• Journal of the Korean Geotechnical Society
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• v.32 no.1
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• pp.45-53
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• 2016

Generally, conventional transport infrastructures consist of compacted granular materials. Their stiffness and response greatly depend on the particle sizes and distributions, and application of loading on the surface over a foundation may induce deformation in both the surface and the underlying foundations. Therefore, a better understanding of the deformation characteristics on granular materials and the prediction are needed. For this reason, an attempt to evaluate and predict deformation of coarse materials based on the discrete element method is presented in this paper. An algorithm for particle distribution curve analysis was formulated and incorporated into the discrete element program. The results show that the discrete element model with particle distribution curve is suitable for estimating stress deformation in a pre-peak response. Unlike conventional uniform or random particle distribution, the response can be obtained by the use of the proper model and approach.

• The Korean Journal of Pharmacology
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• v.30 no.2
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• pp.205-215
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• 1994

It is well known that chronic stimulation with CCK gives rise to growth of exocrine pancreas and to increased content of enzyme proteins in pancreas. However, littls Is known about changes of the secretory function of exocrine pancreas which has been chronically stimulated with CCK, especially about the responsiveness to secretagogues such as CCK, caerulein and carbachol. The present study was performed to investigate the effect of camostat on secretory profiles and the responsiveness to secretagogues of exocrine pancreas by observing in vitro amylase release stimulated by cholecystokinin-octapeptide(CCK-8) and carbachol in dispersed isolated pancreatic acini from camostat-treated rats for 4 or 10 days. The results summarized as follows : 1) The maximal effective concentration of CCK-8 in amylase release in the camostat treated group was greater than control group, but that of carbachol was not different between groups. 2) Analysis of the stimulated amylase release as the percentage of the maximal response revealed that camostat treatment caused right-shift of the dose-response curve of CCK-8. Camostat did not cause significant changes in the dose-response curve of carbachol. 3) There were considerable increases in the amylase release in the camostat-treated group, compared to the control when acini were stimulated with CCK-8 $10^{-9}\;M$ and carbaochol $10^{-6}\;M$, and higher concentrations. 4) There was a reverse correlation between the tissue content and the maximal release(percent of the total content) of amylase. These results suggest that chronic exposure of exocrine pancreas to increased endogenous CCK can enhance the responsiveness of exocrine enzyme secretion to secretagogues, especially at higher concentrations of CCK and carbachol.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.12 no.3
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• pp.1122-1127
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• 2011

A bumper beam plays the important role of absorbing the bulk of bumper impact energy, so it is extremely important to determine the bumper beam section during the initial stage of car development process. This paper uses the Intermediate Response Surface Models (IRSM) technique for the bumper beam section optimization. By using this method, the nonlinear impact force-deflection curve is changed to an approximated curve. This can avoid the excessive 3D nonlinear FEM analysis during the optimization process. Then, the accuracy of the IRSM models is examined by comparing their results with those of the 3D nonlinear FEM. Finally it is shown that the proposed approach is effective to design the 2.5mph vehicle bumper section.

• Journal of the Earthquake Engineering Society of Korea
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• v.6 no.6
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• pp.25-32
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• 2002

In the seismic designing of bridges, the pile foundation of bridge piers generally have been modeled to have a fixed end for its convenience and conservative designing. The fixed-end assumption, however, produces very conservative results in terms of the pier forces. Therefore, many other design methods are evolved to consider the flexibility of the pile foundation. In this study, the response spectrum analysis was performed for a bridge pier having a pile foundation. The shear force, moment, and displacement, which occurred at the pier column under an earthquake loading, were compared to analyze the effects of the modeling method, soil condition and the input earthquake response spectrum. In most cases, the fixed-end model gives larger design forces than flexible foundation models. However, when a long period earthquake is applied to the bridge pier on a soft clay foundation, it is found that the flexible foundation models give larger design forces than the fixed-end model. In the end, the reliability of several flexible foundation models was verified by comparing their results with those of a numerical analysis that considers the soil-structure interaction phenomenon in a rigorous manner.

• The Korean Journal of Pain
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• v.20 no.2
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• pp.92-99
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• 2007

Background: A correlation between a T-type voltage activated calcium channel (VACC) and pain mechanism has not yet been established. The purpose of this study is to find out the effect of ethosuximide and mibefradil, representative selective T-type VACC blockers on postoperative pain using an incisional pain model of rats. Methods: After performing a plantar incision, rats were stabilized on plastic mesh for 2 hours. Then, the rats were injected with ethosuximide or mibefradil, intraperitoneally and intrathecally. The level of withdrawal threshold to the von Frey filament near the incision site was determined and the dose response curves were obtained. Results: After an intraperitoneal ethosuximide or mibefradil injection, the dose-response curve showed a dose-dependent increase of the threshold in a withdrawal reaction. After an intrathecal injection of ethosuximide, the threshold of a withdrawal reaction to mechanical stimulation increased and the increase was dose-dependent. After an intrathecal injection of mibefradil, no change occurred in either the threshold of a withdrawal reaction to mechanical stimulation or a dose-response curve. Conclusions: The T-type VACC blockers in a rat model of postoperative pain showed the antihyperalgesic effect. This effect might be due to blockade of T-type VACC, which was distributed in the peripheral nociceptors or at the supraspinal level. Further studies of the effect of T-type VACC on a pain transmission mechanism at the spinal cord level would be needed.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.28 no.1C
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• pp.31-40
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• 2008

