• Molecules and Cells
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• v.39 no.10
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• pp.734-741
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• 2016

Granulocyte-macrophage colony stimulating factor (GM-CSF) has a role in inducing emergency hematopoiesis upon exposure to inflammatory stimuli. Although GM-CSF generated murine bone marrow derived cells have been widely used as macrophages or dendritic cells in research, the exact characteristics of each cell population have not yet been defined. Here we discriminated GM-CSF grown bone marrow derived macrophages (GM-BMMs) from dendritic cells (GM-BMDCs) in several criteria. After C57BL/6J mice bone marrow cell culture for 7 days with GM-CSF supplementation, two main populations were observed in the attached cells based on MHCII and F4/80 marker expressions. GM-BMMs had $MHCII^{low}F4/80^{high}$ as well as $CD11c^+CD11b^{high}CD80^-CD64^+MerTK^+$ phenotypes. In contrast, GM-BMDCs had $MHCII^{high}F4/80^{low}$ and $CD11c^{high}CD8{\alpha}^-CD11b^+CD80^+CD64^-MerTK^{low}$ phenotypes. Interestingly, the GM-BMM population increased but GM-BMDCs decreased in a GM-CSF dose-dependent manner. Functionally, GM-BMMs showed extremely high phagocytic abilities and produced higher IL-10 upon LPS stimulation. GM-BMDCs, however, could not phagocytose as well, but were efficient at producing $TNF{\alpha}$, $IL-1{\beta}$, IL-12p70 and IL-6 as well as inducing T cell proliferation. Finally, whole transcriptome analysis revealed that GM-BMMs and GM-BMDCs are overlap with in vivo resident macrophages and dendritic cells, respectively. Taken together, our study shows the heterogeneicity of GM-CSF derived cell populations, and specifically characterizes GM-CSF derived macrophages compared to dendritic cells.

• Korean Journal of Health Education and Promotion
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• v.20 no.4
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• pp.51-65
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• 2003

Objectives： To examine the regional mortality differences in The Republic of Korea according to geographic location. Methods： All 232 administrative districts of the Republic of Korea in 1998 were studied according to their geographic locations by dividing each district into three categories； "metropolis," "urban," and "rural". Crude mortality rates for doth sexes from total deaths as well as the three major causes of death in Korea (cardiovascular disease, cancer, and external causes) were calculated with raw data from the "1998 report on the causes of death statistics" and resident registration data. Standardized mortality ratios (SMR) were calculated using the indirect standardization method. Poisson regression analyses were performed to examine the effects of geographic locations on the risk of death. To correct for the socioeconomic differences of each region, the percentage of old ($\geq$ 65 years old) population, the number of privately owned cars per 100 population, and per capita manufacturing production industries were included in the model. Results： Most SMRs were the lowest in the metropolis and the highest in the rural areas. These differences were more prominent in men and in deaths from external causes. In deaths from cancer in women, the rural region showed the lowest SMR. In Poisson regression analysis after correcting for regional socioeconomic differences, the risk of death from all causes significantly increased in both urban (OR＝1.111) and rural (OR＝1.100) regions, except for rural women, compared to the metropolis region. In men, the rural region showed higher risk (OR＝1.180) than the urban region (OR＝1.l51). For cardiovascular disease and cancer, significant differences were not found between geographic locations, except in urban women for cardiovascular disease (OR＝1.151) and in rural women for cancer (OR＝0.887), compared to metropolis women. In deaths from external causes, the risk ratios significantly increased in both urban and rural regions and an increasing tendency from the metropolis to the rural region was clearly observed in both sexes. Conclusions： Regional mortality differences according to geographic location exist in The Republic of Korea and further research and policy approaches to reduce these differences are needed. to reduce these differences are needed.

• Asian Journal for Public Opinion Research
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• v.11 no.3
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• pp.257-273
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• 2023

Conducting face-to-face surveys is difficult and cost prohibitive, necessitating a new attempt to build a probability-based panel in South Korea. Since 99.9% of adult Koreans own a mobile phone, mobile phone numbers provide a viable sampling frame. Random digit dialing (RDD) surveys were conducted August-December 2021. Of the 288,056 valid phone numbers dialed, 13,655 respondents between the ages of 19 and 69 completed a phone survey. These respondents were later invited by text message to join a panel; 3,202 of these (23.4% or 1.2% based on the number initially contacted) joined the panel. When compared to official government statistics like resident registration data, the census, or the Social Survey, this new probability-based panel can be said to be representative of the Korean population on the basis of age, gender, location, marital status, and household size after weighting is applied. However, even after weighting, panel members are more educated than the general population, white-collar workers and self-employed people are overrepresented, and blue-collar workers are underrepresented. As of February 2023, this panel has grown to 10,471 participants with plans to continue to invite more panel members in the same way. Based on the comparisons in this paper, we can regard this panel as a cost-effective, probability-based panel that may be used for various kinds of public opinion research, by researchers both within and outside of Korea. As we continue to refine and grow this panel, we hope it will become more widely used by researchers as well as provide a model for those building similar panels in other countries.

• Proceeding of Spring/Autumn Annual Conference of KHA
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• 2006.11a
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• pp.281-286
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• 2006

In case of Korea, immovable property like location, land prise or investment value is more highly estimated than quality of life of residents for performance and value of apartment house, because of limited land area or high density of population. But the high level of life has recently caused the increasing demand in better life. As there is no cases to provide the house in bulk due to the housing market condition, it is necessary to evaluate performance and value of structure, disaster prevention safety, habitability, antiquated condition of building and equipment, maintenance condition and so on that has importantly influence on resident's life quality. So, this study aims to understand the actual condition of environmental performance for the present apartment by comparing the designated apartment, which is ready to have completed in Daegu, with the mixed use residential building, which gained the best grade for green building certification system. Also by analyzing and evaluating a right to enjoy sunshine, floor impact noise etc. and indoor air quality.

