• 대한기계학회논문집A
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• 제23권11호
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• pp.1871-1877
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• 1999

An optimal design method using a response surface method for dynamic characteristics of a washer is presented. The proposed method uses the design of experiment and a computer model is used for the experiment. The value of the cost function is estimated using a computer model for each case of the design variable variation. An orthogonal array is used to obtain best cases to be considered with minimum number of experimentation. Using these experimental values, optimal design is performed using a response surface method. The method used in this paper can be applied to any complicated mechanical systems that can be modelled and analyzed by a computer program. The method is applied to the design of dynamic characteristics of a washer.

• 대한기계학회논문집A
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• 제33권11호
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• pp.1288-1293
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• 2009

This paper discusses about modeling method to simulate a nonlinear behavior like sliding or rocking of two stacked body system under earthquake condition. A double body system design can be an option to reduce seismic response of a component in comparison to a single body system for free standing structures. Therefore, according to the priority of components, the structure is to be designed by proper ratio of partition in their height for improvement of seismic capability and structural integrity. Nonlinear modeling and analysis using simple rigid body and dynamic system has been performed to check the trend in such cases. As a result, one of the two bodies can be chosen to reduce the seismic response from energy absorption of the other one by appropriate application of friction ratios not only in slip-slip condition but in slip-rock condition.

• Structural Engineering and Mechanics
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• 제62권2호
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• pp.139-142
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• 2017

For the conventional computational methods for structural reliability analysis, the common limitations are long computational time, large number of iteration and low accuracy. Thus, a new novel method for structural reliability analysis has been proposed in this paper based on response surface method incorporated with an improved genetic algorithm. The genetic algorithm is first improved from the conventional genetic algorithm. Then, it is used to produce the response surface and the structural reliability is finally computed using the proposed method. The proposed method can be used to compute structural reliability easily whether the limit state function is explicit or implicit. It has been verified by two practical engineering cases that the algorithm is simple, robust, high accuracy and fast computation.

• Steel and Composite Structures
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• 제5권5호
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• pp.345-358
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• 2005

The response of single story buildings and other case studies are investigated to observe trends in response and to develop a better understanding of the impact of some design parameters on the seismic response of CBF. While it is recognized that many parameters have an influence on the behavior of braced frames, the focus of this study is mostly on quantifying energy dissipation in compression and its effectiveness on seismic performance. Based on dynamic analyses of single story braced frame and case studies, it is found that a bracing member designed with bigger R and larger KL/r results in lower normalized cumulative energy, i.e., cumulative compressive energy normalized by the corresponding tensile energy (${\sum}E_C/E_T$), in both cases.

• Earthquakes and Structures
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• 제26권1호
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• pp.1-15
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• 2024

Isolation technology has been proven effective in reducing the seismic response of superstructures, where most of the deformation is concentrated in the isolation layer. However, in cases of earthquakes with intensities surpassing the fortification level of the area, or severe near-fault earthquakes, the isolation layer may experience excessive deformation, resulting in damage to the isolation bearings or collisions with the retaining wall or surrounding buildings. In this study, a finite element model using ABAQUS is established and compared with experimental test results to deeply investigate the influence of limit devices on the isolation layer and its response to the superstructure. The findings reveal that a larger limiter stiffness and a smaller reserved gap can achieve a more effective limiting effect. Nevertheless, a smaller reserved gap and a larger limiter stiffness may result in increased response of the superstructure. Therefore, rational selection of the reserved gap and limiter stiffness is crucial to reduce the acceleration response.

