• 대한한방내과학회지
• /
• 제40권4호
• /
• pp.567-581
• /
• 2019

Objective: This study aimed to evaluate the inhibitory effects of SGX01 on the lung injuries of COPD mice model. Materials and Methods: This study was carried out in two ways: in vitro and in vivo. In vitro, L929 cells were challenged with LPS, and then treated with six concentrations of SGX01 (10, 30, 50, 100, 300, and $500{\mu}g/ml$) and analyzed by ELISA. In vivo, C57BL/6 mice were challenged with LPS and cigarette smoking solution (CSS), and then treated with a vehicle only (control group), dexamethasone 3 mg/kg (dexa group), or a SGX01 200 mg/kg (SGX01 group). After sacrifice, the BALF or lung tissue was analyzed with Cytospin, FACS, ELISA, real-time PCR and H&E, and Masson's trichrome staining. Results: SGX01 significantly decreased NO, $TNF-{\alpha}$, and IL-6 on L929 cells challenged with LPS. In the COPD model, SGX01 significantly inhibited the increase of neutrophils, $TNF-{\alpha}$, IL-17A, CXCL-1, MIP2, CD8+ cells in BALF, and $TNF-{\alpha}$, $IL-1{\beta}$ mRNA expression in lung tissue. It also decreased the severity of the histological lung injury. Conclusion: This study suggests the usability of SGX01 for COPD patients by controlling lung tissue injury.

• 한국환경보건학회지
• /
• 제42권3호
• /
• pp.141-146
• /
• 2016

In South Korea, many cases of humidifier disinfectant-associated lung injury (HDLI) have been reported among people who used humidifier products containing humidifier disinfectant (HD). The objectives of this study are to estimate both airborne HD concentration in the room where HD was used and the amount of humidifier disinfectant absorbed into the respiratory system. Information and data on the HDs were collected using a structured questionnaire and home environmental investigations include the volume of HD (ml) and hours used per day, concentration of disinfectants contained in the HD brand (${\mu}g/ml$), volume of the room ($m^3$), assumed ventilation rate ($m^3/hr$) and breathing rate assumed ($m^3/hr$). We used children aged under five years old as a sample and estimated both airborne HD concentrations and amount of HD absorbed into the respiratory system. The estimated airborne concentration of HD in the room ranged from 68 to $369{\mu}g/m^3$ for PHMG (polyhexamethylene guanidine phosphate) and from 16 to $239{\mu}g/m^3$ for PGH (oligo (2-(2-ethoxy) ethoxyethyl guanidine). The amount of HD absorbed in the respiratory system per day was estimated to range from 227 to $1,225{\mu}g$ for PHMG and from 53 to $794{\mu}g$ for PGH. In conclusion, a great amount of HD was likely absorbed into respiratory system, likely beyond the level of the capacity of the immune system to remove the HD absorbed.

• 대한한방내과학회지
• /
• 제37권6호
• /
• pp.961-977
• /
• 2016

Objectives: This study was designed to analyze the treatment effects of Eunhwayeongyo-tang through retrospective chart reviews. We also checked the correlation between each pair of variables of the symptoms and curative rates of patients with cough. Methods: Thirty-three patients with cough who had satisfied the selection criteria were retrospectively reviewed through their basic medical records, nasal endoscopy, and questionnaires about cough on their first and second visits. The questionnaires used were "The questionnaire on clinical symptoms of cough & sputum", Leicester Cough Questionnaire Korean Version (LCQ-K), Total Nasal Symptom Scores (TNSS), Visual Analog Scale (VAS), and "Cold-heat patterns". The improvement rate, calculated by "The questionnaire on clinical symptoms of cough & sputum" was considered to be clinically effective if reduction of symptoms scored more than 30%. The state of nasopharyngeal mucosa was assessed to categorize the cold-heat patterns of the upper respiratory tract and for diagnosis. Results: According to this study, cough and sputum improved by $57.22{\pm}37.76%$. Most patients (76%) improved significantly after $12.18{\pm}6.59days$ of taking Eunhwayeongyo-tang. The cure rates of 26 patients among the 33 patients were judged as effective. All the mean scores of the questionnaires and the anterior nasal cavity states were significantly improved on the patients' second visits. After $18.39{\pm}15.68days$, 30 patients were completely cured and ended treatment. The nasopharyngeal mucosa states of all patients were categorized as heat patterns. Conclusions: The conditions of the patients with nasopharyngitis significantly improved after taking Eunhwayeongyo-tang. All of the patients had pharyngitis or rhinitis. The cold-heat pattern of nasopharyngeal mucosa was a significant indicator of upper respiratory inflammation diagnosis.

