• Title/Summary/Keyword: Resistant model

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Modeling of composite MRFs with CFT columns and WF beams

  • Herrera, Ricardo A.;Muhummud, Teerawut;Ricles, James M.;Sause, Richard
    • Steel and Composite Structures
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    • v.43 no.3
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    • pp.327-340
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    • 2022
  • A vast amount of experimental and analytical research has been conducted related to the seismic behavior and performance of concrete filled steel tubular (CFT) columns. This research has resulted in a wealth of information on the component behavior. However, analytical and experimental data for structural systems with CFT columns is limited, and the well-known behavior of steel or concrete structures is assumed valid for designing these systems. This paper presents the development of an analytical model for nonlinear analysis of composite moment resisting frame (CFT-MRF) systems with CFT columns and steel wide-flange (WF) beams under seismic loading. The model integrates component models for steel WF beams, CFT columns, connections between CFT columns and WF beams, and CFT panel zones. These component models account for nonlinear behavior due to steel yielding and local buckling in the beams and columns, concrete cracking and crushing in the columns, and yielding of panel zones and connections. Component tests were used to validate the component models. The model for a CFT-MRF considers second order geometric effects from the gravity load bearing system using a lean-on column. The experimental results from the testing of a four-story CFT-MRF test structure are used as a benchmark to validate the modeling procedure. An analytical model of the test structure was created using the modeling procedure and imposed-displacement analyses were used to reproduce the tests with the analytical model of the test structure. Good agreement was found at the global and local level. The model reproduced reasonably well the story shear-story drift response as well as the column, beam and connection moment-rotation response, but overpredicted the inelastic deformation of the panel zone.

Sensitivity Analysis on Ecological Factors Affecting Forest Fire Spreading: Simulation Study (산불확산에 영향을 미치는 생태학적 요소들간의 민감도 분석: 시뮬레이션 연구)

  • Song, Hark-Soo;Lee, Sang-Hee
    • Korean Journal of Agricultural and Forest Meteorology
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    • v.15 no.3
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    • pp.178-185
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    • 2013
  • Forest fires are expected to increase in severity and frequency under global climate change and thus better understanding of fire dynamics is critical for mitigation and adaptation. Researchers with different background, such as ecologists, physicists, and mathematical biologists, have developed various simulation models to reproduce forest fire spread dynamics. However, these models have limitations in the fire spreading because of the complicated factors such as fuel types, wind, and moisture. In this study, we suggested a simple model considering the wind effect and two different fuel types. The two fuels correspond to susceptible tree and resistant tree with different probabilities of transferring fire. The trees were randomly distributed in simulation space with a density ranging from 0.0 (low) to 1.0 (high). The susceptible tree had higher value of the probability than the resistant tree. Based on the number of burnt trees, we then carried out the sensitivity analysis to quantify how the forest fire patterns are affected by wind and tree density. The statistical analysis showed that the total tree density had greatest effect on the forest fire spreading and wind had the next greatest effect. The density of the susceptible tree was relatively lower factor affecting the forest fire. We believe that our model can be a useful tool to explore forest fire spreading patterns.

3D-QSAR Analysis on the Fungicidal Activity of N-phenyl-O-phenylthionocarbamate Analogues against Gray Mold (Botrytis cinerea) (잿빛곰팡이병균(Botrytis cinerea)에 대한 N-Phenyl-O-phenyl-thionocarbamate 유도체들의 살균활성에 관한 3D-QSAR 분석)

