• Journal of Ginseng Research
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• v.43 no.3
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• pp.460-474
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• 2019

Background: Ginsenoside compound K (CK) is a promising drug candidate for rheumatoid arthritis. This study examined the impact of polymorphisms in NR1I2, adenosine triphosphate-binding cassette (ABC) transporter genes on the pharmacokinetics of CK in healthy Chinese individuals. Methods: Forty-two targeted variants in seven genes were genotyped in 54 participants using Sequenom MassARRAY system to investigate their association with major pharmacokinetic parameters of CK and its metabolite 20(S)-protopanaxadiol (PPD). Subsequently, molecular docking was simulated using the AutoDock Vina program. Results: ABCC4 rs1751034 TT and rs1189437 TT were associated with increased exposure of CK and decreased exposure of 20(S)-PPD, whereas CFTR rs4148688 heterozygous carriers had the lowest maximum concentration ($C_{max}$) of CK. The area under the curve from zero to the time of the last quantifiable concentration ($AUC_{last}$) of CK was decreased in NR1I2 rs1464602 and rs2472682 homozygous carriers, while $C_{max}$ was significantly reduced only in rs2472682. ABCC4 rs1151471 and CFTR rs2283054 influenced the pharmacokinetics of 20(S)-PPD. In addition, several variations in ABCC2, ABCC4, CFTR, and NR1I2 had minor effects on the pharmacokinetics of CK. Quality of the best homology model of multidrug resistance protein 4 (MRP4) was assessed, and the ligand interaction plot showed the mode of interaction of CK with different MRP4 residues. Conlusion: ABCC4 rs1751034 and rs1189437 affected the pharmacokinetics of both CK and 20(S)-PPD. NR1I2 rs1464602 and rs2472682 were only associated with the pharmacokinetics of CK. Thus, these hereditary variances could partly explain the interindividual differences in the pharmacokinetics of CK.

• The Korean Journal of Archival Studies
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• no.50
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• pp.97-138
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• 2016

This study presents the problems in the records management of special project teams at J University. Methods for the improvement plan were also proposed in this study. To achieve these objectives, five special project teams from J University, which were supported by the Ministry of Education, were selected. To collect relevant information, twelve staff members and experts were then interviewed. The records produced by the projects should be managed as evidence of the project evaluation and transparent budget execution. Proper management can be a good material for research. However, the management of project teams is vulnerable in comparison with the records of other universities. The main reason is that although the project team produces various types of records, it has not been recognized as the Department of Processing. Another reason is that the project teams are temporary institutions and do not possess authority over the entire project process. To solve the aforementioned problems, this study proposes improvement plans in the following aspects: institutional, cognitive, administrational, and systemic. In the institutional and cognitive aspects, policy and regulation were set up. In the administrational aspect, the relation and role of each element were defined. In conclusion, the plans for building the Combined Archives System were suggested. In addition the methods on how to connect with the KORUS-which will be introduced in 2017-and the system currently being used are proposed.

• Journal of Science Education
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• v.43 no.1
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• pp.94-118
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• 2019

The purpose of this study is to explore the multi-faceted understanding and issues of science subject matter competencies from the trends of competency-based curriculum discourse, and to examine the relationship between general core competencies and science subject matter competencies. First, we examined the theoretical background of competency-based curriculum focusing on behaviorism, humanism, and its comprehensive synthesis. After that, we reviewed OECD's competency-related projects (DeSeCo; OECD Education 2030), US Next-Generation Science Standards (NGSS) and Korea's 2015 Revised National Curriculum from the viewpoint of competency-based curriculum. After that, we summarized and systematically analyzed a list of competencies, 105 general core competencies and 45 science subject matter competencies proposed by 15 important documents from home and abroad. The results of this study are as follows: First, the issues of the proper number, appropriate dimension, and how individual competencies should be unique and independent were pointed, in terms of defining and categorizing competencies. Second, it was suggested that the competency items are presented in various dimensions such as personal-micro dimension, community meso-dimension, and social-macro dimension. Meso-dimension was placed on both general core competencies and subject matter competencies. Third, in the relationship between general core competencies and subject matter competencies, the former emphasizes macro-dimension, and the latter emphasizes micro-dimension, revealing an existing gap, and where the two can meet each other is the meso-dimension. These discussions are thought to provide insight into the understanding of competencies in the national curriculum, including the 2015 Revised National Curriculum.

