• Tuberculosis and Respiratory Diseases
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• 제71권6호
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• pp.476-479
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• 2011

The Streptococcus milleri group, which also includes S. anginosus, S. intermedius and S. constellatus, is found in the oropharynx, upper respiratory tract, gastrointestinal tract, and urogenital tract mucosa. Bacteria in the Streptococcus milleri group are associated with bacteremia and abscess formation. Most of the reports of of Streptococcus milleri group (SMG) infection occur in patients with underlying medical conditions. Predisposing factors that have been associated with S. milleri group empyema include mucosal disturbances (sinusitis, periodontal disease, enteric disease), preceding to pneumonia, thoracic surgery, malignancy, neurological disease, alcohol abuse, and also diabetes mellitus. We report on a 42-year-old man with mental retardation. He who suffered from dyspnea and a fever that he had developed for over 14 days. S. constellatus and anaerobic bacterias (Prevotella buccae and Micromonas micros) were cultured. The patient was treated with the drainage of pleural effusion and clindamycin and levofloxacin.

• Pediatric Infection and Vaccine
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• 제6권1호
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• pp.131-135
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• 1999

신생아 시기에 호흡기 바이러스 감염은 증상이 다양하게 나타나 진단하기가 힘든 면이 있으나 본 증례와 같이 뚜렷한 호흡기 증상이 있는 경우 적극적인 진단과 치료가 필요하다고 사료되며 고위험군 환자에게 RSV 유행 시기에 앞서 예방이 중요하다고 생각한다.

• Tuberculosis and Respiratory Diseases
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• 제39권2호
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• pp.194-198
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• 1992

Mycoplasma pneumoniae produces illness in man ranging from mild upper respiratory tract infection to severe bronchitis and pneumonia. We experienced a case of mycoplasma pneumonia complicated with acute respiratory failure, cold agglutinin hemolytic anemia, pleural effusion, Raynaud's phenominon and hepatitis in 27-year-old female. She was diagnosed as having mycoplasma pneumonia by detecting mycoplasma antibody and cold agglutinin test and treated effectively with erythromycin.

• Tuberculosis and Respiratory Diseases
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• 제77권5호
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• pp.219-222
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• 2014

Pneumatosis intestinalis (PI) is a very rare condition that is defined as the presence of gas within the subserosal or submucosal layer of the bowel. PI has been described in association with a variety of conditions including gastrointestinal tract disorders, pulmonary diseases, connective tissue disorders, organ transplantation, leukemia, and various immunodeficiency states. We report a rare case of a 74-year-old woman who complained of dyspnea during the management of acute asthma exacerbation and developed PI; but, it improved without any treatment.

• Clinical and Experimental Pediatrics
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• 제58권7호
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• pp.245-250
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• 2015

Purpose: Wheezing following viral lower respiratory tract infections (LRTIs) in children <2 years of age is an important risk factor for the development of asthma later in life; however, not all children with viral LRTIs develop wheezing. This study investigated risk factors for the development of wheezing during viral LRTIs requiring hospitalization. Methods: The study included 142 children <2 years of age hospitalized for LRTIs with at least one virus identified as the cause and classified them into children diagnosed with LRTIs with wheezing (n=70) and those diagnosed with LRTIs without wheezing (n=72). Results: There were no significant differences in the viruses detected between the two groups. Multivariate logistic regression analysis showed that, after adjusting for potentially confounding variables including sex and age, the development of wheezing was strongly associated with parental history of allergic diseases (adjusted odds ratio [aOR], 20.19; 95% confidence interval [CI], 3.22-126.48), past history of allergic diseases (aOR, 13.95; 95% CI, 1.34-145.06), past history of hospitalization for respiratory illnesses (aOR, 21.36; 95% CI, 3.77-120.88), exposure to secondhand smoke at home (aOR, 14.45; 95% CI, 4.74-44.07), and total eosinophil count (aOR, 1.01; 95% CI, 1.01-1.02). Conclusion: Past and parental history of allergic diseases, past history of hospitalization for respiratory illnesses, exposure to secondhand smoke at home, and total eosinophil count were closely associated with the development of wheezing in children <2 years of age who required hospitalization for viral LRTIs. Clinicians should take these factors into consideration when treating, counseling, and monitoring young children admitted for viral LRTIs.

• 동의생리병리학회지
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• 제19권4호
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• pp.1039-1045
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• 2005

In order to evaluate the in vivo synergic effect of Eunkyo-san which was a traditional poly-herbal formula has been used in the treatment of respiratory diseases in Korea, with quinolone antibiotics, ciprofloxacin (CPFX), the viable bacterial number and histopathological changes were monitored after experimental respiratory infection with S. pneumoniae ATCC 6303. The obtained results were as follows: In CPFX groups, the viable bacterial numbers were significantly decreased compared to that of control group and these were more dramatically decreased compared to that of single treatment with CPFX, respectively in concomitant treated groups with Eunkyo-san. In control group, severe infiltration of inflammatory cells, hemorrhage and hypertrophy of alveolar linings were demonstrated at microscopical levels. However, these abnormal histopathological changes were significantly decreased compared to that of control group in CPFX groups, and these were more dramatically decreased compared to that of single treatment with CPFX, respectively in concomitant treated groups with Eunkyo-san. In CPFX groups, the LSA (luminal surface of alveoli $\%$) were significantly increased compared to that of control group and these were more dramatically decreased compared to that of single treatment with CPFX, respectively in concomitant treated groups with Eunkyo-san. According to these results, it is considered as the in vivo antibacterial activity of CPFX was dramatically increased by concomitant use of Eunkyo-san against S. pneumoniae ATCC 6303 infection of respiratory tract.

