• Title/Summary/Keyword: Research Program

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Comprehensive Study of Microsatellite Instability Testing and Its Comparison With Immunohistochemistry in Gastric Cancers

  • Yujun Park;Soo Kyung Nam;Soo Hyun Seo;Kyoung Un Park;Hyeon Jeong Oh;Young Suk Park;Yun-Suhk Suh;Sang-Hoon Ahn;Do Joong Park;Hyung-Ho Kim;Hye Seung Lee
    • Journal of Gastric Cancer
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    • v.23 no.2
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    • pp.264-274
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    • 2023
  • Purpose: In this study, polymerase chain reaction (PCR)-based microsatellite instability (MSI) testing was comprehensively analyzed and compared with immunohistochemistry (IHC) for mismatch repair (MMR) protein expression in patients with gastric cancer (GC). Materials and Methods: In 5,676 GC cases, PCR-based MSI testing using five microsatellites (BAT-26, BAT-25, D5S346, D2S123, and D17S250) and IHC for MLH1 were performed. Reevaluation of MSI testing/MLH1 IHC and additional IHC for MSH2, MSH6, and PMS2 were performed in discordant/indeterminate cases. Results: Of the 5,676 cases, microsatellite stable (MSS)/MSI-low and intact MLH1 were observed in 5,082 cases (89.5%), whereas MSI-high (MSI-H) and loss of MLH1 expression were observed in 502 cases (8.8%). We re-evaluated the remaining 92 cases (1.6%) with a discordant/indeterminate status. Re-evaluation showed 1) 37 concordant cases (0.7%) (18 and 19 cases of MSI-H/MMR-deficient (dMMR) and MSS/MMR-proficient (pMMR), respectively), 2) 6 discordant cases (0.1%) (3 cases each of MSI-H/pMMR and MSS/dMMR), 3) 14 MSI indeterminate cases (0.2%) (1 case of dMMR and 13 cases of pMMR), and 4) 35 IHC indeterminate cases (0.6%) (22 and 13 cases of MSI-H and MSS, respectively). Finally, MSI-H or dMMR was observed in 549 cases (9.7%), of which 47 (0.8%) were additionally confirmed as MSI-H or dMMR by reevaluation. Sensitivity was 99.3% for MSI testing and 95.4% for MMR IHC. Conclusions: Considering the low incidence of MSI-H or dMMR, discordant/indeterminate results were occasionally identified in GCs, in which case complementary testing is required. These findings could help improve the accuracy of MSI/MMR testing in daily practice.

A Study on the Mid- to Long-term Public Library Expansion Plan in Daegu City (대구시 중장기 공공도서관 확충방안 연구)

  • Hee-Yoon Yoon;Seon-Kyung Oh
    • Journal of the Korean Society for Library and Information Science
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    • v.57 no.3
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    • pp.97-117
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    • 2023
  • The purpose of this study is to suggest a mid- to long-term expansion plan to resolve the blind spot and alleviate the imbalance of public library services in Daegu City. The research methods for this purpose included literature review, related laws and statistical data analysis, case study, and opinion survey. As a result, the first service area was set as a total of 14 areas based on administrative districts(Jung-gu, Seo-gu, Nam-gu, and Dalseong-gun each have one, Dong-gu and Buk-gu each have two, and Suseong-gu and Dalseo-gu have three each). Second, the expansion scenario for public libraries in Daegu City was proposed to add 26 libraries by the final target year (2032) based on the trend of national library growth over the past 13 years (2008-2020) and the forecast for the next 10 years (2023-2032). Third, the construction scenarios for each basic local government, excluding the Daegu representative library, are as follows: One library each in Jung-gu, Seo-gu, and Nam-gu; two libraries in Suseong-gu; three libraries in Dalseong-gun; four libraries in Dong-gu; and seven libraries each in Buk-gu and Dalseo-gu. In terms of floor area, it is proposed to add a total of 17 branch libraries with a minimum legal standard of 330-2,499㎡, four central libraries with 2,500-4,999㎡ each, and four central libraries with 5,000-9,999㎡ each. On the premise of these conditions, Daegu City and public libraries should focus on creating an inclusive and open community space, creating a digital platform, strengthening the library operation and cooperation system centered on Daegu representative library, developing collections and specializing services for local hub libraries, enhancing various knowledge information and program services, managing key library indicators and improving social contribution.

