• Journal of Korean Neurosurgical Society
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• v.50 no.5
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• pp.426-433
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• 2011

Objective : The Histoculture Drug Response Assay (HDRA), which measures chemosensitivity using minced tumor tissue on drug-soaked gelfoam, has been expected to overcome the limitations of in vitro chemosensitivity test in part. We analyzed interim results of HDRA in malignant gliomas to see if the test can deserve further clinical trials. Methods : Thirty-three patients with malignant gliomas were operated and their tumor samples were examined for the chemosensitivity to 10 chosen drugs by HDRA. The most sensitive chemotherapy regimen among those pre-established was chosen based on the number of sensitive drugs or total inhibition rate (IR) of the regimen. The response was evaluated by 3 month magnetic resonance image. Results : Among 13 patients who underwent total resection of the tumor, 12 showed no evidence of disease and one patient revealed progression. The response rate in 20 patients with residual tumors was 55% (3 complete and 8 partial responses). HDRA sensitivity at the cut-off value of more than one sensitive drug in the applied regimen showed a sensitivity of 100%, specificity of 60% and predictability of 70%. Another cut-off value of >80% of total IR revealed a sensitivity of 100%, specificity of 69%, and predictability of 80%. For 12 newly diagnosed glioblastoma patients, median progression-free survival of the HDRA sensitive group was 21 months, while that of the non-sensitive group was 6 months ($p$=0.07). Conclusion : HDRA for malignant glioma was inferred as a feasible method to predict the chemotherapy response. We are encouraged to launch phase 2 clinical trial with chemosensitivity on HDRA.

• Journal of the Korean Geosynthetics Society
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• v.16 no.1
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• pp.73-83
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• 2017

Laboratory and in-situ tests were conducted to evaluate the cone factors for the layers with low plasticity containing a lot of silty and sand soils from the west coast (Incheon, Hwaseong and Gunsan areas) and its applicability was evaluated based on these results. The cone factors were evaluated from 19 to 23 based on unconfined compression strengths (qu), from 13 to 13.8 based on simple CU strengths and from 11.6 to 13.1 based on field vane strengths, respectively. The unconfined compression strengths of undisturbed silty soil samples with low plasticity were considerably underestimated due to the change of in-situ residual effective stress during sampling. Half of unconfined compression strength (qu/2) based cone factors of silty soils with low plasticity fluctuated and were approximately 1.8 times higher than simple CU based values of these soils. When evaluating cone factors of these soils, it should be judged overall on the physical properties such as the grain size distribution and soil plasticity and on the fluctuation of the corrected cone resistance and the sleeve friction due to the distribution of sandseam in the ground including pore pressure parameter.

• Transactions of the Korean Society of Automotive Engineers
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• v.22 no.2
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• pp.141-147
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• 2014

This study aims to investigate the influence of bevel angles on the fatigue life of V-groove butt-welded joints with back-plates made by SM490A steel material, generally used for excavators, because changes in the geometry, material and surface properties of welded regions affect the fatigue life of welded structures. Butt type test specimens were prepared by the $CO_2$ welding of rolled steel plates (SM50A steel) with a thickness of 13.5 mm at a welding speed of 30 cm/min and these Butt type test specimens had two different groove angles, which are $40^{\circ}$ (A type) and $30^{\circ}$ (B type). In order to investigate differences in fatigue life between two types, 4-point bending fatigue tests were conducted with a stress ratio of R=0.1 under the cyclic loading environment at a frequency of 5 Hz at room temperature. The fatigue life of A type specimens was approximately 7% higher than that of B type specimens. The stress concentration factors calculated by finite element analysis were 2.16 for A type and 2.25 for B type, whose difference was caused by the influence of the back-plates of butt-welded structures. The current results could provide important guidelines to determine the V-groove angle of butt-welded joints with a satisfactory fatigue life, although under severe operating conditions.

