• 한국작물학회:학술대회논문집
• /
• 한국작물학회 2021년도 추계학술대회
• /
• pp.147-147
• /
• 2021

• 한국작물학회:학술대회논문집
• /
• 한국작물학회 2021년도 추계학술대회
• /
• pp.163-163
• /
• 2021

• 한국작물학회:학술대회논문집
• /
• 한국작물학회 2021년도 추계학술대회
• /
• pp.88-88
• /
• 2021

• 한국작물학회:학술대회논문집
• /
• 한국작물학회 2021년도 추계학술대회
• /
• pp.41-41
• /
• 2021

• Toxicological Research
• /
• 제24권3호
• /
• pp.175-182
• /
• 2008

DNA-dependent protein kinase(DNA-PK) is involved in joining DNA double-strand breaks induced by ionizing radiation or V(D)J recombination and is activated by DNA ends and composed of a DNA binding subunit, Ku, and a catalytic subunit, DNA-PKcs. It has been suggested that DNA-PK might be $2^{nd}$ upstream kinase for protein kinase B(PKB). In this report, we showed that Ser473 phosphorylation in the hydrophobic-motif of PKB is blocked in DNA-PK knockout mouse embryonic fibroblast cells(MEFs) following insulin stimulation, while there is no effect on Ser473 phosphorylation in DNA-PK wild type MEF cells. The observation is further confirmed in human glioblastoma cells expressing a mutant form of DNA-PK(M059J) and a wild-type of DNA-PK(M059K), indicating that DNA-PK is indeed important for PKB activation. Furthermore, the treatment of cells with doxorubicin, DNA-damage inducing agent, leads to PKB phosphorylation on Ser473 in control MEF cells while there is no response in DNA-PK knockout MEF cells. Together, these results proposed that DNA-PK has a potential role in insulin signaling as well as DNA-repair signaling pathway.

• 한국환경성돌연변이발암원학회:학술대회논문집
• /
• 한국환경성돌연변이발암원학회 2002년도 Molecular and Cellular Response to Toxic Substances
• /
• pp.163-163
• /
• 2002

• 한국환경성돌연변이발암원학회:학술대회논문집
• /
• 한국환경성돌연변이발암원학회 2003년도 춘계학술대회
• /
• pp.55-55
• /
• 2003

• 한국동물번식학회:학술대회논문집
• /
• 한국동물번식학회 2002년도 춘계학술발표대회 발표논문초록집
• /
• pp.181-181
• /
• 2002

• 해양환경안전학회:학술대회논문집
• /
• 해양환경안전학회 2009년도 춘계학술발표회
• /
• pp.25-25
• /
• 2009

• Bulletin of the Korean Chemical Society
• /
• 제34권10호
• /
• pp.3129-3132
• /
• 2013