• Journal of Magnetics
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• v.17 no.1
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• pp.19-26
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• 2012

This paper deals with the performance analysis and estimation of the electrical parameters of a permanent magnet synchronous generator (PMSG) for hydrokinetic energy conversion applications using vortex induced vibration (VIV). The analytical solutions for the magnetic fields produced by permanent magnets (PMs) and stator winding currents are obtained using a 2D polar coordinate system and a magnetic vector potential. An analytical expression for the 2D permeance is also derived, which takes into account stator skew effects. Based on these magnetic field solutions and the 2D permeance function, electrical circuit parameters such as the backemf constant and the air-gap inductance are obtained analytically. The performances of the PMSG are investigated using the estimated electrical circuit parameters and an equivalent circuit (EC). All analytical results are validated extensively using 2D finite element (FE) analyses. Experimental measurements for parameters such as the back-emf and inductance are also presented to confirm the analyses.

• Journal of Plant Biotechnology
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• v.43 no.2
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• pp.174-180
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• 2016

Licorice plant (Glycyrrhiza spp.) is an important herb, but the major portion of the national demand is imported to Korea because the domestic production base is vulnerable. We performed basic molecular breeding research for domestic cultivation and production. All publicly available G. uralensis EST sequences, which totaled 56,089, were assembled into 4,821 unigenes and examined for microsatellites. Eight polymorphic microsatellite loci were identified and 16 G. uralensis and 6 G. glabra accessions, which were collected from different locations, were genotyped using the microsatellites. Genetic diversity within the accessions was estimated by construction of a dendrogram. The dendrogram was clustered into two groups. The results showed that there is a correlative genetic relationship between species. The microsatellite markers were found to be useful for diversity analysis as they are able to successfully distinguish the Glycyrrhiza accessions.

• Journal of Agricultural Extension & Community Development
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• v.4 no.1
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• pp.269-281
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• 1997

This study intended to compare rural development programs between China and Thailand, focused on research and extension activities. In China, Agricultural Science Administration(ASC) took charges in agricultural research, and under the ASC there were 39 agricultural organizations throughout the country. There were distinctive differences as to condition of agricultural areas, under-developed area at middle and developing area by sea and river. To improve agricultural production in China, diffusion of new agricultural technology would be important along with supplying equipment such as soil test kits, plant nutrition analysis sets and vehcles for extension educators. In Thailand, under the Ministry of Agriculture & Cooperatives, there were five departments, seven divisions and eight national enterprises. Among them, Department of Agriculture was in charge of agricultural research while the Department of Agricultural Extension for extension services. Each department had sub-division and provincial organization including personnel management and budget. However, the relationships and consistency between the Department of Agriculture and the Department of Agricultural Extension needed to be improved for better cooperation of research and extension.

• Proceedings of the Korea Institute of Fire Science and Engineering Conference
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• 2005.05a
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• pp.69-74
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• 2005

• Proceedings of the Microbiological Society of Korea Conference
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• 2005.05a
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• pp.203.4-203
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• 2005

• 한국초전도학회:학술대회논문집
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• v.12
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• pp.72-72
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• 2002

• Biomolecules & Therapeutics
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• v.31 no.1
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• pp.73-81
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• 2023

Sirtuins (SIRTs) belong to the nicotinamide adenine dinucleotide (NAD+)-dependent class III histone deacetylase family. They are key regulators of cellular and physiological processes, such as cell survival, senescence, differentiation, DNA damage and stress response, cellular metabolism, and aging. SIRTs also influence carcinogenesis, making them potential targets for anticancer therapeutic strategies. In this study, we investigated the anticancer properties and underlying molecular mechanisms of a novel SIRT1 inhibitor, MHY2251, in human colorectal cancer (CRC) cells. MHY2251 reduced the viability of various human CRC cell lines, especially those with wild-type TP53. MHY2251 inhibited SIRT1 activity and SIRT1/2 protein expression, while promoting p53 acetylation, which is a target of SIRT1 in HCT116 cells. MHY2251 treatment triggered apoptosis in HCT116 cells. It increased the percentage of late apoptotic cells and the sub-G1 fraction (as detected by flow cytometric analysis) and induced DNA fragmentation. In addition, MHY2251 upregulated the expression of FasL and Fas, altered the ratio of Bax/Bcl-2, downregulated the levels of pro-caspase-8, -9, and -3 proteins, and induced subsequent poly(ADP-ribose) polymerase cleavage. The induction of apoptosis by MHY2251 was related to the activation of the caspase cascade, which was significantly attenuated by pre-treatment with Z-VAD-FMK, a pan-caspase inhibitor. Furthermore, MHY2251 stimulated the phosphorylation of c-Jun N-terminal kinase (JNK), and MHY2251-triggered apoptosis was blocked by pre-treatment with SP600125, a JNK inhibitor. This finding indicated the specific involvement of JNK in MHY2251-induced apoptosis. MHY2251 shows considerable potential as a therapeutic agent for targeting human CRC via the inhibition of SIRT1 and activation of JNK/p53 pathway.

