• Korean Journal of Biological Psychiatry
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• v.21 no.4
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• pp.168-174
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• 2014

Objectives Sensory gating dysfunctions in patients with schizophrenia and bipolar disorder have been investigated through two similar methods ; P50 suppression and prepulse inhibition paradigms. However, recent studies have demonstrated that the two measures are not correlated but rather constitute as distinct neural processes. Recent studies adopting spectral frequency analysis suggest that P50 suppression reflects the interaction between gamma and other frequency bands. The aim of the present study is to investigate which frequency component shows more significant interaction with gamma band. Methods A total of 108 mood disorder patients and 36 normal subjects were included in the study. The P50 responses to conditioning and test stimuli with an intra-pair interval of 500 msec were measured in the study population. According to P50 ratio (amplitude to the test stimulus/amplitude to the conditioning stimulus), the subjects with P50 ratio less than 0.2 were defined as suppressed group (SG) ; non-suppressed group (NSG) consisted of P50 ratio more than 0.8. Thirty-five and 25 subjects were included in SG and NSG, respectively. Point-to-point correlation coefficients (PPCCs) of both groups were calculated between two time-windows : the first window (S1) was defined as the time-window of one hundred millisecond after the conditioning auditory stimulus and the second window (S2) was defined as the time-window of 100 msec after the test auditory stimulus. Spectral frequency analysis was performed to investigate which frequency band results in the difference of PPCC between SG and NSG. Results Significant reduction of PPCC between S1 and S2 was observed in the SG (Pearson's r = 0.24), compared to PPCC of the NSG (r = 0.58, p < 0.05). In spectral frequency analysis, gamma band showed "phase-reset" and similar responses after the two auditory stimuli in suppressed and non-suppressed group. However in the case of alpha band, comparison showed significantly low PPCC in SG (r = -0.14) compared to NSG (r = 0.36, p < 0.05). This may be reflecting "phase-out" of alpha band against gamma band at approximately 50 msecs after the test stimulus in the SG. Conclusions Our study suggests that normal P50 suppression is caused by phase-out of alpha band against gamma band after the second auditory stimulus. Thus it is demonstrated that normal sensory gating process is constituted with attenuated alpha power, superimposed on consistent gamma response. Implications of preserved gamma and decreased alpha band in sensory gating function are discussed.

• Culinary science and hospitality research
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• v.21 no.1
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• pp.210-224
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• 2015

The purpose of this study is to identify the effects of involvement in temple food on overall satisfaction, recommendation, and revisit intention. From June 15 to August 30, 2014, for those who have participated in temple stay at four temples in South Korea, the self-administered survey was conducted. Of a total of 400 questionnaires, 289 were employed for the analyses, which accounted for 72% of response rate. Results shows that the involvement in temple food positively influenced experience driven by motivation in temple stay. Considering a particular research topic of temple stay, it implies that the involvement in temple food plays a key role in affecting emotional and social value relating to experience in temple stay. Entertaining, educational, aesthetic, deviated factors created by this experience will contribute to making special memories and feeling great enjoyment. In addition, emotional and social value by temple food have a positive effect on recommendation and revisit intention through experience satisfaction. Furthermore, experiential factor was significant to overall satisfaction, revisit and recommendation intention. Social and emotional value according to involvement in temple food, in terms of conclusions in this study, influenced a reduction of stress and improvement of enjoyment. These values relating to involvement in temple food, therefore, are assumed to be the causal relationship with experiential factor and satisfaction in temple stay and subsequently will be regarded as determinants in defining temple food as a heathy dish.

