• The Korean Journal of Community Living Science
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• v.18 no.4
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• pp.715-724
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• 2007

홍화 (Carthamus tinctorius)는 오래 전부터 각종 감염성 질환이나 암을 치료하는데 효과가 있는 것으로 알려져 왔다. 최근 각종 천연산물에 사람과 동물의 건강을 증진시키는 효과가 있는 것이 밝혀지면서, 홍화의 면역조절 효과에 대한 관심이 높아지고 있으나 이에 대한 과학적 자료가 부족한 실정이다. 따라서, 본 연구는 홍화의 면역 조절 활성을 확인하기 위해 수행되었으며, 면역능 실험을 위해 주로 이용되는 실험용 닭(White Leghorn chickens)에게 홍화잎을 첨가한 실험식이를 3주간 급여한 후 관련 요인들을 분석하였다. 실험 결과, 홍화잎을 섭취한 실험동물에서 비장 면역세포의 증식이 많았고, $Y{\delta}$-TCR+ 세포의 비율이 높아졌으며, 십이지장에서는 IFN-Y, IL-8, IL-10, IL-15 및 NK-lysin 같은 사이토카인의 발현이 높아졌다. 따라서, 홍화잎은 식이와 함께 급여하였을 때 면역 증강 효과가 있는 것으로 밝혀졌으며, 홍화잎을 이용한 각종 제품 개발이 기대된다.

• International Journal of Computer Science & Network Security
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• v.21 no.12spc
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• pp.586-596
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• 2021

Software organisations follow different methodologies for the development of software. The software development methodologies are mainly divided into two categories, including plan-driven and agile development. To attain project success, it is very significant to consider risk management during whole project. Agile development is considered risk-driven, but many risks are unreported at the industrial level. The risks can be divided into three categories, including (i) development risks, (ii) organisations risks, and (iii) people-oriented risks. This paper deals with Development risks specifically. Several risks related to development are faced by people working in the industry while dealing with agile development. Their management among the industry is a big issue, so this paper emphasises ARMF based on development-related risks by following agile development. This research work will help software organisations to prevent different project-related risks during agile development. The risks are elicited at two-level, (i) literature-based and (ii) IT industry based. A systematic literature review was performed for eliciting the agile risks from the literature. Detailed case studies and survey research methods were applied for eliciting risks from IT industry. Finally, we merged the agile development risks from literature with standard industrial risks. Hence, we established an agile risk mitigation framework ARMF based on agile development and present a groundwork established in light of empirical examination for extending it in future research.

• Steel and Composite Structures
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• v.16 no.3
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• pp.289-303
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• 2014

In recent, development of construction and design technology gives taller, larger and heavier steel framed structures. With the tendency of increasing high-rise building, this study is strongly related to structural system, one of significant components in structural design. This study presents an innovative structural system, with high performance steel material, diagrid. Its detail, structural analysis, and structural experiments are all included for the development of new structures.

• Molecules and Cells
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• v.41 no.2
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• pp.103-109
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• 2018

Calcium ions are involved in the regulation of diverse cellular processes. Fourteen genes encoding calcium binding proteins have been identified in Dictyostelium. CBP7, one of the 14 CBPs, is composed of 169 amino acids and contains four EF-hand motifs. Here, we investigated the roles of CBP7 in the development and cell migration of Dictyostelium cells and found that high levels of CBP7 exerted a negative effect on cells aggregation during development, possibly by inhibiting chemoattractant-directed cell migration. While cells lacking CBP7 exhibited normal development and chemotaxis similar that of wild-type cells, CBP7 overexpressing cells completely lost their chemotactic abilities to move toward increasing cAMP concentrations. This resulted in inhibition of cellular aggregation, a process required for forming multicellular organisms during development. Low levels of cytosolic free calcium were observed in CBP7 overexpressing cells, which was likely the underlying cause of their lack of chemotaxis. Our results demonstrate that CBP7 plays an important role in cell spreading and cell-substrate adhesion. cbp7 null cells showed decreased cell size and cell-substrate adhesion. The present study contributes to further understanding the role of calcium signaling in regulation of cell migration and development.

• Animal Bioscience
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• v.35 no.2_spc
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• pp.317-331
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• 2022

The aim of the present investigation is to determine the nutritional composition of various insects and their potential uses as alternative protein sources in animal diets. The feeding industry requires production systems that use accessible resources, such as feed resources, and concentrates on the potential impacts on production yield and nutritional quality. Invertebrate insects, such as black soldier flies, grasshoppers, mealworms, housefly larvae, and crickets, have been used as human food and as feed for nonruminants and aqua culture while for ruminants their use has been limited. Insects can be mass-produced, participating in a circular economy that minimizes or eliminates food- and feed-waste through bioconversion. Although the model for formula-scale production of insects as feed for domestic animals has been explored for a number of years, significant production and transformation to being a conventional protein resource remains to be deeply investigated. This review will focus on the nutritional composition of various insects and their potential use as alternative protein sources, as well as their potential use to promote and support sustainable animal production. Furthermore, nutritional compositions, such as high protein, lauric acid omega 6, and omega 3, and bioactive compounds, such as chitin, are of great potential use for animal feeding.

