• Journal of Periodontal and Implant Science
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• 제52권2호
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• pp.127-140
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• 2022

Purpose: In dental avulsion, delayed replantation usually has an uncertain prognosis. After tooth replantation, complex inflammatory responses promote a return to periodontal tissue homeostasis. Various types of cytokines are produced in the inflammatory microenvironment, and these cytokines determine the periodontal tissue response. This study aimed to identify the gene expression profiles of replanted teeth and evaluate the functional differences between immediate and delayed replantation. Methods: Maxillary molars from Sprague-Dawley rats were extracted, exposed to a dry environment, and then replanted. The animals were divided into 2 groups according to the extra-oral time: immediate replantation (dry for 5 minutes) and delayed replantation (dry for 60 minutes). Either 3 or 7 days after replantation, the animals were sacrificed. Periodontal soft tissues were harvested for mRNA sequencing. Hallmark gene set enrichment analysis was performed to predict the function of gene-gene interactions. The normalized enrichment score (NES) was calculated to determine functional differences. Results: The hallmark gene sets enriched in delayed replantation at 3 days were oxidative phosphorylation (NES=2.82, Q<0.001) and tumor necrosis factor-alpha (TNF-α) signaling via the nuclear factor kappa light chain enhancer of activated B cells (NF-κB) pathway (NES=1.52, Q=0.034). At 7 days after delayed replantation, TNF-α signaling via the NF-κB pathway (NES=-1.82, Q=0.002), angiogenesis (NES=-1.66, Q=0.01), and the transforming growth factor-beta signaling pathway (NES=-1.46, Q=0.051) were negatively highlighted. Conclusions: Differentially expressed gene profiles were significantly different between immediate and delayed replantation. TNF-α signaling via the NF-κB pathway was marked during the healing process. However, the enrichment score of this pathway changed in a time-dependent manner between immediate and delayed replantation.

• 해양환경안전학회지
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• 제28권5호
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• pp.700-711
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• 2022

본 연구에서는 칠발도, 거문도, 동해에서 20년 이상 관측된 파랑자료를 16 방위별 극치확률분석을 통해 재현빈도별 심해설계파를 산정하였고, 이 값을 방향을 고려하지 않은 전방향파의 심해설계파와 비교하였다. Weibull 분포함수를 확률분포함수로 사용하였으며, 최소자승법을 사용해서 매개변수를 결정하였다. 추정된 분포함수는 Kolmogorov-Smirnov 방법을 사용하여 적합도를 검증하였다. 그 결과 방향별로 구한 심해설계파가 전방향파의 심해설계파보다 모든 방향에서 상대적으로 작은 것으로 나타났다. 파향별로 구한 50년 빈도 설계파고는 칠발도, 거문도, 동해에서 각각 7.46 m(NNE), 12.05 m(S), 9.69 m(SSW)가 최대값이지만, 전방향파로 구한 설계파고는 각각 7.91 m, 13.82 m, 10.38 m이었다. 이는 현재 해양 및 연안 구조물 설계에 사용하고 있는 16 방위별 심해설계파고가 과소산정되었을 가능성이 있음을 보여준다.

• Journal of Chest Surgery
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• 제56권5호
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• pp.336-345
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• 2023

Background: The objective of this study was to demonstrate the safety, efficacy, and feasibility of intraoperative monitoring of the recurrent laryngeal nerves during thoracoscopic and robotic 3-field esophagectomy. Methods: This retrospective analysis details our initial experience using intraoperative nerve monitoring (IONM) during minimally invasive 3-field esophagectomy. Data were obtained from a prospectively maintained database and electronic medical records. The study included all patients who underwent minimally invasive (video-assisted thoracic surgery/robotic) transthoracic esophagectomy with neck anastomosis. The patients were divided into those who underwent IONM during the study period and a historical cohort who underwent 3-field esophagectomy without IONM at the same institution. Appropriate statistical tests were used to compare the 2 groups. Results: Twenty-four patients underwent nerve monitoring during minimally invasive 3-field esophagectomy. Of these, 15 patients underwent thoraco-laparoscopic operation, while 9 received a robot-assisted procedure. In the immediate postoperative period, 8 of 24 patients (33.3%) experienced vocal cord paralysis. Relative to a historical cohort from the same institution, who were treated with surgery without nerve monitoring in the preceding 5 years, a 26% reduction was observed in the nerve paralysis rate (p=0.08). On follow-up, 6 of the 8 patients with vocal cord paralysis reported a return to normal vocal function. Additionally, patients who underwent IONM exhibited a higher nodal yield and a decreased frequency of tracheostomy and bronchoscopy. Conclusion: The use of IONM during minimally invasive 3-field esophagectomy is safe and feasible. This technique has the potential to decrease the incidence of recurrent nerve palsy and increase nodal yield.