  • Sung, Nack-Do;Park, Kee-Han;Jang, Seok-Chan;Soung, Min-Kyu
    • The Korean Journal of Pesticide Science
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    • v.11 no.2
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    • pp.59-66
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    • 2007
  • Three dimensional quantitative structure-activity relationships (3D-QSARs) on the fungicidal activity of N-phenyl-O-phenylthionocarbamate analogues against resistant and sensitive gray mold (Botrytis cinerea) (RBC & SBC) were studied quantitatively using CoMFA and CoMSIA methods. The correlation coefficient and predict- ability of optimized CoMFA model with the atom based fit alignment were better ($r^2$ & $q^2=CoMFA{\gg}CoMSIA$) than that of CoMSIA model. And statistical values of the models on the fungicidal activity against SBC were showed higher ($r^2=SBC{\gg}RBC$) than that of RBC. In CoMFA models, steric field on the activity was more influenced than electrostatic field. And in case of CoMSIA models, the influence of CoMSIA field on the activity against RBC and SBC was differ from each other but the influence of H-bond donor field was same to the two fungi. It is revealed that the selectivity factor with CoMFA model on the fungicidal activity between the two fungi was caused on the difference of steric field. Therefore, it is predicted that the large steric field with meta- and para-substituents on the N-phenyl ring will be improved to the fungicidal activity with SBC.

Assessment of Lodged Damage Rate of Soybean Using Support Vector Classifier Model Combined with Drone Based RGB Vegetation Indices (드론 영상 기반 RGB 식생지수 조합 Support Vector Classifier 모델 활용 콩 도복피해율 산정)

  • Lee, Hyun-jung;Go, Seung-hwan;Park, Jong-hwa
    • Korean Journal of Remote Sensing
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    • v.38 no.6_1
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    • pp.1489-1503
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    • 2022
  • Drone and sensor technologies are enabling digitalization of agricultural crop's growth information and accelerating the development of the precision agriculture. These technologies could be able to assess damage of crops when natural disaster occurs, and contribute to the scientification of the crop insurance assessment method, which is being conducted through field survey. This study was aimed to calculate lodged damage rate from the vegetation indices extracted by drone based RGB images for soybean. Support Vector Classifier (SVC) models were considered by adding vegetation indices to the Crop Surface Model (CSM) based lodged damage rate. Visible Atmospherically Resistant Index (VARI) and Green Red Vegetation Index (GRVI) based lodged damage rate classification were shown the highest accuracy score as 0.709 and 0.705 each. As a result of this study, it was confirmed that drone based RGB images can be used as a useful tool for estimating the rate of lodged damage. The result acquired from this study can be used to the satellite imagery like Sentinel-2 and RapidEye when the damages from the natural disasters occurred.

Establishment of an Efficient Agrobacterium Transformation System for Eggplant and Study of a Potential Biotechnologically Useful Promoter

  • Claudiu Magioli;Ana Paula Machado da Rocha;Pinheiro, Marcia-Margis;Martins, Gilberto-Sachetto;Elisabeth Mansur
    • Journal of Plant Biotechnology
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    • v.2 no.1
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    • pp.43-49
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    • 2000
  • An efficient and reliable Agrobacterium transformation procedure based on TDZ (thidiazuron)-induced organogenesis was established and applied to six Brazilian eggp1ant varieties. Optimum transgenic plants recovery was achieved upon the study of the following parameters affecting transformation efficiency, using F-100 variety as a model: i) explant source; ii) pre-culture period; iii) physical state of the pre-culture medium and iv) coculture conditions. The highest frequency of kanamycin-resistant calli derived from leaf explants (5%) was obtained without a pre-culture period and co-cultivation for 24 h in liquid medium followed by five days on solid RM (regeneration medium). For cotyledon explants, best results were achieved upon a pre-culture of 24 h in liquid RM and a co-cultivation period of 24 h in liquid RM followed by three days in solid RM, resulting in a transformation Sequency of 22.7%. Kanamycin-resistant organogenic calli were also obtained from cultivars Emb, Preta Comprida, Round nose Shaded, Campineira and Florida Market. The expression pattern of an epidermis-specific promoter was studied using transformants expressing a chimaeric construct comprised by the promoter Atgrp-5 transcriptionally fused to the coding region of the gus gene. The expression pattern was similar to that previously observed in tobacco and Arabidopsis thaliana, with preferential expression at the epidermis and the stem phloem. These results support the idea that the Atgrp-5 promoter can be used to drive defense genes in these tissues, which are sites of pathogen interaction and spread, in programs for the genetic improvement of eggplant.

