• Korean Journal of Radiology
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• v.23 no.6
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• pp.664-673
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• 2022

Objective: To evaluate the performance of baseline clinical characteristics and pretherapeutic histogram parameters derived from T2 mapping of the extraocular muscles (EOMs) in the prediction of treatment response to intravenous glucocorticoid (IVGC) therapy for active and moderate-to-severe thyroid-associated ophthalmopathy (TAO) and to investigate the effect of fat-suppression (FS) in T2 mapping in this prediction. Materials and Methods: A total of 79 patients clinically diagnosed with active, moderate-to-severe TAO (47 female, 32 male; mean age ± standard deviation, 46.1 ± 10 years), including 43 patients with a total of 86 orbits in the responsive group and 36 patients with a total of 72 orbits in the unresponsive group, were enrolled. Baseline clinical characteristics and pretherapeutic histogram parameters derived from T2 mapping with FS (i.e., FS T2 mapping) or without FS (i.e., conventional T2 mapping) of EOMs were compared between the two groups. Independent predictors of treatment response to IVGC were identified using multivariable analysis. Receiver operating characteristic (ROC) curve analysis was performed to evaluate the predictive performance of the prediction models. Differences between the models were examined using the DeLong test. Results: Compared to the unresponsive group, the responsive group had a shorter disease duration, lower kurtosis (FS-kurtosis), lower standard deviation, larger 75th, 90th, and 95th (FS-95th) T2 relaxation times in FS mapping and lower kurtosis in conventional T2 mapping. Multivariable analysis revealed that disease duration, FS-95th percentile, and FS-kurtosis were independent predictors of treatment response. The combined model, integrating all identified predictors, had an optimized area under the ROC curve of 0.797, 88.4% sensitivity, and 62.5% specificity, which were significantly superior to those of the imaging model (p = 0.013). Conclusion: An integrated combination of disease duration, FS-95th percentile, and FS-kurtosis was a potential predictor of treatment response to IVGC in patients with active and moderate-to-severe TAO. FS T2 mapping was superior to conventional T2 mapping in terms of prediction.

• Journal of the Earthquake Engineering Society of Korea
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• v.22 no.3
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• pp.113-119
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• 2018

The probabilistic seismic safety assessment is one of the methodology to evaluate the seismic safety of the nuclear power plants. The site characteristics of the nuclear power plant should be reflected when evaluating the seismic safety of the nuclear power plant. The Korea seismic characteristics are strong in high frequency region and may be different from NRC Regulatory Guide 1.60, which is the design spectrum of nuclear power plants. In this study, seismic response of a nuclear power plant structure by Pohang earthquake (2017.11.15. (KST)) is investigated. The Pohang earthquake measured at the Cheongsong seismic observation station (CHS) is scaled to the peak ground acceleration (PGA) of 0.2 g and the seismic acceleration time history curve corresponding to the design spectrum is created. A nuclear power plant of the containment building and the auxiliary buildings are modeled using OPENSEES to analyze the seismic response of the Pohang earthquake. The seismic behavior of the nuclear power plant due to the Pohang earthquake is investigated. And the seismic performances of the equipment of a nuclear power plant are evaluated by the HCLPF. As a result, the seismic safety evaluation of nuclear power plants should be evaluated based on site-specific characteristics of nuclear power plants.

• Transactions of the Korean Society of Mechanical Engineers A
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• v.22 no.2
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• pp.458-466
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• 1998

In this work, a frequency domain method is tested numerically and experimentally to improve nonlinear model parameters using the frequency response function at the nonlinear element connected point of structure. This method extends the force-state mapping technique, which fits the nonlinear element forces with time domain response data, into frequency domain manipulations. The force-state mapping method in the time domain has limitations when applying to complex real structures because it needd a time domain lumped parameter model. On the other hand, the frequency domain method is relatively easily applicable to a complex real structure having nonlinear elements since it uses the frequency response function of each substurcture. Since this mehtod is performed in frequency domain, the number of equations required to identify the unknown parameters can be easily increased as many as it needed, just by not only varying excitation amplitude bot also selecting excitation frequency domain method has some advantages over the classical force-state mapping technique in the number of data points needed in curve fit and the sensitivity to response noise.

• Advances in Computational Design
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• v.1 no.1
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• pp.105-117
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• 2016

The objective of this work is to study the restraining effect in fire resistance of framed structures and to evaluate the global response of reinforced concrete frames when exposed to fire based on advanced finite element method. To study the response a single portal frame is analyzed. The effect of floor slab on this frame is studied by modeling a beam-column-slab assembly. The evolution of temperature distribution, internal stresses and deformations of the frame subjected to ISO 834 standard fire curve for both the frames are studied. The thermal and structural responses are evaluated and a comparison of results of individual members and entire structure is done. From the study it can be seen that restraining forces has significant influence on both stresses and deflection and overall response of the structure when compared to individual structural member. Among the various structural elements, columns are the critical members in fire and failure of column causes the failure of entire structure. The fire rating of various structural elements of the frame is determined by various failure criteria and is compared with IS456 2000 tabulated fire rating.

• Transactions of the Korean hydrogen and new energy society
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• v.26 no.2
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• pp.184-191
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• 2015

As the power electronics system increases the frequency, the power loss and thermal management are paid more attention. This research presents a real time model of dissipation power with junction temperature response for 120kw IGBT inverter which is applied to the thermal management of high power IGBT inverter. Since the computational time is critical for real time simulation, look-up tables of IGBT module characteristic curve are implemented. The power loss from IGBT provides a clue to calculate the temperature of each module of IGBT. In this study, temperature of each layer in IGBT is predicted by lumped capacitance analysis of layers with convective heat transfer. The power loss and temperature of layers in IGBT is then communicated due to mutual dependence. In the dynamic model, PWM pulses are employed to calculation real time IGBT and diode power loss. Under Matlab/Simulink$^{(R)}$ environment, the dynamic model is validated with experiment. Results showed that the dynamic response of power loss is closely coupled with effective thermal management. The convective heat transfer is enough to achieve proper thermal management under guideline temperature.