• Journal of Ginseng Research
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• v.41 no.3
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• pp.284-289
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• 2017

Background: Compound FK506 is an immunosuppressant agent that is frequently used to prevent rejection of solid organs upon transplant. However, nephrotoxicity due to apoptosis and inflammatory response mediated by FK506 limit its usefulness. In this study, the protective effect of Korean Red Ginseng (KRG) against FK506-induced damage in LLC-PK1 pig kidney epithelial cells was investigated. Methods: LLC-PK1 cells were exposed to FK506 with KRG and cell viability was measured. Western blotting and RT-PCR analyses evaluated protein expression of MAPKs, caspase-3, and KIM-1. TLR-4 gene expression was assessed. Caspase-3 activities were also determined. The number of apoptotic cells was measured using an image-based cytometric assay. Results: The reduction in LLC-PK1 cell viability by $60{\mu}M$ FK506 was recovered by KRG cotreatment in a dose-dependent manner. The phosphorylation of p38, p44/42 MAPKs (ERK), KIM-1, cleaved caspase-3, and TLR-4 mRNA expression was increased markedly in LLC-PK1 cells treated with $60{\mu}M$ FK506. However, with the exception of p-ERK, elevated levels of p-p38, KIM-1, cleaved caspase-3, and TLR-4 mRNA expression were significantly decreased after cotreatment with KRG. Activity level of caspase-3 was also attenuated by KRG cotreatment. Moreover, image-based cytometric assay showed that apoptotic cell death was increased by $60{\mu}M$ FK506 treatment, whereas it was decreased after cotreatment with KRG. Conclusion: Taken together, these results suggest that the molecular mechanism of KRG in the FK506-induced nephrotoxicity may lead to the development of an adjuvant for the inhibition of adverse effect FK506 in the kidney.

• Proceedings of the Korea Water Resources Association Conference
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• 2010.05a
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• pp.1457-1460
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• 2010

최근 기후변화로 인해 태풍 등과 같은 집중성 강우가 많이 발생하고 있고, 강우시 유출 등으로 인한 유역내 발생하는 토양침식으로 인해 유역의 하천을 비롯하여 유출구에서의 탁수 및 유사 발생 문제는 우리나라 뿐만 아니라 전 세계적으로 심각한 환경문제로 대두되고 있다. 강우시 유역에서 발생하는 이러한 탁수문제를 효과적으로 해결하기 위하여 여러 최적관리기법 (Best Management Practices, BMPs) 들이 제안되어왔다. 본 연구의 목적은 볏짚매트 사용으로 인한 토양유실 저감 실측자료를 바탕으로 볏짚매트를 다양한 경사지 밭에 적용하였을 경우 유역에서의 토양유실 저감효과를 평가하기 위한 모델링 기법을 개발하는데 있다. 볏짚 매트의 효과를 Soil and Water Assessment Tool (SWAT) 모형으로 모의하기 위해서는 볏짚매트의 효과를 모형에서 반영할 수 있는 인자를 선택하여 최적의 인자값을 산정해야 한다. 본 연구에서는 유사 저감 효과 실험 결과를 VFSMOD-W 모형을 이용하여 USLE P 인자값을 도출하였으며, 경사도에 따른 USLE-P 값을 산정하여, SWAT 모형에 입력자료로 사용하였다. 분포형 모형과는 달리 준분포형 모형인 SWAT 모형은 소유역내 수문학적 반응단위별로 유출, 유사, 그리고 비점오염 발생을 평가하는데 이때 Hydrologic Response Unit (HRU)의 지형정보가 활용된다. 이 지형정보는 SWAT 유사 평가시 매우 민감한 변수중의 하나이기 때문에 유역 단위 유사 평가시 정확한 지형자료의 입력이 요구된다. 그러나 SWAT 모형은 소유역내 HRU의 경사도 및 경사장을 직접 산정하지 않고, 소유역의 평균경사도를 기준으로 하여 산정된 경사도를 소유역내 모든 HRU에 동일하게 적용하는 단점이 있다. 본 연구에서는 준분포 모형인 SWAT 모형의 단점을 개선하기 위하여 SWAT Spatially Distributed (SD)-HRU를 적용하였다. 이를 통해 다양한 경사지 밭에서의 볏짚매트의 효과를 분석할 수 있게 되었다. 볏짚매트 미적용시 모의 기간내 유사량 총합은 74,954.42 ton 이고, 월평균 유사량은 814.72 ton 으로 산정되었고, 볏짚매트를 적용하였을 경우 모의 기간내 (2000년 1월 - 2007년 8월) 유사량 총합은 48,460.55 ton 이고, 월평균 유사량은 526.75 ton 으로 볏짚매트를 적용하지 않았을 때보다 약 35.35 % 저감된 값을 보였다. SD-HRU를 적용하고 각 농경지의 경사도에 따라 USLE P 값을 수정하여 볏짚매트에 의한 효과를 분석하였을 때, 볏짚매트를 적용하지 않았을 때 보다 볏짚매트를 적용하였을 때 모의 기간내 약 35% 정도의 유사량이 감소된 것을 알 수 있었다. 본 연구결과에서 보여주는 바와 같이 고랭지 지역에서의 영농활동 시 볏짚매트를 설치한다면 강우시 발생하는 토양유실을 효과적으로 저감시킬 수 있을 것이라 판단된다.

