• Journal of Sensor Science and Technology
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• v.5 no.5
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• pp.1-10
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• 1996

Solar cells made of the edge-defined film-fed growth Si are characterized using current-voltage, surface photovoltage, electron beam induced current, electron microprobe, scanning electron microscopy, and electron backscattering. The weak temperature dependence of the I-V curves in the EFG solar cells is due to a voltage variable shunt resistance giving higher diode ideality factors than the ideal one. The voltage variable shunt resistance is modeled by a modified recombination mechanism which includes carrier tunneling to distributed impurity energy states in the band gap within the space-charge region. The junction integrity and the substrate quality are characterized simultaneously by combining I-V and surface photovoltage (SPV) measurements. The diode ideality factors and the surface photovoltages characterize the junction integrity while the SPV diffusion lengths characterizes the substrate quality. Most of the measured samples show the voltage variable shunt resistance although how serious it is depends on the solar cell efficiency. The voltage variable shunt resistance is understood as one of the most important factors of the degradation of EFG solar cells.

• Journal of Physiology & Pathology in Korean Medicine
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• v.35 no.4
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• pp.117-123
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• 2021

Gefitinib, a first generation epidermal growth factor receptor tyrosine kinase inhibitor (EGFR TKI), provides obvious clinical benefit in patients with EGFR-mutant non-small cell lung cancer (NSCLC). However, patients ultimately develop gefitinib resistance which mainly caused by EGFR T790M secondary mutation. In the current study, we investigated whether the root extract of Scutellaria baicalensis (SB) overcomes gefitinib resistance. Gefitinib-resistant H1975 human NSCLC cells (EGFR L858R/T790M double mutant) were treated with gefitinib and/or ethanol extract of SB (ESB) to evaluate the effect of ESB on the gefitinib sensitivity. The cell viability was measured by MTT assay and trypan blue exclusion assay. The colony-forming ability was evaluated by anchorage-dependent colony formation assay. Combined treatment with gefitinib and ESB markedly decreased the cell viability and colony formation than single treatment with gefitinib or ESB in H1975 cells. In addition, cells treated with both gefitinib and ESB exhibited a significant increase of sub-G1 DNA content which indicates apoptotic cells compared with those treated with gefitinib or ESB alone. As a molecular mechanism, combined treatment with gefitinib and ESB strongly downregulated the phosphorylation of ERK and JNK than single treatment with gefitinib or ESB. Taken together, our results demonstrate that ESB sensitizes H1975 cells to gefitinib treatment. We cautiously propose that ESB can be used in combination with gefitinib for the advanced NSCLC patients with acquired resistance to EGFR TKIs.

• Journal of Korean Society of Water and Wastewater
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• v.35 no.6
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• pp.425-436
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• 2021

In this study, chemically enhanced steam cleaning(CESC) was applied as a novel and efficient method for the control of organic and inorganic fouling in ceramic membrane filtration. The constant filtration regression model and the resistance in series model(RISM) were used to investigate the membrane fouling mechanisms. For total filtration, the coefficient of determination(R²) with an approximate value of 1 was obtained in the intermediate blocking model which is considered as the dominant contamination mechanism. In addition, most of the coefficient values showed similar values and this means that the complex fouling was formed during the filtration period. In the RISM, R _c/R _f increased about 4.37 times in chemically enhanced steam cleaning compared to physical backwashing, which implies that the internal fouling resistance was converted to cake layer resistance, so that the membrane fouling hardly to be removed by physical backwashing could be efficiently removed by chemically enhanced steam cleaning. The results of flux recovery rate showed that high-temperature steam may loosen the structure of the membrane cake layer due to the increase in diffusivity and solubility of chemicals and finally enhance the cleaning effect. As a consequence, it is expected that chemically enhanced steam cleaning can drastically improve the efficiency of membrane filtration process when the characteristics of the foulant are identified.

• Steel and Composite Structures
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• v.46 no.6
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• pp.773-791
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• 2023

Connections with damage concentrated to pre-selected components can enhance seismic resilience for moment resisting frames. These pre-selected components always yield early to dissipate energy, and their energy dissipation mechanisms vary from one to another, depending on their position in the connection, geometry configuration details, and mechanical characteristics. This paper presents behaviour insights on two types of beam-to-beam connections that the angles were designed as energy dissipation components, through the results of experimental study and finite element analysis. Firstly, an experimental programme was reviewed, and key responses concerning the working mechanism of the connections were presented, including strain distribution at the critical section, section force responses of essential components, and initial stiffness of test specimens. Subsequently, finite element models of three specimens were established to further interpret their behaviour and response that were not observable in the tests. The moment and shear force transfer paths of the composite connections were clarified through the test results and finite element analysis. It was observed that the bending moment is mainly resisted by axial forces from the components, and the dominant axial force is from the bottom angles; the shear force at the critical section is primarily taken by the slab and the components near the top flange. Lastly, based on the insights on the load transfer path of the composite connections, preliminary design recommendations are proposed. In particular, a resistance requirement, quantified by a moment capacity ratio, was placed on the connections. Design models and equations were also developed for predicting the yield moment resistance and the shear resistance of the connections. A flexible beam model was proposed to quantify the shear resistance of essential components.

