• Title/Summary/Keyword: Resistance mechanisms

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Identification of shear transfer mechanisms in RC beams by using machine-learning technique

  • Zhang, Wei;Lee, Deuckhang;Ju, Hyunjin;Wang, Lei
    • Computers and Concrete
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    • v.30 no.1
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    • pp.43-74
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    • 2022
  • Machine learning technique is recently opening new opportunities to identify the complex shear transfer mechanisms of reinforced concrete (RC) beam members. This study employed 1224 shear test specimens to train decision tree-based machine learning (ML) programs, by which strong correlations between shear capacity of RC beams and key input parameters were affirmed. In addition, shear contributions of concrete and shear reinforcement (the so-called Vc and Vs) were identified by establishing three independent ML models trained under different strategies with various combinations of datasets. Detailed parametric studies were then conducted by utilizing the well-trained ML models. It appeared that the presence of shear reinforcement can make the predicted shear contribution from concrete in RC beams larger than the pure shear contribution of concrete due to the intervention effect between shear reinforcement and concrete. On the other hand, the size effect also brought a significant impact on the shear contribution of concrete (Vc), whereas, the addition of shear reinforcements can effectively mitigate the size effect. It was also found that concrete tends to be the primary source of shear resistance when shear span-depth ratio a/d<1.0 while shear reinforcements become the primary source of shear resistance when a/d>2.0.

Radiation Effects on Polypropylene for Biomedical Application (Polypropylene의 방사선멸균에있어 제 첨가제들에 의한 영향)

  • Khang, Gil-Son;Lee, Hai-Bang
    • Proceedings of the KOSOMBE Conference
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    • v.1995 no.11
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    • pp.134-137
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    • 1995
  • Studies on the formulations of the additives such as antioxidants, crosslinking agent, and trans-stilbeneoxide (StO) with polypropylene (PP) have been carried out to improve the resistance of gamma radiation sterilization. The irradiated PP and ethylene-propylene copolymers samples with control and additives were characterized by mechanical tester, colorimetry, and Fourier transform infrared spectroscopy with total attenuated reflectance mode (FTIR-ATR). Crosslinking agent and StO formulated PP showed remarkable radiation resistance and minimum discoloration. Also, radiation resistance of ethylene propylene copolymers with 3% of ethylene contents was better than that of PP homopolymers in the case of no additives. The proposed mechanisms of radiation stabilization with additives are also discussed.

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Hydrolysis Resistance and Mechanical Property Changes of Glass Fiber Filled Polyketone Composites Upon Glass Fiber Concentration

  • Kim, Sung Min;Kim, Kwang-Jea
    • Elastomers and Composites
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    • v.52 no.1
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    • pp.1-8
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    • 2017
  • Hydrolysis resistance and mechanical property changes of polyketone (POK)/glass fiber (GF) composites were investigated for GF concentrations varying between 30 and 50%. The hydrolysis resistance of GF filled POK and polyamide66 (PA66, hydrolysis resistant grade) composites were compared. As shown by the experimental results, increasing the immersion time of the composites in a monoethylene glycol (MEG)/water solution at $120^{\circ}C$ had no impact or resulted in slightly decreased mechanical properties such as the tensile strength, tensile modulus, and strain at break in case of POK composites, whereas the mechanical properties of PA66 composites showed a significant drop. Increasing GF concentrations increased the tensile strength, tensile modulus, flexural strength, and flexural modulus of POK composites; however, impact strength did not show significant changes. Hydrolysis mechanisms of POK and PA66 are discussed.

Restriction-modification system and genetic variability of Xanthomonas oryzae pv. oryzae

  • Choi, Seong-Ho
    • Proceedings of the Korean Society of Plant Pathology Conference
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    • 1995.06b
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    • pp.21-25
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    • 1995
  • ;Bacterial blight caused by Xanthomonas oryzae pv. Olyzae is one of the most important diseases of rice. Host resistance, which relies on single, dominant resistance genes, is the only reliable method to control the disease at present. Pathogenic variation of the bacteria has been shown to follow the deployment of resistance genes in commercial cultivars. Information on the factors and the mechanisms for genetic variation of this pathogen is limited. Further, we have no clear evidence of whether population variability is due to sexual recombination or to variation introduced by mutations or intragenic recombination in a clonally maintained population.(omitted)itted)

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Relationship Between Plant Viral Encoded Suppressor to Post-transcriptional Gene Silencing and Elicitor to R Gene-specific Host Resistance

  • Park, Chang-Won;Feng Qu;Tao Ren;T. Jack Morris
    • The Plant Pathology Journal
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    • v.20 no.1
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    • pp.22-29
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    • 2004
  • Many important horticultural and field crops are susceptible to virus infections or may possess a degree of resistance to some viruses, but become infected by others. Plant viruses enter cells through the presence of wounds, and replicate intracellularly small genomes that encode genes required for replication, cell-to-cell movement and encapsidation. There are numerous evidences from specific virus-host interactions to require the involvement of host factors and steps during viral replication cycle. However, viruses should deal with host defense responses either by general or specific mechanisms, targeting viral components or genome itself. On the other hand, the host plants have also adapted to defend themselves against viral attack by operating different lines of resistance responses. The defense-related interactions provide new insights into the complex molecular strategies for hosts for defense and counter-defense employed by viruses.

