• 한국독성학회:학술대회논문집
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• 한국독성학회 2001년도 International Symposium on Signal transduction in Toxicology
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• pp.138-138
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• 2001

The purpose of the present studies was to investigate the effects of subchronic paternal treatment of cyclophosphamide (CP) and acrolein on male fertility and early embryonic development. Two approaches were pursued. The first was to perform in vivo test for observing the adverse effects of CP and acrolein on the function og male reproductive system and pregnancy outcome.(omitted)

• Molecules and Cells
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• 제40권4호
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• pp.280-290
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• 2017

Several lines of evidence suggest that endoplasmic reticulum (ER) stress plays a critical role in the pathogenesis of many neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis. Protein tyrosine phosphatase 1B (PTP1B) is known to regulate the ER stress signaling pathway, but its role in neuronal systems in terms of ER stress remains largely unknown. Here, we showed that rotenone-induced toxicity in human neuroblastoma cell lines and mouse primary cortical neurons was ameliorated by PTP1B inhibition. Moreover, the increase in the level of ER stress markers ($eIF2{\alpha}$ phosphorylation and PERK phosphorylation) induced by rotenone treatment was obviously suppressed by concomitant PTP1B inhibition. However, the rotenone-induced production of reactive oxygen species (ROS) was not affected by PTP1B inhibition, suggesting that the neuroprotective effect of the PTP1B inhibitor is not associated with ROS production. Moreover, we found that MG132-induced toxicity involving proteasome inhibition was also ameliorated by PTP1B inhibition in a human neuroblastoma cell line and mouse primary cortical neurons. Consistently, downregulation of the PTP1B homologue gene in Drosophila mitigated rotenone- and MG132-induced toxicity. Taken together, these findings indicate that PTP1B inhibition may represent a novel therapeutic approach for ER stress-mediated neurodegenerative diseases.

• 한국레이저가공학회지
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• 제16권4호
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• pp.7-11
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• 2013

The surface oxidation of magnesium was performed by Plasma electrolytic oxidation treatment method. And the optical reflectance spectra of the oxidation layers are studied. In the PEO process, the growth of the oxide layer take place at room temperature. Surface roughness of the obtained result, the average surface roughness is $0.08{\mu}m$ difference. The reason seems to the influence of the $Na^+$.

• Journal of Microbiology and Biotechnology
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• 제33권2호
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• pp.203-210
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• 2023

Taste is classified into five types, each of which has evolved to play its respective role in mammalian survival. Sour taste is one of the important ways to judge whether food has gone bad, and the sour taste receptor (PKD2L1) is the gene behind it. Here, we investigated whether ʟ-pyroglutamic acid interacts with sour taste receptors through electrophysiology and mutation experiments using Xenopus oocytes. R299 of hPKD2L1 was revealed to be involved in ʟ-pyroglutamic acid binding in a concentration-dependent manner. As a result, it is possible to objectify the change in signal intensity according to the concentration of ʟ-pyroglutamic acid, an active ingredient involved in the taste of kimchi, at the molecular level. Since the taste of other ingredients can also be measured with the method used in this experiment, it is expected that an objective database of taste can be created.

• 한국동물번식학회:학술대회논문집
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• 한국동물번식학회 2004년도 춘계학술발표대회
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• pp.189-189
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• 2004

Histone acetylation as epigenetic marker plays a critical role in gene expression through the interaction of nucleosomes with DNA, modulating the efficiency which RNA-polymerase can interact with promotors to initiate transcription. After fertilization, highly acetylated chromatin takes place and maintain during 1cell stages. The hyperacetylation may lead minor genome activation for survival and cleavage, and then may affect embryonic genome activation and development to balstocyst. (omitted)

• Asian Journal of Innovation and Policy
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• 제7권3호
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• pp.438-456
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• 2018

This study aims to understand the importance of commercialization of research and development projects and examines key factors that allow successful technology transfer and commercialization. Given the characteristics of the railway research project, and assuming that R&D input factors would vary depending on the technology readiness level and the degree of research convergence, this study analyzes the moderating effect of each R&D input factor on technology transfer and commercialization to determine their eventual impact. Through this study, it was found that it was necessary to proceed to technology transfer and commercialization of the national research and development projects via strategic workforce composition and allocation of research funding given the subjects and development goals of R&D projects.