• Journal of the Korean Society for Aeronautical & Space Sciences
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• v.30 no.5
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• pp.94-100
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• 2002

This paper is concerned with the development, and performance test of LIPCA (Lightweight Piezo-composite Curved Actuator) that is lighter than other conventional piezo-composite type actuators. LIPCA is composed of top fiber composite layers with a high modulus and low CTE (Coefficient of Thermal Expansion), a middle PZT cermaic wafer, and base layers with a high modulus and high CTE. The performance of each actuator was evaluated using an actuator test system consisting of an actuator supporting jig, a high voltage actuating power supplier, and a non-contact laser measuring system. The simply supported condition actuator was excited by the power supplier with 1.0Hz cycle and up to $100\sim400V_{pp}$. The displacement at the center point of actuator was measured with non-contact laser displacement measuring system, It has been shown that the LIPCA-C2 can 34% decrease in mass and 13% increase in displacement compared to THUNDER.

• Food Quality and Culture
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• v.3 no.2
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• pp.64-68
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• 2009

This descriptive analysis study investigated the sensory characteristics and the drivers of liking for seven types of makgeolli differing in grain composition and pasteurization conditions. Six trained panelists participated in the descriptive analysis. In the consumer acceptance test involving 23 males and 34 females, two of the seven varieties were excluded due to their similar sensory characteristics. Analysis of variance, principal component analysis, and partial least square regression analysis were conducted. Sensory characteristics of makgeolli varied markedly depending on the ingredients and processing methods. Makgeolli samples with relatively high content of millet flour were characterized as being smooth and strong, with a roasted carbohydrate flavor, whereas samples with enriched rice content were rated high in attributes such as bitterness, carbonation, and residual flavor. Sourness decreased in pasteurized samples. Participant's age rather than gender influence the liking for makgeolli. Older consumers tend to prefer samples with stronger flavor than did younger consumers. Clustering consumer groups based on the preference for makgeolli samples provided profound insight concerning the beverage aspects that were appealing, which should be useful in consumer targeting of particular varieties of makgeolli.

• The Korean Journal of Pain
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• v.10 no.2
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• pp.214-219
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• 1997

Background: Epidural neural blockade with local anesthetics combined with steroids has been in clinical trials for patients with low back pain. But pain treatment of low back pain remains somewhat problematic. Many patients with low back pain have epidural fibrosis and adhesions proved with magnetic resonance imaging(MRI) examination. These findings might play an important role in the origin of back pain. Present study was aims to investigate the effect of epidural adhesiolysis in patients with low back pain. Methods: We investigated 76 patients suspected with epidural fibrosis and adhesion was suspected. Nerve pathology was demonstrated and epidural fibrosis suspected or proved with MRI examination. 17G needle specially designed by Racz was inserted at sacral hiatus and catheter was inserted untill its tip was located at lesion site under fluoroscopic guidance. Injection of contrast dye was achieved and prospected spread of agents. Injection of 0.25% bupivacaine, triamcinolone, and 10% hypertonic saline via catheter were carried out daily for 3 days. Evaluation included assessment of pain relief (Numerical Rating Scale; NRS) post-epidural adhesiolysis 3 days, 1 week, and 3 months. We also looked for complication of epidural adhesiolysis. Results: Statistical analysis(Friedman nonparametric repeated measures test and Dune's multiple comparison test) demonstrated NRS was significantly less during 3 months after epidural adhesiolysis(P<0.05). Especially, there is a extremely significance in post-epidural adhesiolysis 3 days (P<0.001). Only four patients reported any complications the most common symptom among three persistent headache but disappeared after a few months without residual sequelae. Conclusion: We conclude epidural adhesiolysis is a safe and effective method of pain therapy for low back pain with proven lumbo-sacral fibrosis and adhesion. A direct visualization by epiduroscopy may be more useful to the resulting functional changes after epidural adhesiolysis.

