• Journal of the Korean Society for Aeronautical & Space Sciences
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• v.31 no.3
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• pp.15-22
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• 2003

The fatigue crack growth model is derived and the retardation model is proposed. The fatigue crack growth model considers the residual plastic stretch on the crack surface which results from the plastic deformation at the tip of fatigue crack. The fatigue crack growth rate is calculated by using the cumulative fatigue damage and plastic strain energy in the material elements at the crack tip. This model gives the crack growth rate in reasonable agreement with test data for aluminum alloy AL6061-T651 and 17-4PH casting steel. The fatigue crack growth retardation model is based on the residual plastic stretch produced from a tensile overload which reduced the plastic strain range of the following load cycles. A strip-yield model of a crack tip plasticity is used for the calculation of a plastic zone size. The proposed retardation model characterized the observed features and delayed retardation of the fatigue crack growth under tensile overload.

• Journal of Aerospace System Engineering
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• v.1 no.1
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• pp.45-52
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• 2007

This paper analyzed the extension effects of fatigue life and the application of pre-indentation in aircraft structural material such as aluminum alloys. The test specimen used the thin sheet of aluminum alloy with a single-edged notch. The experiments were conducted after making the pre-crack under a constant amplitude loading. As the fatigue life extension technique, the pre-indentation making an indent on the predicted path of crack propagation was applied. The work presented here discussed about a proper mathematical relation between crack growth rate and the range of stress intensity factor and about the generalization of crack growth mechanism with large retardation effect. A technique to enhance the applicability of pre-indentation if also mentioned.

• Journal of Nuclear Fuel Cycle and Waste Technology(JNFCWT)
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• v.19 no.4
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• pp.459-467
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• 2021

In the majority of countries, the upper limit of buffer temperature in a repository is set to below 100℃ due to the possible illitization. This smectite-to-illite transformation is expected to be detrimental to the swelling functions of the buffer. However, if the upper limit is increased while preventing illitization, the disposal density and cost-effectiveness for the repository will dramatically increase. Thus, understanding the characteristics and creating a database related to the buffer under the elevated temperature conditions is crucial. In this study, a strategy to investigate the bentonite found in Korea under the elevated temperatures from a mineral transformation and radionuclides retardation perspective was proposed. Certain long-term hydrothermal reactions generated the bentonite samples that were utilized for the investigation of their mineral transformation and radionuclide retardation characteristics. The bentonite samples are expected to be studied using in-situ synchrotron-based X-Ray Diffraction (XRD) technique to determine the smectite-to-illite transformation. Simultaneously, the 'high-temperature and high-pressure mineral alteration measurement system' based on the Diamond Anvil Cell (DAC) will control and provide the elevated temperature and pressure conditions during the measurements. The kinetic models, including the Huang and Cuadros model, are expected to predict the time and manner in which the illitization will become detrimental to the performance and safety of the repository. The sorption reactions planned for the bentonite samples to evaluate the effects on retardation will provide the information required to expand the current knowledge of repository optimization.

• Proceedings of the Korean Society of Precision Engineering Conference
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• 1994.10a
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• pp.826-830
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• 1994

Making Brinell indentations facing each other near the crack tip is very effective method in increasing fatigue life. In this paper, fatigue test was performed after indentation to investigate the effect of thickness of specimen. The results show that fatigue lives increased my making indentation and retardation cycle is inverse proportional to thickness of specimen.

• Journal of Korean Neurosurgical Society
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• v.66 no.6
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• pp.642-651
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• 2023

Objective : Endothelial colony-forming cells (ECFCs) have been reported to play an important role in the pathogenesis of moyamoya disease (MMD). We have previously observed stagnant growth in MMD ECFCs with functional impairment of tubule formation. We aimed to verify the key regulators and related signaling pathways involved in the functional defects of MMD ECFCs. Methods : ECFCs were cultured from peripheral blood mononuclear cells of healthy volunteers (normal) and MMD patients. Low-density lipoproteins uptake, flow cytometry, high content screening, senescence-associated β-galactosidase, immunofluorescence, cell cycle, tubule formation, microarray, real-time quantitative polymerase chain reaction, small interfering RNA transfection, and western blot analyses were performed. Results : The acquisition of cells that can be cultured for a long time with the characteristics of late ECFCs was significantly lower in the MMD patients than the normal. Importantly, the MMD ECFCs showed decreased cellular proliferation with G1 cell cycle arrest and cellular senescence compared to the normal ECFCs. A pathway enrichment analysis demonstrated that the cell cycle pathway was the major enriched pathway, which is consistent with the results of the functional analysis of ECFCs. Among the genes associated with the cell cycle, cyclin-dependent kinase inhibitor 2A (CDKN2A) showed the highest expression in MMD ECFCs. Knockdown of CDKN2A in MMD ECFCs enhanced proliferation by reducing G1 cell cycle arrest and inhibiting senescence through the regulation of CDK4 and phospho retinoblastoma protein. Conclusion : Our study suggests that CDKN2A plays an important role in the growth retardation of MMD ECFCs by inducing cell cycle arrest and senescence.