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Gene flow from herbicide resistant genetically modified rice to conventional rice (Oryza sativa L.) cultivars

  • Han, Sung Min;Lee, Bumkyu;Won, Ok Jae;Hwang, Ki Seon;Suh, Su Jeoung;Kim, Chang-Gi;Park, Kee Woong
    • Journal of Ecology and Environment
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    • v.38 no.4
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    • pp.397-403
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    • 2015
  • Rice (Oryza sativa L.) is an important feeding crop in Asia, and utilization of genetically modified (GM) rice is highly demanding. For co-existence of GM rice and non-GM rice, the proper confinement measures should be provided. Thus, we surveyed gene flow from herbicide resistant GM rice to the conventional rice cultivars in the field tests. Gene flow frequency decreased with increasing distance between the pollen donor and recipients and did not exceed more than 1% even at the nearest distance. In single recipient model plot, a maximum gene flow frequency was observed at the shortest distance and hybrid was detected up to 12 m from the pollen donor. The direction of gene was coincided with the dominant wind direction. Gene flow assessment to multiple recipient plots was conducted under the high raining season by chance, and abrupt decline of gene flow frequency and maximum distance were resulted. According to the survey results, current regulation for isolation distance is reasonable for environmental safety or for general crop production. However, we suggest an alternative measure for GM rice cultivation that should be supplemented to overcome the out of estimation and in the environment asking higher security levels.

Up-regulation of HOXB cluster genes are epigenetically regulated in tamoxifen-resistant MCF7 breast cancer cells

  • Yang, Seoyeon;Lee, Ji-Yeon;Hur, Ho;Oh, Ji Hoon;Kim, Myoung Hee
    • BMB Reports
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    • v.51 no.9
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    • pp.450-455
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    • 2018
  • Tamoxifen (TAM) is commonly used to treat estrogen receptor (ER)-positive breast cancer. Despite the remarkable benefits, resistance to TAM presents a serious therapeutic challenge. Since several HOX transcription factors have been proposed as strong candidates in the development of resistance to TAM therapy in breast cancer, we generated an in vitro model of acquired TAM resistance using ER-positive MCF7 breast cancer cells (MCF7-TAMR), and analyzed the expression pattern and epigenetic states of HOX genes. HOXB cluster genes were uniquely up-regulated in MCF7-TAMR cells. Survival analysis of in slico data showed the correlation of high expression of HOXB genes with poor response to TAM in ER-positive breast cancer patients treated with TAM. Gain- and loss-of-function experiments showed that the overexpression of multi HOXB genes in MCF7 renders cancer cells more resistant to TAM, whereas the knockdown restores TAM sensitivity. Furthermore, activation of HOXB genes in MCF7-TAMR was associated with histone modifications, particularly the gain of H3K9ac. These findings imply that the activation of HOXB genes mediate the development of TAM resistance, and represent a target for development of new strategies to prevent or reverse TAM resistance.

Multi-body Dynamic Analysis for Tripod Constant Velocity Joint (트라이포드 타입 등속조인트의 다물체 동역학 해석)