• Journal of Navigation and Port Research
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• v.36 no.2
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• pp.105-112
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• 2012

In order to improve the existing S-57 standard, International Hydrographic Organization(IHO) has developed S-100 standard, a Universal Hydrographic Data Model(UHDM) expanded from ISO 19100 series standard to hydrographic area, and is in the process of its implementation. International Maritime Organization(IMO) has established CMDS based on e-Navigation strategy data standard as International Association of Lighthouse Authorities(IALA) established IHDM based on aids to navigation data standard and each data standard is linked with the S-100 standard. Fundamental concept and core principles of S-100 standard is suitable not only for the development of a wide range of hydrographic data and service production standard, including the next generation ENC, but also the development of product specification of non-hydrographic area. This study has examined the operation principle of S-100 standard and analyzed its implementation process as e-Navigation data in relation with ENC. It also noted the utilization of S-100 standard based e-Navigation and its potential effect via examining the development cases of S-100 standard-based product specification, such as nautical publication, ship reporting and pilot request, digital routing guide, tide and water level transmission and other important data cases of e-Navigation field.

• Korean Journal of Fisheries and Aquatic Sciences
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• v.56 no.6
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• pp.841-849
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• 2023

Corallina pilulifera (CP) is prevalent along the Korean coastline and belongs to the Corallinaceae family, exhibiting growth throughout all seasons. This study confirmed the role of calcium supplementation through CP, calcined CP (CCP), and a commercial calcium powder, highlighting variations in dosage within animal models induced by a calcium-deficient diet. Analysis of calcium absorption was conducted by assessing the serum and urine calcium levels during the feeding periods. Serum calcium content was significantly higher in the control group (CON, 9.79 mg/dL) than in the calcium-deficient model (CDM, 6.15 mg/dL). The calcium content of urine was significantly higher than that of CON (0.20 mg/dL) compared with CDM (0.08 mg/dL). Reticular bone thickness showed no significant differences between the CON and CDM groups. Additionally, micro-CT results demonstrated a reduction in the trabecular volume and a significant difference between the number of strands and the average interval of the reticular bone. In conclusion, CP serves as a promising source of calcium supplementation. Therefore, these findings emphasize that CP is of sufficient value as an industrial material related to calcium metabolism.

• CELLMED
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• v.7 no.2
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• pp.8.1-8.7
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• 2017

Benign prostatic hyperplasia (BPH) is one of the major diseases of the urinary system in older men. WSY-0702 is the extracted from the traditional medicinal plant; Seoritae, and it has effects of anti-obesity, chronic cervical pain, and anti-oxidant. The present study aimed to investigate the therapeutic potential of WSY-0702 in the prevention and treatment of BPH. Several parameters including inflammatory mediators, hormones, and oxidative stress (OS) have been considered to play a role in the development of BPH. Prostate tissue damage and OS may lead to compensatory cellular proliferation with resulting hyperplastic growth. An in vitro study showed that proliferation inhibited the human prostate epithelial cell line RWPE-1 in a dose-dependent manner. In cell line, the cell cycle at the G2/M and G0/G1 phase and downregulated the expression of CyclineB1 (CCNB1) and CyclineD1 (CCND1). In addition, we measured the $H_2O_2$-induced OS damage using RWPE-1 cells. We examined the relative expression of protein involved in the regulation of prostate apoptosis: transforming growth factor (TGF)-${\beta}$, a negative growth factor able to induced prostate apoptosis under physiological conditions. These results suggest that WSY-0702 that can inhibit the growth of prostate epithelial cell by a mechanism that may involve arresting the cell cycle and downregulating CCNB1 and CCND1 expression. In addition, WSY-0702 exposure resulted in significant protective effects in $H_2O_2$-stressed PWPE-1 cells by reduction in TGF-${\beta}$ levels.