• KIEAE Journal
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• v.7 no.2
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• pp.47-55
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• 2007

Development of digital technology has become closely connected with housing environment. Especially for the matured population, it is very important because they need substantial support in their daily lives. Therefore, the purpose of this paper is to identify needs of digital network services for future housing development. Previous researches were limited to digital technology of network systems and its usages. On the other hand, this study focuses on not only the technology but services. This study consists of literatures review and empirical survey. The subjects were the mid-age and pre-elderly between 45 to 65. The analysis of this study results outlined as follows: First, the pre-elderly appeared to have, in general, positive perceptions about digital services of the housing environment. The results of needs for each space's, showed strongly in basic safety and aiding system for memories. Second, there are differences in needs according to respondent's characteristics such as sex, income, job, house type, experience in digital system. Third, there are differences between what they think and what they really responded in both spaces and services. It menas that present planning elements may not attractive and suitable to residents. Therefore it is necessary to redesign the services. In the future, the most important thing is, making comfortable space not convenient space. That is, excluding unnecessary elements and pick up the right ones for resident's real demands.

• Korean Journal of Adult Nursing
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• v.19 no.3
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• pp.401-412
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• 2007

Purpose: The purpose of this study was to determine the relationship between assessed pain, functional status, and emotional status in elderly women with dementia. Methods: The method was a descriptive correlational design. Subjects were sampled from 75 elderly women with dementia who were resident in nursing home. and their pain, functional status(physical function, cognitive function), emotional status(depression, agitation) were measured. The collected data were analyzed for correlations between pain and functional status and for emotional status using the SPSS 11.0 statistical program. Results: The pain degree of the aged women in dementia were as follows; between 0 and 27 points, average 4.04 points, which was a possible point extent. Looking at the grades in detail items, the wry face expression was shown highest, an average of 0.84 points. The relation with cognitive function was(r=-.259, p<.025) a minus relation. And the relation with physical function was (r=.406, p<.001) a plus one. The relation with depression was (r=.462, p<.001), plus one. And (r=.592, p<.001) a plus relation was found with agitation. Conclusion: Pain is associated with impaired functional and emotional status. Major efforts are needed to improve nursing assessment and management of pain in this cognitive impaired population.

• Proceeding of Spring/Autumn Annual Conference of KHA
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• 2009.11a
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• pp.33-36
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• 2009

Korea is the 3rd highest country in population density of the world,furthermore, 1/5 of Korean lives in Seoul with only 0.0% tiny area size. It explains the high-rise apartment has diffused so fast. Regardless of its height, almost all apartments have been planned in a very uniform way, ignoring the possibilities of vertical community and commercial culture. Since considerable number of residents have within building, ways to improve the community and commercial culture need to be explored. One major way to do is providing community space where residents are expected to use in a natural way. The purpose of this research is to identify preferred location of community space in each apartment building. Web guesting survey was used as main methodology. 83 data were collected during mid October, 2009. As results, lobby at the first floor was most favorably selected by super high-rise apartment residents due to convenience, accessibility.

• Korean Journal of Food Science and Technology
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• v.25 no.2
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• pp.171-173
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• 1993

UV-ray air cleaner consisted of 6 watt UV lamp and fan was developed to sanitize air of refrigerator. Light intensity of the lamp showed 5 times of D value of Bacillus subtilis and air velocity around the lamp in holding section was 0.7 m/s, giving 0.33s of the resident time. The performance of air cleaner was tested with bacterial contaminator sprayed with suspension of Bacillus subtilis and hey powder. The device effectively decreased 80% of the population of airborn spore after 100 min operation at room temperature.

• Proceedings of the Korean Geotechical Society Conference
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• 2010.09a
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• pp.1213-1216
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• 2010

Developable areas nearby metropolitan areas, which has high the density of population are limited by highly industrialized. In recent, the redeveloping plans for the finished industrial and resident areas are pushing to resolve this problems. Getting to the exact properties for reclaimed wastes is very important to reuse of landfill. Also, a strategy for how to deal with follow-up measures have to based on the waste characteristics. A lot of environmental problems have been happened in finished waste landfill such as a nasty smell by seepage, pollution of surface and ground water, a poisonous gas and soil contamination. The environment pollution in waste landfill have been studied by many researchers. The goal of this study is estimate the effects for the ground properties with the environmental properties of waste in finished landfill. As the results, the chemical characteristics of seepage in landfill may effect directly or indirectly to capping layer. Therefore, sustainable researches are needed to develop a secure landfill over the long term.

• Architectural research
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• v.12 no.1
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• pp.1-8
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• 2010

This research paper explores selected behavioral outcomes of a multi-sensory environment. An experimental study was conducted at a specialized facility for the ageing in Sweden. The objective was to explore the effects of agitated behaviors of ageing residents with dementia and to identify any short-term effects. Appointed nursing staff was instructed to record physically and verbally agitated behaviors on three occasions; pre-session, mid-session, and post-session. Over seven months, nine participants received sixty-one sessions in the multi-sensory room. ANOVA and Post hoc multiple comparisons were performed to identify the differences in mean between each session. Generally irritated/frustrated behavior and eating/drinking non foods revealed statistically significant differences, while there were no significant results in verbally agitated behavior. One short-term effect was observed in one agitated category; a reduction of generally irritated/frustrated behavior. These results suggest that the multi-sensory environment can have positive effects on some manifestations of agitated behavior. This study proposes that a multi-sensory environment may be recommended as an alternative intervention for physically agitated behavior among this category of residents. However, more research is needed to understand the specific effects and the best use of the multi-sensory environment for this population.