• 대한물리의학회지
• /
• 제8권4호
• /
• pp.559-566
• /
• 2013

PURPOSE: The present study examines how feedback respiratory exercise affects gait performance of stroke patients. METHODS: Forty stroke patients were randomly divided into an experiment group and a control group. For the former group, patients went through a half-hour of training therapy and a half-hour of feedback respiratory device exercise. For the latter group, patients went through 30 minutes of training therapy and a half-hour of motomed exercise. All participants had five training sessions each week for four weeks. For measurement, a GAITRite system was used to examine spatial parameters, and functional ambulation performance before and after the training. RESULT: In terms of spatial parameters, double support ratio, stance phase increased significantly in the experiment group after the walking exercise(p<.05). FAP rose more significantly in the experiment group than in the control group(p<.05). In comparison of two exercise groups, double support ratio, Stance phase, gait velocity, FAP was significant difference(p<.05). CONCLUSION: The experiment results showed that feedback respiratory exercise is effective in enhancing gait performance.

• KSII Transactions on Internet and Information Systems (TIIS)
• /
• 제13권11호
• /
• pp.5527-5545
• /
• 2019

Through-wall ultra-wide band (UWB) radar has been considered as one of the preferred and non-contact technologies for the targets detection owing to the better time resolution and stronger penetration. The high time resolution is a result of a larger of bandwidth of the employed UWB pulses from the radar system, which is a useful tool to separate multiple targets in complex environment. The article emphasised on human subject localization and detection. Human subject usually can be detected via extracting the weak respiratory signals of human subjects remotely. Meanwhile, the range between the detection object and radar is also acquired from the 2D range-frequency matrix. However, it is a challenging task to extract human respiratory signals owing to the low signal to clutter ratio. To improve the feasibility of human respiratory signals detection, a new method is developed via analysing the standard deviation based kurtosis of the collected pulses, which are modulated by human respiratory movements in slow time. The range between radar and the detection target is estimated using joint time-frequency analysis (JTFA) of the analysed characteristics, which provides a novel preliminary signature for life detection. The breathing rates are obtained using the proposed accumulation method in time and frequency domain, respectively. The proposed method is validated and proved numerically and experimentally.

• 대한임상독성학회지
• /
• 제18권1호
• /
• pp.42-46
• /
• 2020

Tetramine toxicity due to sea snail ingestion is generally mild and has a good prognosis. Tetramine toxicity acts on the acetylcholine receptor, affecting the neuromuscular junction and autonomic nervous system. A 78-year-old female patient visited the emergency room with vomiting and dyspnea after eating sea snails. At the time of admission, the vital signs recorded were 140/80 mmHg-105/min-24/min-36.5℃, and 90% oxygen saturation. Arterial blood test revealed hypercapnia (pCO₂ 58.2 mmHg) and respiratory acidosis (pH 7.213, HCO₃^- 22.5 mmol/L), whereas other blood tests showed no specific findings. Due to decreased consciousness and hypoxia, endotracheal intubation and mechanical ventilation were administered to the patient. Successful weaning was accomplished after 12 hrs, and the patient was discharged without any further complications. Although tetramine toxicity rarely results in acute respiratory failure due to paralysis of the respiratory muscle, caution is required whilst treating the patient.

• Child Health Nursing Research
• /
• 제15권3호
• /
• pp.291-298
• /
• 2009

Purpose: Effects of information on management practices for children suffering from respiratory communicable diseases and their parents were investigated. Methods: The experimental group consisted of 30 children who were in-patients suffering from a respiratory communicable disease and their parents. During their hospitalization, for 30 min each day, the children and their parents received education that included information about disease management including symptoms, prevention and environmental hygiene. The information was developed using illustrations and photoshop. The control group consisted of 30 children who were in-patients and their parents. They received the usual nursing care without any of the above education. The instruments used in this study were the bibliographies of respiratory disease management. ${\chi}^2$ test, independent t-test, and Mann-Whitney U test with SPSS 11.5 were used to analyze the data. Results: Significant differences between the experimental and control groups were found for management of symptoms (Z=4.350, ,0<.001) and environmental hygiene (Z=4.033, p=.000), but not for prevention (Z=4.033, p=.149). Conclusion: The results indicate that providing information was effective for management practice of symptoms and environmental hygiene, but not for prevention management for the children and their parents. Therefore programs should be developed to promote prevention management.

