• Journal of Korean Society of Occupational and Environmental Hygiene
• /
• v.20 no.4
• /
• pp.217-224
• /
• 2010

The purity methods to determine LOD/LOQ using standard deviation of the residual, intercept and blank by IUPAC and ACS describe many of the pitfalls and pose significant challenges to analytical chemists. Therefore, the aim of this study is the development of the simple, easy, convenient and statistically significant method to determine LOD in quantitative analysis of organic solvents by GC. The new approaching method by linearization in the given concentration range used coefficient of variation ; ${\sigma}_{n-1}$/S(standard deviation, ${\sigma}_{n-1}$ and average, S) of sensitivity(Response/concentration). The comparison of results among the purity methods(IUPAC and ACS) and the linearization have been fulfilled the F-test for standard deviations and t-test for LOD range values. The results of F-test and t-test are satisfied within 95 % confidence level, respectably. The LOD values determined by the new procedure are n-Hexane 0.0116 mg/$m^3$, Toluene 0.0807 mg/$m^3$, and o-Xylene 0.0494 mg/$m^3$. Because the standard deviation of the residual, intercept and blank and the slope of calibration curve are not calculated and the new approaching method use the coefficient of variation of sensitivity by linearization, this new method is simple, easy, convenient and statistically significant. In future, many chemical analysts will expect to applicate and routinely use this method in the all quantitative analysis.

• The Korean Journal of Physiology and Pharmacology
• /
• v.21 no.4
• /
• pp.385-395
• /
• 2017

Vasoconstrictive properties of sympathomimetic drugs are the basis of their widespread use as decongestants and possible source of adverse responses. Insufficiently substantiated practice of combining decongestants in some marketed preparations, such are those containing phenylephrine and lerimazoline, may affect the overall contractile activity, and thus their therapeutic utility. This study aimed to examine the interaction between lerimazoline and phenylephrine in isolated rat aortic rings, and also to assess the substrate of the obtained lerimazoline-induced attenuation of phenylephrine contraction. Namely, while lower concentrations of lerimazoline ($10^{-6}M$ and especially $10^{-7}M$) expectedly tended to potentiate the phenylephrine-induced contractions, lerimazoline in higher concentrations ($10^{-4}M$ and above) unexpectedly and profoundly depleted the phenylephrine concentration-response curve. Suppression of NO with NO synthase (NOS) inhibitor $N^w$-nitro-L-arginine methyl ester (L-NAME; $10^{-4}M$) or NO scavanger $OHB_{12}$ ($10^{-3}M$), as well as non-specific inhibition of $K^+$-channels with tetraethylammonium (TEA; $10^{-3}M$), have reversed lerimazoline-induced relaxation of phenylephrine contractions, while cyclooxygenase inhibitor indomethacin ($10^{-5}M$) did not affect the interaction between two vasoconstrictors. At the receptor level, non-selective 5-HT receptor antagonist methiothepin reversed the attenuating effect of lerimazoline on phenylephrine contraction when applied at $3{\times}10^{-7}$ and $10^{-6}M$, but not at the highest concentration ($10^{-4}M$). Neither the 5-$HT_{1D}$-receptor selective antagonist BRL 15572 ($10^{-6}M$) nor 5-$HT_7$ receptor selective antagonist SB 269970 ($10^{-6}M$) affected the lerimazoline-induced attenuation of phenylephrine activity. The mechanism of lerimazoline-induced suppression of phenylephrine contractions may involve potentiation of activity of NO and $K^+$-channels and activation of some methiothepin-sensitive receptors, possibly of the 5-$HT_{2B}$ subtype.

• Clinical and Experimental Pediatrics
• /
• v.45 no.7
• /
• pp.902-905
• /
• 2002

The most common form of genetic nephrogenic diabetes insipidus(NDI), a rare inherited disorder, is congenital and is transmitted in an X-linked recessive mode. It is refractory to the antidiuretic effect of normal to moderately increased levels of plasma arginine vasopressin(AVP) but, in some cases, may respond to high levels of the hormone or its analogue, deamino-D-arginine vasopressin(DDAVP). X-linked congenital NDI has now been linked to over 128 different mutations in diverse coding regions of the AVP receptor 2(AVPR2) gene. The functional effects of these mutations vary from complete loss of responsiveness to a simple shift to the right in the dose response curve. We report a case of congenital partial NDI, with transversion of A to G at codon 280 of the AVPR2 gene, resulting in a subsequent change of amino acid from tyrosine to cysteine, and that has been effective with hydrochlorothiazide and high dose of DDAVP.

