• 한국세라믹학회지
• /
• 제35권5호
• /
• pp.429-436
• /
• 1998

The mechanical properties and damage mode of {{{{ {Y}_{2 } {O}_{3} }}-doped tetragonal (Y-TZP) can-didated as biomaterials were performed under indentation stress-strain curve critical load for yield and cracking strength degradation and fatigue behavior with Hertzian indentation tests. This material shows the brittle behavior which is confirmed by indentation stress-strain response. The critical load for cracking(Pc) is much higher than that for yields (Py) indicating crack resistance Strength were strongly dependant on contact area and there were no degradation when the indenter size was ${\gamma}$=3.18 mm suggesting that Y-TZP should be highly damage tolerant to the blunt contacts. Multi-cycle contact were found to be innocuous up to {{{{ {10 }^{6 } }} cycles at 500N and {{{{ {10 }^{5 } }} cycles at 1000N in water. On the other hand contacts at {{{{ {10 }^{6 } }} cycles at 1000 N in water did show some signs of incipient degradation. By contrast contacts with Vickers indenter pro-duced substantial strength losses at much lower loads suggesting that the mechanical integrity of this ma-terial would be compromised by inadvertent sharp contacts.

• 한국세라믹학회지
• /
• 제27권4호
• /
• pp.529-535
• /
• 1990

This paper describes the factors which control the impedance-relative humidity characteristics of the TiO2-V2O5 humidity sensor. To obtain the quantitative relationships between impedance and many manufacturing parameters such as V2O5mol%, the sintering time and temperature, various sets of samples are preared and tested. With changing relative hymidity from 20% to 80%, it is measrued that the corresponding capacitance and impedance from the semicircles which complex impedance plots make. As a result we found that the impedance-relative humidity characteristics are mainly controlled by the doping amount of V2O5 total pore volume and bulk resistence of the elements. We can assume the equivalent circuits of each samples and finally control the sintering time to get a linear humidity impedance response curve which plays an important role in device making. 4mol% V2O5-TiO2 specimen sintered at 90$0^{\circ}C$ for 10min. show liear log(Z) vs. RH characteristics and 10mol% V2O5-TiO2 specimen sintered at the same temp. for 20min. show linear (Z) vs. RH.

• Advances in concrete construction
• /
• 제1권4호
• /
• pp.289-304
• /
• 2013

A reliable concrete constitutive material model is critical for an accurate numerical analysis simulation of reinforced concrete structures under extreme dynamic loadings including impact or blast. However, the formulation of concrete material model is challenging and entails numerous input parameters that must be obtained through experimentation. This paper presents a damage scale analytical model to characterize concrete material for its pre- and post-peak behavior. To formulate the damage scale model, statistical regression and finite element analysis models were developed leveraging twenty existing experimental data sets on concrete compressive strength. Subsequently, the proposed damage scale analytical model was implemented in the finite element analysis simulation of a reinforced concrete pier subjected to vehicle impact loading and the response were compared to available field test data to validate its accuracy. Field test and FEA results were in good agreement. The proposed analytical model was able to reliably predict the concrete behavior including its post-peak softening in the descending branch of the stress-strain curve. The proposed model also resulted in drastic reduction of number of input parameters required for LS-DYNA concrete material models.

• Asian Pacific Journal of Cancer Prevention
• /
• 제15권5호
• /
• pp.1937-1941
• /
• 2014

Aims: To evaluate anti-cancer activity of Asparagus racemosus (AR) leaf extract on UOK146, a renal cell carcinoma cell line, and explore its mechanism of action. Materials and Methods: Dried AR leaves were extracted with chloroform and dissolved in DMSO. This extract was applied to UOK146 and cell death was estimated by MTT assay. In addition PRCC-TFE3 fusion transcripts were detected by real time PCR. Results: Extract was found to be cytotoxic with an $IC_{50}$ of 0.9 mg/ml as estimated by dose response curve. Antitumor activity of the permissible doses of the extract was assessed by the down regulation of PRCC-TFE3 fusion transcript (38%) responsible for oncogenicity of the UOK146 cell line. No increment in the BAX, a proapoptotic marker level was observed. Conclusions: Evidence of antiproliferative effect, PRCC-TFE3 fusion transcript inhibition and static BAX level clearly indicate that AR extract provides or elicits an apoptosis independent anticancer effect on RCC cells by some specific mechanism of regulation.

• 한국복합재료학회:학술대회논문집
• /
• 한국복합재료학회 2003년도 춘계학술발표대회 논문집
• /
• pp.129-134
• /
• 2003

The importance of understanding the response of structural composites to impact and CAI cannot be overstated to develop analytical models for impact damage and CAI strength predictions. This paper presents experimental findings observed from quasi-static lateral load tests, low velocity impact tests, CAI strength and open hole compressive strength tests using 3mm thick composite plates ($[45/-45/0/90]_{3s}$ - IM7/8552). The conclusion is drawn that damage areas for both quasi-static lateral load and impact tests are similar and the curves of several drop weight impacts with varying energy levels (between 5.4 J and 18.7 J) fallow the static curve well. In addition, at a given energy the peak force is in good agreement between the static and impact cases. From the CAI strength and open hole compressive strength tests, it is identified that the failure behaviour of the specimens was very similar to that observed in laminated plates with open holes under compression loading. The residual strengths are in good agreement with the measured open hole compressive strengths, considering the impact damage site as an equivalent hole. The experimental findings suggest that simple analytical models for the prediction of impact damage area and CAI strength can be developed on the basis of the failure mechanism observed from the experimental tests.

