMT), angiogenesis, DNA repair, and gene expression. Accumulating evidence indicates that TERT may facilitate most steps of the invasion-metastasis cascade. In this review, we summarize important advances that have revealed some of the mechanisms by which TERT facilitates tumor metastasis, providing an update on the non-canonical functions of telomerase beyond telomere maintaining.

• Preventive Nutrition and Food Science
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• v.22 no.2
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• pp.81-89
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• 2017

Healthy aging has become a major goal of public health. Many studies have provided evidence and theories to explain molecular mechanisms of the aging process. Recent studies suggest that epigenetic mechanisms are responsible for life span and the progression of aging. Epigenetics is a fascinating field of molecular biology, which studies heritable modifications of DNA and histones that regulate gene expression without altering the DNA sequence. DNA methylation is a major epigenetic mark that shows progressive changes during aging. Recent studies have investigated aging-related DNA methylation as a biomarker that predicts cellular age. Interestingly, growing evidence proposes that nutrients play a crucial role in the regulation of epigenetic modifiers. Because various nutrients and their metabolites function as substrates or cofactors for epigenetic modifiers, nutrition can modulate or reverse epigenetic marks in the genome as well as expression patterns. Here, we will review the results on aging-associated epigenetic modifications and the possible mechanisms by which nutrition, including nutrient availability and bioactive compounds, regulate epigenetic changes and affect aging physiology.

• BMB Reports
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• v.52 no.1
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• pp.86-108
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• 2019

In multi-cellular organisms, the control of gene expression is key not only for development, but also for adult cellular homeostasis, and gene expression has been observed to be deregulated with aging. In this review, we discuss the current knowledge on the transcriptional alterations that have been described to occur with age in metazoans. First, we discuss age-related transcriptional changes in protein-coding genes, the expected functional impact of such changes, and how known pro-longevity interventions impact these changes. Second, we discuss the changes and impact of emerging aspects of transcription in aging, including age-related changes in splicing, lncRNAs and circRNAs. Third, we discuss the changes and potential impact of transcription of transposable elements with aging. Fourth, we highlight small ncRNAs and their potential impact on the regulation of aging phenotypes. Understanding the aging transcriptome will be key to identify important regulatory targets, and ultimately slow-down or reverse aging and extend healthy lifespan in humans.

• Journal of Industrial Technology
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• v.35
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• pp.47-53
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• 2015

Recent extreme weather events and natural disasters are causing rapid aging of the ancient structures with cultural value. It has threatened the safety and management. The construction design documents are not kept for such long time. Even if they are, they seem to be mismatched with the design structures due to corrosive effects. For these reasons, Korea has been facing difficulties in maintenance, reengineering and safety evaluation. In this study, three dimensional point cloud surface of bobsleigh is obtained using 3D LiDAR scanner. The obtained structure is compared with the original design and found to be highly accurate. The study shows the application of reverse engineering technique and its potential use for other civil structures.

• Journal of Life Science
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• v.29 no.10
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• pp.1071-1079
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• 2019

In this study, we investigated the antioxidant and anti-aging activities of Schisandra chinensis seed fractions by adding them to UVB-irradiated HaCaT cells and analyzing the suppression of matrix metalloproteinases (MMPs). An electron-donating assay, ABTS radical scavenging assay, and hydrogen peroxide scavenging assay showed that the ethyl acetate fraction of S. chinensis seed (SCEAf) has scavenging activities. A collagenase inhibition activity assay showed that SCEAf had inhibitory effects of over 92.3% at $500{\mu}g/ml$ concentration. An MTT assay was performed to determine the cytotoxicity of SCEAf in HaCaT cells and the results showed that SCEAf increased cellular viability in a concentration-dependent manner. In addition, SCEAf was found to increase the viability of cells irradiatged by UVB $50mJ/cm^2$. To examine the anti-aging effects of SCEAf on HaCaT cells irradiated with UVB $50mJ/cm^2$, the expression of MMP-1 and -3 was analyzed by Western blotting and reverse-transcription polymerase chain reaction. The results showed that MMP-1 and -3 proteins and mRNA levels were downregulated in a concentration-dependent manner in response to SCEAf. These results suggest that SCEAf can prevent aging and alleviate aging symptoms by inhibiting collagenase activity in skin keratinocytes damaged by UVB. Therefore, S. chinensis seeds may have the potential for use as functional ingredients with anti-aging effects in the cosmetic and food industries.

• Proceedings of the KIEE Conference
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• 1999.07d
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• pp.1566-1568
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• 1999

Aging properties of distribution cables due to irradiation of radiaition rays was investigated. Samples of XLPE are fabricated as hot press, then radiation rays irradiated $0\sim100$Mrad and measured aging properties in the voltage range of $0\sim10$ KV. Voltage-current characteristics of hysteresis curves and the relationship between forward and reverse current due to irradiation of radiaition rays are discussed.