Validation of a physical activity classification table in Korean adults and elderly using a doubly labeled water method (한국 성인과 노인을 대상으로 이중표식수법을 이용한 신체활동분류표 타당도 평가)

  • Hye-Ji Han ;Ha-Yeon Jun;Jonghoon Park;Kazuko Ishikawa-Takata;Eun-Kyung Kim
    • Journal of Nutrition and Health
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    • v.56 no.4
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    • pp.391-403
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    • 2023
  • Purpose: This study evaluated the validity of a physical activity classification table (PACT) based on total energy expenditure (TEE) and physical activity level (PAL) measured using the doubly labeled water (DLW) method in Korean adults and the elderly. Methods: A total of 141 (male 70, female 71) adults and elderly were included. The reference standards TEEDLW, PALDLW were measured over a 14-day period using DLW. A 24-hour physical activity diary was kept for three days (two days during the week and one day on the weekend). PALPACT was calculated by classifying the activity type and intensity using the PACT. PALPACT was multiplied by resting energy expenditure measured by indirect calorimetry to estimate TEEPACT. Results: The mean age of the study participants was 50.5 ± 18.8 years, and the mean body mass index was 23.4 ± 3.3 kg/m2. A comparison of TEEDLW and TEEPACT by sex and age showed no significant differences. The bias, the difference between TEEDLW and TEEPACT, was male 17.3 kcal/day and female -4.5 kcal/day. The percentage of accurate predictions (values within ± 10% of the TEEDLW) of TEEPACT was 58.6% in males and 54.9% in females, with the highest prediction values in the age group 40-64 years (70.9%) in males and over 65 years (73.9%) in females. The spearman correlation coefficient (r) between TEEPACT and TEEDLW was 0.769, indicating a significant positive correlation (p < 0.001). Conclusion: In this study, the use of a new PACT for calculating TEE and PAL was evaluated as valid. A web version of the software program and a smartphone application need to be developed using PACT to make it easier to apply for research purposes.

A Pilot Survey Examining Satisfaction for Integrated Medicine Based on Critical Pathways for Acute Facial Palsy

  • Min-Jung Ko;Sang-Yeup Chae;Seungeun Lee;Dongmin Lee;Jaeho Song;Jinkyung Park;Jung-Hyun Kim;Bonhyuk Goo;Yeon-Cheol Park;Byung-Kwan Seo;Yong-Hyeon Baek;Sang-Soo Nam
    • Journal of Acupuncture Research
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    • v.40 no.3
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    • pp.245-251
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    • 2023
  • Background: The incidence of facial palsy has been increasing. Many patients consult both Korean and Western physicians; however, no critical pathway (CP) for facial palsy has been established based on integrated medicine including Korean medicine, Western medicine, and complementary and alternative medicine. Thus, we developed and implemented an integrated CP for patients with acute facial palsy and investigated the satisfaction with CP. Methods: Overall, 20 patients who received treatment following the CP and 20 medical staff members involved in their care responded to a questionnaire survey. The questionnaire was developed based on a review of previous studies and focused on the satisfaction with the CP. Results: Patients' satisfaction score with the integrated CP was ≥ 4.4 for all items using a 5-point Likert-type scale. Smooth and cooperative treatment procedures, time-saving practices, and a clear explanation of the integrated treatment plan were satisfactory factors. Additionally, they preferred incorporating specialized facial massage and receiving education on self-exercise or massage techniques as complementary therapies. The medical staff members expressed a high level of satisfaction with the CP; however, the work division and treatment guidelines must be improved. Conclusion: An integrated CP program for acute facial palsy was implemented, and the satisfaction levels of patients and medical staff members were assessed. The results revealed high levels of satisfaction, and several improvements identified will be incorporated into clinical practice going forward.

The Effects of Emerging Infectious Disease Knowledge and Clinical Practice Stress on Nursing Students' Coping with Stress (신종감염병지식과 임상실습스트레스가 간호대학생의 스트레스대처방식에 미치는 영향)

  • So Young Lee;Hey Kyoung Kim
    • Journal of the Korean Applied Science and Technology
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    • v.40 no.3
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    • pp.507-520
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    • 2023
  • The purpose of this study is to inquire into the effect on the coping with stress by the knowledge of Emerging infectious disease, clinical practice stress. A research was held to the nursing students living in Seoul and Chungbuk from September 10 to October 10, 2022, 259copies of the data were used for the final analysis, Pearson's correlation coefficient and Multiple linear regressions was used. As a result of the study, there was a positive correlation between clinical practice stress due to burden of work, practice education environment stress, and active coping with stress. Clinical practice stress due to interpersonal conflicts, conflicts with patients, burden of work, and undesirable role models was positively correlated with passive coping with stress. Satisfaction of clinical practice, practical educational environment stress and gender accounted for 15.0% of the total variance in the active stress coping, and burden of work accounted for 7% of the total variance in the passive stress coping. Consequently, this study could be suggested as a basis for counseling and developing practical education program for active coping with stress.

