• Journal of the Computational Structural Engineering Institute of Korea
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• v.30 no.3
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• pp.207-214
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• 2017

High voltage electric power transmitter GIS(Gas Insulated Switchgear) above 72.5kV needs to satisfy domestic Korean peninsular standard(ES-6110-0002) in KEPCO with respect to normal and special operation conditions which include internal gas pressure, dead weight, wind and seismic load. Some other requirements not described in Korean standard can be applied from other international standards such as IEC(International Electronical Committee) 62271-203 and 62271-207. The GIS is a kind of pressure vessel structure made of aluminum and filled with SF6 gas of internal pressure 0.4~0.5MPa. Finite element analysis of GIS is performed with such operational loads including seismic loading and the stability and reliability is determined according to ASME BPVC(Boiler and Pressure Vessel Code) SEC. VIII standard where the allowable stress level of the pressure vessel is suggested. The result shows that the stress of GIS is satisfied the allowable stress level and the safety factor is about 2.3 for Korean peninsular standard.

• Journal of the Korea Concrete Institute
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• v.26 no.3
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• pp.351-360
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• 2014

The purpose of this research is to introduce the simplified equivalent frame model for the equivalent lateral force procedure, the response spectrum procedure and nonlinear procedure according to ASCE7-10 in order to reduce the time of performance and reasonably evaluate the effect of applying the damping system with the various conditions for the analysis and the variable. In this research, the seismic performance assessment and the design of the damping system were conducted through the nonlinear time history analysis based on the performance based seismic design in ASCE7-10 in regard to applying the damping system to apartment buildings which is lately issued. The optimal design based on the 75% of seismic base shear was performed for an apartment building. The seismic performance assessment were conducted to check the safety of the building, and the economic evaluation was performed by comparing the amount of resource for the optimal designed building with the amount of resource for the original building. In addition, hysteresis dampers was applied to the apartment building, and the suggested equivalent frame model was performed using the damping system design in ASCE7-10, then its control effects were proved in the full scale model of the apartment building which was used in this research.

• Journal of Radiation Protection and Research
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• v.37 no.1
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• pp.35-40
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• 2012

Several neutron measuring devices were tested under the neutron fields characterized with two distinct kinds of thermal and fast neutron spectrum. These neutron fields were constructed by the mixing of both thermal neutron fields and fast neutron fields. The thermal neutron field was constructed using by a graphite pile with eight AmBe neutron sources. The fast neutron field of 14 MeV was made by a DT neutron generator. In order to change the fraction of fast neutron fluence rate in each neutron fields, a neutron generator was placed in the thermal neutron field at 50 cm and 150 cm from the reference position. The polyethylene neutron collimator was used to make moderated 14 MeV neutron field. These neutron spectra were measured by using a Bonner sphere system with an LiI scintillator, and dosimetric quantities delivered to neutron surveymeters were determined from these measurement results.

• Transactions of the Korean Society of Mechanical Engineers A
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• v.37 no.5
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• pp.715-722
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• 2013

Gas insulated switchgear is large-sized electric equipment for providing a reliable supply of electric power. Recently, seismic tests of electric equipment using a shaking table have been mandated because seismic performance has become an increasingly important issue. However, basic analysis methods continue to be used because some electric equipment is too large for shaking table facilities. Thus, a reliable analysis method should be developed for large-scale electric equipment. This study aims to evaluate the seismic qualification of a 245kV GIS in accordance with IEEE-693 and to validate the analysis method by comparing it with test results. Both the test and the analysis showed that the 245kV GIS has proper seismic safety. Furthermore, the differences between the analysis and the test results are less than 10% for an accurately given mass, stiffness, and input acceleration. It is expected that this study can be used for the seismic qualification of large-scale electrical structures.

• Journal of Yeungnam Medical Science
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• v.16 no.2
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• pp.219-227
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• 1999

Background: In contrast to a healthy person, patients who have acute lower respiratory tract infection with underlying pulmonary diseases have various pathogens, a rapidly progressive downhill course, and a poor response to prior antimicrobial therapy. Broad spectrum antibacterial therapy is needed for full evaluation. Materials and Methods: To evaluate the efficacy and safety of cefpirome, we administered 1gm cefpirome, twice a day to 30 patients, who had signs and symptoms of acute lower respiratory infection regardless of their underlying disease, except to those who had an allergic history to antibiotics or severe systemic diseases. Results: The results were as follows: 1) Among 30 cases, 21 cases(70.0%) showed excellent improvement, and 7 cases(23.3%) showed good improvement in their symptoms and signs of acute lower respiratory infection. 2) In 14 cases with isolated pathogens, we observed bacteriologic eradication in 11 cases(78. 6%). 3) Significant side effects were not found. Conclusion: Above results suggest that cefpirome was effective as a monotherapy in patients with acute lower respiratory infection, especially on those with an underlying chronic obstructive pulmonary disease(COPD).