• Molecular & Cellular Toxicology
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• v.4 no.2
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• pp.132-137
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• 2008

Differential gene expression profiling was carried out in the hepatic tissue of medaka fish, Oryzias latipes, after exposure to an organophosphorus pesticide (OPP), Iprobenfos (IBP), a widely used pesticide in agri- and fish-culture, using a medaka cDNA micro array. Twenty six kinds of differentially expressed candidate genes, with 15 and 11 induced and repressed in their gene expressions, respectively, were associated with cytoskeleton (3.8%), development (7.7%), immune (7.7%), metabolism (30.8%), nucleic acid/protein binding (42.3%) and reproduction (7.7%). Of these genes, changes at the transcription level of five were re-evaluated by real-time quantitative PCR (qRT-PCR). Considering the known function of authentic genes, the effects of IBP on the biological activity and pathological aspects in medaka fish were discussed. The identified genes could be used as molecular biomarkers for biological responses to OPPs contamination in an aquatic environment.

• Journal of Korea Trade
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• v.25 no.5
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• pp.58-73
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• 2021

Purpose - In the context of economic globalization and the continuous development of international trade, as countries around the sea peninsula, port construction is particularly important. Based on the research on the influencing factors of port logistics development based on the allocation analysis, QCA (Qualitative Comparative Analysis) provides the basis for the planning and policy of port logistics development and has important theoretical value and practical significance for improving the level of port logistics management, reducing logistics operating costs and increasing economic benefits. In the tide of global integration for the development of port logistics, promote the growth of foreign trade economy of the city. It is also of great significance to the development and progress of commerce and trade. Design/methodology - Based on the relevant data samples of various ports in South Korea, this paper uses fsQCA (fuzzy set Qualitative Comparative Analysis) to integrate and analyze the influence mechanism of port logistics development and extracts five influencing factors of port logistics development, including the port's scale and infrastructure in the hard environment, port-neighboring enterprises in the soft environment, hinterland economy and government support. Findings - The five factors are unable to separately constitute the necessary and sufficient conditions of port logistics development, only a combined model can influence lake port logistics development. The scale and infrastructure of the port itself and port-neighboring ring enterprises are the main core conditions, which work together on the port, affect the throughput capacity of the port, and promote the development of port logistics. When the port-neighboring enterprises are not complete and the scale is low, the growth of port throughput will be restrained and the development of port logistics will be affected, whether the hinterland economic benefits are general, the development of port-neighboring enterprises is insufficient, or the government supports are limited. Originality/value - Through the research on the development of port logistics in South Korea from the perspective of configuration, this paper finds the configuration influence of hard environment and soft environment on the development of port logistics, which has important theoretical and practical significance for better promoting the development of port logistics in South Korea.

• Proceedings of the Korean Magnestics Society Conference
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• 2015.11a
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• pp.38-38
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• 2015

• Journal of the Korean Society of Food Science and Nutrition
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• v.43 no.8
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• pp.1228-1235
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• 2014

We investigated the antioxidant activities and effects of soy-sprout extracts (SE) against $H_2O_2$-induced oxidative stress in HepG2 cells. The major free amino acids were asparagine, valine, pheylalanine, histidine, isoleucine, and leucine in SE. Both soy-spout extract by enzyme (SEE) and soy-spout extract by ultra high pressure (SEP) showed higher contents compared with soy-sprout water extract (SEW). The total polyphenol and isoflavone contents were highest in SEE. SEE had the highest DPPH and ABTS radical scavenging activities as well. To determine the effects of SE on $H_2O_2$-induced oxidative damage, cell viability was measured using XTT assay. Pre-treatment with SEE and SEP significantly increased cell viability compared with $H_2O_2$-treated control cells by 29% and 32%, respectively. These results indicate that SEE and SEP possess antioxidant activity.

• Development and Reproduction
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• v.17 no.3
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• pp.215-220
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• 2013

Recently, the RNA/DNA-binding protein FUS, Fused in sarcoma, was shown to play a role in growth, differentiation, and morphogenesis in vertebrates. Because little is known about Fus, we investigated its expression pattern in murine tooth development. In situ hybridization of mouse mandibles at specific developmental stages was performed with a DIG-labeled RNA probe. During early tooth development, Fus was detected in the dental epithelium and dental mesenchyme at 11 days postcoitum (dpc) and 12 dpc. From 14 dpc, Fus was strongly expressed in the dental papilla and the cervical loop of the dental epithelium. At postnatal day 4 (PN4), Fus expression was observed in the odontoblasts, ameloblasts, the proliferation zone of the pulp, and the cervical loop. At PN14, the expression pattern of Fus was found to be maintained in the odontoblasts and the proliferation zone of the pulp. Furthermore, Fus expression was especially strong in the Hertwig's epithelial root sheath (HERS). Therefore, this study suggests that Fus may play a role in the HERS during root development.