• Proceedings of the KIEE Conference
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• 2005.10b
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• pp.511-513
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• 2005

The fuel cell system has inherent limitation such as slow response time and low fuel economy especially at the low power region, and thus, the battery system has come to be used to compensate for the fuel cell system. This type of hybrid configuration has many advantages, however, the energy management strategy is essentially required. The work in this paper presents survey on recent power management strategies for fuel cell hybrid electric vehicles. For three power management strategies: basic control method. object function-based control method, and fuzzy logic-based control method. each strategy is reviewed and discussed with other strategy.

• Neonatal Medicine
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• v.17 no.2
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• pp.168-180
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• 2010

Acute renal failure (ARF) is common in the neonatal period, however, there are no uniform treatment strategies of ARF. The main treatment strategies are conservative management including medical treatment and the renal replacement therapy. Because ARF in the newborn is commonly acquired by hypoxic ischemic injury and toxic insults, removal of all the offending causes is important. Aminoglycoside, indomethacin, and amphotericin-B are the most common nephrotoxic drugs of ARF. To relieve the possible prerenal ARF, initial fluid challenge can be followed by diuretics. If there is no response, fluid restriction and correction of electrolyte imbalance should begin. Adequate nutritional support and drug dosing according to the pharmacokinetics of such drugs will be difficult problems. Renal replacement therapies may be provided by peritoneal dialysis, intermittent hemodialysis, or hemofiltration. New promising agents, bioartificial kidney, and stem cell will enable us to extend our therapeutic repertoire.

• Korean Journal of Biological Psychiatry
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• v.5 no.2
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• pp.155-161
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• 1998

Mood disorder is a medical illness resulting from the disorder of CNS neurotransmission and its principal therapeutic tool is pharmacotherapy. Psychotherapeutic drugs for mood disorder have some clinical limitations which are due to no or partial response, decreased compliance for drug by the side effects, and delayed therapeutic effects. So, general hope of all clinicians that mood diorder will respond to a single psychotherapeutic agent may be the exception rather than the rule. Recently, combined drug treatments have become increasingly popular to overcome the clinical limitations of individual agent in mood disorder. Combined treatments are usually used for augmenting or initiating rapidly the effect of drug, and for treating different target symptoms or drug side effects. When combined treatments being tried, knowledge of the action mechanism, pharmacokinetics, and pharmacodynamics is crucial to cope with the possible adverse reactions of drugs.

• Molecules and Cells
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• v.37 no.8
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• pp.575-584
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• 2014

Potassium is a macronutrient that is crucial for healthy plant growth. Potassium availability, however, is often limited in agricultural fields and thus crop yields and quality are reduced. Therefore, improving the efficiency of potassium uptake and transport, as well as its utilization, in plants is important for agricultural sustainability. This review summarizes the current knowledge on the molecular mechanisms involved in potassium uptake and transport in plants, and the molecular response of plants to different levels of potassium availability. Based on this information, four strategies for improving potassium use efficiency in plants are proposed; 1) increased root volume, 2) increasing efficiency of potassium uptake from the soil and translocation in planta, 3) increasing mobility of potassium in soil, and 4) molecular breeding new varieties with greater potassium efficiency through marker assisted selection which will require identification and utilization of potassium associated quantitative trait loci.

• Management & Information Systems Review
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• v.27
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• pp.149-172
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• 2008

Since the 9/11 terror attack, the event which caused supply chain disruption, supply chain security has becomes more important than ever before. Furthermore, such company's logistics strategies conflicting supply chain security as increased global sourcing, JIT manufacturing are increasing supply chain vulnerability. It could burden for global companies to strengthen supply chain security because not only it requires additional investment cost but also changes of companiy's global logistics strategy. However, on the other hand, supply chain visibility and resilience can be improved through supply chain security. In addition, it allows companies to stabilize supply chain structure as well as rapid and flexible response to market demand. The key issue is balancing between efficiency and supply chain security. To do this, identifying risk elements under the supply chain and assessing vulnerability of each supply chain components should be performed before developing efficient supply chain security management system without obstructing supply chain efficiency.

• Proceedings of the KIPE Conference
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• 2005.07a
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• pp.538-541
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• 2005

Most realistic control systems contain nonlinearities of some form. One nonlinearity commonly found in control systems is a saturating element. If integral control is applied to such a system to eliminate steady state error, an undesired side effect known as integrator windup may occur when lage setpoint changes are made. This effect leads to a characteristic step response with a large overshoot and a very high settling time. To avoid this situation, many different anti-windup strategies have been suggested. But existing strategies remain over shoot and high settling time. This paper proposes a new anti-windup strategy for PI speed controllers. When the speed control system is changed P controller to PI controller. Integrator has an appropriate initial value. This value results over shoot and high settling time. The SIMULINK/MATLAB-based comparative simulation results and experiment results of speed controller have shown its superior control performance to that of a proposed anti-windup speed controller.