• Bulletin of the Korean Chemical Society
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• 제33권2호
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• pp.717-720
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• 2012

• 한국수산과학회지
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• 제39권6호
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• pp.460-465
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• 2006

An 8-week feeding trial was conducted to investigate the effects of dietary supplementation with probiotics as a feed additive for Juvenile olive flounder (Paralichthys olivaceus). Three experimental diets supplemented with Bacillus polyfermenticus (BP), Bacillus licheniformis (BL), or Bacillus polyfermenticus plus Saccharomyces cerevisiae, (BP+SC) at $1.0{\times}10^7CFU/kg$ diet on a dry-matter basis were prepared. The basal diet was used as a control. After the 8-week feeding trial, the respiratory burst activity (NBT assay) of fish fed the BP + SC diet was significantly higher than that of fish fed the control diet. Fish fed the BP, BL and BP + SC diets had significantly lower cumulative mortality than did fish fed the control diet after the third day of the challenge test (P<0.05). However, there were no significant differences among fish fed the experimental diets in weight gain, feed efficiency, protein efficiency ratio, hematosomatic index, condition factor, survival rate, or Iysozyme activity. Results could suggest that dietary B. polyfermenticus, B. licheniformis, and B. polyfermenticus +S. cerevisiae enhance nonspecific immunity and disease resistance in juvenile olive flounder.

• 한국경제지리학회지
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• 제15권4호
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• pp.550-569
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• 2012

본 연구에서는 중국 베이징시(북경시(北京市)) 중관촌(中關村) 클러스터를 사례로 첨단산업 연구개발 네트워크의 특성을 기업간, 산 학, 산 연, 산 관에 초점을 두고 고찰하였다. 분석결과는 다음과 같다. 중관촌(中關村) 클러스터 기업의 국제경쟁력을 제고시키기 위해서는 연구개발의 강화가 요구된다. 기업의 연구개발 네트워크 실태를 조사한 결과를 살펴보면, 조사 대상 기업들은 현재에도 어느 정도는 연구개발 네트워크가 활성화되고 있다. 특히 기업의 협력 대상별 연구개발 네트워크의 내용에 있어서 차이는 있으나, 기업들은 다양한 내용으로 연구개발 네트워크를 이용하고 있다. 그러나 연구개발 네트워크가 어느 정도 자리잡은 수준에 이르고 있지만 아직까지 기업들이 연구개발 네트워크를 구축하는데 많은 애로가 있는 것이 사실이다. 따라서 본문은 기업들이 연구개발 네트워크를 형성하는데 애로점을 해결하기 위해 개선방안을 제시하였다.

• 한국군사과학기술학회지
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• 제20권1호
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• pp.81-89
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• 2017

This study investigates store separation characteristics of an unmanned aerial vehicle having generic stealth configuration over unsteady flow of an internal bay. Free-drop wind tunnel tests are conducted to simulate bomb releases from an internal weapons bay while high-speed camera images are taken. The images are analyzed to examine the effects of flow velocity, angle of attack, flap deflection and the ejector force application on the store separation trajectories. For the free-drop wind tunnel tests, Froude Scaling is applied to match the dynamic similarity for the bomb model, and the ejector force is simulated by using small pneumatic cylinders. The results indicate that the test bomb model safely separates from the internal bay at the given test conditions and configurations. It is also observed that the effects of the flow velocity and ejector force application have greater impacts on the separation trajectories than those of angle of attack and flap deflection.