• Journal of Convergence for Information Technology
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• v.9 no.6
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• pp.26-34
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• 2019

This descriptive convergence research is to get basic data for educational program by investigating awareness on pediatric nurses and nursing prospects after pediatric clinical practicum among 143 junior nursing students. Using SPSS/Win 21.0, t-test, ANOVA, Pearson correlation coefficient and stepwise multiple regression were carried out. The awareness of subjects on pediatric nurses was $4.09{\pm}0.61$ on a scale of 5, which was higher than the traditional and social ones, and nursing prospects' was $3.31{\pm}0.65$ on a scale of 5. There're significant differences partially in awareness on pediatric nurses according to sex, age, satisfaction in nursing and practium hospitals. Awareness on nursing prospects of those who had average satisfaction in nursing was higher than others(p<.002). There was a positive correlation between subvaribles of awareness on pediatric nurses and nursing prospects(r=.287~.510, p<.01), Traditional and social awareness were the significant factors on nursing prospects in hierarchical multiple regression, and the explannation rate was 29.2%(p<.001). It's needed to raise awareness on nursing prospects by improving traditional and social awareness on pediatric nurses.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.20 no.5
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• pp.384-393
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• 2019

This study was conducted to investigate the factors influencing the contraceptive behavior of male and female university students. Data were collected after receiving the written consent of 238 university students in G city during the period from September 22 to November 23 in 2017. Data analysis was performed using the SPSS PASW 18.0 program. The results revealed that 56.7% of the subjects used contraceptives, and 23.9% used condoms. Male students were more exposed to sexual content than female students (t=6.02, p=0.000) and had an open sexual attitude (t=5.38, p=0.000). Female students showed high scores on subjective norms (t=-3.51 p=0.000) and acceptable and positive contraceptive attitudes (t=-4.21, p=0.000). Among factors influencing the contraceptive attitude of males, the subjective norm was 3.6%. Female students had a 25.5% influence on contraceptive attitude, contraception, sexual education frequency, and sexual content exposure. It is suggested that sexual education and sexual counseling programs be developed to form positive attitudes toward contraceptives through iterative research.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.20 no.4
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• pp.648-655
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• 2019

This paper proposes the differential development of a Taekwondo electronic body protector. For this development, the most suitable sensor system was selected after analyzing and testing various sensor methods (magnetic sensors, electric capacity sensors, contact switch sensors, and piezo-film sensors) that could be applied in the electronic body protector, the selected sensors were distributed to the body and feet to make a more precise hit score, unlike the existing system in which all sensors are centralized on the body. Furthermore, it aims to illuminate using a lightweight film-type piezoelectric sensor on the body protector. In the case of an existing electronic body protector, all sensors and network device were concentrated on the body protector, so users need to purchase a set if they want it. On the other hand, the proposed system cloud can be used individually using a smart scoring WEP program. The effects of decreasing weight by up to 20% were compared with those of the existing system. Setting up a test facility is very difficult, so more study will be needed to analyze the effects of a hit.

• Management & Information Systems Review
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• v.38 no.1
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• pp.121-139
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• 2019

This study aims to identify the change of customer participation(CP) which is essential to the service industry as the relationship between the customer and the employee develops. The latent growth modeling analysis based on the longitudinal data is utilized to examine the pattern of the change. This is based on the fact that CP needs to be understood in the relationship and is to confirm the change in CP by the development of the relationship. Given the dynamics of the relationship, we intend to overcome the limitations of previous cross-sectional researches by revealing the trajectory of CP in the relationship through the longitudinal data. We also want to examine which variables in the relationship can facilitate changes of CP. Research has shown that CP is significantly changed with the development of the relationship when we analyzed it through latent growth modeling. This confirms that CP needs to be understood in the relationship. In addition, 'relationship proneness' variable and 'dependence to provider' variable have positive effects on the initial values of CP, but they have not been established to promote the changes of CP. Consequently, when considering the dynamics of relationships, it is important to recognize that CP is also dynamic. This study sought to get out of the cross-sectional and fragmented understanding of CP that is dynamic. Through this, we would like to propose the successful operation of the customer management program of service firms in relation to CP. This will lead to the success of service encounter where appropriate CP levels at each stage of relationship development can be achieved.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.20 no.5
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• pp.372-383
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• 2019