• Tuberculosis and Respiratory Diseases
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• v.75 no.5
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• pp.181-187
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• 2013

The emergence of new therapeutic agents for non-small cell lung cancer (NSCLC) implies that histologic subtyping and molecular predictive testing are now essential for therapeutic decisions. Histologic subtype predicts the efficacy and toxicity of some treatment agents, as do genetic alterations, which can be important predictive factors in treatment selection. Molecular markers, such as epidermal growth factor receptor (EGFR) mutation and anaplastic lymphoma kinase (ALK) rearrangement, are the best predictors of response to specific tyrosine kinase inhibitor treatment agents. As the majority of patients with NSCLC present with unresectable disease, it is therefore crucial to optimize the use of tissue samples for diagnostic and predictive examinations, particularly for small biopsy and cytology specimens. Therefore, each institution needs to develop a diagnostic approach requiring close communication between the pulmonologist, radiologist, pathologist, and oncologist in order to preserve sufficient biopsy materials for molecular analysis as well as to ensure rapid diagnosis. Currently, personalized medicine in NSCLC is based on the histologic subtype and molecular status. This review summarizes strategies for tissue acquisition, histologic subtyping and molecular analysis for predictive testing in NSCLC.

• Educational Technology International
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• v.16 no.2
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• pp.249-272
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• 2015

This study is a theoretical exploration of project-based service-learning and its application in designing pre-dental curricula. As a response to the limitation of community service courses, service-learning has been implemented as pedagogy in higher education practices. Service-learning connects service and learning by engaging students in activities that address community needs with intentionally designed learning opportunities while adding value to and transforming both service and learning. Project-based service-learning is an extended and more active version of service-learning. Whereas service activities are arranged by instructors in the original service-learning, project-based service-learning provides students with opportunities for exploring problems and root causes on site and then devising and implementing solutions of their own using their talents and creativity. This study proposes a theoretical approach to project-based service-learning and suggests six design components, namely, related curriculum, reflection, reciprocity, service and community engagement, evaluation and recognition, and creative problem solving. Based on the components, 20 design strategies are formulated. The exploration is aimed to provide design guides for professionals attempting to implement project-based service-learning in higher education.

• The Journal of the Convergence on Culture Technology
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• v.5 no.2
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• pp.83-91
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• 2019

The purpose of this study was to investigate the relationship among the variables and the influence of premenstrual syndrome and stress response on the learning flow of nursing students. Method : The participants were 162 nursing students in K city, who were surveyed between June 1 and June 10, 2018, using self-report questionnaire. Result: There were positive correlation between premenstrual syndrome of participants and stress response(r=.389, p<.001). There were negative correlation between premenstrual syndrome and learning flow(r=-1.93, p<.014), between stress response and learning flow(r=-.216 p<.001). The variables for learning flow where stress response(${\beta}=-.314$, p<.001) and Psychological change of menstruation(${\beta}=-.358$, p<.001), with a coefficient of determination($R^2$) of 30.3%. The result of this study will be useful in preparing basic date for improvement of the learning flow of the nursing students and it will be necessary to develop educational programs and strategies related with the premenstrual syndrome and stress response disposition.

• Journal of Microbiology and Biotechnology
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• v.33 no.5
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• pp.600-606
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• 2023

Dengue virus (DENV) is a widespread arbovirus. To efficiently establish infection, DENV evolves multiple strategies to hijack the host innate immune response. Herein, we examined the inhibitory effects of DENV serotype 2 (DENV2) nonstructural proteins on RIG-I-directed antiviral immune response. We found that DENV2 NS2A, NS2B, NS4A, and NS4B significantly inhibited RIG-I-mediated IFN-β promoter activation. The roles of NS2B in RIG-I-directed antiviral immune response are unknown. Our study further showed that NS2B could dose-dependently suppress RIG-I/MAVS-induced activation of IFN-β promoter. Consistently, NS2B significantly decreased RIG-I- and MAVS-induced transcription of IFNB1, ISG15, and ISG56. Mechanistically, NS2B was found to interact with MAVS and IKKε to impair RIG-I-directed antiviral response. Our findings demonstrated a previously uncharacterized function of NS2B in RIG-I-mediated antiviral response, making it a promising drug target for anti-DENV treatments.