• Steel and Composite Structures
• /
• 제23권1호
• /
• pp.31-40
• /
• 2017

This article aims at presenting multi objective optimization of parameters that affect crashworthiness characteristics of bi-tubular structures using Taguchi method with grey relational analysis. To design the experiments, the $L_9$ orthogonal array has been used and based on that, the inner tubes have been fabricated by varying the three influence factors such as reference diameter, length difference and numbers of sides of the polygon with three levels, but all the outer cylinders have the same diameter and length 90 mm and 135 mm respectively. Then, the tailor made bi-tubular steel structures were subjected into quasi static axial compression. From the test results it is found that the crushing behaviors of bi-tubular structures with different combinations were fairly significant. The important responses (crashworthiness indicators) specific energy absorption and crush force efficiency have been evaluated from load - displacement curve. Finally optimal levels of parameters were identified using grey relational analysis, and significance of parameters was determined by analysis of variance. The optimum crashworthiness parameters are reference diameter 80 mm, length difference 0 mm and number of sides of polygon is 3, i.e., triangle within the selected nine bi-tube combinations.

• Journal of Microbiology and Biotechnology
• /
• 제15권1호
• /
• pp.192-196
• /
• 2005

Abstract Oligotrophic microbial fuel cells (MFCs) were tested for the continuous monitoring of low biochemical oxygen demand (BOD) by using artificial wastewater, containing glucose and glutamate, as check solution. Ten times diluted trace mineral solution was used to minimize the background current level, which is generated from the oxidation of nitrilotriacetate used as a chelating agent. The feeding rate of 0.53 ml/min could increase the sensitivity from 0.16 to 0.43 ${\mu}$A/(mg BOD/l) at 0.15 ml/min. The dynamic linear range of the calibration curve was between 2.0 and 10.0 mg BOD/l, and the response time to the change of 2 mg BOD/l was about 60 min. The current signal from an oligotroph-type MFCs increased with the increase in salts concentration, and the salt effect could be eliminated by 50 mM phosphate buffer.

• Journal of Mechanical Science and Technology
• /
• 제20권11호
• /
• pp.1801-1812
• /
• 2006

In this paper, a 4-wheel vehicle model including the effects of tire slip was considered, along with variable parameter sliding control, pushrod force as the end control parameter, and an antilock sliding control, in order to improve the performance of the vehicle longitudinal response. The variable sliding parameter is made to be proportional to the square root of the pressure derivative at the wheel, in order to compensate for large pressure changes in the brake cylinder. A typical tire force-relative slip curve for dry road conditions was used to generate an analytical tire force-relative slip function, and an antilock sliding control process based on the analytical tire force-relative slip function was used. A retrofitted brake system, with the pushrod force as the end control parameter, was employed, and an average decay function was used to suppress the simulation oscillations. Simulation results indicate that the velocity and spacing errors were slightly larger than the results that without considering wheel slip effect, the spacing errors of the lead and follower were insensitive to the adhesion coefficient up to the critical wheel slip value, and the limit for the antilock control on non-constant adhesion road condition was determined by the minimum of the equivalent adhesion coefficient.

• Biomolecules & Therapeutics
• /
• 제3권3호
• /
• pp.192-198
• /
• 1995

The affinity of mequitazine, a non-sedating antihistamine, for muscarinic receptors was evaluated in the guinea-pig ventricle and ileum by in vitro binding techniques and functional studies. In binding studies, [$^3$H]quinuclidinyl benzilate (QNB) identified a single class of muscarinic receptors with similar apparent $K_{D}$ value of about 100 pM in two tissues. Mequitazine inhibited [$^3$H]QNB binding to muscarinic receptors competitively. Analysis of the mequitazine inhibition curve of [$^3$H]QNB binding to ventricular microsome and ileal homogenate indicated the presence of a single homogeneous binding site with Ki value of 25 nM and 18 nM, respectively. In functional studies, mequitazine caused parallel rightward shifts of concentration-response curves for carbachol and histamine in the isolated guinea-pig ileum. The slope values obtained from Schild plot analysis for the antagonistic action of mequitazine on muscarinic and histamine $H_1$-receptors were not significantly different from unity. The p $A_2$values of mequitazine for muscarinic and histamine $H_1$-receptors were about 7.6 ( $K_{M}$= 25.1 nM) and 8.88 ( $K_{H}$= 1.32 nM), respectively. These results indicate that the muscarinic receptor blocking action of mequitazine is 15 times less potent than the $H_1$receptor blocking action, but high concentration of this drug may cause the peripheral muscarinic receptor blocking effect.t.t.t.

• 한국통계학회:학술대회논문집
• /
• 한국통계학회 2005년도 춘계 학술발표회 논문집
• /
• pp.17-23
• /
• 2005

In this paper we consider the well-known semiparametric proportional hazards models for survival analysis. These models are usually used with few covariates and many observations (subjects). But, for a typical setting of gene expression data from DNA microarray, we need to consider the case where the number of covariates p exceeds the number of samples n. For a given vector of response values which are times to event (death or censored times) and p gene expressions(covariates), we address the issue of how to reduce the dimension by selecting the significant genes. This approach enables us to estimate the survival curve when n ${\ll}$p. In our approach, rather than fixing the number of selected genes, we will assign a prior distribution to this number. The approach creates additional flexibility by allowing the imposition of constraints, such as bounding the dimension via a prior, which in effect works as a penalty To implement our methodology, we use a Markov Chain Monte Carlo (MCMC) method. We demonstrate the use of the methodology to diffuse large B-cell lymphoma (DLBCL) complementary DNA (cDNA) data and Breast Carcinomas data.