Controlled Plasma Treatment for Edge Contacts of Graphene (그래핀의 엣지 접합 (Edge Contact)을 위한 플라즈마 처리 연구)

  • Yue, Dewu;Ra, Chang-Ho;Liu, Xiaochi;Daeyeong, Daeyeong;Yu, Won-Jong
    • Proceedings of the Korean Institute of Surface Engineering Conference
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    • 2014.11a
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    • pp.293-293
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    • 2014
  • The applicability of graphene has been demonstrated in the electronic fields. But, high performance of graphene is limited by the contact resistance (Rc) at the metal-graphene interface. Recently, Rc was found to be improved by forming edge-contacted graphene via theoretical simulation. Based on the differences between the surface and edge contacts at the M-G interface, we demonstrate "edge-contacted" graphene through the use of a controlled plasma processing technique that generates the edge structure of the bond and significantly reduces the contact resistance. The contact resistance attained by using pre-plasma processing was of $270{\Omega}{\cdot}{\mu}m$. Mechanisms of pre-plasma process leading to low Rc was revealed by SEM and Raman spectroscopy. In the end, controlled pre-plasma processing enabled to fabricate CVD-graphene field effect transistors with an enhanced adhesion and improved carrier mobility.

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Fundamental Aspects of Resistance Sintering under Ultrahigh Pressure Consolidation

  • Zhou, Zhangjian;Kim, Ji-Soon;Yum, Young-Jin
    • Journal of Powder Materials
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    • v.19 no.1
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    • pp.19-24
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    • 2012
  • The consolidation results of fine tungsten powders, W-Cu composite and W/Cu FGM by using a novel method combining resistance sintering with ultra high pressure have been reviewed. The densification effects of the consolidation parameters, including pressure, input power and sintering time, have been investigated. The sintering mechanism of this method was quite different from other sintering methods. Particle rearrangement, sliding, distortion and crushing due to the ultra high pressure are the dominant mehanisms at the initial stage, then the dominant sintering mechanisms are transient arc-fused processes controlled by the input power.

Sliding Wear and Corrosion Resistance of Copper-based Overhead Catenary for Traction Systems

  • Kwok, C.T.;Wong, P.K.;Man, H.C.;Cheng, F.T.
    • International Journal of Railway
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    • v.3 no.1
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    • pp.19-27
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    • 2010
  • In the present study, the electrical sliding wear and corrosion resistance of pure copper (Cu) and six age-hardened copper alloys (CuCr, CuZr, CuCrZr, CuNiSiCr, CuBe and CuBeNi) were investigated by a pin-on-disc tribometer and electrochemical measurement. Various copper-based alloys in the form of cylindrical pin were forced to slide against a counterface stainless steel disc in air under unlubricated condition at a sliding velocity of 31 km/h under normal load up to 20 N with and without electric current. The worn surface of and wear debris from the specimens were studied by scanning electron microscopy. Both mechanical wear and electrical arc erosion were the wear mechanisms for the alloys worn at 50 A. Owing to its good electrical conductivity, high wear and corrosion resistance, CuCrZr is a promising candidate as the overhead catenary material for electric traction systems.

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Endodontic biofilms: contemporary and future treatment options

  • Yoo, Yeon-Jee;Perinpanayagam, Hiran;Oh, Soram;Kim, A-Reum;Han, Seung-Hyun;Kum, Kee-Yeon
    • Restorative Dentistry and Endodontics
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    • v.44 no.1
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    • pp.7.1-7.10
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    • 2019
  • Apical periodontitis is a biofilm-mediated infection. The biofilm protects bacteria from host defenses and increase their resistance to intracanal disinfecting protocols. Understanding the virulence of these endodontic microbiota within biofilm is essential for the development of novel therapeutic procedures for intracanal disinfection. Both the disruption of biofilms and the killing of their bacteria are necessary to effectively treat apical periodontitis. Accordingly, a review of endodontic biofilm types, antimicrobial resistance mechanisms, and current and future therapeutic procedures for endodontic biofilm is provided.

Update of early phase clinical trials in cancer immunotherapy

  • Lee, Dae Ho
    • BMB Reports
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    • v.54 no.1
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    • pp.70-88
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    • 2021
  • Immunotherapy has revolutionized the landscape of cancer treatment and become a standard pillar of the treatment. The two main drivers, immune checkpoint inhibitors and chimeric antigen receptor T cells, contributed to this unprecedented success. However, despite the striking clinical improvements, most patients still suffer from disease progression because of the evolution of primary or acquired resistance. This mini-review summarizes new treatment options including novel targets and interesting combinational approaches to increase our understanding of the mechanisms of the action of and resistance to immunotherapy, to expand our knowledge of advances in biomarker and therapeutics development, and to help to find the most appropriate option or a way of overcoming the resistance for cancer patients.