• 대한토목학회논문집
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• 제26권5B호
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• pp.439-446
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• 2006

본 연구에서는 강수량 및 기온과 같은 수문기상자료의 비선형 동역학적 성분을 추출하기 위해 웨이블렛 변환을 적용하여 대상자료를 재현기간별 성분으로 분리하였다. 변환을 위한 기저함수로는 Daubechies의 9번 ('db9') 웨이블렛 함수를 사용하였다. 또한 웨이블렛 변환의 스케일의 증가에 따른 각 분리단계에서 추출된 상세성분과 근사성분이 비선형 동역학적 특성을 지니는지를 판단하기 위하여 상관차원분석을 이용하였다. 즉 수문기상자료내에 비선형 동역학적 성질을 지니는 성분을 추출하기 위한 방법론으로써 웨이블렛 변환과 상관차원분석의 결합을 제안하였으며, 도출된 결과는 일반적으로 원자료를 이용할 경우에는 파악하기 어려운 대상자료의 시간에 따른 비선형적 변화를 분리 추출하기 위해 본 연구에서 제안한 방법이 적합함을 보이고 있다.

• 한국수자원학회:학술대회논문집
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• 한국수자원학회 2022년도 학술발표회
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• pp.305-305
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• 2022

A better approach for assessing meteorological drought occurrences is increasingly important in mitigating and adapting to the impacts of climate change, as well as strategies for developing early warning systems. The present study defines meteorological droughts as a period with an abnormal precipitation deficit based on monthly precipitation data of 18 gauging stations for the Han River watershed in the past (1974-2015). This study utilizes a Bayesian parameter estimation approach to analyze the effects of climate change on future drought (2025-2065) in the Han River Basin using the Coupled Model Intercomparison Project Phase 6 (CMIP6) with four bias-corrected general circulation models (GCMs) under the Shared Socioeconomic Pathway (SSP)2-4.5 scenario. Given that drought is defined by several dependent variables, the evaluation of this phenomenon should be based on multivariate analysis. Two main characteristics of drought (severity and duration) were extracted from precipitation anomalies in the past and near-future periods using the copula function. Three parameters of the Archimedean family copulas, Frank, Clayton, and Gumbel copula, were selected to fit with drought severity and duration. The results reveal that the lower parts and middle of the Han River basin have faced severe drought conditions in the near future. Also, the bivariate analysis using copula showed that, according to both indicators, the study area would experience droughts with greater severity and duration in the future as compared with the historical period.

• 영어영문학
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• 제58권4호
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• pp.701-721
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• 2012

This paper aims to revisit William Faulkner's Absalom, Absalom! by focusing on the corporeal body and its role in dismantling the Southern ideology of white patriarchy. The latter, which is represented by Thomas Sutpen and his attempt to establish a white male dynasty, is a symbolic space in which the corporeal body turns into a symbolic one through the process of inscribing social ideologies on it. However, this symbolic space is also a contending site between the two bodies. The symbolic body of Sutpen cannot entirely erase its corporeal traces, and therefore the corporeal body, which is buried but nonetheless existent, threatens to undermine rules and premises of the symbolic order. Given that, this paper approaches Faulkner's critique of the Southern white patriarchal ideology from the tension that the corporeal body and the symbolic body create. The 'flesh' roughly corresponds to racial and sexual otherness, namely black flesh and the homoerotic desire of male body. Although they-as the matter of race and that of gender - function in different levels of signification, they still share a common purpose in revealing the logical paradox within Sutpen's symbolic order. The idea of pure whiteness that Sutpen subscribes to is a concept that prerequisites the existence of blackness. Likewise, his idea of male homosociality based upon patriarchal legacy stands precariously on the verge of disintegrating into homoetoricism. As internal otherness that Sutpen's symbolic order cannot fully incorporate, the corporeal body functions to indicate the limitation of Sutpen's Design and its body-signification process.

• Safety and Health at Work
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• 제14권4호
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• pp.445-450
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• 2023

Background: The impact of COVID-19 infection on workers' work function persists even after the acute phase of the infection. We studied this phenomenon in Japanese workers. Methods: We conducted a one-year prospective cohort study online, starting with a baseline survey in December 2020. We tracked workers without baseline work functioning impairment and incorporated data from 14,421 eligible individuals into the analysis. We estimated the incidence rate ratio for new onset of work functioning impairment due to COVID-19 infection during follow-up, using mixed-effects Poisson regression analysis with robust variance. Results: Participants reporting infection between January and December 2021 showed a significantly higher incidence of new work functioning impairment (adjusted incidence rate ratio: 2.18, 95% confidence interval: 1.75-2.71, p < 0.001). The formality of the recuperation environment correlated with a higher risk of work functioning deterioration in infected individuals (p for trend <0.001). Conclusion: COVID-19-infected workers may continue to experience work difficulties due to persistent, post-acute infection symptoms. Companies and society must urgently provide rehabilitation and social support for people with persistent symptoms, recognizing that COVID-19 is not just a transient acute infection.

