• 시스템엔지니어링학술지
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• 제2권1호
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• pp.48-53
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• 2006

A web-based program life-cycle management(PLM) system is introduced to implement the system engineering processes and to provide the development traceability online. This information system aims for the realization of essential system engineering management techniques currently applied to the space launch system development program including management of configuration and data based on the work breakdown structure(WBS), WBS, bill of materials and mass properties. The system enhances communication and gives access to the development data with relevant information such as data-to-data relation and approval status/history through the web, and preserve all of the development data throughout the program life-cycle. Further improvement of the system is planned to implement the program management processes and co provide integrated information useful for the programmatic decision making.

• 보건교육건강증진학회지
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• 제33권3호
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• pp.1-11
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• 2016

Objectives: The challenging issue of public health program is to strengthen partnership and network between health resources. This study identified the structure and characteristics of school health program network. Methods: In this paper we collected data from schools and organizations in 4 local communities in 2014 that participated to school health program. Using social network analysis techniques we measured the number of component, diameter, density, average degree, node centralization for each network. Results: We determined that networks shared some common organizational structure such as less density, low average degree, and short diameter. Networks were dominated by the health center, and directions of collaborations between nodes were mostly one-way. Conclusions: These findings can help to depict the network of school health program. The further research is necessary to define causal relationship between network effectiveness and public health outcomes.

• 산업경영시스템학회지
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• 제29권1호
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• pp.94-100
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• 2006

The risk management is an organized method for identifying and measuring risk and for selecting, developing, and implementing options for the handling of risk. The risk management covers all programatic and technical factors which affect the system development performance, cost, and schedule. While technical issues are primary concern for systems engineering, the three elements(performance, cost, and schedule) must be balanced for a successful risk management process. This paper proposes the risk management process for the KSLV-I(Korea Space Launch Vehicle-I) program using computer-aided systems engineering tool, Cradle. The risk management process of KSLV-I program is similar to the general risk management process, but it has its own specific features to manage large-scale complex characteristics of KSLV-I program.

• 한국국방경영분석학회지
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• 제16권2호
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• pp.56-74
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• 1990

Programming-in-the-Large refers to software development environment and includes the organization and representation of a system structure, module decomposition, component dependence analysis, seperate compilation, subsystem and composition identification. The most intricate problem in this environment is the mastery of the structural complexity of large software systems. Ada programming language is tailored to the needs for building of large, integrated software systems from many program units. The visibility graph generating model presented in this paper transforms Ada source program into a visibility graph with nodes for program units and edges for visibility relations among program units. The system description in terms of program units and their visibility relations produced by this model can be utilized for some apects of Programming-in-the-Large environment and also assists designeers, programmers, integrators and maintainers in defining, understanding and exploring the structure of evolving software systems. The model designed and implemented in Ada programming language runs on PCs and will remain useful both in practice and as experimental tool.

• Bulletin of the Korean Chemical Society
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• 제32권1호
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• pp.201-207
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• 2011

Peroxisome proliferator-activated receptors (PPARs) are members of nuclear receptors and their activation induces regulation of fatty acid storage and glucose metabolism. Therefore, the $PPAR\gamma$ is a major target for the treatment of type 2 diabetes mellitus. In order to generate pharmacophore model, 1080 known agonists database was constructed and a training set was selected. The Hypo7, selected from 10 hypotheses, contains four features: three hydrogen-bond acceptors (HBA) and one general hydrophobic (HY). This pharmacophore model was validated by using 862 test set compounds with a correlation coefficient of 0.903 between actual and estimated activity. Secondly, CatScramble method was used to verify the model. Hence, the validated Hypo7 was utilized for searching new lead compounds over 238,819 and 54,620 chemical structures in NCI and Maybridge database, respectively. Then the leads were selected by screening based on the pharmacophore model, predictive activity, and Lipinski's rules. Candidates were obtained and subsequently the binding affinities to $PPAR\gamma$ were investigated by the molecular docking simulations. Finally the best two compounds were presented and would be useful to treat type 2 diabetes.

• Archives of Pharmacal Research
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• 제26권8호
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• pp.585-590
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• 2003

Activity-guided fractionation of the EtOAc-soluble extract of the whole plants of Sida acuta using a bioassay based on the induction of quinone reductase (OR) in cultured Hepa 1c1c7 mouse hepatoma cells, led to the isolation of ten active compounds of previously known structure, quindolinone (1), cryptolepinone (2), 11-methoxyquindoline (3), N-trans-feruloyltyramine (4), vomifoliol (5), loliolide (6), 4-ketopinoresinol (7), scopoletin (8), evofolin-A (9), and evofolin-B (10), along with five inactive compounds of known structure, ferulic acid, sinapic acid, syringic acid, ($\pm$)-syringaresinol, and vanillic acid. These isolates were identified by physical and spectral data measurement. A new derivative of quindolinone, 5,10-dimethylquindolin-11-one (1a) was synthesized and characterized spectroscopically. Of the active substances, compounds 1-3 and 1a exhibited the most potent QR activity, with observed CD (concentration required to double induction) values ranging from 0.01 to 0.12 $\mu$ g/mL. Six compounds were then evaluated in a mouse mammary organ culture assay, with cryptolepinone (2), N-trans-feruloyltyramine (4), and 5,10-dimethylquindolin-11-one (1a) found to exhibit 83.3, 75.0, and 66.7% inhibition of 7,12-dimethylbenz[a]anthracene-induced preneoplastic lesions, respectively, at a dose of 10 $\mu\textrm{g}$/mL.