This study presents the assessment of pseudostatic approach for obtaining the internal response of Single Column/Shaft subjected to earthquake loading. In numerical procedure, various lateral load transfer characteristics (p-y curve and Bi-linear curve) were used to model the nonlinear behavior of soil reactions including soil-pile interaction. The analysis using nonlinear soil model could estimate the seismic performance of soil-pile system, despite its relative simplicity. It was found that lateral behavior of single column/shaft obtained from the response displacement method was larger than those by seismic intensity method. To investigate the effects of soil-pile rigidity and pile head condition on the internal pile response, parametric studies were carried out for various soil models. The results from numerical analysis showed that lateral deflection was decreased with fixed condition of pile head and decreasing the soil-pile rigidity. The seismic analysis using Bi-linear model of JRA could reasonably predict the lateral behavior of Single Column/Shaft.

• Earthquakes and Structures
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• v.25 no.3
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• pp.199-208
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• 2023

Seismic performance analysis is one of the fundamental steps in the design of new or retrofitting buildings. In the seismic performance analysis, the adapted spectral acceleration curve for a given site mainly governs the seismic behavior of buildings. Since every soil site (class) has a different impact on the spectral accelerations of input motions, different spectral acceleration curves have to be involved for every soil class that the building is located on top of. Modern seismic design codes (e.g., Eurocode 8, EC8, or Turkish Building Earthquake Code, TBEC) provide design response spectra for all the soil classes to be used in the building design or retrofitting. This research aims to evaluate the EC8 and TBEC based design response spectra using the spectra of real earthquake input motions that occurred (and were recorded at only soil classes A, B and C, no recording is available at soil class D) in a specific area in Turkey. It also conducts response spectrum analyses of 5, 10 and 13 floor reinforced concrete building models under EC8, TBEC and actual spectral response curves. The results indicate that the EC8 and especially TBEC given design response spectra cannot be able to represent the mean actual spectral acceleration curves at soil classes A, B and C. This is particularly observed at periods higher than 0.3 s, 0.42 s and 0.55 s for the TBEC design response spectra, 0.54 s, 0.65 s and 0.84 s for the EC8 design response spectra at soil classes A, B and C, respectively. This is also reflected to the shear forces of three building models, as actual spectral acceleration curves lead to the highest shear forces, followed by the shear forces obtained from EC8 and, then, the TBEC design response spectra.

• Journal of Korea Multimedia Society
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• v.16 no.11
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• pp.1261-1271
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• 2013

Zoom tracking involves the automatic adjustment of the focus motor in response to the zoom motor movements for the purpose of keeping an object of interest in focus, and is typically achieved by moving the zoom and focus motors in a zoom lens module so as to follow the so-called "trace curve", which shows the in-focus motor positions versus the zoom motor positions for a specific object distance. Thus, one can simply implement zoom tracking by following the most closest trace curve after all the trace curve data are stored in memory. However, this approach is often prohibitive in practical implementation because of its large memory requirement. Many other zoom tracking methods such as GZT, AZT and etc. have been proposed to avoid large memory requirement but with a deteriorated performance. In this paper, we propose a new zoom tracking method called 'Approximate Feedback Zoom Tracking method (AFZT)' on DM36x-based IP network camera, which does not need large memory by approximating nearby trace curves, but generates better zoom tracking accuracy than GZT or AZT by utilizing focus value as feedback information. Experiments through real implementation shows the proposed zoom tracking method improves the tracking performance and works in real-time.

• Journal of The Korean Society of Agricultural Engineers
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• v.54 no.4
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• pp.93-103
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• 2012

A suction-saturation control technique based on flow pump system was developed to investigate hydraulic properties in unsaturated soils. The flow pump system is designed based on the principle of the axis-translation technique and triaxial equipment, and gives the suction-time and suction-saturation curves, the primary relationship needed for interpreting the response of unsaturated soils and link between theory and the material properties in unsaturated soil mechanics. Using the suction-saturation control technique, suction-time relationship and soil-water retention curve (SWRC) during hydraulic hysteresis were investigated with different net confining pressures and porosities. Three types of soils-two sands and a silt were used in this paper. This paper showed the effect of the hysteresis on the SWRC due to different net confining pressures and porosities. This means that a careful decision must be made as to which condition is to be modeled, since the delicate difference of the conditions in physical modeling can cause the different experimental output.

• The Transactions of the Korean Institute of Electrical Engineers A
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• v.54 no.2
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• pp.79-87
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• 2005

At present Cournot model is one of the most commonly used theories to analyze the gaming situation in oligopoly market. But there exist several problems to apply this model to electricity market. The representative one is to obtain the inverse demand curve able to be induced from the relationship between market price and demand response. In Cournot model, each player offers their generation quantity to accomplish maximum profit, which is accomplished by reducing their quantity compared with available total capacity. As stated above, to obtain the probable Cournot equilibrium to reflect real market situation, we have to induce the correct demand function first of all. Usually the correlation between price and demand appears on the long-term basis through the statistical data analysis (for example, regression analysis) or by investigating consumer utility functions of several consumer groups classified as residential, industrial, and commercial. However, the elasticity has a tendency to change continuously according to the total market demand size or the level of market price. Therefore it should be updated as trading period passes by. In this paper we propose a method for inducing and updating this price elasticity of demand function for more realistic market equilibrium.