• Earthquakes and Structures
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• v.13 no.1
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• pp.51-58
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• 2017

Passive dynamic vibration absorbers (DVAs) are often used to suppress the excessive vibration of a large structure due to their simple construction and low maintenance cost compared to other vibration control techniques. A new type of passive DVA consists of two pendulums connected with spring and dashpot element is investigated. This research evaluated the performance of the DVA in reducing the vibration response of a two degree of freedom shear structure. A model for the two DOF vibration system with the absorber is developed. The nominal absorber parameters are calculated using a Genetic Algorithm(GA) procedure. A parametric study is performed to evaluate the effect of each absorber parameter on performance. The simulation results show that the optimum condition for the absorber frequencies and damping ratios is mainly affected by pendulum length, mass, and the damping coefficient of the pendulum's hinge joint. An experimental model validates the theoretical results. The simulation and experimental results show that the proposed technique is able be used as an effective alternative solution for reducing the vibration response of a multi degree of freedom vibration system.

• Nuclear Engineering and Technology
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• v.54 no.1
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• pp.374-385
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• 2022

In order to investigate the application of 3D base-seismic isolation system in nuclear power plants (NPPs), comprehensive analysis of constitution and design theory for 3-dimensional combined isolation bearing (3D-CIB) was presented and derived. Four different vertical stiffness of 3D-CIB was designed to isolate the nuclear island (NI) building. This paper aimed at investigating the isolation effectiveness of 3D-CIB through modal analysis and dynamic time-history analysis. Numerical results in terms of dynamic response of 3D-CIB, relative displacement response, acceleration and floor response spectra (FRS) of the superstructure were compared to validate the reliability of 3D-CIB in mitigating seismic response. The results showed that 3D-CIB can significantly attenuate the horizontal acceleration response, and a fair amount of the vertical acceleration response reduction of the upper structure was still observed. 3D-CIB plays a significant role in reducing the horizontal and vertical FRS, the vertical FRS basically do not vary with the floor height. The smaller the vertical stiffness of 3D-CIB is, the better the vertical isolation effectiveness is, whereas, it will increase the displacement and the rocking effect of superstructure. Although the advantage of 3D-CIB is that the vertical stiffness can be flexibly adjusted, it should be designed by properly accounting for the balance between the isolation effectiveness and displacement control including rocking effect. The results of this study can provide the technical basis and guidance for the application of 3D-CIB to engineering structure.

• Korean Journal of Pharmacognosy
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• v.50 no.4
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• pp.277-284
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• 2019

Rumex crispus is known to have anticancer, antioxidant, antibacterial, and bone loss inhibitory activities. Mast cells are critical immune cells that induce a type 1 IgE-mediated allergic reaction. However, there are no reports of inhibitory effects of Rumex crispus on mast cells and allergic reactions. In this study, we performed some experiments to investigate whether Rumex crispus ethanol extract(RCE) has any inhibitory effect on antigen-induced type I allergic response in vitro and in vivo. RCE inhibited degranulation of IgE-mediated mast cells(IC₅₀, ~57 ㎍/ml) and cytokine production such as TNF-α and IL-4 in a dose-dependent manner. In vivo, RCE significantly inhibited passive cutaneous anaphylaxis(PCA)(ED₅₀, ~198 mg/kg) in mice. Furthermore, RCE inhibited degranulation of MCs in ear tissue of mice with PCA. Mechanism studies showed that RCE inhibited the activation of Syk and Syk-dependent pathway such as LAT, PLC-γ, Akt, and MAP Kinase. Our results demonstrate for the first time that RCE inhibits type I hypersensitive response by suppressing the activity of Syk in mast cells, thereby reducing degranulation and cytokine production. Taken together, RCE could be used as a novel therapeutic material to suppress allergic diseases.

• Earthquakes and Structures
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• v.4 no.2
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• pp.203-217
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• 2013

In recent decades, it has been realized that increasing the lateral stiffness of structure subjected to lateral loads is not the only parameter enhancing safety or reducing damage. Factors such as ductility and damping govern the structural response due to lateral loads. Despite the significant contribution of damping in resisting lateral loads, especially at resonance, there is no accurate mathematical representation for it. The main objective of this study is to develop a damping identification procedure for linear systems based on a mixed numerical-experimental approach, assuming viscous damping. The proposed procedure has been applied to a laboratory experiment associated with a numerical model, where a hollow rectangular steel cantilever column, having three lumped masses, has been fixed on a shaking table subjected to different exciting waves. The modal damping ratio has been identified; in addition, the effect of adding filling material to the hollow specimen has been studied in relation to damping enhancement. The results have revealed that the numerically computed response based on the identified damping is in a good fitting with the measured response. Moreover, the filling material has a significant effect in increasing the modal damping.

• International Journal of Naval Architecture and Ocean Engineering
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• v.9 no.1
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• pp.114-125
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• 2017

This paper addresses a study of inner-tank sloshing effect on motion responses of a Floating Liquefied Natural Gas (FLNG) system, through experimental analysis and numerical modeling. To investigate hydrodynamic characteristics of FLNG under the conditions of with and without LNG-tank sloshing, a series of numerical simulations were carried out using potential flow solver SESAM. To validate the numerical simulations, model tests on the FLNG system was conducted in both liquid and solid ballast conditions with 75% tank filling level in height. Good correlations were observed between the measured and predicted results, proving the feasibility of the numerical modeling technique. On the verified numerical model, Response Amplitude Operators (RAOs) of the FLNG with 25% and 50% tank filling levels were calculated in six degrees of freedom. The influence of tank sloshing with varying tank filling levels on the RAOs has been presented and analyzed. The results showed that LNG-tank sloshing has a noticeable impact on the roll motion response of the FLNG and a moderate tank filling level is less helpful in reducing the roll motion response.