• Journal of Life Science
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• v.23 no.12
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• pp.1495-1500
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• 2013

The objective of this study was to evaluate the anti-melanogenic effects of Hizikia fusiforme (HF) fractions in ${\alpha}$-melanocyte stimulating hormone-induced B16F10 mouse melanoma cells. Ethanol extractions of Hizikia fusiforme (EEHF) were subjected to fraction by using dichloromethane (CFHF), ethyl acetate (EAFHF), butanol (BFHF), and water (WFHF). EEHF, CFHF, and EAFHF inhibited tyrosinase activity and melanin synthesis in B16F10 mouse melanoma cells in a dose-dependent manner. The melanin contents were inhibited by 40.5% and 33.2% in response to treatment with 50 ${\mu}g/ml$ of EEHF and CFHF, respectively. In addition, tyrosinase activities showed a 53.3% and 54.1% reduction in treatment with 50 ${\mu}g/ml$ of EEHF and CFHF. Western blotting analysis showed that EEHF, CFHF, and EAFHF inhibited tyrosinase, TRP-1, TRP-2, and MITF expression in a dose-dependent manner. In conclusion, these findings indicate that ethanol and dichloromethane fractions of Hizikia fusiforme, which inhibit melanin synthesis and tyrosinase activity, are effective skin-whitening agents.

• The Korean Journal of Mycology
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• v.11 no.4
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• pp.169-175
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• 1983

For the classification of 531 isolates of Fusarium moniliforme from infected rice plants, five criteria were employed for clarifying the mycological difference from I to IV based on host symptoms, conidial formation, septate of macroconidia, color of mycelium on the culture, and fungicide response. Four strains I, II, III, and IV were detected and Strain IV was the most prevalent one. Based on mycological characteristics, macroconidia with 6 or 7 septate were mostly produced by Strains I and II. Four septate macroconidia were mostly formed by Strain III while Strain IV mostly formed 3 septate macroconidia. Strain I was reddish purple (5RP 5/4) on both the bottom and the surface of the media. Strain II produced reddish purple(5RP 3/2) on both the bottom and the surface of the media. Strain I produced mostly macroconidia in pionnotes on the media surface while Strain II produced mostly microconidia in pionnotes on the media surface. Both of Strain III and IV produced mostly macroconidia in sporodochia on the surface of the mycelium. Strain IV was less reduction of germination and caused abnormal elongation of all parts of the plants, but did not kill the plants in nursery boxes. Strain III killed fewer plants than Strain IV. As above results, isolates of F. moniliforme were classified into four strains I, II, III, and IV, on the basis of five criteria.

• Korean Journal of Medicinal Crop Science
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• v.11 no.1
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• pp.31-39
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• 2003

The antioxidative activities and biological properties in the EtOAc extracts and purified extracts of Orostachys japonicus were measured by assay of DPPH, xanthine/xanthine oxidase and mammalian cells(2-12). Scavenging of DPPH radical and inhibition of xanthine/xanthine oxidase of EtOAc extracts were showed the highest activity in the arable land and in September. The S-4 fraction showed the highest activity among the silica-gel column chromatography fractions. LH-4 fraction showed higher activity than the other fractionsins in assay of DPPH and xanthine/xanthine oxidase. Fatty acids and phenolic compounds were identified by GC/MS and main compounds were 1,2,3-benzenetriol, alpha-androsta-7,14-diene in LH-4 fraction. The activities of POD and SOD in samples havested on different habitats were high such as arable land> intermountain> seashore. That of POD and SOD in crude extracts of late stage were higher than early stage. Isozyme bands of crude extracts samplinged in all habitats and all growing stages showed two bands and the signal intensity showed strongly according to passage of growing stage. The purified extracts of LH-4 fraction showed excellent inhibition effect in proliferation of HL-60 cells and markedly suppressed colony formation in mouse fibroblast cells. Dose response between partially purified extracts(400ppm) and negative control did not produced statistically significant reduction in colony formation.