• Proceedings of the Korean Institute of Electrical and Electronic Material Engineers Conference
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• 2004.11a
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• pp.289-292
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• 2004

반도체 소자의 파괴 원인으로는 주로 열, 전압, 전류, 진동 및 압력 등이 있다. 이 중에서 전압과 열을 스트레스 인자로 적용하여 가속열화 시험을 진행하였다. 전압 및 열에 의한 소자의 열화정도를 파악하기 위해 현재 상용화되어 있는 Phase Control Thyristor 중 $V_{DRM}\;=\;1500V,\;V_{BRM}\;=\;1500V, \;T_{HS}\;=\;-40{\sim}125^{\circ}C$ 정도의 사양을 가지는 소자를 사용하였다. 열화에 의한 여러 가지 변동특성 중에서 소자의 순방향 및 역방향 항복특성의 변화와 누설전류의 변화에 대해 실험을 통해 알아보았다.

• Journal of Family Resource Management and Policy Review
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• v.15 no.2
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• pp.1-21
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• 2011

Housing selections of the elderly depends on various changing factors as they get old. Among those factors, housing satisfaction might be one of the most predictable and crucial factor. This study is focused on the casual effect of housing satisfaction on the elderly's likelihood of selection among three alternatives of housing type. The sample was selected from 349 elderly aged above 65 who were living in Jeonju area, and was analyzed from multiple regressions and casual analysis. The results could be summarized as follows; First, the elderly preferred 'their own house living at present (aging in place)' among three housing type. Second, factors that influenced on housing satisfaction of the elderly were condition of health, economic status, living with spouse or not, level of social activities, and family supports. Third, the elderly who were male, without spouse living in single-family houses, in better health condition and with lower educational level were having more likelihood of selection of present housing. The elderly who were having more likelihood to select reverse mortgage payment were male, with spouse, living in apartment houses, the older, in worse health conditions and economic status. And the elderly who were male, with spouse, living in apartment houses, and in worse health conditions were having more likelihood to select national rental housing.

• Journal of the Korean Society for Heat Treatment
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• v.36 no.5
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• pp.277-284
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• 2023

Hardness and damping characteristics of fine discontinuous precipitates (DPs) microstructure generated by low temperature long term isothermal aging were investigated in comparison with those of T6 heat-treated microstructure composed of DPs and continuous precipitates (CPs) in Mg-9%Al alloy. In this study, T6 and fine DPs microstructures were obtained by isothermal aging at 453 K for 24 h and at 413 K for 336 h, respectively, after solution treatment at 693 K for 24 h. The DPs microstructure exhibited higher hardness than the T6 microstructure, which is related to the lower (α + β) interlamellar spacing of the DPs. The DPs microstructure possessed better damping capacity than the T6 microstructure in the strain-amplitude independent region, whereas in the strain-amplitude dependent region, the reverse behavior was observed. The damping tendencies depending on strain-amplitude were discussed based on the microstructural features of the T6 and DPs microstructures.

• Current Optics and Photonics
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• v.6 no.3
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• pp.227-235
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• 2022

To investigate the aging-related physiological functions of organic light-emitting diodes (OLEDs), we examined mRNA expression changes in aging-related genes due to oxidative stress inhibition by 630-nm red light OLEDs. As a result of irradiating 630-nm OLED with an intensity of 5 mW/cm² for 15 min, the viability of dermal fibroblasts significantly increased by 1.3-fold. In addition, reactive oxygen species generated by H₂O₂ were significantly reduced about 4.9-fold by irradiation with 630-nm OLED. Quantitative reverse-transcription polymerase chain reaction results showed that 630-nm OLEDs altered aging-related gene mRNA expression levels through antioxidant activity. The mRNA expression levels of matrix metalloproteinase1 (MMP1) and MMP9 decreased significantly, by about 2.2- and 2.5-fold, compared to the control group, whereas those of collagen, type I, and alpha 1 increased significantly, by 4.9-fold. The mRNA expression levels of cancer suppression genes p16 and p53 in dermal fibroblasts were also significantly reduced by 630-nm OLED irradiation, by about 1.4- and three-fold, respectively, compared to the control. Overall, it was confirmed that 630-nm OLED irradiation lowered the level of ROS formation induced by H₂O₂ in dermal fibroblasts, and that this antioxidant effect could regulate the mRNA expression levels of aging- and tumor suppression-related genes. This study shows a link between 630-nm OLED irradiation and anti-aging physiological functions such as antioxidant function, and suggests the potential of OLEDs as a useful light source for skin care.