• Pediatric Infection and Vaccine
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• 제19권2호
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• pp.71-78
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• 2012

목적: 보카바이러스는 2005년 소아의 비인두 흡입물에서 처음으로 발견된 호흡기 바이러스로서 현재 전세계적으로 발견되고 있고 국내에서도 보카바이러스 호흡기 감염증이 보고되고 있다. 이번 연구는 중합효소 연쇄 반응(PCR)을 이용한 보카바이러스의 분리 및 유전자 분석을 통하여 2010년 국내에서 유행하였던 보카바이러스의 계통 및 유전적 변이를 알아보고자 하였다. 방법: 2010년 1월부터 2010년 12월까지 세브란스 어린이병원에 하기도 감염증으로 입원한 소아에서 비인두 흡입 검체를 채취하였다. 다중 중합효소 연쇄 반응을 이용하여 12종의 바이러스에 대한 분자진단이 이루어졌고 이 중 보카바이러스 양성인 검체에 대하여 보카바이러스 1-4형에 특이적인 VP1/2 유전자 염기서열을 기반으로 하는 시발체를 이용한 중합효소 연쇄 반응을 시행하여 얻은 증폭산물의 염기서열분석을 확인하여 계통 분석을 시행하였다. 결과: 전체 953명의 소아 중 141명(14.8%)에서 보카바이러스가 검출되었고, 61.7%에서 다른 바이러스와의 중복감염을 보였다. 염기서열분석 결과 모두 보카바이러스 1형으로 확인되었고 보카바이러스 2, 3, 4형은 검출되지 않았다. 검출된 모든 보카바이러스의 염기서열들은 98% 이상의 염기유사도를 보였다. 결론: 2010년 국내에서 유행한 보카바이러스 호흡기 감염은 유전학적으로 모두 보카바이러스 1형에 의한 것이었고, 동정된 균주들은 높은 염기유사도를 보였다. 아직까지 국내에서 보카바이러스의 변이는 미미한 상태이지만 향후 보카바이러스 호흡기 감염의 유행시 지속적인 유전자형의 추적관찰이 필요하다.

• 한국임상수의학회지
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• 제17권1호
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• pp.32-44
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• 2000

The Korean native goat has been extensively used in the experimental work. Compared to those experimental work employing the goat, reports on their diseases have been scarcely documented. In the present communication, authors reviewed the literatures pertaining to the diseases of the Korean native goat. Diseases of the respiratory system, the alimentary tract, the liver, the musculoskeletal system, the skin, the urogenital system, the nervous system, the eye, and the heart were reviewed. And then metabolic, toxic, and parasitic diseases were reviewed. Of those diseases reviewed, diseases of the heart and kidney, and metabolic and toxic diseases were wholly artificially-induced. Except the parasitic diseases, a considerable number of diseases of other organ systems were also artificially-induced. And the parasitic diseases reported were confined to the internal parasites. Authors feel that the known occurrence of diseases would help diagnose new disease in the goat.

• Tuberculosis and Respiratory Diseases
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• 제46권6호
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• pp.861-868
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• 1999

재발성 다발성 연골염은 전신 연골에 염증반응을 특징으로 하는 드문 전신 질환으로, 대개 외이나 비부의 연골 침범이 가장 흔한 증상이나, 이러한 특징적 증상 없이 기도에 연골염의 형태로 발현하는 경우도 드물게 보고되어 있다. 저자들은 최근 64세 남자에서 흔히 발생하는 연골의 침범에 의한 전형적인 증상없이 미만성 기도 연골 침범으로 발현한 재발성 다발성 연골염 1예를 경험하였기에 문헌고찰과 함께 보고하는 바이다.

• IMMUNE NETWORK
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• 제21권1호
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• pp.11.1-11.10
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• 2021

Coronavirus causes an infectious disease in various species and crosses the species barriers leading to the outbreak of zoonotic diseases. Due to the respiratory diseases are mainly caused in humans and viruses are replicated and excreted through the respiratory tract, the nasal fluid and sputum are mainly used for diagnosis. Early diagnosis of coronavirus plays an important role in preventing its spread and is essential for quarantine policies. For rapid decision and prompt triage of infected host, the immunochromatographic assay (ICA) has been widely used for point of care testing. However, when the ICA is applied to an expectorated sputum in which antigens are present, the viscosity of sputum interferes with the migration of the antigens on the test strip. To overcome this limitation, it is necessary to use a mucolytic agent without affecting the antigens. In this study, we combined known mucolytic agents to lower the viscosity of sputum and applied that to alpha and beta coronavirus, porcine epidemic diarrhea virus (PEDV) and Middle East respiratory syndrome coronavirus (MERS-CoV), respectively, spiked in sputum to find optimal pretreatment conditions. The pretreatment method using tris(2-carboxyethyl)phosphine (TCEP) and BSA was suitable for ICA diagnosis of sputum samples spiked with PEDV and MERS-CoV. This sensitive assay for the detection of coronavirus in sputum provides an useful information for the diagnosis of pathogen in low respiratory tract.