• Journal of the Korean Geosynthetics Society
• /
• v.14 no.4
• /
• pp.129-137
• /
• 2015

Recently, offshore wind farms are increasingly expected, because there are huge resource and large site in offshore. Jeju island has optimum condition for constructing a wind energy farm. Unlike the mainland, Jeju island has stratified structure distribution between rock layers sediments due to volcanic activation. In these case, it can be occur engineering problems in whole structures as well as the safety of foundation as the thickness and distribution of sediment under top rock layer can not support sufficiently the structure. One of the most obvious applications of the pressuremeter test is the solution of the problem of laterally loaded piles. A hyperbolic non-linear p-y criterion for rock is developed in this study that can be used in LPILE program, to predict the deflection, moment, and shear reponses of a shaft under the applied lateral loads. Finally, a comparison between the predicted and measured response at two different sites is shown to give an idea of the accuracy of the IFP method.

• Journal of the Earthquake Engineering Society of Korea
• /
• v.14 no.3
• /
• pp.59-68
• /
• 2010

Seismic performances of existing structures should be assessed with more accuracy for cost-effective retrofits. Existing bridges are assessed by the current guidelines in which a simple method has been adapted considering the technical level of engineers of the historical time of construction. Recently many probabilistic approaches have been performed to reflect the uncertainties of seismic input motions. Structures are modeled frequently with the neglection of soil foundations or modeled occasionally with elastic soil spring elements to consider the effect of the soil on the structural response. However, soil also shows nonlinearity under seismic events, so this characteristic should be reflected in order to obtain a more accurate assessment. In this study, a 6-span continuous bridge has been analyzed under various seismic events, in which the soil was represented by equivalent linear spring elements having different properties according to the intensities of the input motions experienced. The seismic vulnerabilities with respect to the failure of piers and the dropping of the super-structure were evaluated on the basis of the analysis results.

• Korean Journal of Optics and Photonics
• /
• v.14 no.4
• /
• pp.473-479
• /
• 2003

The purpose of this study is to recover the CIE XYZ tristimulus values of original colors from scanner output signals, and to reproduce true colors on the monitor. The process of this study is composed of three steps; scanner characterization, chromatic adaptation transformation, and color space transformation between and sRGB. Especially, in the process of recovery, scanner stimuli were obtained accurately by dividing the non-linear photometric response curve into two parts. As the result of test to EPSON Expression 1680 scanner, the average color difference between true and recovered XYZ for 228 target colors, 22 test neutrals, and 36 test colors were 1.49, 0.97, and 1.42 $\Delta$ $E_{UV}$ *, respectively. With the transformation from illuminant D50 to illuminant D65, the input signals to sRGB monitor were predicted. Finally, it could be found that displayed colors with predicted input signals were very consistent with true colors. with true colors.

• Development and Reproduction
• /
• v.7 no.1
• /
• pp.1-7
• /
• 2003

Most animals, including human beings, live in a cyclic pattern of lift that is influenced by the ambient changes of environment. The regular changes occurred by rotation of the Earth itself its revolving around the Sun, and the local environment, are reflected by the distinct behavior in the living organisms. These regular changes of environment have been imprinted into the genes within the living organisms through the evolutionary process over a long period of time. The genes are expressed by rhythms during the process of fetal development followed by growth. The environmental modifications ultimately are settled in genes, serving as a biological clock that is located putatively in the hypothalamus. Thus the biological clock governs a large number of rhythms and affects the time of birth and death lift expectancy, behavior, physiology, cell division, biochemical reaction, etc. The rhythms are readjusted to the changes of environmental cues. The biological clock has the great advantage of predicting and preparing the regular changes of environment.