• Asian Pacific Journal of Cancer Prevention
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• 제16권15호
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• pp.6627-6632
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• 2015

Background: We conducted a study exploring the clinical safety and efficacy of decitabine in patients with acute myeloid leukemia (AML) and myelodysplastic syndromes (MDS), combined with a complex karyotype. Materials and Methods: From April 2009 to September 2013, a total of 35 patients with AML/MDS combined with a complex karyotype diagnosed in the First Affiliated Hospital of Soochow University were included for retrospective analysis. All patients were treated with decitabine alone ($20mg/m^2$ daily for 5 days) or combination AAG chemotherapy (Acla 20mg qod*4d, Ara-C $10mg/m^2$ q12h*7d, G-CSF $300{\mu}g$ qd, the dose of G-CSF adjusted to the amount in blood routinely). Results: In 35 patients, 15 exhibited a complete response (CR), and 6 a partial response (PR), the overall response rate (CR+PR) being 60% (21 of 35). Median disease-free survival was 18 months and overall survival was 14 months. In the 15 MDS patients with a complex karyotype, the CR rate was 53.3% (8 of 15); in 20 AML patients with complex karyotype, the overall response rate was 65% (13 of 20). The response rate of decitabine alone (22 cases) was 56.5% (13 of 22), while in the combination chemotherapy group (13 cases), the effective rate was 61.5% (8 of 13)(P>0.05). There are 15 patients with chromosome 7 aberration, after treatment with decitabine, 7 CR, 3 PR, overall response rate was 66.7% (10 of 15). Of 18 patients with 3 to 5 kinds of chromosomal abnormalities, 66.7% demonstrated a response; of 17 with more than 5 chromosomal abnormalities, 52.9% had a response. In the total of 35 patients, with one course (23 patients) and ${\geq}$two courses (12 patients), the overall response rate was 40.9% and 92.3% (P<0.05). Grade III to IV hematological toxicity was observed in 27 cases (75%). Grade III to IV infections were clinically documented in 7 (20%). Grades I to II non-hematological toxicity were infections (18 patients), haematuria (2 patients), and bleeding (3 patients). With follow-up until September 2013, 7 patients were surviving, 18 had died and 10 were lost to follow-up. In the 6 cases who underwent allogeneic hematopoietic stem cell transplantation (HSCT) all were still relapse-free survivors. Conclusions: Decitabine alone or combination with AAG can improve outcome of AML/MDS with a complex karyotype, there being no significant difference decitabine in inducing remission rates in patients with different karyotype. Increasing the number of courses can improve efficiency. This approach with fewer treatment side effects in patients with a better tolerance should be employed in order to create an improved subsequent chance for HSCT.

• Asian Pacific Journal of Cancer Prevention
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• 제17권2호
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• pp.807-813
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• 2016

Triple-negative breast cancers constitute about 15% of all cases, but despite their higher response to neoadjuvant chemotherapy, the tumors are very aggressive and associated with a poor prognosis as well as a higher risk of early recurrence. This study was retrospectively performed on 101 patients with stage II and III invasive breast cancer who received 6-8 cycles of neo-adjuvant chemotherapy. Out of the total, 23 were in the triple negative breast cancer subgroup. Nuclear Ki-67 expression in both the large cohort group (n=101) and triple negative breast cancer subgroup (n=23) and its relation to the pathological response were evaluated. The purpose of the study was to identify the predictive value of nuclear protein Ki-67 expression among patients with invasive breast cancers, involving the triple negative breast cancer subgroup, treated with neoadjuvant chemotherapy in correlation to the rate of pathological complete response. The proliferation marker Ki-67 expression was highest in the triple negative breast cancer subgroup. No appreciable difference in the rate of Ki-67 expression in triple negative breast cancer subgroup using either a cutoff of 14% or 35%. Triple negative breast cancer subgroup showed lower rates of pathological complete response. Achievement of pathological complete response was significantly correlated with smaller tumor size and higher Ki-67 expression. The majority of triple negative breast cancer cases achieved pathological partial response. The study concluded that Ki-67 is a useful tool to predict chemosensitivity in the setting of neoadjuvant chemotherapy for invasive breast cancer but not for the triple negative breast cancer subgroup.