Plant Proteins in Relation to Health-related Quality of Life in South Korean Individuals Aged 50 Years or Older: Korea National Health and Nutrition Examination Survey 2016-2018 (50세 이상 한국인의 식물성 단백질 섭취와 건강 관련 삶의 질과의 연관성: 국민건강영양조사 2016-2018)

  • Jun, Sook-Hyun;Lee, Jung Woo;Shin, Woo-Kyoung;Kim, Yookyung
    • Journal of Korean Home Economics Education Association
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    • v.34 no.4
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    • pp.1-18
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    • 2022
  • This study aimed to investigate the association between plant protein intake and health-related quality of life (HRQoL) in Korean individuals aged 50 years or older. Using the 2016-2018 Korea National Health and Nutrition Examination Survey data, 7,956 participants (3,434 men and 4,522 women) were included in the study. HRQoL was measured using the Euro-quality of life five-dimension (EQ5D), composed of physical function, self-care, daily activities, pain/discomfort, and anxiety/depression problems. The EQ5D estimates were converted into an EQ5D index score. The association between daily intake of plant proteins and HRQoL was evaluated using regression analysis. The intake of total plant protein, legume nut seed (LNS), and fermented bean (FERMB) proteins were all positively associated with HRQoL in both men and women (p < 0.01). Of EQ5D's five dimensions, physical function and daily activities were most commonly associated with plant protein intake. Compared to LNS protein or FERMB protein intake, total plant protein intake showed a better association with HRQoL. In conclusion, a significant association was observed between plant protein intake and HRQoL. It suggests that adequate intake of plant protein might be helpful for the maintenance or improvement of HRQoL in Korean adults.

Effects of Self-Leadership, Empathic Ability, and Depression on the Interpersonal Skills of Nursing Students (간호대학생의 셀프리더십, 공감능력과 우울이 대인관계능력에 미치는 영향)

  • Mi-Young Kim;Yooun-Sook Choi
    • Journal of The Korean Society of Integrative Medicine
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    • v.11 no.3
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    • pp.115-126
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    • 2023
  • Purpose : This study sought to determine the influence of nursing students' self-leadership, empathic ability, and depression on their interpersonal skills. Methods : This study applied a descriptive survey research design involving a self-report questionnaire. The participants were 315 nursing students in B city. Data were collected from April 27 to May 6, 2022. The data were analyzed using the percentage, mean, standard deviation, t-test, ANOVA, Scheffé test, Pearson's correlation coefficients, and multiple regression with IBM SPSS/WIN 23.0 program. Results : The participants' self-leadership score was 3.63±.65, their empathic ability score was 3.35±.40, their depression score was .84±.50, and their interpersonal skills score was 3.64±.80. Among the sub-categories, others' temperament scored the highest at 3.70±.86, followed by communication at 3.67±.86 and promoting relationships at 3.53±.86. Interpersonal skills were positively correlated with both self-leadership (r=.48, p<.001) and empathic ability (r=.33, p<.001). Self-leadership was positively correlated with empathic ability (r=.17, p<.05), but, negatively correlated with depression (r=.27, p<.001). The multiple regression analysis revealed, that the factors with the most significant effect on promoting relationships were, in descending order, self-leadership (β=.49, p<.001), empathic ability (β=.19, p<.001), and gender (β=.10, p=.033); the factors affecting others' temperament were, in descending order, self-leadership (β=.37, p<.001), empathic ability (β=.30, p<.001), severe depression (β=.14, p=.008), gender (β=.13, p=.010), and grade (β=-.13, p=.037); while the factors affecting communication were, in descending order, self-leadership (β=.41, p<.001), empathic ability (β=.23, p<.001), and gender (β=.11, p=.035). Moreover, the explanatory power of promoting relationships scored the highest at 31 %, followed by others' temperament at 27 % and communication at 26 %. Conclusion : The results of this study reveal the factors that influence the interpersonal skills of nursing students. To increase the interpersonal skills of nursing students, it is necessary to develop and apply regular curricula and programs designed to strengthen their self-leadership and empathic ability and to reduce their depression through reflecting differences between genders and grades.