• Parasites, Hosts and Diseases
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• 제57권3호
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• pp.319-324
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• 2019

This study aimed to investigate the tick species and give background for tick-borne investigations in Korea. Ticks were collected from the area within 2 km radius of the 4 domestic animal farms, where they were located in mountainous areas and raising animals on pasture, and from animal bodies in 2014 and 2015. In total, 7,973 nymphal and adult ticks were collected from the farms - 7,758 Haemaphysalis longicornis, 198 Haemaphysalis flava, and 17 Ixodes nipponensis, and 1,763 were collected from animals - 729 H. longicornis from cattle; 569 H. longicornis from goats; and 297 H. longicornis, 118 H. flava, 1 I. nipponensis, and 49 Amblyomma testudinarium from wild boars. As more species of ticks were collected from wild boars than domesticated animals and their habitats, various animal hosts should be considered while investigating tick species.

• 한국과학교육학회지
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• 제31권5호
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• pp.663-679
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• 2011

본 연구는 첨단과학 교사연수센터에서 실시한 교사연구경험(Research Experience for Teachers, RET) 프로그램에 참여한 세 명의 과학 교사들을 대상으로 한 사례 연구이다. 교사들은 RET 프로그램이 진행되는 6개월 동안 과학자의 연구실에서 실험 수행 경험을 하였으며, 이 경험을 토대로 학교에서 적용할 수 있는 교수 자료를 개발하였다. 교수법적 내용 지식(Pedagogical Content Knowledge, PCK)을 교사가 전문성을 갖추기 위해 가져야 할 지식으로 규정하고, RET 프로그램을 경험한 후에 나타난 교사들의 전문성의 변화와 그들의 전문성 발달에 영향을 미치는 요인을 탐색하였다. 3명의 참여 교사들은 RET 프로그램에 참여함으로써 과학 교수 지향, 과학 지식, 학생 지식, 교수 지식, 그리고 자원 지식과 같은 PCK 요소들의 통합된 발달을 보였다. RET 프로그램을 통해서 발달한 PCK 요소들은 학교에서의 교수 실행에 반영되었으며, 시간이 지날수록 교사들이 자신의 PCK 발달을 더욱 명확히 인식하는 것으로 나타났다. 이는 참여 교사들이 RET 프로그램을 통해서 진정한 맥락인 과학자의 연구실에서 ‘합법적인 주변 참여’를 통해서 학습했기 때문에 실제 과학의 과정을 알 수 있었으며, 교수 자료를 개발하는 동안에 새롭게 발달한 PCK요소들과 교사가 이미 가지고 있던 PCK의 통합으로 그들의 PCK가 학교 현장의 실행으로 이어지도록 발달하였기 때문이다. 한편 참여 교사들에 따라서 전문성 발달 요소와 양상에 차이가 있었는데, 이는 RET프로그램에 참여할 때 교사들이 가진 목적이나 그들이 가지고 이미 가지고 있던 PCK의 차이에 기인한 것으로 파악되었다. 본 연구는 연구 경험 제공을 통한과학 교사들의 전문성 발달 프로그램 개발에 의미 있는 시사점을 제공할 수 있을 것으로 보인다.

• 방사성폐기물학회지
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• 제21권1호
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• pp.65-93
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• 2023

Several countries have been operating radioactive waste disposal (RWD) programs to construct their own repositories and have used natural analogues (NA) studies directly or indirectly to ensure the reliability of the long-term safety of deep geological disposal (DGD) systems. A DGD system in Korea has been under development, and for this purpose a generic NA study is necessary. The Korea Atomic Energy Research Institute has just launched the first national NA R&D program in Korea to identify the role of NA studies and to support the safety case in the RWD program. In this article, we review some cases of NA studies carried out in advanced countries considering crystalline rocks as candidate host rocks for high-level radioactive waste disposal. We examine the differences among these case studies and their roles in reflecting each country's disposal repository design. The legal basis and roadmap for NA studies in each country are also described. However because the results of this analysis depend upon different environmental conditions, they can be only used as important data for establishing various research strategies to strengthen the NA study environment for domestic disposal system research in Korea.

• 한국식품영양과학회지
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• 제42권10호
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• pp.1608-1617
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• 2013

본 연구는 과체중 및 비만인 직장인을 대상으로 체중관리 프로그램을 실시하여 체중감량 및 체지방의 감소, 혈액생화학적 변화, 영양지식 및 운동 능력에 대한 효과를 알아보고자 하였다. 전라북도 내 공공기관의 BMI 23 이상 과체중 및 비만인 직원 39명을 연구대상자로 하여 6개월간 프로그램을 실시하였다. 연구결과 남자그룹에서 삼두근 피부두겹 두께가 유의적으로 감소하였고(P<0.05), 남녀 그룹 모두에서 허리둘레, 엉덩이 둘레가 유의적으로 감소하였다(P<0.05). 혈액 생화학적 검사에서는 남자그룹에서 총콜레스테롤(P<0.05)과 LDL-콜레스테롤(P<0.01)이 유의적으로 감소하였다. 복부 컴퓨터단층촬영 결과에서는 남자그룹에서 복부피하지방조직이 유의적으로 감소하였으며(P<0.01), 영양소 섭취 조사결과 여자 그룹에서 철, 비타민 B2와 나이 아신 섭취량이 유의적으로 증가하였다(P<0.05). 영양지식 점수는 남자 그룹에서 유의적으로 증가하였으며(P<0.05), 운동능력 검사에서는 근지구력이 유의적으로 증가하였다(P<0.01). 직장인들의 건강증진뿐만 아니라 근무 능률과 삶의 질 향상을 위해 사업장에도 건강 및 비만관리가 이루어질 수 있는 체계적인 프로그램이 필요하며, 교육 후에도 비만개선의 긍정적인 변화가 지속될 수 있도록 근로 현장과 국가차원의 프로그램이 개발 지원되어야 할 것이다.