• Journal of Korea Water Resources Association
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• v.30 no.2
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• pp.155-163
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• 1997

In this study, drought analysis of annual flows of Jindong, Hyunpoong, and Waekwan stations located at Nakdong River Basins was performed based on multivariate stochastic models. The stochastic models used were multivariate autoregressive model (MAR) and multivariate contemporaneous (MCAR) model. MCAR(1) and MAR(1) models were selected to be a appropriate models for these stations based on skewness test of normality, test of uncorrelated residuals, and correlograms of the residual series of each model. The statistics generated by MCAR(1) model and MAR(1) model resembled very closely those computed from historical series. The drought characteristics such as run len호, run sum, and run intensity were fairly well reproduced for the various lengths of generated annual flows based on the MCAR(1) and MAR(1) models. Thus, these drought characteristics may give the important informations in planning mid or long term water supplying systems.

• Restorative Dentistry and Endodontics
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• v.38 no.4
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• pp.234-240
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• 2013

Objectives: This study evaluated the effects of intraradicular moisture on the pushout bond strength of a fibre post luted with several self-adhesive resin cements. Materials and Methods: Endodontically treated root canals were treated with one of three luting cements: (1) RelyX U100, (2) Clearfil SA, and (3) G-Cem. Roots were then divided into four subgroups according to the moisture condition tested: (I) dry: excess water removed with paper points followed by dehydration with 95% ethanol, (II) normal moisture: canals blot-dried with paper points until appearing dry, (III) moist: canals dried by low vacuum using a Luer adapter, and (IV) wet: canals remained totally flooded. Two 1-mm-thick slices were obtained from each root sample and bond strength was measured using a push-out test setup. The data were analysed using a two-way analysis of variance and the Bonferroni post hoc test with p = 0.05. Results: Statistical analysis demonstrated that moisture levels had a significant effect on the bond strength of luting cements (p < 0.05), with the exception of G-Cem. RelyX U100 displayed the highest bond strength under moist conditions (III). Clearfil SA had the highest bond strength under normal moisture conditions (II). Statistical ranking of bond strength values was as follows: RelyX U100 > Clearfil SA > G-Cem. Conclusions: The degree of residual moisture significantly affected the adhesion of luting cements to radicular dentine.

• Composites Research
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• v.26 no.2
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• pp.129-134
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• 2013

The strength of adhesive joints employed in composite structures under cryogenic environments, such as LNG tanks, is affected by thermal residual stress generated from the large temperature difference between the bonding process and the operating temperature. Aramid fibers are noted for their low coefficient of thermal expansion (CTE) and have been used to control the CTE of thermosetting resins. However, aramid composites exhibit poor adhesion between the fibers and the resin because the aramid fibers are chemically inert and contain insufficient functional groups. In this work, electrospun meta-aramid nanofiber-reinforced epoxy adhesive was fabricated to improve the interfacial bonding between the adhesive and the fibers under cryogenic temperatures. The CTE of the nanofiber-reinforced adhesives were measured, and the effect on the adhesion strength was investigated at single-lap joints under cryogenic temperatures. The fracture toughness of the adhesive joints was measured using a Double Cantilever Beam (DCB) test.

• Earthquakes and Structures
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• v.8 no.3
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• pp.619-637
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• 2015

A field based non-destructive hardness method is being developed to determine plastic strain in steel elements subjected to seismic loading. The focus of this study is on the active links of eccentrically braced frames (EBFs). The 2010/2011 Christchurch earthquake series, especially the very intense February 22 shaking, which was the first earthquake worldwide to push complete EBF systems into their inelastic state, generating a moderate to high level of plastic strain in EBF active links for a range of buildings from 3 to 23 storeys in height. Plastic deformation was confined to the active links. This raised two important questions: what was the extent of plastic deformation and what effect does that have on post-earthquake steel properties? A non-destructive hardness test method is being used to determine a relationship between hardness and plastic strain in active link beams. Active links from the earthquake affected, 23-storey Pacific Tower building in Christchurch are being analysed in the field and laboratory. Test results to date show clear evidence that this method is able to give a good relationship between plastic strain and demand. This paper presents significant findings from this project to investigate the relationship between hardness and plastic strain that warrant publication prior to the completion of the project. Principal of these is the discovery that hot rolled steel beams carry manufacturing induced plastic strains, in regions of the webs, of up to 5%.