• Biomolecules & Therapeutics
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• 제5권2호
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• pp.150-157
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• 1997

Capsaicin cream has been used to attenuate the pain associated with diabetic neuropathy, rheum-atoid arthritis, osteoarthritis and postherpetic neuralgia. But its common side effect, local irritation, limits the use of it and there is still a need for a new analgesic devoid of this side effect. This study was conducted to compare the local irritant effect of DA-5018, a new capsaicin derivative, with that of capsaicin in various animal models and human beings. Capsaicin, applied topically to the mouse ear, produced dose-dependent increase of ear volume and the frequency of ear scratching behavior in mice. Neither ear volume nor scratching behavior was affected by DA-5018. In eye wiping test of rat, DA-5018 was 10 times less irritant than capsaicin. Capsaicin administered intradermally into the rat paw elicited paw lick/lift response with a potency which was three times that of DA-5018. Zostrix-HP (0.075% capsaicin cream), but not DA-50180.3% cream, increased ear volume of rat and induced thermal hyperalgesia in normal and carrageenan inflamed paws. Six day-treatment of Zostrix-HP failed to develop tolerance against this thermal hyperalgesia. In human beings, Zostrix-HP produced burning sensation and itching in more than 90% of volunteers involved and its maximum irritant effect was significantly higher than that of DA-5018 cream. These results suggest that local irritation and burning sensation produced by DA-5018 is much less than capsaicin.

• 한국조사연구학회:학술대회논문집
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• 한국조사연구학회 2002년도 추계학술대회 발표논문집
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• pp.111-127
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• 2002

국가통계의 활용도가 높아질수록 통계에 대한 객관적인 품질평가 필요성도 높아지게 된다. 과거에 대표적인 품질평가지표로 간주되어 온 평균제곱오차나 응답률은 유용성에 많은 문제가 있으므로 통계이용자의 다양한 요구사항을 반영할 수 있는 새로운 품질지표 개발의 필요성이 대두되었다. 따라서 본 논문에서는 정부기관에서 작성하고 있는 표본통계조사를 대상으로 통계작성 절차의 흐름을 분석하고 각 절차별 투입자료와 산출결과를 인식함으로써 최종 집계결과의 품질에 영향을 미칠 수 있는 절차별 품질지표를 개발하는 방법이 연구되었다. 또한 발굴된 절차별 품질지표에 다른 통계간 또는 동일 통계간 품질을 비교할 수 있도록 품질지수 산출방법이 논의되었다.

• Journal of the Korean Data and Information Science Society
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• 제17권4호
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• pp.1349-1364
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• 2006

An analytic approach that provides explicit estimates of risk on cataract and epilation data is evaluated by reasonableness of conceivable relative risk models regarding a simple, odds, logistic or Gompertz regression method, assuming a binomial distribution. In these analyses, we apply relative risk models with two thresholds between epilators and nonepilators from a highly characteristic lesion of which radiation cataract does not occur around 2 gray for a single acute exposure. The risk models are fitted to the data assuming 10 as a constant relative biological effectiveness of neutron. The likelihood of observing the entire data set in these models fitted is evaluated by an individual binary-response array. Estimation of a threshold with or without severe epilation and the 100 ($1-\alpha$)% confidence limits are derived from the maximum likelihood approach. The relative risk model with two thresholds can be expressed as a formula with structure of Background $\times$ RR, where RR includes threshold models with or without epilation. The radiosensitivity of ionizing radiation to cataracts has been examined for the relationship between epilators and nonepilators.

• 한국콘텐츠학회논문지
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• 제13권12호
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• pp.986-994
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• 2013

본 연구는 주요 광고효과모형을 검토하여 광고효과의 발생과정에 대한 광고계의 주류적 인식을 살펴보고, 이를 통하여 광고효과 연구의 한계점과 해결방안을 제시하고자 한다. 문헌연구 결과, 기존의 광고효과 연구는 설득커뮤니케이션의 패러다임 안에서 브랜드태도의 변화에 초점을 맞추어 왔으며 광고효과의 다른 측면은 심도 있게 논의하지 못하였다는 점을 밝혔다. 저자는 급변하는 광고매체환경 속에서 브랜드태도 변화와는 구별되는 새로운 광고효과 연구의 필요성을 제시하고 특히 저관여모형에서 강조하는 브랜드 인식의 틀 제공, 브랜드친숙성, 브랜드현저성의 제고와 같은 보다 다양한 변인에 대한 학문적 관심이 필요하다는 점을 주장하였다.