• Earthquakes and Structures
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• v.21 no.5
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• pp.461-475
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• 2021

Strategic structures are a potential target of the growing terrorist attacks, so their performance under explosion hazard has been paid attention by researchers in the last years. In this regard, the aim of this study is to evaluate the blast-resistance performance of lead-rubber bearing (LRB) base isolation system based on a probabilistic framework while uncertainties related to the charge weight and standoff distance have been taken into account. A sensitivity analysis is first performed to show the effect of explosion uncertainty on the response of base-isolated buildings. The blast fragility curve is then developed for three base-isolated steel moment-resisting buildings with different heights of 4, 8 and 12 stories. The results of sensitivity analysis show that although LRB has the capability of reducing the peak response of buildings under explosion hazard, this control system may lead to increase in the peak response of buildings under some explosion scenarios. This shows the high importance of probabilistic-based assessment of isolated structures under explosion hazard. The blast fragility analysis shows effective performance of LRB in mitigating the probability of failure of buildings. Therefore, LRB can be introduced as effective control system for the protection of buildings from explosion hazard regarding uncertainty effect.

• Structural Engineering and Mechanics
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• v.64 no.2
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• pp.233-241
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• 2017

Earlier numerous studies have been done on implementation of Tuned Liquid Damper (TLD) for structural vibration control by many researchers. As per current review there is no significant study on a sloped bottom TLD. TLD's are passive devices. A TLD is a tank rigidly attached to the structure and filled partially by liquid. When fundamental linear sloshing frequency is tuned to structure's natural frequency large sloshing amplitude is expected. In this study set of experiments are conducted on flat bottom and sloped bottom TLD at beach slope $20^{\circ}$, $30^{\circ}$ and $45^{\circ}$, for different types of structures, mass ratio, and depth ratio to investigate the overall effectiveness of TLD and specific effect of TLD parameters on structural response. This experimental study shows that a properly designed TLD reduces structural response. It is also observed that effectiveness of TLD increases with increase in mass ratio. In this experimental study an effectiveness of sloped bottom TLD with beach slope $30^{\circ}$ is investigated and compared with that of flat bottom TLD in reducing the structural response. It is observed from this study that efficiency of sloped bottom TLD in reducing the response of structure is more as compared to that of flat bottom TLD. It is shown that there is good agreement between numerical simulation of flat bottom and sloped bottom TLD and its experimental results. Also an attempt has been made to investigate the effectiveness of sloped bottom TLD with beach slope $20^{\circ}$ and $45^{\circ}$.

• The Korean Journal of Applied Statistics
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• v.27 no.7
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• pp.1229-1241
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• 2014

Most of sampling surveys have outliers and non-response missing values simultaneously. In that case, due to the effect of outliers, the result of imputation is not good enough to meet a given precision. To overcome this situation, outlier treatment should be conducted before imputation. In this paper in order for reducing the effect of outlier, we study outlier imputation methods and outlier weight adjustment methods. For the outlier detection, the method suggested by She and Owen (2011) is used. A small simulation study is conducted and for real data analysis, Monthly Labor Statistic and Briquette Consumption Survey Data are used.

• Polymer(Korea)
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• v.37 no.3
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• pp.323-331
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• 2013

Hesperidin (Hes) has known to having some functions like protection of blood circulatory system, anti-tumor effect, antioxidant effect and anti-inflammatory effect. The goal of this study is to demonstrate the relationship between Hes and inflammatory through in vitro and in vivo studies using poly(lactic-co-glycolic acid) (PLGA) film including Hes as a tissue engineered scaffold. To confirm the proliferation of cells on fabricated scaffold, cells (RAW 264.7 and NIH/3T3) were seeded on PLGA/Hes film then analyzed with MTT and SEM at 1 and 3 days after seeding. The results from ELISA, RT-PCR, and FACS for anti-oxident and anti-inflammatory effect showed that inflammatory response of PLGA/Hes film decreased more than that of PLGA film. Also, in vivo result confirmed that inflammatory response by implanted PLGA/Hes film decreased more comparing with PLGA film. This is because of anti-inflammatory effect of Hes reducing induced inflammatory cell and accumulation of fibrous capsule. The results showed that PLGA/Hes film's capacity on reducing inflammatory is better than PLGA film because of Hes.

• Journal of Microbiology and Biotechnology
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• v.27 no.3
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• pp.514-523
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• 2017

Carbon catabolite repression is a crucial regulation mechanism in microorganisms, but its characteristic in Rhizopus is still unclear. We extracted a carbon regulation gene, cre, that encoded a carbon catabolite repressor protein (CRE) from Rhizopus stolonifer TP-02, and studied the regulation of CRE by real-time qPCR. CRE responded to glucose in a certain range, where it could significantly regulate part of the cellulase genes (eg, bg, and cbh2) without cbh1. In the comparison of the response of cre and four cellulase genes to carboxymethylcellulose sodium and a simple carbon source (lactose), the effect of CRE was only related to the concentration of reducing sugars. By regulating the reducing sugars to range from 0.4% to 0.6%, a glucose-containing medium with lactose as the inducer could effectively induce cellulases without the repression of CRE. This regulation method could potentially reduce the cost of enzymes produced in industries and provide a possible solution to achieve the largescale synthesis of cellulases.