• Biomedical Science Letters
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• v.16 no.4
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• pp.331-339
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• 2010

This study aims to evaluate the effect of Photodynamic Therapy (PDT) against methicillin-resistant Staphylococcus aureus with high-level mupirocin resistance (Hi-Mup MRSA). To examine the antimicrobial effect of photogem-mediated PDT against Hi-Mup MRSA, CFU quantifications, bacteria cell viability tests, and disk diffusion antimicrobial susceptibility tests were evaluated. In addition, one of PDT mechanisms was investigated by accumulating photogem ($10\;{\mu}g/ml$) in Hi-Mup MRSA. Photogem-mediated PDT properly inhibited the colony formation of Hi-Mup MRSA. Viable bacteria decreased greatly after a PDT application with photogem $10\;{\mu}g/ml$ at energy density $15\;J/cm^2$. The diameter of the inhibition zone around susceptible disks increased after PDT. In addition, we confirmed the accumulation of photogem in bacteria through fluorescent images. These results demonstrated that excellent photosensitization of Hi-Mup MRSA can be achieved using photogem with 630 nm LED irradiation. Thus, PDT may make survival Hi-Mup MRSA inactive.

• Horticultural Science & Technology
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• v.35 no.2
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• pp.243-251
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• 2017

Plants have evolved to adapt to abiotic stresses, such as salt, cold, and drought stress. In this study, we conducted an in-depth analysis of drought resistance mechanisms by constructing a gene co-expression network in Chinese cabbage (Brassica rapa ssp. pekinensis L.). This drought stress co-expression network has 1,560 nodes, 4,731 edges, and 79 connected components. Based on genes that showed significant co-expression in the network, drought tolerance was associated with the induction of reactive oxygen species removal by raffinose family oligosaccharides and inositol metabolism. This network could be a useful tool for predicting the functions of genes involved in drought stress resistance in Chinese cabbage.

• International Journal of Concrete Structures and Materials
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• v.5 no.1
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• pp.57-64
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• 2011

An extensive database has been constructed of reinforced concrete (RC) beam-column connection tests subjected to cyclic lateral loading. All cases within the database experienced joint shear failure, either in conjunction with or without yielding of longitudinal beam reinforcement. Using the experimental database, envelope curves of joint shear stress vs. joint shear strain behavior have been created by connecting key points such as cracking, yielding, and peak loading. Various prediction approaches for RC joint shear behavior are discussed using the constructed experimental database. RC joint shear strength and deformation models are first presented using the database in conjunction with a Bayesian parameter estimation method, and then a complete model applicable to the full range of RC joint shear behavior is suggested. An RC joint shear prediction model following a U.S. standard is next summarized and evaluated. Finally, a particular joint shear prediction model using basic joint shear resistance mechanisms is described and for the first time critically assessed.

• Corrosion Science and Technology
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• v.3 no.6
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• pp.240-244
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• 2004

Recently a variety of electrochemical techniques have been used for the measurement of under-film corrosion of coated steel. Each method has its own characteristic and is suitable to determine some kinds of anti-corrosive mechanisms of coating film. We developed a new under-film corrosion tester (UFCT) which adoped current interrupter technique in principle. Electrochemical parameters can be measured by UFCT. It is possible for the novel under-film corrosion tester to evaluate under-film corrosion of steel covered with high electric resistance coating film which has no defect and is not easy to evaluate it by other methods. Finally some experimental results of protective coating performance obtained by UFCT were discussed.

• Proceedings of the Korean Powder Metallurgy Institute Conference
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• 2006.09b
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• pp.1132-1133
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• 2006

Metal-bonded diamond impregnated tools are being increasingly used in the processing of stone and ceramics, road repair, petroleum exploration, etc. Although the main tool wear mechanisms have been identified, the scientific background is inadequate and fundamental research has to be carried out to better understand the tool field behaviour. This work addresses the complex issues of modelling abrasive wear of the metallic matrix under laboratory conditions. The generated data indicates that the matrix wear resistance can be assessed in a simple manner; whereas tests carried out on diamond impregnated specimens may aid prediction of the tool life in abrasive applications.