The purpose of this study was to investigate the efforts of Knowledge, Attitude and Perceptions of Patient Safety Culture on Fall Prevention Activities in Mental Hospital Nurses. This study is a descriptive research study of 153 nurses working in Busan and Gyeongnam mental health hospitals, the data were collected from April 4 to December 31, 2018. Data were analyzed using IBM SPSS/win 24.0 program, which included t-test, ANOVA and multiple regression analysis. As a result, The attitude toward falls differed depending on subject's license or qualifications, the higher the education level. The higher the level of perceptions of patient safety culture, and the higher the work experience, the more prevention activities toward falls. The higher the perception of patient safety culture, the higher the attitude toward falls. The higher the prevention activities toward falls, the higher the attitude of falls and the perceptions of safety culture. As a result of multiple regression analysis of factors affecting Knowledge, Attitude and Perceptions of Patient Safety Culture on Fall Prevention Activities were 12.5%. Therefore, in order to promote fall prevention activities of mental hospital nurses, the knowledge needs to be expanded through continuous education. Education programs should be developed and provided to change attitudes toward falls. and At the hospital organization level, a wide range of support is required, including changes in the overall human and institutional environment for safety.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.20 no.7
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• pp.520-527
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• 2019

In this study, the technical level and competence of Chungbuk region manufactures were diagnosed and implications for efficiency improvement of cooperation with local universities were derived. The results are as follow. First, in Chungbuk area, 75% of the skilled workers are medium-skilled and high skilled workers. And the life cycle of production products was found to have entered middle/old age. In addition, the industries were overestimating its technology capabilities, including marketing and sales technology, and management technology. Therefore, local universities should develop differentiated program such as technology transfer and commercialization support so that companies can nurture new industries and it is necessary to improve understanding of reality and future prediction ability through various education and seminars. Second, universities in Chungbuk province have failed to meet the practical demands of industry by providing general educational programs such as lifelong education curriculum, rather than the practical training required by industry. First of all, industries needed the practical training programs such as human resource empowerment, technical education and workers' retraining for local industry development. In addition, industries were expected to provide relevant knowledge and infrastructure such as testing, analysis, participation in technology development such as commissioning and joint research. Therefore, universities should prepare customized Industry-Academia Cooperation Programs through industry demand survey in planning. Also, it is necessary to establish various connection points with industry to ensure that industry-academia cooperation will continue and achieve results. Third, the technology of the industries in Chungbuk province was found to be very unrelated to the next generation regional strategic industries. This is not shared vision between industry and local government, Industry-Academia Cooperation Programs will serve as a platform to organize various community entities. Universities will be able to play a key role in between industries and local governments.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.20 no.7
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• pp.317-324
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• 2019

The purpose of this study is to find how the childcare teacher aptitude of students majoring in childcare and education influences their perception of teacher professionalism. To achieve that, a questionnaire survey was conducted with 216 early childhood preservice teachers living in A city. For data processing and analysis, SPSS program was used so as to conduct frequency analysis and calculate the mean and standard deviation. In addition, to test reliability and find relations between variables, Cronbach's ${\alpha}$, correlation analysis, and multiple regression analysis were conducted. As a result, firstly, in terms of the childcare teacher aptitude perceived by the students majoring in childcare and education, they highly perceived an affinity with young children and a sense of calling of their job; in terms of their perception of teacher professionalism, they highly perceived social necessity and vocational ethics. Secondly, early childhood preservice teachers' childcare teacher aptitude had a statistically significant correlation with their perception of teacher professionalism. Thirdly, the sub factors of early childhood preservice teachers' childcare teacher aptitude all positively influenced the sub factors of the perception of teacher professionalism. Given the study results, the students majoring in childcare and education perceived the importance of their aptitude of childcare teacher. In order to provide high-quality childcare service and create the positive aptitude of childcare teacher, it will be necessary to conduct a variety of basic research.