• 간호행정학회지
• /
• 제12권2호
• /
• pp.181-188
• /
• 2006

Purpose: The purpose of study was to determine differences in patient outcomes that exists in terms of Nursing Outcomes Classification (NOC) during hospital days of neurosurgical and respiratory patients. Method: Before starting clinical practicum, nursing students were received two hours' lecture on how to apply NOC to patient care plan and they were required to evaluate patient condition using NOC at the beginning and at the end of their clinical practicum. Data were extracted from 62 neurosurgical patients and 66 respiratory patients and analyzed by frequency and paired t-test. Results: The most frequently used NOC were Pain Level (37.1%), Mobility Level (25.8%), and Bowel Elimination (19.4%) in neurosurgical patients and Nutritional Status (37. 9%), Respiratory Status: Ventilation (37.9%) and Pain Level (25.8%) in respiratory patients. The numbers of outcomes used were 75 and 46 neurosurgical and respiratory patients respectively. During the hospital days, the level of patient outcomes increased significantly in all patient groups. Conclusion: The finding clearly suggests that nursing interventions make differences in patient outcomes and make contribution to the patient health achieved. To more effectively use NOC, however, nursing information system should be developed and included standardized nursing languages regarding nursing diagnoses and interventions.

• Childhood Kidney Diseases
• /
• 제25권2호
• /
• pp.122-127
• /
• 2021

C1q nephropathy is a rare glomerulopathy that typically presents with nephrotic syndrome in children. Treatment with immunosuppressive agents renders patients vulnerable to infection and its complications. Gastroenteritis is common in children, and rotavirus is a leading cause. Extraintestinal manifestations of rotavirus have recently been reported; however, there is a paucity of cases exploring the involvement of a rotavirus on the respiratory system. Acute respiratory distress syndrome (ARDS) is a rapid onset respiratory failure characterized by noncardiogenic pulmonary edema and hypoxemia. Causes of ARDS include sepsis, pneumonia, pancreatitis, aspiration, and trauma. In this paper, we report a case of ARDS after rotavirus infection in a child with C1q nephropathy who had been treated with immunosuppressive agents.

• Journal of Preventive Medicine and Public Health
• /
• 제10권1호
• /
• pp.102-108
• /
• 1977

A study on the sickness distribution and mode of treatment in rural area was conducted during the period from July '75 to Aug. '75 using 1,225 households, 7,918 population (4,017 male, 3,901female) and 343 cases th at found during the period of survey who had beenlived in Nammyon, Hwasoongun, Chonnam. The summarized results were as follows : 1. Average family number per household was 6.5 and prevalence rate was 43.3 (21.2 for male, 22.1 for female). 2. General sickness distribution by classification of disease according to W.H.O. was highest in disease of the nervous system and sense organs (21.3%), and important others were disease of the digestive system (16.9%) and disease of the respiratory system(14.8%). In male, distribution was in order of downward disease of digestive system, disease of nervous system and sense organs, disease of skin, cellular tissue, bones and organs of movement, and disease of respiratory system. In female, distribution was in order of downward disease of nervou s system and sense organs, disease of respiratory system, disease of digestive system, and disease of skin, cellular tssue, bones and organs of movement. 5. Types of treatment in both sexes were showed that home and folkmedicine (41.1%), pharmacy(24.5%), admission to hospital or clinic (16.9%), out-patient clinic (10.8%) and herbmedicine (6.7%) in downward order. Hospital and clinic utility rate was 27.5% (31.5 for male, 24.0 for female) and it was highest in 0-4 age groups and lowest in 40-49 year age groups. 4. Hospital and clinic utility rate was highest in neoplasms, and the other hands, disease of the nervous system and sense organs and disease of the digestive system were the highest groups in the all types of treatment other than hospital and clinic. 5. On the results of treatment not, exactly replied answer was the highest (41.7%) and only 16.0% said complete recovery. In completely recovered cases, hospital and clinic using group was predominant (58.2%) and in aggravated cases, home and folkmedicine using group was highest.