• Geotechnical Engineering
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• v.2 no.3
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• pp.15-26
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• 1986

A great number of different pile-driving formulas are widely used to determine the load-carr-ying capacity during driving. However, engineers have been unable to agree on any particular pile.driving formula because the mechanisms of pile driving action which involves many complications such as hammer-pile-soil interaction could not be solved completely in any practical manner. This paper is presented for the purpose of giving field engineers a reliable analytical procedures for the prediction of pile.driving resistance without resort to electronic computers based on the theory of longitudinal wave transmission in conjunction with the wave equation and on the consideration of the effect of residual stresses induced by reversed friction in pile.

• Journal of Korean Society for Quality Management
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• v.25 no.2
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• pp.15-27
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• 1997

This paper describes a highly accelerated life test (HALT, USPCBT) method for rapid qualification testing of STH PWB(Silver Through Hole Printed Wiring Boards). This method was carried out to be an alternative to the present time-consuming standard 1344 hours life testing(THB). The accelerated life test conditions were $121^{\circ}C$/95%R.H. at 50V bias and without bias. Their results are compared with those observed in the standard 1344 hours life test at $40^{\circ}C$/95%R.H. at 50V bias and without bias. The studies were focused on the samples time-to-failure as well as the associated conduction and failure mechanisms. The abrupt drop of insulation resistance is due to the absorption of water vapour. And the continuous drop of insulation resistance is due to the Ag migration. The ratios of time-to-failure of HALT(USPCBT) to THB were 25 and 11 at 50V bias and without bias respectively.

• Structural Engineering and Mechanics
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• v.56 no.2
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• pp.157-167
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• 2015

The impact behavior of epoxy-based nanocomposites reinforced with carbon nano tube (CNT), carbon nano fiber (CNF) and mixed contents of these nanoparticles was investigated using Izod impact test. The results showed that while the impact strength of nanocomposites containing 1 wt% of CNT and 1 wt% of CNF increased 19% and 13% respectively, addition of mixed contents of these nanofillers (0.5-0.5 wt%) demonstrated higher improvement (21%) in the impact resistance. The trend of the results is explained on the basis of different fracture mechanisms of nanocomposites. Furthermore, the fracture surface of specimens and the dispersion state of nanoenhancers have been studied using scanning electron microscopy (SEM) photographs.

• Microbiology and Biotechnology Letters
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• v.49 no.4
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• pp.467-477
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• 2021

Staphylococcus aureus is a well-known pathogen that can cause diseases in humans. It can cause both mild superficial skin infections and serious deep tissue infections, including pneumonia, osteomyelitis, and infective endocarditis. To establish host infection, S. aureus manages a complex regulatory network to control virulence factor production in both temporal and host locations. Among these virulence factors, staphyloxanthin, a carotenoid pigment, has been shown to play a leading role in S. aureus pathogenesis. In addition, staphyloxanthin provides integrity to the bacterial cell membrane and limits host oxidative defense mechanisms. The overwhelming rise of Staphylococcus resistance to routinely used antibiotics has necessitated the development of novel anti-virulence agents to overcome this resistance. This review presents an overview of the chief virulence determinants in S. aureus. More attention will be paid to staphyloxanthin, which could be a possible target for anti-virulence agents.

• Natural Product Sciences
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• v.28 no.3
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• pp.93-104
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• 2022

Methicillin-resistant Staphylococcus aureus (MRSA) is a serious threat to the global healthcare system. Ineffective and resistance to antibiotic treatments have increased morbidity and mortality rates worldwide. New and effective antibiotics are needed to combat against bacterial resistance. Endophytic fungi are crucial reservoirs of novel bioactive metabolites. In particular, the secondary metabolites show promising therapeutic potential, notably, antibacterial. This review discussed the emerging potential of endophytic fungi as anti-MRSA agents. The ecological sources of endophytic fungi were discussed with the synthesis of bioactive metabolites. The mode of antibacterial actions was elucidated to give a better understanding of the mechanisms involved. This review may serve as an important reference for future discovery and developments of anti-MRSA agents from endophytic fungi.