• Korean Journal of Cleft Lip And Palate
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• v.11 no.2
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• pp.65-70
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• 2008

Cleft lip and/or palate are common birth defects in humans and the causes including multiple genetic and environmental factors are complex. Combinations of genetic, biochemical, and embryological approaches in the laboratory mice are used to investigate the molecular mechanisms underlying normal craniofacial development and the congenital craniofacial malformations including cleft lip and/or palate. Both forward and reverse genetic approaches are used. The forward genetic approach involves identification of causative genes and molecular pathways disrupted by uncharacterized mutations that cause craniofacial malformations including cleft lip and/or cleft palate. The reverse genetic approach involves generation and analyses of mice carrying null or conditional mutations using the Cre-loxP mediated gene targeting techniques.

• Proceedings of the Korean Society of Toxicology Conference
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• 2003.10b
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• pp.119-119
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• 2003

The objective of this study was to determine genotoxic potential of Sophora Japonica Linne Seed Extract(SE). The bacterial reverse mutation test set the treatment levels of SE at 0, 312.5, 625, 1250, 2500, 5000 $\mu\textrm{g}$/plate using Salmonella typhimurium strains (TA1535, TA1537, TA98, TA100) and Escherichia coli WP2uvrA(pKM101). (omitted)

• Journal of the Korean Society of Food Science and Nutrition
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• v.36 no.8
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• pp.960-964
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• 2007

This study was performed to examine the toxicity of Psoralea corylifolia L. by the single-dose oral toxicity tests in rat and bacterial reverse mutation assay. In single-dose oral toxicity tests, 5 mL ethanol extract of P. corylifolia L. were directly injected into 10 rats (5 males and 5 females) at a dosage of 2 g/kg. Death practice was not detected during breeding periods (14 days), and $LD_{50}$ was calculated over 2 g/kg. No difference were observed with control group in the growth rate and histological observations. In bacterial reverse mutation assay, his(-) Salmonella Typhimurium TA98, TA100, TA1535, TA1537 and trp(-) Escherichia coli WP2uvrA (pKM101) were used for assessing the toxicity of ethanol extracts of P. corylifolia L.. No significant difference in formation of the colonies and no dose-dependent increase was observed regardless of the addition of S9 mix. The results showed that ethanol extracts of P. corylifolia L. did not have single-dose oral toxicity and mutagenic toxicity.

• Transactions of the Korean Society of Mechanical Engineers B
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• v.35 no.3
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• pp.269-278
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• 2011

We investigate the heat-transfer and pressure-drop characteristics of fin-and-tube heat exchangers with a copper plate or copper spiral fins. Twenty-four samples with different fin pitches and tube rows were tested. For both configurations, the effect of the fin pitch on the j factor is negligible, and the f factor increases with the fin pitch. The effect of the tube row depends on the configuration. For plate fin-and-tube heat exchangers, the j factor decreases as the row number increases; the reverse is true for spiral exchangers. We explain this by considering the flow pattern. The j factor for plate fin-and-tube heat exchangers is larger than that for spiral exchangers, and the difference decreases as the row number increases. The f factor of the plate fin-and-tube heat exchanger is also larger. We compare our results with existing predictions of correlations.

• Journal of Korean Society of Environmental Engineers
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• v.35 no.11
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• pp.821-826
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• 2013

The purposes of this research are to study on optimal distance between positive and negative electrodes in dust removal chamber. The experiments were performed with electrode-plate gab arranging in order of 3 cm, 2 cm, 1 cm in series while varying influent flow-rate. From the experimental results of dust removal the optimal influent linear velocity was 6 cm/sec and the total mass of attached dust on the surface of electrode-plate was increased as electrode-plate gab is closer. But in case of electrode-plate gab being very close about 1 cm or so, the attached dust on the surface of electrode-plate was shown releasing from electrode-plate due to dust electric-charge changing (reverse ionization). Evantually. optimal distance between positive and negative electrode-plates was about 2 cm and also optimal dust loading rate was about $24mg/min{\cdot}m^2$.

• Transactions of the Korean Society of Automotive Engineers
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• v.11 no.3
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• pp.106-114
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• 2003

The pressure ripple in the delivery port is caused by flow ripple, which is induced by variation of pumping chamber volume. The other reason is the reverse flow from the outlet volume produced by pressure difference between pumping chamber and outlet volume, when the pumping chamber is connected with the outlet volume. In this study, a mathematical model is presented for analyzing discharge pressure ripple, which includes vane detachment, cam ring movement , and fluid inertia effects in V-groove in the side plate. From the analysis and experiment, it was found that V-groove on the side plate, coefficient of spring supporting the cam ring, and average discharge pressure are the main factors of discharge pressure ripple in variable displacement vane pump. The theoretical results, provided in this study, were well agreed with experimental results. The analytical model to estimate the magnitude of pressure ripple in this study is expected to be used f3r the optimal design of the variable displacement vane pump.