• Journal of Nuclear Fuel Cycle and Waste Technology(JNFCWT)
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• v.5 no.2
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• pp.113-122
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• 2007

In this study, uranium migration experiments have been performed using a natural groundwater and a granite core with natural fractures in a glove-box constructed to simulate an appropriate subsurface environment. Groundwater flow experiments using the non-sorbing anionic tracer Br were carried out to analyze the flow properties of groundwater through the fracture of the granite core. The result of the uranium migration experiment showed a breakthrough curve similar to that of the non-sorting Br. This result may imply that uranium migrates as anionic complexes through the rock fracture since uranium can form carbonate complexes at a given groundwater condition. The distribution coefficient $K_d$ of the uranium between the groundwater and the fracture filling material was obtained as low as 2.7 mL/g from a batch sorption experiment. This result agrees well with the result from the migration experiment, showing a faster elution of the uranium through the rock fracture. In order to analyze retardation properties of the uranium through the rock fracture, the retardation factor $R_d({\sim}16.2)$ was obtained by using the $K_d$ obtained from the batch sorption experiment and it was compared with the $R_d({\sim}14.3)$ obtained by using the result from the uranium migration experiment. The values obtained from the both experiments were very similar to each other. This reveals that the retardation of the uranium is mainly occurred by the fracture filling material when the uranium migrates through the fracture of a granite core.

• Korean Journal of Poultry Science
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• v.48 no.2
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• pp.81-90
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• 2021

Avian influenza viruses (AIVs) must utilize host cellular factors to complete their life cycle, and fragile X mental retardation protein (FMRP) has been reported to be a host factor promoting AIV ribonucleoprotein (vRNP) assembly and exports vRNP from the nucleus to the cytoplasm. The functional role of chicken FMRP translational regulator 1 (cFMR1) as a host factor of AIV is, however, poorly understood. In this study, we targeted the cFMR1 gene in DF1 cells using clustered regularly interspaced short palindromic repeats/Cas9-mediated genome editing to examine the functional role of cFMR1 as a host factor of AIV. We found that cFMR1 stimulated viral gene transcription during early stages of the viruses' life cycle and did not affect viral progeny production and viral polymerase activity in DF1 cells 24 hours post infection. cFMR1 overexpression did not exert significant effects on virus production, compared to the control. Therefore, unlike in mammalian systems (e.g., humans or mice), cFMR1 did not play a pivotal role in AIV but only seemed to stimulate viral proliferation during early stages of the viral life cycle. These results imply that the interplay between host factors and AIV differs between mammals and avian species, and such differences should be considered when developing anti-viral drugs for birds or establishing AIV-resistant bird models.

• Metals and materials international
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• v.24 no.6
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• pp.1412-1421
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• 2018

Cold-expanded austenitic high nitrogen steel (HNS) was subjected to investigate the effects of grain size on the stress-controlled high cycle fatigue (HCF) as well as the strain-controlled low cycle fatigue (LCF) properties. The austenitic HNSs with two different grain sizes (160 and $292{\mu}m$) were fabricated by the different hot forging strain. The fine-grained (FG) specimen exhibited longer LCF life and higher HCF limit than those of the coarse-grained (CG) specimen. Fatigue crack growth testing showed that crack propagation rate in the FG specimen was the same as that in the CG specimen, implying that crack propagation rate did not affect the discrepancy of LCF life and HCF limit between two cold-expanded HNSs. Therefore, it was estimated that superior LCF and HCF properties in the FG specimen resulted from the retardation of the fatigue crack initiation as compared with the CG specimen. Transmission electron microscopy showed that the effective grain size including twin boundaries are much finer in the FG specimen than that in the CG specimen, which can give favorable contributions to strengthening.

• Transactions of the Korean Society of Automotive Engineers
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• v.6 no.1
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• pp.27-35
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• 1998

This study describes the influence of combustion parameters on the nitric oxide emission, such as injection timing, air flow rate, injected amount of fuel, and compression ratio of engine. In order to determine the influence factors on the nitric oxide emission, the experiment were investigated with various parameters of engine cycle. According to the results of this study, the retardation of injection timing and the increases of airflow rate, and the decreases of fuel injection amount reduce the nitric oxide concentration in the exhaust emissions. Also, the increases of compression ration of engine increase in the concentration of nitric oxide formation in the combustion chamber. The results of this study give a guideline to decrease the nitric oxide formation by using the simulation program.

• Journal of Welding and Joining
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• v.14 no.2
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• pp.79-89
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• 1996

일정진폭하중과 과대하중비 2.5의 단일 인장과대하중에 의한 4140강 용접부 의 피로균열성장거동을 실온과 -45.deg.C의 저온에서 피로시험과 파면관찰을 통하여 고찰하였다. 이때, 용접부 미시조직의 영향을 평가하기 위해 모재(parent metal), 열영향부(as-welded HAZ), 열처리된 열영향부(PWHT HAZ)로 나누어 응력비 0과 0.5로 CT시험편을 이용하여 피로시험을 실시하였다. 피로균열성장거동은 재료의 미시조직과 온도변화보다는 응력비에 크게 영향을 받았으며, 단일 과대하중에 의한 피로균열성장 지연효과가 모든 재료에서 상당히 크게 나타났다. 전자현미경에 의한 피로파면 관찰 결과, 실온에서는 연성의 스트라이에이숀과 -45.deg.C에서는 의벽개파면과 같은 피로 균열성장거동을 나타내고 있다.