• 한국자동차공학회논문집
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• 제13권6호
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• pp.38-47
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• 2005

In this paper, a regenerative braking algorithm is proposed to make the maximum use of the regenerative braking energy for an independent front and rear motor drive parallel HEV. In the regenerative braking algorithm, the regenerative torque is determined by considering the motor capacity, motor efficiency, battery SOC, gear ratio, clutch state, engine speed and vehicle velocity. To implement the regenerative braking algorithm, HEV powertrain models including the internal combustion engine, electric motor, battery, manual transmission and the regenerative braking system are developed using MATLAB, and the regenerative braking performance is investigated by the simulator. Simulation results show that the proposed regenerative braking algorithm contributes to increasing the battery SOC, which recuperates 60 percent of the total braking energy while satisfying the design specification of the control logic. In addition, a control algorithm which limits the regenerative braking is suggested by considering the battery power capacity and dynamic response characteristics of the hydraulic control module.

• 한국자동차공학회논문집
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• 제19권2호
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• pp.42-49
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• 2011

To expand lean misfire limit and improve combustion stability, the effects of port masking were estimated to secure basic data for applying the mechanism to SI engine instead of asymmetrical port and port throttling devises. For this purpose, various shapes and ratios of masking plates were mounted between port and manifold. The masking effects were evaluated by mixture response test under various load and speed conditions. The results showed that lean misfire limits were expended and fast combustion was observed for all masking shapes and ratios, especially, the effect of diagonal 1/4 masking was remarkable. In conclusion, the port masking method could be easily applied to engine without redesign of port for improving part load performance.

• 국제초고층학회논문집
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• 제5권3호
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• pp.167-176
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• 2016

This paper describes a large tuned mass damper (TMD) developed as an effective seismic control device for an existing highrise building. To realize this system, two challenges needed to be overcome. One was how to support a huge mass that has to move in any direction, and the second was how to control mass displacement that reaches up to two meters. A simple pendulum mechanism with strong wires was adopted to solve the first problem. As a solution to the important latter problem, we developed a high-function oil damper with a unique hydraulic circuit. When the mass velocity reaches a certain value, which was predetermined by considering the permissible displacement, the damper automatically and drastically increases its damping coefficient and limits the mass velocity. This velocity limit function can effectively and stably control the mass displacement without any external power. This paper first examines the requirements of the TMD using a simple model and clarifies the constitution of the actual TMD system. Then the seismic upgrading project of an existing high-rise building is outlined, and the developed TMD system and the results of performance tests are described. Finally, control effects for design earthquakes are demonstrated through response analyses and construction progress is introduced.

• 대한전기학회:학술대회논문집
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• 대한전기학회 2004년도 하계학술대회 논문집 D
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• pp.2374-2376
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• 2004

In this paper, we describe a DSP-based test apparatus for Control Element Drive Mechanism (CEDM). Using this apparatus, we can catch the mechanical and electrical characteristics of CEDM and obtain the information about the improvement of CEDM and the design of CEDM power controller. The test apparatus for CEDM introduced in this paper can input firing angles directly into gate drive circuits of thyristors so that this method can be used to derive the maximum and minimum values of firing angles within available limits for a 3-phase half-wave rectifier. Angle inputs help us understand each coil's response characteristics. Since this apparatus generates a serial sequence for CEDM insertion and withdrawal operations, we may judge whether CEDM works correctly as expected or not in each phase of a step movement.

• 한국해양공학회:학술대회논문집
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• 한국해양공학회 2000년도 춘계학술대회 논문집
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• pp.195-204
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• 2000

In this paper a complicated structural behavior in collision and its effect of energy translation to the collision bulkhead was examined through a methodology of the numerical simulation to obtain a ideal bow construction and a location of collision bulkhead against head on collision. In the present the bow structure is normally designed in consideration of its specific structural arrangements and internal and external loads in these area such as hydrostatic and dynamic pressure, wave impact and bottom slamming in accordance with the Classification rules, and the specific location of collision bulkhead by SOLAS requirement. By these studies the behavior of the bow collapse due to collision was synthetically evaluated for the different size of tankers and its operational speed limits, and by the result of these simulation it provides the optimal design concept for the low construction to prevent the subsequent plastic deformation onto or near to the collision bulkhead boundary and to determine the rational location of collision bulkhead.

• 대한기계학회논문집B
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• 제33권12호
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• pp.947-951
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• 2009

LED has the merits of high reliability, semi-permanent life, rapid-response and its small size for use as light source of head lamp. But the dependence of its performance and life on temperature affect on its practical use. Which dependence makes problem when the LED is heated up to a higher temperature level by self-generation of heat, due to "highly integration" to get enough quantity of light. To solve this problem, effective cooling system is needed that consider conduction, convection and radiation. This study points out the limits of natural convection cooling system and propose of forced convection with heat sink. Also, it describes a correlation between heat sink area and fluid velocity using numerical analysis to optimize the cooling system.