• Journal of Biomedical Engineering Research
• /
• v.22 no.5
• /
• pp.393-402
• /
• 2001

A computational model representative of cardiovascular circulation was built using 12 standard lumped compartments. Especially, both the baroreceptor reflex and the cardiopulmonary reflex control model were implemented to explain the auto-regulation of cardiovascular system. Another important aspect of this model is to utilize the impulse-response curve of the nerve system in transferring the impulse error signals to autonomous nerve system. For the verification of this model, we have computed the normal hemodynamic conditions and compared those with the clinical data. Then. hemodynamic shock of 20% hemorrhage to cardiovascular system was simulated to test the effects of the control system model. The results of these two simulations were well matched with the experimental ones. The steady state LBNP simulation was also performed. The transient changes of hemodynamic variables due to ramp increase of bias pressure of LBNP showed good agreement with the physiological experiments. Numerical solution using only the baroreflex model showed relatively a larger deviation from the experimental data. compared with the one using the control model haying both the baroreflex and the cardiopulmonary reflex systems, which shows an important role of the cardiopulmonary reflex system for the simulation of the hemodynamic behavior of the cardiovascular system .

• Journal of Advanced Research in Ocean Engineering
• /
• v.1 no.4
• /
• pp.239-251
• /
• 2015

In this study, a spectral fatigue analysis was performed for the topside structure of an offshore floating vessel. The topside structure was idealized using beam elements in the SACS program. The fatigue analysis was carried out considering the wave and wind loads separately. For the wave-induced fatigue damage calculation, motion RAOs calculated from a direct wave load analysis and regular waves with different periods and unit wave heights were utilized. Then, the member end force transfer functions were generated covering all the loading conditions. Stress response transfer functions at each joint were produced using the specified SCFs and member end force transfer functions. fatigue damages were calculated using the obtained stress ranges, S-N curve, wave spectrum, heading probability of each loading condition, and their corresponding occurrences in the wave scatter diagrams. For the wind induced fatigue damage calculation, a dynamic wind spectral fatigue analysis was performed. First, a dynamic natural frequency analysis was performed to generate the structural dynamic characteristics, including the eigenvalues (natural frequencies), eigenvectors (mode shapes), and mass matrix. To adequately represent the dynamic characteristic of the structure, the number of modes was appropriately determined in the lateral direction. Second, a wind spectral fatigue analysis was performed using the mode shapes and mass data obtained from the previous results. In this analysis, the Weibull distribution of the wind speed occurrence, occurrence probability in each direction, damping coefficient, S-N curves, and SCF of each joint were defined and used. In particular, the wind fatigue damages were calculated under the assumption that the stress ranges followed a Rayleigh distribution. The total fatigue damages were calculated from the combination with wind and wave fatigue damages according to the DNV rule.

• International Journal of Fluid Machinery and Systems
• /
• v.4 no.3
• /
• pp.334-340
• /
• 2011

Turbo-pumps have weak points, such as the pumping operation is unstable on the positive slope of the head curve and/or the cavitation occurs at the low suction head. To improve simultaneously both weak points, the first author invented the unique pumping unit composed of the tandem impellers and the peculiar motor with the double rotational armatures. The front and the rear impellers are driven by the inner and the outer armatures of the motor, respectively. Both impeller speeds are automatically and smartly adjusted in response to the pumping discharge, while the rotational torques between both impellers/armatures are counter-balanced. Such speeds contribute to suppress successfully not only the unstable operation at the low discharge but also the cavitation at the high discharge, as verified with the axial flow type pumping unit in the previous paper. Continuously, this paper investigates experimentally the effects of the tandem impeller profiles on the pump performances and the rotational speeds against the discharge, using the impellers whose loads are low and/or high at the normal discharge. The worthy remarks are that (a) the unstable operation is suppressed as expected and the shut off power is scarcely large in the smart control, (b) the blade profile contributes to determine the discharge giving the maximum/minimum rotational speed where the reverse flow may incipiently appears at the front impeller inlet, (c) the tandem impeller profiles scarcely affect the rotational speeds, while the loads of the front and the rear impellers are same, but (d) the impeller with the low load must run faster and the impeller with the high load must run slower at the same discharge to take the same rotational torque, and (e) the reverse flow at the inlet and the swirling velocity component at the outlet of the front impeller with the high load require making the rotational speed of the rear impeller with low load fairly faster at the lower discharge.