• Structural Engineering and Mechanics
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• v.67 no.1
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• pp.1-8
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• 2018

Shake table tests performed on five 1:3 reduced scale two story RC moment resisting frames having construction defects, have shown severe joint damageability in deficient RC frames, resulting in joint panels' cover spalling and core concrete crushing. Haunch retrofitting technique was adopted herein to upgrade the seismic resistance of the deficient RC frames. Additional four deficient RC frames were built and retrofitted with steel haunch; both axially stiffer and deformable with energy dissipation, fixed to the beam-column connections to reduce shear demand on joint panels. The as-built and retrofitted frames' seismic response parameters are calculated and compared to evaluate the viability of haunch retrofitting technique. The haunch retrofitting technique increased the lateral stiffness and strength of the structure, resulting in the increase of structure's overstrength. The retrofitting increased response modification factor R by 60% to 100%. Further, the input excitation PGA was correlated with the lateral roof displacement to derive structure response curve that have shown significant resistance of retrofitted models against input excitations. The technique can significantly enhance the seismic performance of deficient RC frames, particularly against the frequent and rare earthquake events, hence, promising for seismic risk mitigation.

• Asian Pacific Journal of Cancer Prevention
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• v.17 no.4
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• pp.2089-2092
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• 2016

Background: The impact of mean platelet volume (MPV) on prognosis, diagnosis and response to therapy in cancer patients has been widely investigated. In the present study, we evaluated whether MPV at diagnosis has predictive value for pathologic complete response (pCR) after neoadjuvant chemotherapy in patients with locally advanced breast cancer (LABC). Materials and Methods: A total of 109 patients with LABC from Akdeniz University and Antalya Research and Training Hospital were evaluated retrospectively. Results: ROC curve analysis suggested that the optimum MPV cut-off point for LABC patients with pCR (+) was 8.15 (AUC:0.378, 95%CI [0.256-0.499], p=0.077). The patients with MPV <8.15 had higher pCR rates (29.2% vs. 13.1%, p=0.038). After binary logistic regression analysis, MPV and estrogen receptor absence were independent predictors for pCR. Conclusions: MPV has an independent predictive value for pCR after neoadjuvant chemotherapy in patients with LABC.

• Earthquakes and Structures
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• v.13 no.6
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• pp.539-549
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• 2017

Existing reinforced concrete frame buildings designed for vertical loads could only suffer severe damage during earthquakes. In recent years, many research activities were undertaken to develop a reliable and practical analysis procedure to identify the safety level of existing structures. The Incremental Dynamic Analysis (IDA) is considered to be one of the most accurate methods to estimate the seismic demand and capacity of structures. However, the executions of many nonlinear response history analyses (NL_RHA) are required to describe the entire range of structural response. The research discussed in this paper deals with the proposal of an efficient Incremental Modal Pushover Analysis (IMPA) to obtain capacity curves by replacing the nonlinear response history analysis of the IDA procedure with Modal Pushover Analysis (MPA). Firstly, In this work, the MPA is examined and extended to three-dimensional asymmetric structures and then it is incorporated into the proposed procedure (IMPA) to estimate the structure's seismic response and capacity for given seismic actions. This new procedure, which accounts for higher mode effects, does not require the execution of complex NL-RHA, but only a series of nonlinear static analysis. Finally, the extended MPA and IMPA were applied to an existing irregular framed building.

• Korean Journal of Plant Resources
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• v.21 no.3
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• pp.210-215
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• 2008

Gene-expression analysis is increasingly important in biological research, with real-time reverse PCR (RTPCR) becoming the method of choice for high-throughput and accurate expression profiling of selected genes. However, this technique requires important preliminary work for standardizing and optimizing the many parameters involved in the analysis. Plant stress studies are more and more based on gene expression. The analysis of gene expression requires sensitive and reproducible measurements for specific mRNA sequence. Several genes are regulated in response to abitoic stresses, such as salinity, and their gene products function in stress response and tolerance. The design of the primers and TaqMan probes for real-time PCR assays were carried out using the Primer $Express^{TM}$ software 3.0. The PCR efficiency was estimated through the linear regression of the dilution curve. To understand the expression pattern of various genes under salt stressed condition, we have developed a unique public resource of 9 stress-related genes in poplar. In this study, real-time RT-PCR was used to quantify the transcript level of 10 genes (9 stress-related genes and 1 house keeping gene) that could play a role in adaptation of Populus davidiana. Real-time RT-PCR analyses exhibited different expression ratios of related genes. The data obtained showed that determination of mRNA levels could constitute a new approach to study the stress response of P. davidiana after adaptation during growth in salinity condition.

• International Journal of High-Rise Buildings
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• v.11 no.3
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• pp.157-170
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• 2022

This paper explains about structural planning and structural design of the high-rise building in Toranomon-Azabudai Project (A Block) which is now under construction. The building is about 330 meters high, has 4.2 aspect ratio, and the outline of the building has shallow curve. We adopted seismic response control structure. The building is a steel rigid frame structure with braces, and it has enough stiffness to obtain its primary natural period to be less than about seven seconds, in consideration of wind response, seismic response and inhabitability for the wind shaking. In terms of business continuity plan, the building has a high seismic performance; value of story drift angle shall be 1/150 or less and members of the building remain almost undamaged while or after a large earthquake. Active mass dumper shall be installed at the top of the building to improve inhabitability while strong wind is blowing.