• BMB Reports
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• v.56 no.11
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• pp.600-605
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• 2023

Intrahepatic cholangiocarcinoma (ICC) is a bile duct cancer and a rare malignant tumor with a poor prognosis owing to the lack of an early diagnosis and resistance to conventional chemotherapy. A combination of gemcitabine and cisplatin is the typically attempted first-line treatment approach. However, the underlying mechanism of resistance to chemotherapy is poorly understood. We addressed this by studying dynamics in the human ICC SCK cell line. Here, we report that the regulation of glucose and glutamine metabolism was a key factor in overcoming cisplatin resistance in SCK cells. RNA sequencing analysis revealed a high enrichment cell cycle-related gene set score in cisplatin-resistant SCK (SCK-R) cells compared to parental SCK (SCK WT) cells. Cell cycle progression correlates with increased nutrient requirement and cancer proliferation or metastasis. Commonly, cancer cells are dependent upon glucose and glutamine availability for survival and proliferation. Indeed, we observed the increased expression of GLUT (glucose transporter), ASCT2 (glutamine transporter), and cancer progression markers in SCK-R cells. Thus, we inhibited enhanced metabolic reprogramming in SCK-R cells through nutrient starvation. SCK-R cells were sensitized to cisplatin, especially under glucose starvation. Glutaminase-1 (GLS1), which is a mitochondrial enzyme involved in tumorigenesis and progression in cancer cells, was upregulated in SCK-R cells. Targeting GLS1 with the GLS1 inhibitor CB-839 (telaglenastat) effectively reduced the expression of cancer progression markers. Taken together, our study results suggest that a combination of GLUT inhibition, which mimics glucose starvation, and GLS1 inhibition could be a therapeutic strategy to increase the chemosensitivity of ICC.

• Research in Plant Disease
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• v.12 no.1
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• pp.15-19
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• 2006

This study was carried out to know pathogenicity of the pathogen isolated in several location of Korea and penetration mechanism of the Pseudocercospora vitis ($(L\acute{e}v)$.) Speg. Inoculation tests at room temperature were performed on both sides of leaves with different isolates of the fungus. The typical symptoms appeared on the abaxial leaf surface, but no symptom was observed on the adaxial leaf surface with all isolates. The average incubation period was nine days, since all symptoms appeared from 8 to 10 days after inoculation. In order to know the mechanism of invasion of P. vitis to grapevine, the behavior of penetration hyphae through stomata were compared in two cultivars having different level of resistance. In order to know the mechanism of resistance of grape vine to P.vitis, two cultivars having different level of resistance were compared by counting the numbers and measuring size of the stomata per leaf. In a susceptible cultivar Campbell Early, the number of stomata was more than that of a resistance cultivar 'Kyoho'. In a susceptible cultivar 'Campbell Early', the fungus entered readily into stomata after inoculation. However, in a resistant cultivar 'Kyoho', the fungus seemed to pass over or surrounded only the guard cells. In comparison of height of guard cells of stomata between the two cultivars, significant differences were observed by scanning electron microscopy and light microscopy. The height of guard cells of 'Campbell Early' showed a little higher than those of 'Kyoho' known to be resistant to the fungus.

• Journal of Korean Society of Forest Science
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• v.81 no.2
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• pp.164-176
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• 1992

This study was conducted to determine the toxic effects of air pollutants on landscaping trees, Pinus densiflora, Pinus koraierasis, Ginkgo biloba, Liriodeytdron tulipifera, Platanus occidentalis and their resistance to the pollutant toxicity in urban and industrial regions of Seoul and Taejon, Korea. Total sulfur content and superoxide dismutase activity were analysed in tree foliage of Pinus densiflora, Pinzes koraiensis, Ginkgo biloba, Liriodendron tulipifera, Platanus occidentalis. In addition, SOD activity was analyzed in the foliage of tree seedlings, i.e. Pinus densijlora, Pinus koraiensis, Ginkgo biloba, Liriodendron tulipifera, with the lurnigation of $SO_2$ in gas chamber 4 hours a day for six days. In all species total sulfur content and SOD activity had a positive correlation. Air pollutants accumulated in tree tissues were supposed to enhance the enzyme activity like SOD providing with the resistance mechanisms. Trees under the air pollution stress increased enzyme activity to develop internal self-resistance against pollutants, but after a critical point enzyme-activity decreased gradually and resulting in injury after all, Deciduous trees had greater filtration capacity than conifers and coniferous trees showed greater resistance against air pollutants than deciduous species. Foliage SOD activity was higher in polluted area than in unpolluted area for most species. Coniferous species and mature trees had higher SOD activity than deciduous seedlings. Especially Pinus koraiensis, Ginkgo biloba and Plcatanus occidentalis had higher SOD activity than other species. The tree species with the high SOD activity showed strong resistance against air pollutants. In 2nd-year needles of Pinus densiflora seedlings and current and 2nd-year needles of Pinus koraiensis seedlings containing high native SOD activity, SOD activity increased with the increase of $SO_2$ level. But in seedlings containing low native SOD activity, SOD activity increased at 0.5ppm $SO_2$ level while it decreased at 1.5 and 2.5ppm $SO_2$. Changes of SOD activity was different between species and in most species SOD seemed to participate in resistance mechanism.