• The KSFM Journal of Fluid Machinery
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• v.13 no.3
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• pp.12-17
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• 2010

The orifice establishment which is improper does to change the entity differential pressure and occurs an error in flow measurement data. Because of this, the thermal power of nuclear power plant could be evaluated excessively and the safety margin could be decreased. In this paper, characters of orifice which is established abnormally was investigated. Specially, the orifice plate which is established in opposition case was modeled and analyzed. Finally, 14.4% was lowly measured differential pressure, when being established in the resultant opposition. And this result with EPRI and NRC experiences was similar.

• Journal of Mechanical Science and Technology
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• v.18 no.10
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• pp.1819-1828
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• 2004

The purpose of this paper is to investigate the effects of slits and swirl vanes on the turbulence augmentation in the flow fields of a gun-type gas burner using an X-type hot-wire probe. The gun-type gas burner adopted in this study is composed of eight slits and swirl vanes located on the surface of an inclined baffle plate. Experiment was carried out at a flow rate of 450 ι/min in burner model installed in the test section of subsonic wind tunnel. Swirl vanes playa role diffusing main flow more remarkably toward the radial direction than axial one, but slits show a reverse feature. Consequently, both slits and swirl vanes remarkably increase turbulence intensity in the whole range of a gun-type gas burner with a cone-type baffle plate.

• Archives of Reconstructive Microsurgery
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• v.21 no.2
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• pp.159-164
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• 2012

Purpose: Soft tissue defect on posterior side of heel exposing Achilles tendon is vulnerable and require thin flap to improve aesthetic and functional results. Reverse superficial sural artery flap is simple and fast procedure, and it can preserves major arteries, supplies reliable constant blood, causes less donor site complication. Authors reviewed our cases and report the clinical results. Materials and Methods: Nine cases of soft tissue defects on the posterior side of heel exposing Achilles tendon were treated with distally based superficial sural artery flap. There were 6 male and 3 female and mean age was 48.4 years. The size of flap was from $4{\times}4cm$ to $10{\times}15cm$ and mean follow-up period was 23 months. Flap survival, postoperative complications were evaluated. Results: All flaps were survived completely without necrosis. There was one case of partial wound dehiscence that needed debridement and repair, and other one case had recurrent discharge that was healed after removal of calcaneal plate. All patient showed acceptable range of ankle motion. Conclusion: Authors suggest that the reverse superficial sural artery flap could be one of the useful treatment options for the soft tissue defect on posterior side of heel exposing Achilles tendon.

• Bulletin of the Korean Chemical Society
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• v.34 no.6
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• pp.1745-1750
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• 2013

A novel green aqueous mobile phase modified with room temperature ionic liquids (RTILs) was employed in the absence of volatile organic solvents or ion-pairing reagents to analyze thiamine, a very polar compound, by reverse phase high performance liquid chromatography (RP-HPLC). Due to its strongly hydrophilic nature, thiamine was eluted near the column dead time ($t_0$) using a mobile phase without adding RTILs or ion-pairing reagents, even if a 100% aqueous mobile phase, which has weak elution power under reverse phase conditions, was used. Thus, 1-ethyl-3-methyl-imidazolium hexafluorophosphate ([EMIM][$PF_6$]), which has the strongest chaotropic effect, was selected as a mobile phase additive to improve retention and avoid baseline disturbances at $t_0$. Various mobile phase parameters such as cation moiety, chaotropic anion moiety, pH and concentration of RTILs were optimized to determine thiamine at the proper retention time. Method validation was performed to assess linearity, intra- and inter-day accuracy and precision, recovery and repeatability; all results were found to be satisfactory. The developed method was also compared to the current official United States Pharmacopoeia (USP) and Korean Pharmacopoeia (KP) methods using an organic mobile phase containing an ionpairing reagent by means of evaluating various chromatographic parameters such as the capacity factor, theoretical plate number, peak asymmetry and tailing factor. The results indicated that the proposed method exhibited better efficiency of thiamine analysis than the official methods, and it was successfully applied to quantify thiamine in pharmaceutical preparations.