• The Korean Journal of Ecology
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• v.26 no.3
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• pp.135-142
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• 2003

Four legume plants showed better growth by the external nitrogen supply rather than the symbiotic nitrogen fixation only under salt additions. In case of Glycine max and Phaseolus angularis, total nitrogen contents decreased by high salinity level but their amino acid levels significantly increased with the increase of salt treatments and indicated high soluble-/insoluble-N ratios. Cassia tora and Albizzia julibrissin contained less amino acids than G. max and P. angularis but total N (esp. insoluble N fraction) increased with higher salt levels. Asparagine occurred as a main amino acid especially in G. max and P. angularis and can be seen as potential N-storage form in these plants. It might be play an important role for the osmoregulation mechanism under the saline condition. Meanwhile, to investigate what kinds of nitrogen sources are effective for overcoming salt stress on soybean plants, various N forms and concentrations (NH₄NO₃-N, NO₃-N, NH₄NO₃-N; 2.5 and 5 mM) were additionally supplied to the salt gradient medium. Soybean plants treated with NH₄NO₃-N showed the best growth up to 40 mM NaCl and NO₃- fed plants indicated good growth even at 80 mM NaCl treatments. Contrary to NH₄NO₃- and NO₃- fed plants, NH₄/sup +/- fed plants showed remarkable growth reduction and died by 40 and 80 mM NaCl treatments after the first harvest (15th day). Consequently, these results suggest that salt excluding and resistant capacities of soybean plants under NaCl treatments are increased in order of NH₄ - N, control, NO₃- N and NH₄NO₃- N depending on N concentration except NH₄- N treatments.

• Korean Journal of Construction Engineering and Management
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• v.16 no.6
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• pp.3-11
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• 2015

The current real estate market is in a state that is considerably shrink due to the recession and long-term reduction of trading. In response, the government recently announced an innovative way for the middle-class residential housing and it is taking the lead to activate the real estate market. Meanwhile, the domestic housing market is entering a transition period, including structural changes of household structure, changes from joeonse to rent increasingly. Also single-member households will rise steeply, so that makes the high demand of small houses. In addition, the domestic construction industry is interested in new technology called Modular building. The Modular construction is an off-site construction system that shorten construction period, eco-friendly building technology and mobility etc, which can be used in various field. Overall, there are two major issues of the current market, one is the change of the real estate market, and the other is the modular construction. This study will propose modular business model in the rental market through the analysis the profitability of the modular business scenarios and IRR analysis.

• Environmental and Resource Economics Review
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• v.27 no.3
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• pp.495-520
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• 2018

Because of structural changes in the international oil market and the economy, it is widely recognized that the impact of oil shocks on the economy has weaken since the mid-1980s. This study tries to examine the validity of the recent perception about the relationship between oils shocks and the economy, estimating the time-varying effects of oil shocks on the Korean economy. The results show that the dynamic effects of oil shocks normalized to a one standard deviation has been relatively constant, in contrast to the recent perception and a number of existing studies. In addition, because the shape of impulse response functions at each point in time spanning from 1984:II to 2017:IV has not been changed significantly, it seems that the propagation mechanism of oil shocks also has not been substantially altered. These findings indicate that even though structural changes of the economy, such as the reduction in the share of oil consumption and the spread of high-efficiency energy technologies, have been rapidly progressed, it is not still enough to offset the negative effects of oil shocks. Rather, it seems that the recent perception about the shrinking effects of oil shocks is mainly due to the assumptions that do not reflect changes in the size of oil shocks. In particular, this problem appears more pronounced in the case of the typical a one standard deviation increase oil shock under homoskedasticity assumption, which is widely adopted in the most VAR analyses. Therefore, in estimating the effects of oil shocks on the economy, it is important to specify the correct model and normalization method, to reflect changes in the size of oil shocks.