  • Song, Myung-Eui;Lim, Young-Hun;Cho, Hui-Je;Bae, Dae-Sung
    • Transactions of the Korean Society of Automotive Engineers
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    • v.18 no.1
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    • pp.1-7
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    • 2010
  • The paper proposes a multi-body dynamic simulation to numerically evaluate the generated axial force(G.A.F) and plunging resistant force(P.R.F) practically related to the shudder and idling vibration of an automobile. A numerical analysis of two plunging types of CV joints, tripod joint(TJ) and very low axial tripod joint(VTJ), is conducted using the commercial program DAFUL. User-defined subroutines of a friction model illustrating the contacted parts of the outboard and inboard joint are subsequently developed to overcome the numerical instability and improve the solution performance. The Coulomb friction effect is applied to describe the contact models of the lubricated parts in the rolling and sliding mechanisms. The numerical results, in accordance with the joint articulation angle variation, are validated with experimentation. The offset between spider and tulip housing is demonstrated to be the critical role in producing the 3rd order component of the axial force that potentially causes the noise and vibration in vehicle. The VTJ shows an excellent behavior for the shudder when compared with TJ. In addition, a flexible nonlinear contact analysis coupled with rigid multi-body dynamics is also performed to show the dynamic strength characteristics of the rollers, housing, and spider.

Study on Environmental Risk Assessment for Potential Effect of Genetically Modified Nicotiana benthamiana Expressing ZGMMV Coat Protein Gene

  • Kim, Tae-Sung;Yu, Min-Su;Koh, Kong-Suk;Oh, Kyoung-Hee;Ahn, Hong-Il;Ryu, Ki-Hyun
    • The Plant Pathology Journal
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    • v.22 no.4
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    • pp.353-359
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    • 2006
  • Transgenic Nicotiana benthamiana plants harboring the coat protein(CP) gene of Zucchini green mottle mosaic virus(ZGMMV) were chosen as a model host for the environmental risk assessment of genetically modified plants with virus resistance. This study was focused on whether new virus type may arise during serial inoculation of one point CP mutant of ZGMMV on the transgenic plants. In vitro transcripts derived from the non-functional CP mutant were inoculated onto the virus-tolerant and -susceptible transgenic N. benthamiana plants. Any notable viral symptoms that could arise on the inoculated transgenic host plants were not detected, even though the inoculation experiment was repeated a total of ten times. This result suggests that potential risk associated with the CP-expressiing transgenic plants may not be significant. However, cautions must be taken as it does not guarantee environmental safety of these CP-mediated virus-resistant plants, considering the limited number of the transgenic plants tested in this study. Further study at a larger scale is needed to evaluate the environmental risk that might be associated with the CP-mediated virus resistant plant.

A comparison of the forces on dome and prism for straight and tornadic wind using CFD model

  • Yousef, Majdi A.A.;Selvam, Panneer R.;Prakash, Jai
    • Wind and Structures
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    • v.26 no.6
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    • pp.369-382
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    • 2018
  • Tornadoes are vertical swirling air formed because of the existence of layers of air with contrasting features of temperature, wind flow, moisture, and density. Tornadoes induce completely different wind forces than a straight-line (SL) wind. A suitably designed building for an SL wind may fail when exposed to a tornado-wind of the same wind speed. It is necessary to design buildings that are more resistant to tornadoes. In tornado-damaged areas, dome buildings seem to have less damage. As a dome structure is naturally wind resistant, domes have been used in back yards, as single family homes, as in-law quarters, man caves, game rooms, storm shelters, etc. However, little attention has been paid to the tornadic wind interactions with dome buildings. In this work, the tornado forces on a dome are computed using Computational Fluid Dynamics (CFD) for tornadic and SL wind. Then, the interaction of a tornado with a dome and a prism building are compared and analyzed. This work describes the results of the tornado wind effect on dome and prism buildings. The conclusions drawn from this study are illustrated in visualizations. The tornado force coefficients on a dome building are larger than SL wind forces, about 120% more in x- and y-directions and 280% more in z-direction. The tornado maximum pressure coefficients are also higher than SL wind by 150%. The tornado force coefficients on the prism are larger than the forces on the dome, about 100% more in x- and y-directions, and about 180% more in z-direction. The tornado maximum pressure coefficients on prism also are greater those on dome by 150% more. Hence, a dome building has less tornadic load than a prism because of its aerodynamic shape.