• Clinics in Shoulder and Elbow
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• 제26권3호
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• pp.267-275
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• 2023

Background: Physical therapy (PT) plays an important role in the recovery of function following anatomic total shoulder arthroplasty (aTSA). While several PT protocols have been published for these patients, there is no standardized protocol for aTSA rehabilitation. This lack of standardization may lead to confusion between patients and physicians, possibly resulting in suboptimal outcomes. This study examines how PT protocols provided by academic orthopedic surgery programs vary regarding therapeutic goals and activities following aTSA. Methods: PT protocols for aTSA available online from the Accreditation Council for Graduate Medical Education accredited orthopedic surgery programs were included for review. Each protocol was analyzed to evaluate it for differences in recommendation of length of immobilization, range of motion (ROM) goals, start time for and progression of therapeutic exercises, and timing for return to functional activity. Results: Of 175 accredited programs, 25 (14.2%) had protocols publicly available, programs (92%) recommended sling immobilization outside of therapy for an average of 4.4±2.0 weeks. Most protocols gave recommendations on starting active forward flexion (24 protocols, range 1-7 weeks), external rotation (22 protocols, range 1-7 weeks), and internal rotation (18 protocols, range 4-7 weeks). Full passive ROM was recommended at 10.8±5.7 weeks, and active ROM was 13.3±3.9 weeks, on average. ROM goals were inconsistent among protocols, with significant variations in recommended ROM and resistance exercise start times. Only 13 protocols (52%) gave recommendations on resuming recreational activities (mean, 17.4±4.4 weeks). Conclusions: Publicly available PT protocols for aTSA rehabilitation are highly variable. Level of evidence: IV.

• Maxillofacial Plastic and Reconstructive Surgery
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• 제30권1호
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• pp.83-91
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• 2008

The goal of reconstruction following ablative therapy for intraoral cancer is the restoration of form and function to permit a return to activities of daily life. Traditional reconstruction includes split thickness skin grafts, myocutaneous flaps and, more recently, various free flaps. Free flaps provide higher level of functional recovery relative to that seen with other techniques but require the complexity of the technique and microvascular anastomosis and thus, extended surgical time and occasionally a second team for harvesting. The platysma myocutaneous cervical flap is a possible alternative for intraoral reconstruction. It is thin and pliable like the tissue provided by the radial forearm free flap. It can be harvested with enough tissue to close most head and neck ablative defects. There is virtually no donor site morbidity involved. This study evaluated 7 patients affected by intraoral squamous cell carcinoma (SCC). All patients underwent the resection of intraoral SCC with neck dissection and subsequent intraoral reconstruction with the superiorly based platysma myocutaneous cervical flap. Flap-related complications occurred in 3 patients. Adjuvant radiation therapy was performed in 3 patients. Average follow-up was 24.1 months after surgery, with a range of 8 to 42 months. All patients presented self assessment of discomfort associated with intraoral recipient sites and cervical donor sites. However, the neck function measured by two-inclinometer technique was within the normal range during relatively long term follow-up period. Our study concluded that superiorly based platysma myocutaneous cervical flap is good alternative to free flaps, especially for relatively smaller defects and for the defects appropriate for the rotation arc of the flap.

• 한국수자원학회논문집
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• 제52권12호
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• pp.985-999
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• 2019

전 세계적으로 극심한 가뭄현상이 반복적으로 발생하고 있으며, 이러한 가뭄을 분석하기 위한 연구가 다수 진행되고 있다. 최근 코플라 함수를 활용한 이변량 가뭄빈도해석에 대한 연구가 다수 진행된 바 있으나, 대부분 지점빈도해석에 국한되어 진행되었으며, 통계적으로 부족한 자료의 기간을 보완하기 위한 대안으로 지역빈도해석 개념을 도입한 연구는 미진한 실정이다. 이러한 점에서 본 연구에서는 기존의 베이지안 기법과 코플라 함수를 연계한 이변량 지역빈도해석 모형을 개발하였다. 최종적으로 이변량 코플라 가뭄 지역빈도해석 모형을 한강유역에 적용하여 2013-2015년에 발생한 가뭄 사상을 평가하였으며, 기존에 개발된 이변량 지점빈도해석 결과와 비교를 통해 모형의 해석결과에 대한 신뢰성을 확보하였다. 결과적으로 이변량 지점빈도해석에 비해 가뭄사상에 대한 결합재현기간의 불확실성 구간이 약 3배 가까이 감소하였으며, DIC 통계량 산정결과 약 15 이상 개선된 것을 확인하였다. 본 연구를 통해 제안된 베이지안 코플라 기반 이변량 가뭄 지역빈도해석 모형은 가뭄자료의 분포특성 및 자료간의 상관성을 효과적으로 재현하는데 유리할 뿐만 아니라, 지역적인 가뭄특성을 효과적으로 평가할 수 있는 장점을 확인할 수 있었다.