• 대한두경부종양학회지
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• 제10권1호
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• pp.74-79
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• 1994

A Phase II study of UFT which is a mixture of Tegafur and Uracil was conducted in two institutions during past two years. Ninty-four patients of head and neck squamous cell carcinoma entered this trial, of which sixty-eight were evaluated. Among those, thirty-six cases were previously untreated and thirty-two cases were recurrent UFT was administrated orally at a daily dose of $400mg/m^2$ for eight weeks. The results were as following: 1) Overall response was 30.88%, but for 38.36% for 36 cases of the untreated cases, 21.88% for 32 cases of recurrent cases. 2) UFT was more effective in early stage and well differentiated squamous cell carcinoma and UFT tended to reduce the tumor size maximally at fourth or fifth week 3) There was no serious side effects except mild gastrointestinal disturbances such as nausea and vomiting, which were recovered immediately after stop or reducing a daily dose. Therefore, UFT therapy is clinically effective for head and neck squamous cell carcinoma and also may be useful for combination or palliative chemotherapy because of mild side effects.

• Journal of Chest Surgery
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• 제12권1호
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• pp.16-22
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• 1979

Clinical evaluation of contact sensitization to 2, 4-dinitro-chlorobenzene [DNCB] was performed in 2 groups: group A [30 patients with non-malignant disease] and group B [30 patients with bronchogenic carcinoma]. Initial sensitization was elicited out by applying 2, 000 ug of DNCB to skin surface of the both group A and B. Subsequently a relatively weak challenge dose, 200 ug of DNCB, was applied 14 days later, showing the satisfactory results of sensitization with minimizing non-specific irritative inflammatory skin response. Delayed cutaneous hypersensitivity reactions shown by spontaneous flare phenomena appeared at the challenge site, and they were assessed 48 hours later. The reaction were graded from +1 to +4 according to the degree of flare or vesicular reaction. The results were as follows: 1. 28 cases [93%] of group A, however, only 18 cases [67%] of group B exhibited delayed cutaneous hypersensitivity reaction to DNCB contact sensitization [P<0.02]. 2. Of group A, the delayed cutaneous hypersensitivity reactions above +2 of DNCB score were 25 cases [83%], meanwhile 11 cases [37%] in group B [P<0.001]. 3. Undifferentiated carcinomas showed highest incidence of anergy to DNCB contact sensitization in the all histologic types of group B. 4. In group B, 8 [42%] of 19 cases who react to DNCB were resectable, whereas only 2 [18 %] of 11 cases who failed to react to DNCB were resectable for curative cancer surgery. These study suggests that cellular immune reaction of group B was depressed remarkably comparing with that of group A.

• 대한치과보철학회지
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• 제29권2호
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• pp.211-223
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• 1991

This study was aimed to observe the histological changes of the edentulous and denture wearing alveolar ridge mucosa. The distribution of Langerhans cells was also observed to investigate the mucosal immune response by denture wearing. The mucosal tissues were obtained from of 12 cases of edentulous nondenture wearers(NDW), 7 cases of denture wearers(DW), and 12 cases of flabby tissues(FT). For the identification of Langerhans cells of the mucosal epithelia, the immunohistochemical stain for S-100 protein was applied. The results were as follows : 1. 7 cases among 12 cases of NDW showed hyperkeratosis, and 5 cases were covered by parakeratosis, whereas 3 cases among 7 cases of DW showed hyperkeratosis, and 4 cases showed parakeratosis on the mucosal epithelium. All cases of both DW and NDW demonstrated epithelial hyperplasia, except. 2 cases of DW, which showed epithelial atrophy. The content of glycogen in the epithelial layer showed the decrease in the group of DW. 2. Both NDW and DW showed the infiltration of chronic inflammatory cells. The collagen fibers tended to be arranged densely and irregularly in cases of denture wearing period more than 10 years. 3. FT showed variable epithelial changes from epithelial atrophy to marked hyperplasia, and the pattern of keratinization was also variable. The collagen fibers tended to be arranged irregularly. 4. The distribution of Langerhans cells showed the increase of 1.84-1.96 times in the group of DW compared with NDW group.