The Effect of Happiness Sharing Kumdo Class Participating Adolescents' Achievement Goal Orientation on Ego-Resiliency and Quality of Life (행복나눔검도교실에 참여하는 청소년의 성취목표성향이 자아탄력성과 삶의 질에 미치는 영향)

  • Kim, Hyung-Ryong
    • Journal of Korea Entertainment Industry Association
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    • v.13 no.7
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    • pp.295-306
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    • 2019
  • The purpose of this study was to Happiness Sharing Kumdo Class Participating Adolescents' achievement goal orientation on ego-resiliency and quality of life and to provide guidance measures for the correct growth of vulnerable participants through the happiness sharing Kumdo class, which will be activated as a sports support program. To achieve the purpose of this research, 236 Adolescent participating in the Happiness Sharing Kumdo Class was selected and surveyed in Seoul, Gyeonggi Province and Incheon. Based on the data collected, the following results were derived by conducting frequency analysis, exploratory factor analysis, reliability analysis, correlation analysis, and multiple regression analysis. First, verification of the effect of achievement goal orientation of Adolescent participating in Happiness Sharing Kumdo Class on ego-resiliency showed that task-orientation has significant influence on diversity, future-orientation, and emotion control, and ego-orientation has significant influence on diversity and emotion control. Second, verification of the effect of achievement goal orientation of Adolescent participating in Happiness Sharing Kumdo Class on quality of life showed that task-orientation has significant influence on quality of physical, psychological, social, environmental and educational quality, and ego-orientation has a significant influence on quality of physical and environmental quality. Third, verification of the effect of ego-resiliency on quality of life by Adolescent participating in Happiness Sharing Kumdo Class showed that diversity has not significant influence all factors of quality of life, but future-orientation has significant influence on quality of psychological and environmental quality, and emotion control has a significant influence on quality of physical, psychological, social and educational quality.

Research on Variables Related with Early Childhood Education Freshmen' Academic Interest - The Relationship Among Academic Self-Efficacy, Character Strengths and Learning Motivation - (전문대학 유아교육과 신입생의 학업흥미 관련 변인 탐색 - 학업적 자기효능감, 성격강점, 학업동기 간의 관계 -)

  • Park, Eun-Ju
    • Journal of Korea Entertainment Industry Association
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    • v.13 no.1
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    • pp.185-197
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    • 2019
  • This study intended to analyze the early childhood education freshmen's academic interest. For this study relationship among academic self-efficacy, character strength and learning motivation. The study subjects were 144 early childhood education freshmen at K-college in Deagu. They answered the survey regarding academic self-efficacy scale, VIA-IS(Values in action inventory of strength) short form scale, school learning motivation scale. The collected data were analyzed by frequency analysis, descriptive statistics, pearson correlation and multiple regression analysis using SPSS 18.0 program. The study finding are as follows. First, the average of academic self-efficacy, character strength and learning motivation of students were near at the intermediate-level. Second, academic self-efficacy, character strength and learning motivation were significantly positive correlated. Third, when examining the relative effect of early childhood education freshmen's academic self-efficacy and character strength on learning motivation, self regulatory efficacy among the sub-factors for academic self-efficacy and courage among the sub-factors for character strengths.

A Study on Construction of Digital Museum Archiving Regarding Dance Costume (무용공연작품 의상을 위한 디지털 뮤지엄 아카이빙 구축)

  • Jeong, Yu-Jin;Yoo, Ji-Young;Baek, Hyun-Soon
    • Journal of Korea Entertainment Industry Association
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    • v.13 no.1
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    • pp.81-88
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    • 2019
  • This article aims to identify the characters and theme shown in dance costume and utilize them from an educational perspective by constructing digital museum archiving, which can be systematically collected, classified and stored from dance costume. It deals with definition of digital museum archiving as theoretical background and examples of how to create digital museum archiving as research content. The role that archiving plays in digital museum and effectiveness have been demonstrated. Archive is a term used to indicate extensive material and its storage and referred to as an integrative model of display in the computer-generated space. When it comes to producing dance costume as a form of digital museum, the museum is to be made in the computer-generated area of dance costume. The museum shows each division of major, medium and minor classification. The major classification divides genre of dance performance into Korean dance, modern dance and ballet. The middle involves choreographers, costume designers. The minor categorization includes newspaper, interviews, performance pictures, and programs. Digital museum has the value of space utilization, creation, culture, utilization of multiple educational programs, offering of digital museum content, two-way communication, and program development of the new display form.