• Journal of Radiation Protection and Research
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• v.24 no.4
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• pp.215-223
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• 1999

Characteristics of radiation field in the steam generator(S/G) water chamber of a PWR were investigated and the anticipated effective dose rates to the worker in the S/G chamber were evaluated by Monte Carlo simulation. The results of crud analysis in the S/G of the Kori nuclear power plant unit 1 were adopted for the source term. The MCNP4A code was used with the MIRD type anthropomorphic sex-specific mathematical phantoms for the calculation of effective doses. The radiation field intensity is dominated by downward rays, from the U-tube region, having approximate cosine distribution with respect to the polar angle. The effective dose rates to adults of nominal body size and of small body size(The phantom for a 15 year-old person was applied for this purpose) appeared to be 36.22 and 37.06 $mSvh^{-1}$) respectively, which implies that the body size effect is negligible. Meanwhile, the equivalent dose rates at three representative positions corresponding to head, chest and lower abdomen of the phantom, calculated using the estimated exposure rates, the energy spectrum and the conversion coefficients given in ICRU47, were 118, 71 and 57 $mSvh^{-1}$, respectively. This implies that the deep dose equivalent or the effective dose obtained from the personal dosimeter reading would be the over-estimate the effective dose by about two times. This justifies, with possible under- or over- response of the dosimeters to radiation of slant incidence, necessity of very careful planning and interpretation for the dosimetry of workers exposed to a non-regular radiation field of high intensity.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.36 no.3
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• pp.349-359
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• 2016

In order to analytically evaluate buffeting responses, the analysis of wind characteristics such as turbulence intensity, turbulence length, gust, roughness coefficient, etc must be a priority. Static aerodynamic force coefficients, flutter coefficients, structural damping ratios, aerodynamic damping ratios and natural frequencies affect the analytical responses. The bridge interested in this paper has being been used for 32 years. As the time passes, current terrain conditions around the bridge are different markedly from the conditions it was built 32 years ago. Also, wind environments were considerably varied by the climate change. For this reason, it is necessary to evaluate the turbulence intensity, length, spectrum and roughness coefficient of the bridge site from full-scale measurements using the structural health monitoring system. The evaluation results indicate that wind characteristics of bridge site is analogous to that of open terrain although the bridge is located on the coastal area. To calculate buffeting responses, the analysis variables such as damping ratios, static aerodynamic force coefficients and natural frequency were evaluated from measured data. The analysis was performed with regard to 4 cases. The evaluated variables from measured data are applied to the first and second analysis cases. And the other analysis cases were performed based on Design Guidelines for Steel Cable Supported Bridges. The calculated responses of each analysis cases are compared with the buffeting response measured at less than 25m/s wind speed. It is verified that the responses by the numerical analysis applying the estimated variables based on full-scale measurements are well agreed with the measured actual buffeting responses under wind speed 25m/s. Also, the extreme wind speed corresponding to a recurrence interval 200 years is derived from Gumbel distribution. The derived wind speed for return period of 200 years is 45m/s. Therefore the buffeting responses at wind speed 45m/s is determined by the analysis applying the estimated variables.

• Asian Pacific Journal of Cancer Prevention
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• v.15 no.2
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• pp.925-928
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• 2014