• Earthquakes and Structures
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• v.18 no.5
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• pp.649-665
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• 2020

One of the most important issues in structural systems is evaluation of the margin of safety in low and mid-rise buildings against the progressive collapse mechanism due to the earthquake loads. In this paper, modeling of collapse propagation in structural elements of RC frame buildings is evaluated by tracing down the collapse points in beam and column structural elements, one after another, under earthquake loads and the influence of column removal is investigated on how the collapse expansion in beam and column structural members. For this reason, progressive collapse phenomenon is studied in 3-story and 5-story intermediate moment resisting frame buildings due to the corner and edge column removal in presence of the earthquake loads. In this way, distribution and propagation of the collapse in progressive collapse mechanism is studied, from the first element of the structure to the collapse of a large part of the building with investigating and comparing the results of nonlinear time history analyses (NLTHA) in presence of two-component accelograms proposed by FEMA_P695. Evaluation of the results, including the statistical survey of the number and sequence of the collapsed points in process of the collapse distribution in structural system, show that the progressive collapse distribution are special and similar in low-rise and mid-rise RC buildings due to the simultaneous effects of the column removal and the earthquake loads and various patterns of the progressive collapse distribution are proposed and presented to predict the collapse propagation in structural elements of similar buildings. So, the results of collapse distribution patterns and comparing the values of collapse can be utilized to provide practical methods in codes and guidelines to enhance the structural resistance against the progressive collapse mechanism and eventually, the value of damage can be controlled and minimized in similar buildings.

• Journal of the Korean Society for Precision Engineering
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• v.23 no.2 s.179
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• pp.199-206
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• 2006

Automatic grease lubricator is equipment that provides adequate amount of fresh grease constantly to the shaft and the bearings of machines. It minimizes the friction heat and reduces the friction loss of machines to the least. This research is to develop automatic grease lubricator by gear driven mechanism with controlled operation time. The ultimate design of this equipment is to lubricate an adequate amount of grease by a simple switch clicking according to the advanced set cycle. The backlash of the gear was minimized to increase the output power. To increase the power of gear mechanism, the binding frequency and the thickness of the coil were changed. To control the rotating cycles of the main shaft according to its set numbers, different resistance and chips were used to design the circuit to controls electrical signals with pulse. The body of the lubricator was analyzed by stress analysis with different constructed angle. The stress analysis for differing loading pressures applied to the exterior body of grease lubricator due to the setup angle, was found that the maximum stress was distributed over the outlet part where the grease lubricator suddenly narrowed contracts. Digital mock-up was analyzed and the rapid prototyping(RP) trial products were tested with PCB circuit and grease. The evaluation of the outlet capacity for RP trial products was conducted, because the friction caused by the outlet on the wall surface was an important factor in the operation of the equipment. Finally, the finishing process was applied to decrease the roughness of the surface to a comparable level and was able to test the performance examination for the product.

• Earthquakes and Structures
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• v.18 no.6
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• pp.691-707
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• 2020

One of the most important issues in structural systems is evaluation of the margin of safety in low and mid-rise buildings against the progressive collapse mechanism due to the earthquake loads. In this paper, modeling of collapse propagation in structural elements of RC frame buildings is evaluated by tracing down the collapse points in beam and column structural elements, one after another, under earthquake loads and the influence of column removal is investigated on how the collapse expansion in beam and column structural members. For this reason, progressive collapse phenomenon is studied in 3-story and 5-story intermediate moment resisting frame buildings due to the corner and edge column removal in presence of the earthquake loads. In this way, distribution and propagation of the collapse in progressive collapse mechanism is studied, from the first element of the structure to the collapse of a large part of the building with investigating and comparing the results of nonlinear time history analyses (NLTHA) in presence of two-component accelograms proposed by FEMA_P695. Evaluation of the results, including the statistical survey of the number and sequence of the collapsed points in process of the collapse distribution in structural system, show that the progressive collapse distribution are special and similar in low-rise and mid-rise RC buildings due to the simultaneous effects of the column removal and the earthquake loads and various patterns of the progressive collapse distribution are proposed and presented to predict the collapse propagation in structural elements of similar buildings. So, the results of collapse distribution patterns and comparing the values of collapse can be utilized to provide practical methods in codes and guidelines to enhance the structural resistance against the progressive collapse mechanism and eventually, the value of damage can be controlled and minimized in similar buildings.