Background: Gestational trophoblastic neoplasia (GTN) is a spectrum of disease with abnormal trophoblastic proliferation. Treatment is based on FIGO stage and WHO risk factor scores. Patients whose score is 12 or more are considered as at extremely high risk with a high likelihood of resistance to first line treatment. Optimal therapy is therefore controversial. Objective: This study was conducted in order to summarize the regimen used for extremely high risk or resistant GTN patients in our institution the in past 10 years. Materials and Methods: All the charts of GTN patients classified as extremely high risk, recurrent or resistant during 1 January 2002 to 31 December 2011 were reviewed. Criteria for diagnosis of GTN were also assessed to confirm the diagnosis. FIGO stage and WHO risk prognostic score were also re-calculated to ensure the accuracy of the information. Patient characteristics were reviewed in the aspects of age, weight, height, BMI, presenting symptoms, metastatic area, lesions, FIGO stage, WHO risk factor score, serum hCG level, treatment regimen, adjuvant treatments, side effects and response to treatment, including disease free survival. Results: Eight patients meeting the criteria of extremely high risk or resistant GTN were included in this review. Mean age was 33.6 years (SD=13.5, range 17-53). Of the total, 3 were stage III (37.5%) and 5 were stage IV (62.5%). Mean duration from previous pregnancies to GTN was 17.6 months (SD 9.9). Mean serum hCG level was 864,589 mIU/ml (SD 98,151). Presenting symptoms of the patients were various such as hemoptysis, abdominal pain, headache, heavy vaginal bleeding and stroke. The most commonly used first line chemotherapeutic regimen in our institution was the VAC regimen which was given to 4 of 8 patients in this study. The most common second line chemotherapy was EMACO. Adjuvant radiation was given to most of the patients who had brain metastasis. Most of the patients have to delay chemotherapy for 1-2 weeks due to grade 2-3 leukopenia and require G-CSF to rescue from neutropenia. Five form 8 patients were still survived. Mean of disease free survival was 20.4 months. Two patients died of the disease, while another one patient died from sepsis of pressure sore wound. None of surviving patients developed recurrence of disease after complete treatment. Conclusions: In extremely high risk GTN patients, main treatment is multi-agent chemotherapy. In our institution, we usually use VAC as a first line treatment of high risk GTN, but since resistance is quite common, this may not suitable for extremely high risk GTN patients. The most commonly used second line multi-agent chemotherapy in our institution is EMA-CO. Adjuvant brain radiation was administered to most of the patients with brain metastasis in our institution. The survival rate is comparable to previous reviews. Our treatment demonstrated differences from other institutions but the survival is comparable. The limitation of this review is the number of cases is small due to rarity of the disease. Further trials or multicenter analyses may be considered.

• Progress in Medical Physics
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• v.12 no.1
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• pp.9-17
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• 2001

The prior purpose of this study is to introduce a optical biopsy and evaluate whether the optical biopsy, real-time, non-invasive technique, is a reliable tool to assess response to radiotherapy Four healthy volunteers, and four patients with inflammatory conditions of the oral cavity participated on the study. was obtained from each person enrolled in the study. Using FastEEM(Ercited Emission Matrix) as a optical biopsy tool, normal and tumor spectra are taken from the normal and the tumor regions. And then second optical biopsy are taken from the tumor regions in 4 patients with time delay at 7days.. Using a diagnostic algorithm, made by Gillenwater based on spectra excited at 337nm The Optical Biopsy turned out to be more suited for tumor diagnostic resulting in significant difference fluorescence spectra. The fluorescence intensity of cancerous tissue showed a higher position. The second fluorescence intensity of optical biopsy of cancerous oral tissue has more smaller than the first result. I conclude that optical biopsy, which technique don't need to remove tissue sample from body, and is a real time , and non-invasive measurement is a reliable tool to access to radiotherapy because FastEEM can do measure the variation of the tissue composition chemical, biological, and morphological after radiotherapy. Based on the fluorescence spectrum are taken from the optical biopsy in normal and tumor spectra as well as tumor spectra after 7days.

• Parasites, Hosts and Diseases
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• v.52 no.1
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• pp.93-97
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• 2014

Subolesin (4D8), the ortholog of insect akirins, is a highly conserved protective antigen and thus has the potential for development of a broad-spectrum vaccine against ticks and mosquitoes. To date, no protective antigens have been characterized nor tested as candidate vaccines against Dermacentor silvarum bites and transmission of associated pathogens. In this study, we cloned the open reading frame (ORF) of D. silvarum 4D8 cDNA (Ds4D8), which consisted of 498 bp encoding 165 amino acid residues. The results of sequence alignments and phylogenetic analysis demonstrated that D. silvarum 4D8 (Ds4D8) is highly conserved showing more than 81% identity of amino acid sequences with those of other hard ticks. Additionally, Ds4D8 containing restriction sites was ligated into the pET-32(a+) expression vector and the recombinant plasmid was transformed into Escherichia coli rosetta. The recombinant Ds4D8 (rDs4D8) was induced by isopropyl ${\beta}$-D-thiogalactopyranoside (IPTG) and purified using Ni affinity chromatography. The SDS-PAGE results showed that the molecular weight of rDs4D8 was 40 kDa, which was consistent with the expected molecular mass considering 22 kDa histidine-tagged thioredoxin (TRX) protein from the expression vector. Western blot results showed that rabbit anti-D. silvarum serum recognized the expressed rDs4D8, suggesting an immune response against rDs4D8. These results provided the basis for developing a candidate vaccine against D. silvarum ticks and transmission of associated pathogens.